がん研究分野の特性等を踏まえた支援活動

2013 Fiscal Year Annual Research Report

• Project Area: がん研究分野の特性等を踏まえた支援活動
• Project/Area Number: 221S0001
• Research Institution: The University of Tokyo
• Principal Investigator: 今井 浩三 東京大学, 医科学研究所, 特任教授 (60117603)
• Co-Investigator(Kenkyū-buntansha): 中村 卓郎 公益財団法人がん研究会, がん研究所 発がん研究部, 副所長 (00180373) ; 山村 研一 熊本大学, 生命資源研究・支援センター, 教授 (90115197) ; 八尾 良司 公益財団法人がん研究会, がん研究所 細胞生物部, 主任研究員 (80291095) ; 高野 洋志 公益財団法人がん研究会, がん研究所 細胞生物部, 研究員 (00241555) ; 高倉 彰 公益財団法人実験動物中央研究所, ICLASモニタリングセンター, 部長 (60167484) ; 中潟 直己 熊本大学, 生命資源研究・支援センター, 教授 (30159058) ; 加藤 秀樹 浜松医科大学, 医学部附属動物実験施設, 准教授 (30142053) ; 豊國 伸哉 名古屋大学, 医学系研究科, 教授 (90252460) ; 鰐渕 英機 大阪市立大学, 大学院医学研究科, 教授 (90220970) ; 小川 勝洋 旭川医科大学, 医学部, 名誉教授 (50045514) ; 渋谷 淳 東京農工大学, (連合)農学研究科(研究院), 教授 (20311392) ; 今井田 克己 香川大学, 医学部, 教授 (90160043) ; 二口 充 名古屋市立大学, 大学院医学研究科, 准教授 (60275120) ; 神田 浩明 公益財団法人がん研究会, がん研究所 病理部, 主任研究員 (90260067) ; 田中 英夫 愛知県がんセンター(研究所), 疫学・予防部, 部長 (60470168) ; 若井 建志 名古屋大学, 医学系研究科, 准教授 (50270989) ; 三上 春夫 千葉県がんセンター(研究所), がん予防センター・がん登録・予防疫学研究部, 部長 (10332355) ; 鈴木 貞夫 名古屋市立大学, 大学院医学研究科, 教授 (20226509) ; 喜多 義邦 滋賀医科大学, 医学部, 助教 (30147524) ; 渡辺 能行 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191809) ; 有澤 孝吉 徳島大学, 大学院ヘルスバイオサイエンス研究部(医学系), 教授 (30203384) ; 田中 恵太郎 佐賀大学, 医学部, 教授 (50217022) ; 嶽崎 俊郎 鹿児島大学, 医歯(薬)学総合研究科, 教授 (50227013) ; 古庄 憲浩 九州大学, 医学研究院, 准教授 (10346786) ; 樋野 興夫 順天堂大学, 医学部, 教授 (90127910) ; 玉腰 暁子 北海道大学, 医学(系)研究科(研究院), 教授 (90236737) ; 江口 英孝 埼玉医科大学, 医学部, 准教授 (00260232) ; 久保 充明 独立行政法人理化学研究所, 統合生命医科学研究センター, 副センター長 (30442958) ; 内藤 真理子 名古屋大学, 医学(系)研究科(研究院), 准教授 (10378010) ; 田原 栄俊 広島大学, 大学院医歯薬保健学研究院(薬), 教授 (00271065) ; 椙村 春彦 浜松医科大学, 医学部, 教授 (00196742) ; 永田 知里 岐阜大学, 大学院医学系研究科, 教授 (30283295) ; 大中 佳三 九州大学, 医学研究院, 講師 (30325518) ; 津金 昌一郎 独立行政法人国立がん研究センター, がん予防・検診研究センター, センター長 (40179982) ; 高山 哲治 徳島大学, 大学院ヘルスバイオサイエンス研究部(医学系), 教授 (10284994) ; 赤座 英之 東京大学, 先端科学技術研究センター, 特任教授 (70010486) ; 高橋 悟 日本大学, 医学部, 教授 (50197141) ; 舛森 直哉 札幌医科大学, 医学部, 准教授 (20295356) ; 内藤 誠二 九州大学, 医学研究院, 教授 (40164107) ; 並木 幹夫 金沢大学, 医学系, 教授 (70155985) ; 藤本 清秀 奈良県立医科大学, 医学部, 教授 (50264867) ; 藤岡 知昭 岩手医科大学, 医学部, 教授 (80173409) ; 堀江 重郎 順天堂大学, 医学(系)研究科(研究院), 教授 (40190243) ; 森 満 札幌医科大学, 医学部, 教授 (50175634) ; 森脇 久隆 岐阜大学, 大学院医学系研究科, 教授 (50174470) ; 神奈木 真理 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (80202034) ; 石田 高司 名古屋市立大学, 大学院医学研究科, 准教授 (80405183) ; 松岡 雅雄 京都大学, ウイルス研究所, 教授 (10244138) ; 山岡 昇司 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90263160) ; 田中 勇悦 琉球大学, 医学(系)研究科(研究院), 教授 (30163588) ; 渡邉 俊樹 東京大学, 大学院新領域創成科学研究科, 教授 (30182934) ; 醍醐 弥太郎 滋賀医科大学, 医学部, 教授 (30345029) ; 高橋 隆 名古屋大学, 大学院医学系研究科, 教授 (50231395) ; 宮城 洋平 地方独立行政法人神奈川県立病院機構神奈川県立がんセンター(臨床研究所), がん分子病態学部, 部長 (00254194) ; 旦 慎吾 公益財団法人がん研究会, がん化学療法センター 分子薬理部, 主任研究員 (70332202) ; 上原 至雅 岩手医科大学, 薬学部, 教授 (50160213) ; 吉田 稔 独立行政法人理化学研究所, 吉田化学遺伝学研究室, 主任研究員 (80191617) ; 井本 正哉 慶應義塾大学, 理工学部(矢上), 教授 (60213253) ; 清宮 啓之 公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 部長 (50280623) ; 深澤 秀輔 国立感染症研究所, 生物活性物質部, 室長 (10218878) ; 川田 学 公益財団法人微生物化学研究会, 微生物化学研究所 沼津支所, 主席研究員 (20300808) ; 長田 裕之 独立行政法人理化学研究所, ケミカルバイオロジー研究領域, 領域長 (80160836) ; 松浦 正明 公益財団法人がん研究会, がん研究所 がんゲノム研究部, 部長 (40173794) ; 馬島 哲夫 公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 研究員 (30311228) ; 水上 民夫 長浜バイオ大学, バイオサイエンス学部, 教授 (80367896) ; 時野 隆至 札幌医科大学, 医学部, 教授 (40202197) ; 鈴木 拓 札幌医科大学, 医学部, 教授 (20381254)
• Keywords: 若手支援 / 国際交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 個別化がん予防 / ATL発症予防 / アカデミア創薬

Research Abstract

総括支援：公開シンポジウム、ワークショップ（日仏、日韓、がん若手：95名参加・発表）、青少年市民公開講座開催。がん研究読本③をネット出版。
個体レベル支援：ES分与等18、Tg作製15、キメラ作製48、F1 29、ES細胞操作20、Flp/Creによるアレル変換19、CRIPR/Cas9関連4、モニタリング（微生物770、遺伝1770）、ジェノタイピング818、保存・クリーニング50系統、病理形態学26を支援、ワークショップ開催。
がん疫学・予防支援：9万9千名の研究者提供生体試料を用いた研究支援。テロメア長測定支援5、aberrant crypt fociをバイオマーカーとした大腸癌予防介入試験支援6、肥満と肝発癌関連実験モデル作成等がん予防への研究支援。HTLV-I研究支援：HTLV-1研究支援として、患者検体の免疫解析、プロウイルス量測定、抗ATLワクチン療法やCCR4抗体治療研究の後方支援、HTLV-1関連単クロン抗体の製造管理・供与、患者登録システムJSPFAD 8500検体の維持運営・検体供与を行なった。
臨床診断研究支援：組織・FFPE872、血清・DNA877のがん試料収集、8研究者に計2486を提供。腎、卵巣がん402からなる組織アレイ構築。肺がん等の15件の診断法検証支援で論文13編に貢献。組織バンク、技術支援と公開講演会開催。
化学療法基盤支援：寄託化合物の分子標的阻害活性評価、化合物ライブラリーの整備・配付。各種薬剤作用関連の遺伝子発現変動、がん新薬開発情報等をDB化、公開。シンポジウム（がん新薬開発合同、食品薬学）開催。
ゲノム・エピゲノム支援：腫瘍組織・FFPE検体等の409がん関連遺伝子の変異について10研究者から271検体を解析。腫瘍組織・正常対照部・細胞株のDNAメチル化解析を実施。3研究者から47遺伝子のプライマーを設計し、238検体を解析。

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

各支援活動とも、計画に沿って順調に支援を続けているが、以下の活動では計画以上の進展を示した。若手研究者支援では、「がん特定領域研究」時代以来の継続による積極的取組が功を奏し、がん研究を初めとする医学生物学系においてリーダーとなる人材が輩出するようになってきた。また、国際交流活動ではフランス、韓国、ドイツとの相互交流がより活発となり、共同研究や人材交流が一層盛んになっている。広報活動として、がん研究の現状を一般にわかりやすく解説したネット出版物「がん研究読本」も好評を得ている。また、市民公開講演会も実施し、本事業の成果を公表し、200人近くの市民が熱心に聴講した。
一方、研究者のネットワーク構築を背景として、臨床診断研究支援を初めとするがん研究者への支援から世界をリードするがん研究の論文成果が着実に挙げられている。さらに、当初の計画では大きな部分を占めてはいなかったが、脳・ゲノム支援活動との連携促進による生命科学系３分野としての活動が開始され、特にモデル動物に関する情報交換が盛んになったことから、今後一層の支援効率化が期待出来る状況になった。平成24年度から追加されたゲノム・エピゲノム解析支援も活動が進展し、患者サンプルのみならずモデル動物の解析態勢も整備されてきている。

Strategy for Future Research Activity

平成22～25年度の支援活動をより強固に継続するとともに、若手研究者を中心として科研費採択課題に対する積極的な支援を行う。がん若手研究シンポジウム及び、日仏・日独・日韓の２国間がんワークショップは本年も開催するが、今後の発展を見据えて育成・交流の成果を挙げたい。個体レベルの研究支援においては、CRISPR/Cas9に代表される最新テクノロジーを利用したモデル動物開発を進めるとともに、病理形態解析に細胞初期化を専門とする研究分担者を加えて、がんと再生・幹細胞研究の連携を推進する。また、個体レベルのがん研究ワークショップを引き続き開催して、支援の成果を公表する。がん疫学・予防支援では、コホート研究で得られた試料のがん研究への利用を倫理面での評価を行いながら推進する。臨床診断研究支援では、プロテオーム解析や組織アレイのさらなる充実化を図り、がん研究者へのヒト検体を用いた解析を支援することで、世界レベルの研究成果の増産を目指す。
化学療法基盤支援活動では、がん研究分野以外への支援も視野に入れた化合物の評価・スクリーニングを進める。がんゲノム・エピゲノム解析支援活動では、上述のように支援体制が整備されたので、ヒト検体・モデル動物検体に対する、遺伝子変異パネルの解析を推進する。
また、生命科学系３分野間の連携を一層促進し、今後の自然科学系の具体的な推進策を立案する。特に、本支援活動が、ボトムアップ支援と最先端技術を開発と一体化した体制を構築するよう検討を進める。

Research Products

• [Journal Article] Mesenchymal stem cells cancel azoxymethane-induced tumor initiation. (2014)
  • Author(s): Nasuno M, Arimura Y, Nagaishi K, Isshiki H, Onodera K, Nakagaki S, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y.
  • Journal Title: STEM CELLS Volume: 32(4) Pages: 913-925
  • DOI: 10.1002/stem.1594.
  • Peer Reviewed
• [Journal Article] Low serum level of high-sensitivity C-reactive protein in a Japanese subject with MODY3. (2014)
  • Author(s): Ohki T, Utsu Y, Morita S, Karim M.F., Sato Y, Yoshizawa T, Yamamura K, Yamada K, Kasayama S, Yamagata K.
