2022 Fiscal Year Final Research Report
"Development of Skeletal Muscle Metabolic Imaging Using Temperature and Blood Flow Measurements with MRI"
Project/Area Number |
21K21260
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Multi-year Fund |
Review Section |
0909:Sports sciences, physical education, health sciences, and related fields
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Research Institution | Juntendo University |
Principal Investigator |
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Project Period (FY) |
2021-08-30 – 2023-03-31
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Keywords | 骨格筋 / MRI / 血流 / 温度 / 筋線維 |
Outline of Final Research Achievements |
We aimed to develop metabolic imaging of lower limb muscles using MRI, and verify it by evaluating blood flow and temperature during exercise. Since it was difficult to speed up temperature imaging to capture changes over time in phantom experiments, we worked on skeletal muscle imaging under exercise stress using T2*map. The T2*map was applied to the tibialis anterior muscle during dorsiflexion using a fixation aid, which enabled measurement of T2* values over time with reduced artifacts. 16 volunteers showed that T2* values increased gradually during exercise and changed most immediately after exercise, and correlation analysis between T2* values and muscle cross-sectional area showed that there was no correlation between T2* values and muscle cross-sectional area.
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Free Research Field |
MRI
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Academic Significance and Societal Importance of the Research Achievements |
これまでに報告された骨格筋線維のMRI研究は運動前後を比較するものが多く、運動中の信号変化を捉えたものはほとんどない。我々は3Dプリンタによる専用の固定具を作製するとともに運動負荷方法を工夫し、運動中のT2*値の変化を捉えることを達成した。この結果、運動中に徐々にT2*値が増加していき、運動直後にT2*値が最も変化するという傾向が明らかとなった。また、その後徐々に運動前のT2*値に戻るという事が判明した。これらは骨格筋のエネルギー代謝に伴う血液中のオキシヘモグロビンとデオキシヘモグロビンのバランスを反映していると考えられ、筋線維の代謝を間接的に捉えているものと考えられる。
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