Genomic epidemiological study of the association between the development of chronic pain and vitamin D

2022 Fiscal Year Final Research Report

• Project/Area Number: 21K21251
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Kanazawa University
• Principal Investigator: SUZUKI Keita 金沢大学, 医学系, 協力研究員 (40758504)
• Project Period (FY): 2021-08-30 – 2023-03-31
• Keywords: 慢性疼痛 / ビタミンD / ビタミンD受容体 / ゲノム疫学

Outline of Final Research Achievements

We focused on five single nucleotide polymorphisms involved in the transcriptional activity of the vitamin D receptor gene in the present study. The association between chronic pain and 25-hydroxyvitamin D was examined according to the genotypes of the five single nucleotide polymorphisms. The results showed a significant association between the prevalence of chronic pain and low 25-hydroxyvitamin D concentrations in the participants with a mutant allele in the binding site for the intestinal-specific transcription factor CDX2 in the promoter region (rs11568820) of the vitamin D receptor.

Free Research Field

疫学

Academic Significance and Societal Importance of the Research Achievements

25水酸化ビタミンDと慢性疼痛の関連については世界的に多くの先行研究がなされているが、国内においては我々のグループからの報告に限られる。また、我々の研究成果は25水酸化ビタミンDと慢性疼痛の関連が対象者の特性によって異なることを示す世界で唯一のものである。得られた知見は、ビタミンD を用いた慢性疼痛の治療・予防法の発展と遺伝子情報を用いた慢性疼痛のオーダーメイドアプローチの確立につなげる。