  • Journal Title: J. Diabetes Invest. Volume: in press. Pages: －
  • Peer Reviewed
• [Journal Article] Autophagy regulation in the pancreatic acinar cells is independent of epidermal growth factor receptor signaling. (2014)
  • Author(s): Ozaki, N., Fukuchi, Y., Tomiyoshi, S., Uehara1, H., Ida, S., Wang, J., Kimi Araki, K., Sibilia, M., Baba, H., and Yamamura, K., and Ohmuraya, M.
  • Journal Title: Biochem. Biophysic. Res. Comm. Volume: in press. Pages: －
  • Peer Reviewed
• [Journal Article] mTORC1 controls the cell cycle of the earliest T-lineage-committed cells and its inactivation eradicates acute lymphoblastic T-cell leukemia in mice. (2014)
  • Author(s): Hoshii, T., Kasada, A., Hatakeyama, N., Ohtani,M., Tadokoro, Y., Naka, K., Ikenoue, T., Ikawa, T., Kawamoto, H., Araki, K., Yamamura, K., Matsuda, S. and Hirao, A.
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: in press. Pages: －
  • Peer Reviewed
• [Journal Article] Rescue In Vitro Fertilization Method for Legacy Stock of Frozen Mouse Sperm. (2014)
  • Author(s): Nakagata, N., Takeo, T., Fukumoto, K., Haruguchi, Y., Kondo, T., Takeshita, Y., Nakamuta, Y., Umeno, T. and Tsuchiyama, S.
  • Journal Title: J Reprod Dev Volume: 60 Pages: 167-170
  • Peer Reviewed
• [Journal Article] Preclinical evaluation of an O(6)-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains. (2014)
  • Author(s): Tsujiuchi T., Natsume A., Motomura K., Kondo G., Ranjit M., Hachisu R., Sugimura I., Tomita S., Takehara I., Woolley M., Barua N.U., Gill S.S., Bienemann A.S., Yamashita Y., Toyokuni S., Wakabayashi T.
  • Journal Title: Am J Transl Res. eCollection 2014 Volume: 6 Pages: 169-78
  • Peer Reviewed
• [Journal Article] A Novel Transgenic Mouse Model Carrying Human Tribbles Related Protein 3 (TRB3) Gene and Its Site Specific Phenotype. (2014)
  • Author(s): Y. Sakai, K. Fukamachi, M. Futakuchi, I. Miyoshi, H. Tsuda, M. Suzui, H. Hayashi.
  • Journal Title: Biol. Pharm. Bull. Volume: in press. Pages: -
  • Peer Reviewed
• [Journal Article] Importance of the progesterone receptor (PR) and the epidermal growth factor receptor (EGFR), but not the estrogen receptor (ER), for chemically induced lung carcinogenesis in female A/J mice. (2014)
  • Author(s): Kishi S., Yokohira M., Yamakawa K., Saoo K., Imaida K.
  • Journal Title: Oncol. Lett. Volume: in press Pages: －
  • Peer Reviewed
• [Journal Article] Cross-boundary Cancer Studies at the University of Tokyo: View from the world of science and reason. (2014)
  • Author(s): Akaza H.
  • Journal Title: Japanese journal of clinical oncology Volume: 44 Suppl 1 Pages: i3-5
  • DOI: 10.1093/jjco/hyt228
  • Peer Reviewed
• [Journal Article] Cross-boundary cancer studies at the University of Tokyo: Surviving cancer in Asia: introduction. (2014)
  • Author(s): Akaza H, Kawahara N.
  • Journal Title: Japanese journal of clinical oncology Volume: 44 Suppl 1 Pages: i1-2
  • DOI: 10.1093/jjco/hyt231
  • Peer Reviewed
• [Journal Article] Japanese Cancer Association Meeting UICC International session--what is cost-effectiveness in cancer treatment? (2014)
  • Author(s): Akaza H, Kawahara N, Roh JK et al.
  • Journal Title: Asian Pacific journal of cancer prevention : APJCP Volume: 15 Pages: 3-10
  • DOI: 10.7314/APJCP.2014.15.1.3
  • Peer Reviewed
• [Journal Article] Associations of dietary patterns with metabolic syndrome and insulin resistance: a cross-sectional study in a Japanese population. (2014)
  • Author(s): Arisawa K, Uemura H, Yamaguchi M et al.
  • Journal Title: J Med Invest Volume: in press Pages: -
  • Peer Reviewed
• [Journal Article] Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose in the Japanese general population. (2014)
  • Author(s): Hara M, Nakamura K, Nanri H, KIta Y, Suzuki S, Ohnaka K, Mikami H, Kubo M, Tanaka H et al.
  • Journal Title: Journal of epidemiology / Japan Epidemiological Association Volume: in press Pages: -
  • Peer Reviewed
• [Journal Article] Retrospective analysis of large-scale research screening of construction workers for the early diagnosis of mesothelioma. (2014)
  • Author(s): Hirohashi T, Igarashi K, Abe M, Hino O et al.
  • Journal Title: Molecular and clinical oncology Volume: 2 Pages: 26-30
  • DOI: 10.3892/mco.2013.197
  • Peer Reviewed
• [Journal Article] GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study. (2014)
  • Author(s): Hishida A, Takashima N, Turin TC, Wakai K, Suzuki S, Mikami H, Ohnaka K, Kubo M, Tanaka H, Kita Y et al.
  • Journal Title: Journal of nephrology Volume: 27 Pages: 143-149
  • DOI: 10.1007/s40620-013-0025-0
  • Peer Reviewed
• [Journal Article] ERC/mesothelin is expressed in human gastric cancer tissues and cell lines. (2014)
  • Author(s): Ito T, Kajino K, Abe M, Hino O et al.
  • Journal Title: Oncology reports Volume: 31 Pages: 27-33
  • DOI: 10.3892/or.2013.2803
  • Peer Reviewed
• [Journal Article] Comparison of plasma levels of nutrients-related biomarkers among Japanese populations in Tokyo, Japan, in Sao Paulo, Brazil, and in Hawaii, USA. (2014)
  • Author(s): Iwasaki M, Franke A, Hamada G, Tsugane S et al.
  • Journal Title: European Journal of Cancer Prevention Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] C-ERC/mesothelin provokes lymphatic invasion of colorectal adenocarcinoma. (2014)
  • Author(s): Kawamata F, Homma S, Kamachi H, Hino O et al.
  • Journal Title: Journal of gastroenterology Volume: 49 Pages: 81-92
  • DOI: 10.1007/s00535-013-0773-6
  • Peer Reviewed
• [Journal Article] ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. (2014)
  • Author(s): Matsuo H, Nakayama A, Sakiyama M, Wakai K et al.
  • Journal Title: Scientific reports Volume: 4 Pages: 3755
  • DOI: 10.1038/srep03755
  • Peer Reviewed
• [Journal Article] Plasma amino acid profiles are associated with biomarkers of breast cancer risk in premenopausal Japanese women. (2014)
  • Author(s): Nagata C, Wada K, Tsuji M et al.
  • Journal Title: Cancer causes & control : CCC Volume: 25 Pages: 143-149
  • DOI: 10.1007/s10552-013-0316-8
  • Peer Reviewed
• [Journal Article] Inverse correlation between serum interleukin-6 and iron levels among Japanese adults: a cross-sectional study. (2014)
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  • Journal Title: BMC hematology Volume: 14 Pages: 6
  • DOI: 10.1186/2052-1839-14-6
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• [Journal Article] Objectively measured physical activity and inflammatory cytokine levels in middle-aged Japanese people. (2014)
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  • DOI: 10.1016/j.ypmed.2014.04.004
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• [Journal Article] Biomarkers for predicting the efficacy of anti-epidermal growth factor receptor antibody in the treatment of colorectal cancer. (2014)
  • Author(s): Okada Y, Miyamoto H, Goji T, Takayama T.
  • Journal Title: Digestion Volume: 89 Pages: 18-23
  • DOI: 10.1159/000356202
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• [Journal Article] IGKC and FcgammaR genotypes and humoral immunity to HER2 in breast cancer. (2014)
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  • Journal Title: Immunobiology Volume: 219 Pages: 113-117
  • DOI: 10.1016/j.imbio.2013.08.005
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• [Journal Article] A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility. (2014)
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  • Journal Title: Human cell Volume: 27 Pages: 1-4
  • DOI: 10.1007/s13577-013-0081-8
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• [Journal Article] High antitumor activity of pladienolide B and its derivative in gastric cancer. (2014)
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  • Journal Title: Cancer science Volume: 105 Pages: 110-116
  • DOI: 10.1111/cas.12317
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• [Journal Article] A novel somatic FGFR3 mutation in primary lung cancer. (2014)
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  • DOI: 10.3892/or.2014.2984
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• [Journal Article] TNK2 gene amplification is a novel predictor of a poor prognosis in patients with gastric cancer. (2014)
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  • Journal Title: Journal of surgical oncology Volume: 109 Pages: 189-197
  • DOI: 10.1002/jso.23482
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• [Journal Article] Counts of Slackia sp. strain NATTS in intestinal flora are correlated to serum concentrations of equol both in prostate cancer cases and controls in Japanese men. (2014)
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  • Journal Title: J Cancer Prev Volume: in press Pages: -
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• [Journal Article] Breakages at YWHAE, FAM22A, and FAM22B loci in uterine angiosarcoma: a case report with immunohistochemical and genetic analysis. (2014)
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  • Journal Title: Pathology, research and practice Volume: 210 Pages: 130-134
  • DOI: 10.1016/j.prp.2013.09.009
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• [Journal Article] An autopsy case of malignant pleural mesothelioma associated with nephrotic syndrome. (2014)
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  • Journal Title: Internal medicine Volume: 53 Pages: 243-246
  • DOI: 10.2169/internalmedicine.53.1313
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• [Journal Article] Advances in cancer epidemiology in Japan. (2014)
  • Author(s): Tanaka H.
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• [Journal Article] Multicenter phase II study of mogamulizumab (KW-0761), a defucosylated anti-CCR4 antibody, in patients with relapsed peripheral T-cell lymphoma and cutaneous T-cell lymphoma. (2014)
  • Author(s): Ogura M*, Ishida T*, Hatake K, Taniwaki M, Ando K, Tobinai K, Fujimoto K, Yamamoto K, Miyamoto T, Uike N, Tanimoto M, Tsukasaki K, Ishizawa K, Suzumiya J, Inagaki H, Tamura K, Akinaga S, Tomonaga M, Ueda R.
  • Journal Title: J Clin Oncol, Volume: 32(11) Pages: 1157-1163
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• [Journal Article] Reactivation of hepatitis B virus in a patient with adult T-cell leukemia-lymphoma receiving the anti-CC chemokine receptor 4 antibody mogamulizumab. (2014)
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  • Journal Title: Hepatol Res. Volume: 44(3) Pages: 354-357
  • DOI: 10.1111/hepr.12117
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• [Journal Article] Multimodal Effects of Small Molecule ROCK and LIMK Inhibitors on Mitosis, and Their Implication as Anti-Leukemia Agents. (2014)
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  • Journal Title: PLoS One Volume: 9(3) Pages: e92402
  • DOI: 10.1371/journal.pone.0092402
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• [Journal Article] A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/β-catenin Pathway. (2014)
  • Author(s): Nishiya N, Oku Y, Kumagai Y, Sato Y, Yamaguchi E, Sasaki A, Shoji M, Ohnishi Y, Okamoto H, Uehara Y.
  • Journal Title: Chem. Biol. Volume: in press. Pages: -
  • DOI: 10.1016/j.chembiol.2014.02.015.
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• [Journal Article] Genetically encoded FRET indicators for live-cell imaging of histone acetylation. (2014)
  • Author(s): Sasaki K, Yoshida M.
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• [Journal Article] 5-Lipoxygenase and CysLT1 regulate EGF‐induced cell migration through Tiam1 upregulation and Rac1 activation. (2014)
  • Author(s): Magi S, Takemoto Y, Kobayashi H, Kasamatsu M, Akita T, Tanaka A, Takano K, Tashiro E, Igarashi Y, Imoto M.
