2022 Fiscal Year Final Research Report
Elucidation of new functions of GPRC5B, a poor prognostic factor mediated by cancer-specific caveola
Project/Area Number |
21K21101
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0907:Oral science and related fields
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Research Institution | Kanagawa Dental College |
Principal Investigator |
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Project Period (FY) |
2021-08-30 – 2023-03-31
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Keywords | GPRC5B / 頭頸部扁平上皮癌 / 癌糖代謝 / 口腔癌 |
Outline of Final Research Achievements |
Comparison of GPRC5B expression levels and 5-year survival rates in each cancer carrier using an open database suggests that GPRC5B may act as a prognostic factor in many cancer types. Molecular biology studies using head and neck squamous cell carcinoma cell lines suggest that GPRC5B is involved in avoidance of glucose starvation-induced apoptosis in head and neck squamous cell cell lines.
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Free Research Field |
口腔癌、頭頸部癌
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Academic Significance and Societal Importance of the Research Achievements |
診断時にGPRC5Bの発現レベルを検討することで、ケトン食療法の治療前効果判定のマーカーとして応用できる可能性がある。GPRC5Bは受容体であるため、結合するリガンドを同定することで将来的に分子標的治療薬(抗体薬)としての応用も十分可能であると考える。
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