  • Journal Title: Cancer Science. Volume: 105 Pages: 290-296
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• [Journal Article] Retinoids and rexinoids inhibit hepatitis C virus independently of retinoid receptor signaling. (2014)
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  • Journal Title: Microbes and Infection Volume: 16 Pages: 114-122.
  • DOI: 10.1016/j.micinf.2013.10.016
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• [Journal Article] Aberrant methylation of microRNA-34b/c is a predictive marker of metachronous gastric cancer risk. (2013)
  • Author(s): Suzuki R, Yamamoto E, Nojima M, Maruyama R, Yamano HO, Yoshikawa K, Kimura T, Harada T, Ashida M, Niinuma T, Sato A, Nosho K, Yamamoto H, Kai M, Sugai T, Imai K, Suzuki H, Shinomura Y.
  • Journal Title: J Gastroenterol Volume: [Epub ahead of print] Pages: -
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• [Journal Article] Methylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer. (2013)
  • Author(s): Shimizu T, Suzuki H, Nojima M, Kitamura H, Yamamoto E, Maruyama R, Ashida M, Hatahira T, Kai M, Masumori N, Tokino T, Imai K, Tsukamoto T, Toyota M.
  • Journal Title: Eur Urol Volume: 63(6) Pages: 1091-1100
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• [Journal Article] Association between genomic alterations and metastatic behavior of colorectal cancer identified by array-based comparative genomic hybridization. (2013)
  • Author(s): Sawada T, Yamamoto E, Suzuki H, Nojima M, Maruyama R, Shioi Y, Akasaka R, Kamimae S, Harada T, Ashida M, Kai M, Adachi Y, Yamamoto H, Imai K, Toyota M, Itoh F, Sugai T.
  • Journal Title: Genes Chromosomes Cancer. Volume: 52(2) Pages: 140-149
  • DOI: 10.1002/gcc.22013
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• [Journal Article] Report of the Japan Diabetes Society/Japanese Cancer Association joint committee on diabetes and cancer. (2013)
  • Author(s): Kasuga M, Ueki K, Tajima N, Noda M, Ohashi K, Noto H, Goto A, Ogawa W, Sakai R, Tsugane S, Hamajima N, Nakagama H, Tajima K, Miyazono K, Imai K.
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• [Journal Article] PADI4 regulates proliferation of hematopoietic stem/multipotent cells via controlling c-Myc expression. (2013)
  • Author(s): Nakashima, K., Arai, S., Suzuki, A., Nariai, Y., Urano, T., Nakayama, M., Ohara, O., Yamamura, K., Yamamoto, K. and Miyazaki, T.
  • Journal Title: Nature Comm. Volume: 4 Pages: 1836
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• [Journal Article] Obesity-associated autoantibody production requires AIM to retain IgM immune complex on follicular dendritic cells. (2013)
  • Author(s): Arai, A., Morita, K., Maehara, K., Iwamura, Y., Honda, S., Nakashima, K., Kurokawa, J., Mori, M., Motoi, Y., Miyake, K., Yamamura, K., Ohara, O., Shibuya, A., Wakeland, E. K., Li, Q.-Z. and Miyazaki, T.
  • Journal Title: Cell Report Volume: 3 Pages: 1187-1198
  • DOI: 10.1016/j.celrep.2013.03.006
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• [Journal Article] Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. (2013)
  • Author(s): Nakahara, M., Tateyama, H., Araki, M., Nakagata, N., Yamamura, K. and Araki, K.
  • Journal Title: Mammal Genome Volume: 24 Pages: 228-239
  • DOI: 10.1007/s00335-013-9452-4
  • Peer Reviewed
• [Journal Article] Investigations of motility and fertilization potential in thawed cryopreserved mouse sperm from cold-stored epididymides. (2013)
  • Author(s): Takeo, T., Fukumoto, K., Kondo, T., Haruguchi, Y., Takeshita, Y., Nakamuta, Y., Tsuchiyama, S., Yoshimoto, H., Shimizu, N., Li, MW., Kinchen, K., Vallelunga, J., Lloyd, KC. and Nakagata, N.
  • Journal Title: Cryobiology. Volume: 68(1) Pages: 12-7
  • DOI: 10.1016/j.cryobiol.2013.10.007. Epub 2013 Nov 4.
  • Peer Reviewed
• [Journal Article] Applications of cryopreserved unfertilized mouse oocytes for in vitro fertilization. (2013)
  • Author(s): Nakagata, N., Takeo, T., Fukumoto, K., Kondo, T., Haruguchi, Y., Takeshita, Y., Nakamuta, Y., Matsunaga, H., Tsuchiyama, S., Ishizuka, Y. and Araki, K.
  • Journal Title: Cryobiology. Volume: 67(2) Pages: 188-92
  • DOI: 10.1016/j.cryobiol.2013.06.011.Epub 2013.
  • Peer Reviewed
• [Journal Article] Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. (2013)
  • Author(s): Yoshimoto, S., Loo, TM., Atarashi, K., Kanda, H., Sato, S., Oyadomari, S., Iwakura, Y., Oshima, K., Morita, H., Hattori, M., Honda, K., Ishikawa, Y., Hara, E. and Ohtani N.
  • Journal Title: Nature Volume: 499 Pages: 97-101
  • DOI: 10.1038/nature12347
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• [Journal Article] Novel mouse model for Gardner syndrome generated by a large-scale ENU mutagenesis program. (2013)
  • Author(s): Toki, H., Inoue, M., Motegi, H., Minowa, O., Kanda, H., Yamamoto, N., Ikeda, A., Karashima, Y., Matsui, J., Kaneda, H., Miura, I., Suzuki, T., Masuya, H., Wakana, S., Gondo, Y., Shiroishi, T., Akiyama, T., Yao, R. and Noda, T.
  • Journal Title: Cancer Science Volume: 104 Pages: 937-944
  • DOI: 10.1111/cas.12161.
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• [Journal Article] Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. (2013)
  • Author(s): Hotta H., Hamamura K., Yamashita K,. Shibuya H., Tokuda N., Hashimoto N., Furukawa K., Yamamoto N., Hattori H., Toyokuni S., Ueda M., Furukawa K.
  • Journal Title: Glycoconj J Volume: 30 Pages: 585-597
  • DOI: 10.1007/s10719-012-9458-2.
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• [Journal Article] CD146 and IMP3 predict prognosis of asbestos-induced rat mesothelioma. (2013)
  • Author(s): Okazaki Y., Nagai H., Chew S.H., Jiang L., Funahashi S., Tsujimura T. and Toyokuni S.
  • Journal Title: Cancer Sci Volume: 104 Pages: 989-995
  • DOI: 10.1111/cas.12185.
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• [Journal Article] Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats. (2013)
  • Author(s): Nagai H., Okazaki Y., Chew S.H., Misawa N., Miyata Y., Shinohara N. and Toyokuni S.
  • Journal Title: Pathol Int Volume: 63 Pages: 457-462
  • DOI: 10.1111/pin.12093.
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• [Journal Article] Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelila carcinogenesis in rats. (2013)
  • Author(s): Nagai H., Okazaki Y., Chew S.H., Misawa N., Yasui H. and Toyokuni S.
  • Journal Title: Cance Prev Res Volume: 6 Pages: 1222-30
  • DOI: 10.1158/1940-6207.CAPR-13-0244.
  • Peer Reviewed
• [Journal Article] A novel reporter rat strain that expresses LacZ upon Cre-mediated recombination. (2013)
  • Author(s): K. Fukamachi, H. Tanaka, Y. Sakai, D.B. Alexander, M. Futakuchi, H. Tsuda, M. Suzui.
  • Journal Title: Genesis Volume: 51 Pages: 268-274
  • DOI: 10.1002/dvg.22371.
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• [Journal Article] Promotive effects of cell proliferation and chromosomal instability induced by tribbles-related protein 3 in mouse mammary tumor cells. (2013)
  • Author(s): Y. Sakai, K. Fukamachi, M. Futakuchi, H. Hayashi, M. Suzui.
  • Journal Title: Oncology reports Volume: 30 Pages: 64-70
  • DOI: 10.3892/or.2013.2441.
  • Peer Reviewed
• [Journal Article] Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles. (2013)
  • Author(s): J. Xu, M. Futakuchi, D.B. Alexander, K. Fukamachi, T. Numano, M. Suzui, H. Shimizu, T. Omori, J. Kanno, A. Hirose, H. Tsuda.
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  • DOI: 10.1007/s00204-013-1086-5.
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• [Journal Article] Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. (2013)
  • Author(s): Toba, S., Tamura, Y., Kumamoto, K., Yamada, M., Takao, K., Hattori, S., Miyakawa, T., Kataoka, Y., Azuma, M., Hayasaka, K., Amamoto, M., Tominaga, K., Wynshaw-Boris, A., Wanibuchi, H., Oka, Y., Sato, M., Kato, M., Hirotsune, S.
  • Journal Title: Sci Rep Volume: 3 Pages: 1224
  • DOI: 10.1038/srep01224.
  • Peer Reviewed
• [Journal Article] MUC5AC protects pancreatic cancer cells from TRAIL-induced death pathways. (2013)
  • Author(s): Hoshi, H., Sawada, T., Uchida, M., Iijima, H., Kimura, K., Hirakawa, K., Wanibuchi, H.
  • Journal Title: Int J Oncol Volume: 42 Pages: 887-893
  • DOI: 10.3892/ijo.2013.1760.
  • Peer Reviewed
• [Journal Article] Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways. (2013)
  • Author(s): Kakehashi, A., Hagiwara, A., Imai, N., Nagano, K., Nishimaki, F., Banton, M., Wei, M., Fukushima, S., Wanibuchi, H.
  • Journal Title: Toxicol Appl Pharmacol Volume: 273 Pages: 390-400
  • DOI: 10.1016/j.taap.2013.09.016.
  • Peer Reviewed
• [Journal Article] Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitroso-tris-chloroethylurea in mice. (2013)
  • Author(s): Tago, Y., Yamano, S., Wei, M., Kakehashi, A., Kitano, M., Fujioka, M., Ishii, N., Wanibuchi, H.
  • Journal Title: Cancer Sci. Volume: 104 Pages: 1560-1566
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• [Journal Article] Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line. (2013)
  • Author(s): Takahashi, K., Tanaka, M., Inagaki, A., Wanibuchi, H., Izumi, Y., Miura, K., Nagayama, K., Shiota, M., Iwao, H.
  • Journal Title: Int J Oncol Volume: 43 Pages: 1985-1991
  • DOI: 10.3892/ijo.2013.2135.
  • Peer Reviewed
• [Journal Article] Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DAN damage in rats. (2013)
  • Author(s): Wei, M., Yamada, T., Yamano, S., Kato, M., Kakehashi, A., Fujioka, M., Tago, Y., Kitano, M., Wanibuchi, H.
  • Journal Title: Toxicol Appl Pharmacol Volume: 273 Pages: 1-9
  • DOI: 10.1016/j.taap.2013.08.022.
  • Peer Reviewed
• [Journal Article] L-leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes. (2013)
  • Author(s): Xie, X.L., Kakehashi, A., Wei, M., Yamano, S., Takeshita, M., Yunoki, T., Wanibuchi, H.
  • Journal Title: Food Chem Toxicol Volume: 59 Pages: 137-144
  • DOI: 10.1016/j.fct.2013.05.044.
  • Peer Reviewed
• [Journal Article] Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer. (2013)
  • Author(s): Yabushita, S., Fukamachi, K., Kikuchi, F., Ozaki, M., Miyata, K., Sukata, T., Deguchi, Y., Tanaka, H., Kakehashi, A., Kawamura, S., Uwagawa, S., Wanibuchi, H., Suzui, M., Alexander, D.B., Tsuda, H.
  • Journal Title: Pancreas Volume: 42 Pages: 1034-1039
  • DOI: 10.1097/MPA.0b013e3182883624.
  • Peer Reviewed
• [Journal Article] Napsin A is possibly useful marker to predict the tumorigenic potential of lung bronchiolo-alveolar hyperplasia in F344 rats. (2013)
  • Author(s): Yokohira M., Kishi S., Yamakawa K., Nakano Y., Ninomiya F., Kinouch S., Tanizawa J., Saoo K., Imaida K.
  • Journal Title: Exp. Toxicol. Pathol. Volume: 66 Pages: 117-23
  • DOI: 10.1016/j.etp.2013.11.002. Epub 2013 Dec 2.
  • Peer Reviewed
• [Journal Article] Gender-dependent effects of gonadectomy on lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in female and male A/J mice. (2013)
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  • Journal Title: Oncol Rep Volume: 30 Pages: 2632-2638
  • DOI: 10.3892/or.2013.2759. Epub 2013 Oct 1
  • Peer Reviewed
• [Journal Article] Strain differences in pleural mesothelial cell reactions induced by potassium octatitanate fibers (TISMO) infused directly into the thoracic cavity. (2013)
  • Author(s): Yokohira M., Nakano Y., Yamakawa K., Kishi S., Ninomiya F., Saoo K., Imaida K.
  • Journal Title: Exp. Toxicol. Pathol. Volume: 65(6) Pages: 925-932
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  • Peer Reviewed
• [Journal Article] Challenges and outlook for the UICC-Asian Regional Office. (2013)
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  • Journal Title: Asian Pacific journal of cancer prevention : APJCP Volume: 14 Pages: 4935-4937
  • DOI: 10.7314/APJCP.2013.14.8.4935
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• [Journal Article] Union for International Cancer Control International Session: healthcare economics: the significance of the UN Summit non-communicable diseases political declaration in Asia. (2013)
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  • Journal Title: Cancer science Volume: 104 Pages: 773-778
  • DOI: 10.1111/cas.12142
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• [Journal Article] CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men. (2013)
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  • Journal Title: World journal of gastroenterology : WJG Volume: 19 Pages: 4023-4030
  • DOI: 10.3748/wjg.v19.i25.4023
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• [Journal Article] Coffee consumption, serum gamma-glutamyltransferase, and glucose tolerance status in middle-aged Japanese men. (2013)
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  • Journal Title: Clinical chemistry and laboratory medicine Volume: 51 Pages: 1233-1239
  • DOI: 10.1515/cclm-2012-0700
  • Peer Reviewed
• [Journal Article] MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study. (2013)
  • Author(s): Hishida A, Okada R, Guang Y, Naito M, Wakai K, Suzuki S, Mikami H, Kubo M, Tanaka H et al.
  • Journal Title: International urology and nephrology Volume: 45 Pages: 1613-1620
  • DOI: 10.1007/s11255-013-0432-0
  • Peer Reviewed
• [Journal Article] Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study. (2013)
  • Author(s): Hishida A, Okada R, Naito M, Wakai K, Suzuki S, Mikami H, Arisawa K, KUbo M, Tanaka H et al.
  • Journal Title: Journal of clinical biochemistry and nutrition Volume: 53 Pages: 15-20
  • DOI: 10.3164/jcbn.13-17
  • Peer Reviewed
• [Journal Article] Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study. (2013)
  • Author(s): Hishida A, Wakai K, Naito M, Suzuki S, Mikami H, Ohnaka K, Watanabe Y, Arisawa K, Kubo M, Tanaka H et al.
  • Journal Title: PPAR research 2013 Volume: - Pages: 980471
  • DOI: 10.1155/2013/980471
  • Peer Reviewed
• [Journal Article] Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese--the J-MICC Study. (2013)
  • Author(s): Hishida A, Wakai K, Okada R, Suzuki S, Mikami H, Kubo M, Tanaka H, Naito M et al.
  • Journal Title: Endocrine journal Volume: 60 Pages: 237-243
  • DOI: 10.1507/endocrj.EJ12-0307
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• [Journal Article] Establishment and characterization of a mutagenized cell line exhibiting the 'cell-in-cell' phenotype at a high frequency. (2013)
  • Author(s): Kahyo T, Sugimura H.
  • Journal Title: Genes to cells : devoted to molecular & cellular mechanisms Volume: 18 Pages: 1042-1052
  • DOI: 10.1111/gtc.12092
  • Peer Reviewed
• [Journal Article] Identification and association study with lung cancer for novel insertion polymorphisms of human endogenous retrovirus. (2013)
  • Author(s): Kahyo T, Tao H, Shinmura K, Sugimura H et al.
  • Journal Title: Carcinogenesis Volume: 34 Pages: 2531-2538
  • DOI: 10.1093/carcin/bgt253
  • Peer Reviewed
• [Journal Article] Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci. (2013)
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  • Journal Title: Hypertension Volume: 62 Pages: 853-859
  • DOI: 10.1161/HYPERTENSIONAHA.113.01148
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• [Journal Article] Association of inflammatory gene polymorphisms and conventional risk factors with arterial stiffness by age. (2013)
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  • Journal Title: Journal of epidemiology / Japan Epidemiological Association Volume: 23 Pages: 457-465
  • DOI: 10.2188/jea.JE20130054
  • Peer Reviewed
• [Journal Article] Visualization of phosphatidylcholine (16:0/16:0) in type II alveolar epithelial cells in the human lung using imaging mass spectrometry. (2013)
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  • Journal Title: Pathology international Volume: 63 Pages: 195-200
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• [Journal Article] Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4. (2013)
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  • Journal Title: Cancer science Volume: 104 Pages: 1295-302
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• [Journal Article] SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. (2013)
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• [Journal Article] CD74-ROS1 fusion transcripts in resected non-small cell lung carcinoma. (2013)
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  • Journal Title: Oncology reports Volume: 30 Pages: 1675-1680
  • DOI: 10.3892/or.2013.2630
  • Peer Reviewed
• [Journal Article] The N-ERC index is a novel monitoring and prognostic marker for advanced malignant pleural mesothelioma. (2013)
  • Author(s): Mori T, Tajima K, Hirama M, Hino O et al.
  • Journal Title: Journal of thoracic disease Volume: 5 Pages: 145-148
  • DOI: 10.3978/j.issn.2072-1439.2013.03.03
  • Peer Reviewed
• [Journal Article] Large-scale survey of frequency of forest walking and related factors in a Japanese population inhabiting a large city, and comparison of an urban area and a rural area. (2013)
  • Author(s): Morita E, Aoyama K, Tamura T, Naito M, Wakai K et al.
  • Journal Title: Journal of Forest Research Volume: 18 Pages: 454-461
  • DOI: 10.1007/s10310-012-0375-9
  • Peer Reviewed
• [Journal Article] Endoscopic Molecular Imaging: Status and Future Perspective. (2013)
  • Author(s): Muguruma N, Miyamoto H, Okahisa T, Takayama T.
  • Journal Title: Clinical endoscopy Volume: 46 Pages: 603-610
  • DOI: 10.5946/ce.2013.46.6.603
  • Peer Reviewed
• [Journal Article] Gene-gene combination effect and interactions among ABCA1, APOA1, SR-B1, and CETP polymorphisms for serum high-density lipoprotein-cholesterol in the Japanese population. (2013)
  • Author(s): Nakamura A, Niimura H, Kuwabara K, Takezaki T, Wakai K, Suzuki S, Ohnaka K, Mikami H, Kubo M, Tanaka H et al.
  • Journal Title: PloS one Volume: 8 Pages: e82046
  • DOI: 10.1371/journal.pone.0082046
  • Peer Reviewed
• [Journal Article] A common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. (2013)
  • Author(s): Nakayama A, Matsuo H, Shimizu T, Wakai K et al.
  • Journal Title: Human cell Volume: 26 Pages: 133-136
  • DOI: 10.1007/s13577-013-0073-8
  • Peer Reviewed
• [Journal Article] Prostate cancer stem-like cells/cancer-initiating cells have an autocrine system of hepatocyte growth factor. (2013)
  • Author(s): Nishida S, Hirohashi Y, Torigoe T, Masumori N et al.
  • Journal Title: Cancer science Volume: 104 Pages: 431-436
  • DOI: 10.1111/cas.12104
  • Peer Reviewed
• [Journal Article] Mesothelin expression is a prognostic factor in cholangiocellular carcinoma. (2013)
  • Author(s): Nomura R, Fujii H, Abe M, Hino O et al.
  • Journal Title: International surgery Volume: 98 Pages: 164-169
  • DOI: 10.9738/INTSURG-D-13-00001.1
  • Peer Reviewed
• [Journal Article] Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone. (2013)
  • Author(s): Ofude M, Mizokami A, Kumaki M, Namiki M et al.
  • Journal Title: Anticancer research Volume: 33 Pages: 4453-4461
  • Peer Reviewed
• [Journal Article] Endoscopy of Aberrant Crypt Foci: The Expert Approach. (2013)
  • Author(s): Okamoto K, Takaoka T, Muguruma, Takayama T N et al.
  • Journal Title: Video Journal and Encyclopedia of GI Endoscopy Volume: 1 Pages: 357-358
  • DOI: 10.1016/S2212-0971(13)70156-0
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-alpha promotes cholestasis-induced liver fibrosis in the mouse through tissue inhibitor of metalloproteinase-1 production in hepatic stellate cells. (2013)
  • Author(s): Osawa Y, Hoshi M, Yasuda I, Moriwaki H et al.
  • Journal Title: PloS one Volume: 8 Pages: e65251
  • DOI: 10.1371/journal.pone.0065251
  • Peer Reviewed
• [Journal Article] Liver acid sphingomyelinase inhibits growth of metastatic colon cancer. (2013)
  • Author(s): Osawa Y, Suetsugu A, Matsushima-Nishiwaki R, Moriwaki H et al.
  • Journal Title: The Journal of clinical investigation Volume: 123 Pages: 834-843
  • DOI: 10.1172/JCI65188
  • Peer Reviewed
• [Journal Article] Racially restricted contribution of immunoglobulin Fcgamma and Fcgamma receptor genotypes to humoral immunity to human epidermal growth factor receptor 2 in breast cancer. (2013)
  • Author(s): Pandey JP, Namboodiri AM, Kistner-Griffin E, Tsugane S et al.
  • Journal Title: Clinical and experimental immunology Volume: 171 Pages: 273-277
  • DOI: 10.1111/cei.12018
  • Peer Reviewed
• [Journal Article] The effect of acyclic retinoid on the metabolomic profiles of hepatocytes and hepatocellular carcinoma cells. (2013)
  • Author(s): Qin XY, Wei F, Tanokura M, Moriwaki H et al.
  • Journal Title: PloS one Volume: 8 Pages: e82860
  • DOI: 10.1371/journal.pone.0082860
  • Peer Reviewed
• [Journal Article] Gender-Specific Associations of Perceived Stress and Coping Strategies with C-Reactive Protein in Middle-Aged and Older Men and Women. (2013)
  • Author(s): Shimanoe C, Otsuka Y, Hara M, Tanaka K et al.
  • Journal Title: International journal of behavioral medicine Volume: - Pages: -
  • DOI: 10.1007/s12529-013-9341-y
  • Peer Reviewed
• [Journal Article] D2-40-positive lymphatic vessel invasion is not a poor prognostic factor in stage I lung adenocarcinoma. (2013)
  • Author(s): Shimizu K, Funai K, Sugimura H et al.
  • Journal Title: Pathology international Volume: 63 Pages: 201-205
  • DOI: 10.1111/pin.12048
  • Peer Reviewed
• [Journal Article] Obesity and hepatocellular carcinoma: targeting obesity-related inflammation for chemoprevention of liver carcinogenesis. (2013)
  • Author(s): Shimizu M, Tanaka T, Moriwaki H.
  • Journal Title: Seminars in immunopathology Volume: 35 Pages: 191-202
  • DOI: 10.1007/s00281-012-0336-6
  • Peer Reviewed
• [Journal Article] Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1. (2013)
  • Author(s): Shiotani B, Nguyen HD, Hakansson P, Tahara H et al.
  • Journal Title: Cell reports Volume: 3 Pages: 1651-1662
  • DOI: 10.1016/j.celrep.2013.04.018
  • Peer Reviewed
• [Journal Article] Early-onset diffuse gastric cancer associated with a de novo large genomic deletion of CDH1 gene. (2013)
  • Author(s): Sugimoto S, Yamada H, Takahashi M, Sugimura H et al.
  • Journal Title: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Volume: - Pages: -
  • DOI: 10.1007/s10120-013-0278-2
  • Peer Reviewed
• [Journal Article] Editorial: an obsession with subtyping gastric cancer. (2013)
  • Author(s): Sugimura H.
  • Journal Title: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Volume: 16 Pages: 451-453
  • DOI: 10.1007/s10120-013-0243-0
  • Peer Reviewed
• [Journal Article] Obesity/weight gain and breast cancer risk: findings from the Japan collaborative cohort study for the evaluation of cancer risk. (2013)
  • Author(s): Suzuki S, Kojima M, Tokudome S, Wakai K, Tamakoshi A et al.
  • Journal Title: Journal of epidemiology / Japan Epidemiological Association Volume: 23 Pages: 139-145
  • DOI: 10.2188
  • Peer Reviewed
• [Journal Article] Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2. (2013)
  • Author(s): Takayama T, Takaoka N, Nagata M, Sugimura H et al.
  • Journal Title: Clinical genetics Volume: - Pages: -
  • DOI: 10.1111/cge.12292
  • Peer Reviewed
• [Journal Article] Significant association of urokinase plasminogen activator Pro141Leu with serum lipid profiles in a Japanese population. (2013)
  • Author(s): Tamura T, Morita E, Kawai S, Naito M, Wakai K et al.
  • Journal Title: Gene Volume: 524 Pages: 363-367
  • DOI: 10.1016/j.gene.2013.04.046
  • Peer Reviewed
• [Journal Article] Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women. (2013)
  • Author(s): Tanaka M, Budhathoki S, Hirata A, Ohnaka K et al.
  • Journal Title: BMC endocrine disorders Volume: 13 Pages: 39
  • DOI: 10.1186/1472-6823-13-39
  • Peer Reviewed
• [Journal Article] Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model. (2013)
  • Author(s): Tsuda M, Okamoto K, Muguruma N, Takayama T et al.
  • Journal Title: Journal of gastroenterology and hepatology Volume: 28 Pages: 1616-1623
  • DOI: 10.1111/jgh.12287
  • Peer Reviewed
• [Journal Article] Wake-up stroke: incidence, risk factors and outcome of acute stroke during sleep in a Japanese population. Takashima Stroke Registry 1988-2003. (2013)
  • Author(s): Turin TC, Kita Y, Rumana N et al.
  • Journal Title: European neurology Volume: 69 Pages: 354-359
  • DOI: 10.1159/000346124
  • Peer Reviewed
• [Journal Article] Abundant daily non-sedentary activity is associated with reduced prevalence of metabolic syndrome and insulin resistance. (2013)
  • Author(s): Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K et al.
  • Journal Title: Journal of endocrinological investigation Volume: 36 Pages: 1069-1075
  • DOI: 10.3275/9066
  • Peer Reviewed
• [Journal Article] Consumption of coffee, not green tea, is inversely associated with arterial stiffness in Japanese men. (2013)
  • Author(s): Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K et al.
  • Journal Title: European journal of clinical nutrition Volume: 67 Pages: 1109-1114
  • DOI: 10.1038/ejcn.2013.132
  • Peer Reviewed
• [Journal Article] A family history of diabetes is not associated with arterial stiffness in non-diabetic Japanese population. (2013)
  • Author(s): Uemura H, Katsuura-Kamano S, Yamaguchi M, Arisawa K et al.
  • Journal Title: Open J Epidemiol Volume: 3 Pages: 177-183
  • DOI: 10.4236/ojepi.2013.34026
  • Peer Reviewed
• [Journal Article] Genome-wide association study of genetic factors related to confectionery intake: potential roles of the ADIPOQ gene. (2013)
  • Author(s): Wakai K, Matsuo K, Matsuda F et al.
  • Journal Title: Obesity Volume: 21 Pages: 2413-2419
  • DOI: 10.1002/oby.20316
  • Peer Reviewed
• [Journal Article] Dietary polyphenols and colorectal cancer risk: the Fukuoka colorectal cancer study. (2013)
  • Author(s): Wang ZJ, Ohnaka K, Morita M et al.
  • Journal Title: World journal of gastroenterology : WJG Volume: 19 Pages: 2683-2690
  • DOI: 10.3748/wjg.v19.i17.2683
  • Peer Reviewed
• [Journal Article] Management of prostate cancer in Asia: resource-stratified guidelines from the Asian Oncology Summit 2013 (2013)
  • Author(s): Williams S, Chiong E, Lojanapiwat B, Akaza H et al.
  • Journal Title: The lancet oncology Volume: 14 Pages: e524-34
  • DOI: 10.1016/S1470-2045(13)70451-0
  • Peer Reviewed
• [Journal Article] Relationship of dietary factors and habits with sleep-wake regularity. (2013)
  • Author(s): Yamaguchi M, Uemura H, Katsuura-Kamano S, Arisawa K et al.
  • Journal Title: Asia Pacific journal of clinical nutrition Volume: 22 Pages: 457-465
  • DOI: 10.6133/apjcn.2013.22.3.01
  • Peer Reviewed
• [Journal Article] Potential contribution of a novel Tax epitope-specific CD4+ T cells to graft-versus-Tax effects in adult T-cell leukemia patients after allogeneic hematopoietic stem cell transplantation. (2013)
  • Author(s): Tamai Y, Hasegawa A, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Eto T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, and Kannagi M.
  • Journal Title: J. Immunol Volume: 190 Pages: 4382-4392
  • DOI: 10.4049/ JImmunol.1202971
  • Peer Reviewed
• [Journal Article] Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudin induces p53 signaling and apoptosis in HTLV-1-infected cells. (2013)
  • Author(s): Kinpara S, Kijiyama M, Takamori A, Hasegawa A, Sasada A, Masuda T, Tanaka Y, Utsunomiya A, and Kannagi M.
  • Journal Title: Retrovirology Volume: 10 Pages: 52
  • DOI: 10.1186/ 1742-4690-10-52
  • Peer Reviewed
• [Journal Article] Stevens-Johnson Syndrome associated with mogamulizumab treatment of Adult T-cell leukemia/lymphoma. (2013)
  • Author(s): Ishida T, Ito A, Sato F, Kusumoto S, Iida S, Inagaki H, Morita A, Akinaga S, Ueda R.
  • Journal Title: Cancer Sci. Volume: 104 Pages: 647-650
  • DOI: 10.1111/cas.12116
  • Peer Reviewed
• [Journal Article] Impact of GVHD on allogeneic hematopoietic cell transplantation for adult T-cell leukemia-lymphoma focusing on preconditioning regimens: nationwide retrospective study Biology of Blood and Marrow Transplantation. (2013)
  • Author(s): Ishida T, Hishizawa M, Kato K, Tanosaki R, Fukuda T, Takatsuka Y, Eto T, Miyazaki Y, Hidaka M, Uike N, Miyamoto T, Tsudo M, Sakamaki H, Morishima Y, Suzuki R, Utsunomiya A.
  • Journal Title: Biol Blood Marrow Transplant. Volume: 19 Pages: 1731-1739
  • DOI: 10.1016/j.bbmt.2013.09.014
  • Peer Reviewed
• [Journal Article] Characterization of simian T-cell leukemia virus type 1 in naturally infected Japanese macaques as a model of HTLV-1 infection. (2013)
  • Author(s): Miura M, Yasunaga J-I, Tanabe J, Sugata K, Zhao T, Ma G, Miyazato P, Ohshima K, Kaneko A, Watanabe A, Saito A, Akari H and Matsuoka M.
  • Journal Title: Retrovirology Volume: 10 Pages: 118
  • DOI: 10.1186/1742-4690-10-118.
  • Peer Reviewed
• [Journal Article] HTLV-1 bZIP factor induces inflammation through labile Foxp3 expression. (2013)
  • Author(s): Yamamoto-Taguchi N, Satou Y, Miyazato P, Ohshima K, Nakagawa M, Katagiri K, Kinashi T, and Matsuoka M.
  • Journal Title: PLoS Pathogens Volume: 9 Pages: e1003630
  • DOI: 10.1371/journal.ppat.1003630.
  • Peer Reviewed
• [Journal Article] HTLV-1 bZIP factor dysregulates the Wnt pathways to support proliferation and migration of adult T-cell leukemia cells. (2013)
  • Author(s): Ma G, Yasunaga J-I, Fan J, Yanagawa S-I, Matsuoka M.
  • Journal Title: Oncogene Volume: 32 Pages: 4222-4230
  • DOI: 10.1038/onc.2012.450
  • Peer Reviewed
• [Journal Article] Natural OX40L expressed on human T cell leukemia virus type-I-immortalized T cell lines interferes with infection of activated peripheral blood mononuclear cells by CCR5-utilizing human immunodeficiency virus. (2013)
  • Author(s): Kasahara D, Takara A, Takahashi Y, Kodama A, Tanaka R, Ansari AA, Tanaka Y.
  • Journal Title: Virol J. Volume: 18 Pages: 10:338
  • DOI: 10.1186/1743-422X-10-338.
  • Peer Reviewed
• [Journal Article] Increased expression of OX40 isassociated with progressive disease in patients with HTLV-1-associatedmyelopathy/tropical spastic paraparesis. (2013)
  • Author(s): Saito M, Tanaka R, Arishima S, Matsuzaki T, Ishihara S, Tokashiki T, Ohya Y, Takashima H, Umehara F, Izumo S, Tanaka Y.
  • Journal Title: Retrovirology. Volume: 10 Pages: 51
  • DOI: 10.1186/1742-4690-10-51
  • Peer Reviewed
• [Journal Article] HTLV-1 Tax oncoprotein stimulates ROS production and apoptosis in T cells by interacting with USP10. (2013)
  • Author(s): Takahashi M, Higuchi M, Makokha GN, Matsuki H, Yoshita M, Tanaka Y, Fujii M.
  • Journal Title: Blood. Volume: 122(5) Pages: 715-725
  • DOI: 10.1182/blood-2013-03-493718.
  • Peer Reviewed
• [Journal Article] Genome-wide determinants of proviral targeting, clonal abundance and expression in natural HTLV-1 infection. (2013)
  • Author(s): Melamed A, Laydon DJ, Gillet NA, Tanaka Y, Taylor GP, Bangham CR.
  • Journal Title: PLoS Pathog. Volume: 9(3) Pages: e1003271
  • DOI: 10.1371/journal.ppat.1003271.
  • Peer Reviewed
• [Journal Article] Adult T-cell leukemia cells are characterized by abnormalities of Helios expression that promotes T-cell growth. (2013)
  • Author(s): Asanuma S, Yamagishi M, Kawanami K, Nakano K, Sato-Otsubo A, Muto S, Sanada M, Yamochi T, Kobayashi S, Utsunomiya A, Iwanaga M, Yamaguchi K, Uchimaru K, Ogawa S, Watanabe T.
  • Journal Title: Cancer Sci Volume: 104(8) Pages: 1097-1106
  • DOI: 10.1111/cas.12181
  • Peer Reviewed
• [Journal Article] Forefront studies on HTLV-1 oncogenesis. (2013)
  • Author(s): Mahieux R, Watanabe T.
  • Journal Title: Front Microbiol Volume: 4 Pages: 156
  • DOI: 10.3389/fmicb.2013.00156
  • Peer Reviewed
• [Journal Article] Viral interference with host mRNA surveillance, the nonsense-mediated mRNA decay (NMD) pathway, through a new function of HTLV-1 Rex: implications for retroviral replication. (2013)
  • Author(s): Nakano K, Ando T, Yamagishi M, Yokoyama K, Ishida T, Ohsugi T, Tanaka Y, Brighty D-W, Watanabe T.
  • Journal Title: Microbes Infect Volume: 15(6-7) Pages: 491-505
  • DOI: 10.1016/j.micinf.2013.03.006
  • Peer Reviewed
• [Journal Article] RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. (2013)
  • Author(s): Oshita H, Nishino R, Takano A, Fujitomo T, Aragaki M, Kato T, Akiyama H, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y.
  • Journal Title: Mol Cancer Res Volume: 11 Pages: 937-951
  • DOI: 10.1158/1541-7786.MCR-12-0685-T
  • Peer Reviewed
• [Journal Article] A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer using Genomic Analyses. (2013)
  • Author(s): Daigo Y, Takano A, Teramoto K, Chung S, Nakamura Y.
  • Journal Title: Clin Pharmacol Ther Volume: 94 Pages: 218-223
  • DOI: 10.1038/clpt.2013.90.
  • Peer Reviewed
• [Journal Article] Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition. (2013)
  • Author(s): Kogurea M, Takawa M, Cho HS, Toyokawa G, Hayashi K, Tsunoda T, Kobayashi T, Daigo Y, Sugiyama M, Atomi Y, Nakamura Y, Hamamoto R.
  • Journal Title: Cancer Lett Volume: 336 Pages: 76-84
  • DOI: 10.1016/j.canlet.2013.04.009.
  • Peer Reviewed
• [Journal Article] NKX2-1/TTF-1: an enigmatic oncogene that functions as a double-edged sword for cancer cell survival and progression. (2013)
  • Author(s): Yamaguchi T, Hosono Y, Yanagisawa K, Takahashi T.
  • Journal Title: Cancer Cell Volume: 23 Pages: 718-723
  • DOI: 10.1016/j.ccr.2013.04.002
  • Peer Reviewed
• [Journal Article] Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis. (2013)
  • Author(s): Yamashita Y, Akatsuka S, Shinjo K, Yatabe Y, Kobayashi H, Seko H, Kajiyama H, Kikkawa F, Takahashi T, Toyokuni S.
  • Journal Title: PLoS ONE Volume: 8 Pages: e57724
  • DOI: 10.1371/journal.pone.0057724
  • Peer Reviewed
• [Journal Article] Secretome-based identification of TFPI2, a novel serum biomarker for detection of ovarian clear cell adenocarcinoma. (2013)
  • Author(s): Arakawa N, Miyagi E, Nomura A, Morita E, Ino Y, Ohtake N, Miyagi Y, Hirahara F, Hirano H.
  • Journal Title: J Proteome Res Volume: 12(10) Pages: 4340-4350
  • DOI: 10.1021/pr400282j.
  • Peer Reviewed
• [Journal Article] Rapid detection of SNP (c.309T>G) in the MDM2 gene by the Duplex SmartAmp method. (2013)
  • Author(s): Enokida Y, Shimizu K, Atsumi J, Lezhava A, Tanaka Y, Kimura Y, Soma T, Hanami T, Kawai Y, Usui K, Okano Y, Kakegawa S, Ogawa H, Miyamae Y, Miyagi Y, Nakayama H, Ishikawa T, Hayashizaki Y, Takeyoshi I.
  • Journal Title: PLoS ONE Volume: 8(4) Pages: e60151
  • DOI: 10.1371/journal.pone.0060151
  • Peer Reviewed
• [Journal Article] Total synthesis of bicyclic depsipeptides spiruchostatins C and D and investigation of their histone deacetylase inhibitory and antiproliferative activities. (2013)
  • Author(s): Narita K, Fukui Y, Sano Y, Yamori T, Ito A, Yoshida M, Katoh T.
  • Journal Title: Eur. J. Med. Chem. Volume: 60 Pages: 295-304
  • DOI: 10.1016/j.ejmech.2012.12.023
  • Peer Reviewed
• [Journal Article] HCV NS3 protease enhances liver fibrosis via binding to and activating TGF-β type I receptor. (2013)
  • Author(s): Sakata K, Eda S, Lee E, Hara M, Imoto M, Kojima S.
  • Journal Title: Scientific Reports. Volume: 3 Pages: 3243
  • DOI: 10.1038/srep03243
  • Peer Reviewed
• [Journal Article] Inhibition of ATP citrate lyase induces an anticancer effect via reactive oxygen species: AMPK as a predictive biomarker for therapeutic impact. (2013)
  • Author(s): Migita T, Okabe S, Ikeda K, Igarashi S, Sugawara S, Tomida A, Taguchi R, Soga T, Seimiya H.
  • Journal Title: Am J Pathol. Volume: 182(5) Pages: 1800-1810
  • DOI: 10.1016/j.ajpath.2013.01.048
  • Peer Reviewed
• [Journal Article] Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2. (2013)
  • Author(s): Kawada M, Inoue H, Ohba S, Hatano M, Amemiya M, Hayashi C, Usami I, Abe H, Watanabe T, Kinoshita N, Igarashi M, Masuda T, Ikeda D, Nomoto A.
  • Journal Title: J Antibiot (Tokyo) Volume: 66(9) Pages: 543-548
  • DOI: 10.1038/ja.2013.42.
  • Peer Reviewed
• [Journal Article] Spectomycin B1 as a novel SUMOylation inhibitor that directly binds to SUMO E2. (2013)
  • Author(s): Hirohama M, Kumar A, Fukuda I, Matsuoka S, Igarashi Y, Saitoh H, Takagi M, Shin-Ya K, Honda K, Kondoh Y, Saito T, Nakao Y, Osada H, Zhang KY, Yoshida M, Ito A.
  • Journal Title: ACS Chem Biol. Volume: 8(12) Pages: 2635-2642
  • DOI: 10.1021/cb400630z
  • Peer Reviewed
• [Journal Article] Identification of small molecule inhibitors of p27Kip1 ubiquitination by high-throughput screening. (2013)
  • Author(s): Ooi LC, Watanabe N, Futamura Y, Sulaiman SF, Darah I, Osada H.
  • Journal Title: Cancer Sci. Volume: 104(11) Pages: 1461-1467
  • DOI: 10.1111/cas.12246
  • Peer Reviewed
• [Journal Article] Ridaifen-SB8, a novel tamoxifen derivative, induces apoptosis via reactive oxygen species-dependent signaling pathway. (2013)
  • Author(s): Guo WZ, Shiina I, Wang Y, Umeda E, Watanabe C, Uetake S, Ohashi Y, Yamori T, Dan S.
  • Journal Title: Biochem Pharmacol. Volume: 86(9) Pages: 1272-1284
  • DOI: 10.1016/j.bcp.2013.08.020.
  • Peer Reviewed
• [Journal Article] Lysine-Specific Demethylase 1-Selective Inactivators: Protein-Targeted Drug Delivery Mechanism. (2013)
  • Author(s): Ogasawara D, Itoh Y, Tsumoto H, Kakizawa T, Mino K, Fukuhara K, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Miyata N, Suzuki T.
  • Journal Title: Angew. Chem. Int. Ed. Volume: 52 Pages: 8620- 8624
  • DOI: 10.1002/anie.201303999
  • Peer Reviewed
• [Journal Article] Identification of the KDM2/7 Histone Lysine Demethylase Subfamily Inhibitor and its Antiproliferative Activity. (2013)
  • Author(s): Suzuki T, Ozasa H, Itoh Y, Zhan P, Sawada H, Mino K, Walport L, Ohkubo R, Kawamura A, Yonezawa M, Tsukada Y, Tumber A, Nakagawa H, Hasegawa M, Sasaki R, Mizukami T, Schofield CJ, Miyata N.
  • Journal Title: J. Med. Chem. Volume: 56 Pages: 7222-7231
  • DOI: 10.1021/jm400624b
  • Peer Reviewed
• [Journal Article] RASSF1A methylation indicates a poor prognosis in hepatoblastoma patients. (2013)
  • Author(s): Honda S, Miyagi H, Suzuki H, Minato M, Haruta M, Kaneko Y, Hatanaka KC, Hiyama E, Kamijo T, Okada T, Taketomi A.
  • Journal Title: Pediatr Surg Int Volume: 29 Pages: 1147-1152
  • Peer Reviewed
• [Presentation] Cancer as a ferrotoxic disease. Symposium 1: Redox-active ion in disease pathology and treatment. (2014)
  • Author(s): Toyokuni S.
  • Organizer: 17th Biennial Meeting of the Society for Free Radical Research International
  • Place of Presentation: Kyoto International Conference Center, Kyoto, Japan
  • Year and Date: 20140323-20140326
  • Invited
• [Presentation] A combination of the anti-fibroblast growth factor receptor 1 monoclonal antibody and interferon-a/b supresses human hepatic cancer cells in vitro and in vivo (2014)
  • Author(s): Kato Y, Hiromi H, Tujisaki M, Matsune T, Sasaki S, Hinoda Y, Shinomura Y, Imai K
  • Organizer: 41 Congress of the International Society of Oncology and Biomarkers
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 20140315-20140318
• [Presentation] Critical factors in multi-walled carbon nanotubes in mesothelial carcinogenesis. (2014)
  • Author(s): Toyokuni S.
  • Organizer: The 46th Fullerenes-Nanotubes-Graphene General Symposium.
  • Place of Presentation: The University of Tokyo, Ito International Research Center 、東京都文京区
  • Year and Date: 20140303-20140305
  • Invited
• [Presentation] 骨微小環境における腫瘍細胞増殖メカニズム：動物モデルを用いた解析 (2014)
  • Author(s): 二口 充
  • Organizer: 平成25年度「個体レベルでのがん支援活動」ワークショップ 2014
  • Place of Presentation: 琵琶湖ホテル、滋賀県大津市
  • Year and Date: 20140217-20140218
• [Presentation] Impact of interferon response in HTLV-1 infection: a molecular mechanism of AZT/IFN-a therapy for ATL. (2014)
  • Author(s): Kannagi M, Kinpara S, Hasegawa A.
  • Organizer: 第4回発がんスパイラル国際シンポジウム
  • Place of Presentation: Sapporo
  • Year and Date: 20140210-20140211
  • Invited
• [Presentation] Isoflavones in Japanese and Caucasian men with prostate cancer in Hawaii (2014)
  • Author(s): Fukagai T, Akaza H, Ogawa Y, Carlile R, Namiki T, Lederer JL, Maskarinec G, Tsuji H, Moriyama K, Fujimoto K, Hirao Y, Namiki M
  • Organizer: 2014 Genitourinary Cancer Symposium
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20140129-20140203
• [Presentation] Invited lecture 2: Role of iron in carcinogenesis. (2014)
  • Author(s): Toyokuni S.
  • Organizer: SFRR India
  • Place of Presentation: Lonavala, India
  • Year and Date: 20140127-20140130
  • Invited
• [Presentation] Growh of malignant tumor in the bone microenvironment. (2013)
  • Author(s): M. Futakuchi
  • Organizer: The 18th Korea- Japan Cancer Research Workshop 2013
  • Place of Presentation: Gifu
  • Year and Date: 20131129-20131201
  • Invited
• [Presentation] HTLV-1 bZIP factor determines cell tropism (2013)
  • Author(s): Matsuoka M
  • Organizer: The 3rd French Japanese Cancer Research Workshop
  • Place of Presentation: Hotel Mercure Toulouse Compans Caffarelli, Toulouse, France.
  • Year and Date: 20131120-20131123
• [Presentation] シンポジウム１ 細胞ストレス応答の分子機構と疾患病態：酸化ストレスによる発がん機構の解明 (2013)
  • Author(s): 豊國伸哉
  • Organizer: 第8回臨床ストレス応答学会
  • Place of Presentation: 信州大学、松本市
  • Year and Date: 20131115-20131116
• [Presentation] 生活習慣病の遺伝子環境交互作用の解明を目指して：日本多施設共同コーホート研究－佐賀地区－（特別講演） (2013)
  • Author(s): 田中恵太郎
  • Organizer: 第78回日本民族衛生学会総会
  • Place of Presentation: 佐賀市
  • Year and Date: 20131115-20131116
• [Presentation] ヒトT細胞白血病ウイルス1型による発がん：TaxとHBZの拮抗と協調 (2013)
  • Author(s): 松岡雅雄、安永純一朗
  • Organizer: 第61回日本ウイルス学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
  • Year and Date: 20131110-20131112
• [Presentation] ウイルス複製を有利にするHTLV-1 Rexの新たな機能と宿主細胞への影響 シンポジウム１発癌ウイルス (2013)
  • Author(s): 渡邉俊樹
  • Organizer: 第6１回日本ウイルス学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 20131110-20131112
  • Invited
• [Presentation] ゼブラフィッシュ胚を用いたWnt/β-catenin経路ケミカルサプレッサーの探索 (2013)
  • Author(s): 西谷直之, 河野富一, 上原至雅.
  • Organizer: 日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 20131101-20131102
• [Presentation] その研究に、阻害剤キットあります―化学療法基盤支援活動 (2013)
  • Author(s): 川田学
  • Organizer: 日本薬学会生薬天然物部会主催・第5回食品薬学シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 20131101-20131102
• [Presentation] Oocyte cryopreservation and IVF (2013)
  • Author(s): Takeo, T., Ishizuka,Y., Fukumoto, K., Kondo, T., Haruguchi, Y., Takeshita, Y., Nakamuta, Y., Umeno, T., Tsuchiyama, S., Nakagata, N.
  • Organizer: 1st Oceania Transgenic Technology/Cryopreservation Symposium
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 20131031-20131101
  • Invited
• [Presentation] Critical factors in multi-walled carbon nanotubes for mesothelial carcinogenesis. (2013)
  • Author(s): Toyokuni S, Nagai H, Okazaki Y, Chew SH, Akatsuka S, Jiang L and Ichihara G.
  • Organizer: 6th International Symposium on Nanotechnology, Occupational and Environmental Health.
  • Place of Presentation: Nagoya Congress Center, Nagoya, Japan
  • Year and Date: 20131028-20131031
  • Invited
• [Presentation] In vitro fertilization using frozen-thawed genetically engineered mouse sperm derived from cold-transported epididymides (2013)
  • Author(s): Nakagata, N., Fukumoto, K., Haruguchi, Y., Kondo, T., Takeshita, Y., Nakamuta, Y., Matsunaga, H., Umeno, T., Nishimura, M., Iwamoto, M., Takahashi, F., Kohagura, E., Tsuchiyama, S., Takeo, T.
  • Organizer: 64th AALAS National Meeting
  • Place of Presentation: Baltimore, MD USA
  • Year and Date: 20131027-20131031
• [Presentation] Genetic techniques: Classical and advanced methods. Seminar: Quality animals are essential for quality research. (2013)
  • Author(s): Katoh, H.
  • Organizer: 64th AALAS National Meeting.
  • Place of Presentation: Baltimore, MD, USA.
  • Year and Date: 20131027-20131031
• [Presentation] Plenary talk 2. Role of iron in carcinogenesis. (2013)
  • Author(s): Toyokuni S.
  • Organizer: 6th Biennial Meeting of Society for Free Radical Research Asia
  • Place of Presentation: Chang Gung University, Tao-Yuan, Taiwan
  • Year and Date: 20131016-20131019
  • Invited
• [Presentation] パネルディスカッション1「C型肝炎を背景とした肝細胞癌―予防から再発治療まで―」非環式レチノイドと分岐鎖アミノ酸を用いた肝発癌抑制―肥満関連肝発癌抑制と両剤の併用投与による相乗的肝癌細胞増殖抑制―． (2013)
  • Author(s): 清水雅仁、白上洋平、森脇久隆．
  • Organizer: JDDW2013
  • Place of Presentation: 東京
  • Year and Date: 20131009-20131012
• [Presentation] シンポジウム：がん研究とモデル動物（モデレーター、座長） モデル動物から明らかになった過剰鉄と発がんの親和性 (2013)
  • Author(s): 豊國伸哉
  • Organizer: 第７２回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 20131003-20131005
• [Presentation] Growth of malignant tumor in the bone microenvironment; mechanism of bone metastasis and its therapeutic targets. (2013)
  • Author(s): M. Futakuchi, K. Fukamachi, M. Suzui.
  • Organizer: 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜、横浜市
  • Year and Date: 20131003-20131005
• [Presentation] ”移民研究から推定されるがん予防効果”、シンポジウム: 19:がん疫学研究：国民全体および個別化の確かながん予防実現に向けて (2013)
  • Author(s): 岩崎 基、津金昌一郎
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 20131003-20131005
• [Presentation] 「ATLに対するHTLV-1 Tax特異的T細胞応答賦活化ペプチドパルス樹状細胞を用いた免疫療法」第一相臨床試験, (2013)
  • Author(s): Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Tanosaki R, Utsunomiya A, Matsuoka M, Teshima T, Akashi K, Okamura J, Kannagi M and Uike N.
  • Organizer: 第72回日本癌学会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] リンパ腫におけるエピジェネティック依存的なmiRNAの発現異常とシグナル伝達系の活性化 (2013)
  • Author(s): 山岸誠、片野晴隆、中川翔太、中野和民、太田泰徳、比島恒和、岡田誠治、渡邉俊樹
  • Organizer: 腫瘍別シンポジウム、第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 20131003-20131005
• [Presentation] Multifaceted dissection of genetic regulatory circuitry involved in the pathogenesis of lung cancers. (2013)
  • Author(s): Takahashi T.
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] Geranylgeranyltransferase as a potential molecular target for Wnt/beta-catenin pathway inhibitors (2013)
  • Author(s): Nishiya N, Oku Y, Uehara Y.
  • Organizer: 日本癌学会 第72回総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] 抗がん剤探索アプローチの変遷と最近の話題 (2013)
  • Author(s): 清宮啓之
  • Organizer: 日本癌学会学術総会（モーニングレクチャー）
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] Chemical biology for anticancer agents(抗がん剤のケミカルバイオロジー) (2013)
  • Author(s): 長田裕之
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 20131003-20131005
• [Presentation] <Poster Session: Genitourinary Malignancies - Prostate Cancer> A multicenter Phase 1-2 study of enzalutamide in Japanese patients with castration-resistant prostate cancer (CRPC), who had received combined androgen blockade (CAB) (2013)
  • Author(s): Akaza H, Uemura H, Tsukamoto T, Ozono S, Ogawa O, Sakai H, Oya M, Namiki M, Ohashi Y, Naito S
  • Organizer: The European Cancer Congress 2013
  • Place of Presentation: Amsterdam, Netherlands
  • Year and Date: 20130927-20131001
• [Presentation] 骨微小環境における前立腺癌および乳癌の増殖メカニズムに着目した骨転移治療薬の開発と展開 (2013)
  • Author(s): 二口 充
  • Organizer: 第24回新薬創製懇話会
  • Place of Presentation: 沼津
  • Year and Date: 20130925-20130926
  • Invited
• [Presentation] “Chemistry and biology of Xanthohumol, an inhibitor of Valosin-Containing Protein.” (2013)
  • Author(s): 井本正哉
  • Organizer: EMBO Workshop【AAA+ proteins: from mechanism and disease to targets】
  • Place of Presentation: Germany・Neuss
  • Year and Date: 20130916-20130920
• [Presentation] How human T-cell leukemia virus type 1 induces diseases (2013)
  • Author(s): Matsuoka M
  • Organizer: FRONTIERS OF RETROVIROLOGY
  • Place of Presentation: Churchill College, Cambridge University, UK.
  • Year and Date: 20130916-20130918
• [Presentation] Hematological neoplasms and viral Infections (2013)
  • Author(s): Watanabe T
  • Organizer: XXVI Symposium IACRLRD
  • Place of Presentation: Lingotto Conference Center, Torino, Italy
  • Year and Date: 20130911-20130914
• [Presentation] Molecular Pathogenesis by HTLV-1 bZIP Factor (2013)
  • Author(s): Matsuoka M
  • Organizer: The 15th Annual International Meeting of the Institute of Human Virology
  • Place of Presentation: Moscow, Russia
  • Year and Date: 20130908-20130912
• [Presentation] ラットのアスベスト誘発中皮腫発がんモデルにおいてDeferasirox投与は 間質上皮移行を促進する (2013)
  • Author(s): 豊國伸哉、永井裕崇、岡崎泰昌、周 珊瑚、三澤伸明、安井裕之
  • Organizer: 第３７回日本鉄バイオサイエンス学会学術集会
  • Place of Presentation: JA共済ビル・カンファレンスホール、東京
  • Year and Date: 20130907-20130908
• [Presentation] Applications of Cryopreserved Mouse Oocytes for In vitro Fertilization Using Fresh， Cold-stored and Frozen Sperm (2013)
  • Author(s): Ishizuka,Y., Yoshimoto,H., Sakoh, K., Nakao, S., Horikoshi, Y., Hirose, Y., Takeuji, S., Sakai, Y., Maeda, Y., Hachiya, M., Mukunoki, A., Takeo, T., Nakagata,N.
  • Organizer: ANZLAA conference
  • Place of Presentation: Perth, Australia
  • Year and Date: 20130904-20130906
• [Presentation] シンポジウム「レチノイド研究温故知新―レチノイドの新たな作用点を求めて―」非環式レチノイドによる肝発癌化学予防 ―Chemoprevention of hepatocellular carcinoma by acyclic retinoid― (2013)
  • Author(s): 清水雅仁、森脇久隆
  • Organizer: 日本レチノイド研究会第24回学術集会
  • Place of Presentation: 東京
  • Year and Date: 20130830-20130831
• [Presentation] ウィルス複製を有利にするHTLV-1 Rexの新たな機能の可能性と宿主細胞への影響 (2013)
  • Author(s): 中野和民、安東友美、山岸誠、横山弘一、唐澤伸明、橋爪大明、高橋隆太郎、高橋碧、石田尚臣、大杉剛生、田中勇悦、David W. Brighty、渡邉俊樹
  • Organizer: 第２回ATLシンポジウム、第6回HTLV-1研究会・シンポジウム
  • Place of Presentation: 東京大学医科学研究所
  • Year and Date: 20130823-20130825
• [Presentation] ヒトT細胞白血病ウイルス1型の病原性発現機構 (2013)
  • Author(s): 松岡雅雄
  • Organizer: 第37回阿蘇シンポジウム
  • Place of Presentation: 阿蘇リゾートグランヴィリオホテル（熊本）
  • Year and Date: 20130802-20130803
• [Presentation] Establishment of a live young mouse production system using unfertilized oocytes cryopreserved via a simple vitrification method (2013)
  • Author(s): Nakagata, N., Takeo, T., Fukumoto, K., Kondo, T., Takeshita, Y., Nakamuta, Y., Tsuchiyama, S., Kohagura, E., Iwamoto, M., Takahashi, F., Ishizuka,Y.
  • Organizer: CRYO2013
  • Place of Presentation: North Bethesda Marriott and Conference Center, Washington, DC. USA
  • Year and Date: 20130728-20130731
• [Presentation] International cold-transport of cauda epididymides taken from C57BL/6 mice (2013)
  • Author(s): Nakagata, N., Takeo, T., Fukumoto, K., Kondo, T., Haruguchi, Y., Takeshita, Y., Nakamuta, Y., Matsunaga, H., Umeno, T., Nishimura, M., Tsuchiyama, S., Iwamoto, M., Takahashi, F., Kohagura, E., Guan, M., Fray, D, M., Kinchen, K., Lee, M., Lloyd, K.
  • Organizer: SSR2013
  • Place of Presentation: Montreal, Quebec, Canada
  • Year and Date: 20130722-20130726
• [Presentation] シンポジウム１：環境物質による発がんリスクとその予防 「アスベスト発がん機構の解明から早期発見・予防への展開」 (2013)
  • Author(s): 豊國 伸哉
  • Organizer: 第20回日本がん予防学会
  • Place of Presentation: 日本薬学会長井記念館、東京都
  • Year and Date: 20130705-20130706
• [Presentation] シンポジウム：老化と酸化ストレス、そして、再生へ「酸化ストレスと老化の新たな展開」 酸化ストレスと発がんから老化を考える (2013)
  • Author(s): 豊國 伸哉
  • Organizer: 第28回老化促進モデルマウス（ＳＡＭ）研究協議会
  • Place of Presentation: 愛知学院大学、名古屋市
  • Year and Date: 20130705-20130706
  • Invited
• [Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」肝および内臓脂肪の炎症制御を介した分岐鎖アミノ酸による肥満・糖尿病関連肝腫瘍形成の抑制 (2013)
  • Author(s): 清水雅仁、寺倉大志、河内隆宏、白上洋平、田中卓二、森脇久隆
  • Organizer: 第20回日本がん予防学会
  • Place of Presentation: 東京
  • Year and Date: 20130705-20130706
• [Presentation] ワークショップ「炎症および傷害物質に関連した発がんと予防」非アルコール性脂肪肝炎関連肝発癌新規モデルとペントキシフィリンによる発癌抑制効果 (2013)
  • Author(s): 白上洋平、清水雅仁、森脇久隆、清島満
  • Organizer: 第20回日本がん予防学会
  • Place of Presentation: 東京
  • Year and Date: 20130705-20130706
• [Presentation] Allogeneic BM transplantation in ATL: Whom to transplant and which modality to use? Can we go beyond BM transplantation? (2013)
  • Author(s): Kannagi M.
  • Organizer: 16th International Conference on Human Retrovirology HTLV and Related Viruses, Clinical trial workshop.
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20130626-20130630
  • Invited
• [Presentation] IFN-α suppresses HTLV-1 expression via PKR in infected cells and renders them susceptible to AZT through p53 activation in AZT/IFN-α treatment. (2013)
  • Author(s): Kinpara S, Kijiyama M, Takamori A, Hasegawa A, Sasada A, Masuda T, Tanaka Y, Utsunomiya A, Kannagi M.
  • Organizer: 16th International Conference on Human Retrovirology HTLV and Related Viruses
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20130626-20130630
• [Presentation] Uike N. The phase-I study of a therapeutic vaccine to ATL patients with autologous dendritic cells pulsed with peptides corresponding to Tax-specific CTL epitopes. (2013)
  • Author(s): Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Choi I, Fukuda T, Takaishi S, Tanosaki R, Utsunomiya A, Miura O, Matsuoka M, Teshima T, Akashi K, Okamura J, Kannagi M,
  • Organizer: 16th International Conference on Human Retrovirology HTLV and Related Viruses.
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20130626-20130630
• [Presentation] Augmentation of donor-derived Tax-specific CTL responses by a novel Tax epitope-specific CD4+ helper T-cells in ATL patients after allogeneic hematopoietic stem cell transplanation. (2013)
  • Author(s): Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M.
  • Organizer: 16th International Conference on Human Retrovirology HTLV and Related Viruses.
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20130626-20130630
• [Presentation] State of the Art Lecture and Session Summary (2013)
  • Author(s): Matsuoka M
  • Organizer: 16th International Conference on Human Retrovirology: HTLV and Related Viruses 2013
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20130626-20130630
• [Presentation] Molecular hallmarks of adult T cell leukemia: miRNA, pigenetics, and emerging signaling abnormalities (2013)
  • Author(s): Yamagishi M, Fujikawa D, Kurokawa N, Soejima A, Takahashi R, Sakai N, Nakagawa S, Nakano K, Kobayashi S, Utsunomiya A, Yamaguchi K, Uchimaru K, Ogawa S, Watanabe T
  • Organizer: 16th International Conference on Human Retrovirology HTLV and Related Viruses
  • Place of Presentation: Montreal, Canada
  • Year and Date: 20130626-20130629
• [Presentation] 多層カーボンナノチューブの発がん性を決定する物性因子の発見 シンポジウムI：「アイデア」 (2013)
  • Author(s): 豊國 伸哉
  • Organizer: 第３６回日本がん疫学・分子疫学研究会
  • Place of Presentation: 岐阜大学サテライトキャンパス、岐阜市
  • Year and Date: 20130620-20130621
  • Invited
• [Presentation] 日本多施設共同コーホート研究 （J-MICC Study）―そのミッションと現状― (2013)
  • Author(s): 若井建志, 田中英夫
  • Organizer: 第36回日本がん疫学・分子疫学研究会
  • Place of Presentation: 岐阜
  • Year and Date: 20130620-20130621
• [Presentation] The Efficacy and Safety of Mogamulizumab (KW-0761) in Multicenter Phase II Study for Patients with Relapsed Peripheral or Cutaneous T-Cell Lymphoma (abs 041) (2013)
  • Author(s): Ueda R, Ogura M, Ishida T, Hatake K, Taniwaki M, Ando K, Tobinai K, Fujimoto K, Yamamoto K, Miyamoto T, Uike N, Tanimoto M, Tsukasaki K, Ishizawa K, Suzumiya J, Inagaki H, Tamura K, Akinaga S, Tomonaga M.
  • Organizer: 12th International Conference on Malignant Lymphoma.
  • Place of Presentation: Lugano, Switzerland.
  • Year and Date: 20130619-20130622
• [Presentation] Combination of Mogamulizumab (KW-0761) with VCAP-AMP-VECP (mLSG15) is Well Tolerated and Effective as an Initial Therapy for Aggressive Adult T-Cell Leukaemia-Lymphoma (ATL) (abs 154) (2013)
  • Author(s): Takemoto T, Ishida T, Jo T, Uozumi K, Suzushima H, Yamamoto K, Uike N, Saburi Y, Nosaka K, Utsunomiya A, Tobinai K, Fujiwara H, Ishitsuka K, Yoshida S, Taira N, Moriuchi Y, Imada K, Miyamoto T, Tsukasaki K, Tomonaga M, Ueda R.
  • Organizer: 12th International Conference on Malignant Lymphoma.
  • Place of Presentation: Lugano, Switzerland.
  • Year and Date: 20130619-20130622
• [Presentation] ナノ材料（ＣＮＴ）の物性と発がん性 シンポジウム４：ナノマテリアルの評価開発手法における今後の課題 (2013)
  • Author(s): 豊國 伸哉
  • Organizer: 第４０回日本毒性学会学術年会
  • Place of Presentation: 幕張メッセ 国際会議場、千葉市
  • Year and Date: 20130617-20130619
  • Invited
• [Presentation] EPIGENETIC DEREGULATION OF MIRNA IN MALIGNANT LYMPHOMAS (2013)
  • Author(s): Yamagishi M, Watanabe T
  • Organizer: 18th Congress of EHA
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 20130612-20130616
• [Presentation] Genetic monitoring for inbreds and closed colony strains. (2013)
  • Author(s): Katoh, H.
  • Organizer: Workshop: Aspects of genetic monitoring in redents. 12th FELASA/SECAL Congress.
  • Place of Presentation: Barcelona, Spain.
  • Year and Date: 20130610-20130613
• [Presentation] 酸化ストレスによるゲノム変化と発がん シンポジウム２：細胞ストレス応答の破綻と病態 (2013)
  • Author(s): 豊國伸哉、蒋 麗、岡崎泰昌、山下依子、赤塚慎也
  • Organizer: 第１０２回日本病理学会総会
  • Place of Presentation: ロイトン札幌・さっぽろ芸文館、札幌
  • Year and Date: 20130606-20130608
• [Presentation] ワークショップ「胆汁酸研究の最新のシンポ」胆汁酸による肝細胞障害および肝線維化におけるTNF-αの役割 (2013)
  • Author(s): 清水雅仁、寺倉大志、森脇久隆
  • Organizer: 第49回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 20130606-20130607
• [Presentation] Randomized phase II study of mogamulizumab (KW-0761) plus VCAP-AMP-VECP (mLSG15) versus mLSG15 alone for newly diagnosed aggressive adult T-cell leukemia-lymphoma (ATL). (2013)
  • Author(s): Jo T, Ishida T, Takemoto S, Suzushima H, Uozumi K, Yamamoto, K Uike N, Saburi Y, Nosaka K, Utsunomiya A, Tobinai K, Fujiwara H, Ishitsuka K, Yoshida S, Taira N, Moriuchi Y, Imada K, Miyamoto T, Tomonaga M, Ueda R.
  • Organizer: 2013 ASCO Annual Meeting
  • Place of Presentation: Chicago, USA
  • Year and Date: 20130531-20130604
• [Presentation] How Human T-cell Leukemia Virus Type 1 induces leukemia (2013)
  • Author(s): Matsuoka M
  • Organizer: The 4th JSH International Symposium 2013
  • Place of Presentation: YAMATOYA-HONTEN, Ehime.
  • Year and Date: 20130524-20130525
• [Presentation] 我が国におけるHTLV-1／ATL研究の現状、大河内メモリアルシンポジウム１:HTLV-1の現状 (2013)
  • Author(s): 渡邉俊樹
  • Organizer: 第61回日本輸血・細胞治療学会総会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 20130516-20130518
  • Invited
• [Presentation] Trans-Pacific variation in outcomes for men treated with primary androgen deprivation therapy for localized prostate cancer (2013)
  • Author(s): Cooperberg M, Hinotsu S, Namiki M, Carroll P, Akaza H
  • Organizer: 2013 AUA Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 20130504-20130508
• [Presentation] TTF-1/NKX2-1: an enigmatic oncogene that functions as a double-edged sword in lung adenocarcinoma. (2013)
  • Author(s): Takahashi T.
  • Organizer: SNUCRI & SNUCH Cancer Symposium.
  • Place of Presentation: Jeju, Korea.
  • Year and Date: 20130502-20130504
• [Presentation] 「再生医療における非臨床試験とは：ヒトiPS細胞を用いたヒト化マウス」
  • Author(s): 山村研一
  • Organizer: 第22回熊本大学医学部附属病院 臨床カンファレンス
  • Place of Presentation: 熊本
• [Presentation] ヒト化マウスによるヒト疾患解析
  • Author(s): 山村研一
  • Organizer: 平成25年度「個体レベルでのがん支援活動」ワークショップ 2014（特別講演）
  • Place of Presentation: 琵琶湖ホテル、滋賀県大津市
• [Presentation] 動物実験における実験結果の信頼性を確保するために‐統御の重要性の再考‐
  • Author(s): 高倉 彰
  • Organizer: 第47回日本実験動物技術者協会総会シンポジウム
  • Place of Presentation: 岡山
• [Presentation] J-MICC Study委員会．個別化予防を目指したゲノムコホート研究．
  • Author(s): 田中英夫、若井建志
  • Organizer: 第20回日本がん予防学会
  • Place of Presentation: 東京
• [Presentation] 日本人のがん個別化予防の実現に向けたがん分子疫学研究の方向性
  • Author(s): 田中英夫
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 日本多施設共同コーホート研究（J-MICC STUDY)の進捗とBBJなどのバイオバンク、ゲノムコーホートとの連携
  • Author(s): 田中英夫
  • Organizer: オーダーメイド医療の実現プログラム 平成 25 年度 一般公開シンポジウム
  • Place of Presentation: 東京
• [Presentation] ゲノムコーホート研究の「倫理的」課題とは？
  • Author(s): 田中英夫
  • Organizer: 「オーダーメイド医療の実現プログラム」シンポジウム「日本のゲノムコホート研究とバイオバンクの倫理的課題―信頼と責任を考える」
  • Place of Presentation: 東京
• [Presentation] コンプリヘンシブがパネルと半導体シークエンサーによる千葉J-MICCコホートゲノム解析
  • Author(s): 三上春夫、永瀬浩喜他
  • Organizer: 第72回日本癌学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 半導体次世代シークエンサーによるリスク集団特異的がん関連遺伝子多型解析
  • Author(s): 三上春夫、永瀬浩喜他
  • Organizer: 第51回日本癌治療学会
  • Place of Presentation: 国立京都国際会館、京都市
• [Presentation] Semiconductor-based next-gen sequencing reveals cancer risk-associated genetic variations in Chiba J-MICC cohort study.
  • Author(s): J. Katayama, Y. Hayashi, H. Mikami, H. Kageyama, M. Ohira, S. Yokoi, H. Nagase .
  • Organizer: American Society of Human Genetics
  • Place of Presentation: Boston Convention & Exhibition Center. Boston, MA USA
• [Presentation] 基調講演「ゲノム・コホート研究とバイオバンクにおける倫理的配慮とは」
  • Author(s): 玉腰暁子
  • Organizer: 「オーダーメイド医療の実現化プログラム」シンポジウム「日本のゲノムコホート研究とバイオバンクの倫理的課題―信頼と責任を考える」
  • Place of Presentation: 大手町サンケイプラザホール, 東京
• [Presentation] Secretory mechanism and functions of senescence-associated exosomes
  • Author(s): H. Tahara, M. Okada, M. Muneoka and A. Nakamura
  • Organizer: ISEV 2013
  • Place of Presentation: Park Plaza Hotel, Boston, MA USA
• [Presentation] 老化を誘導する核酸抗かん剤にむけた exosome DDSの開発
  • Author(s): 田原栄俊
  • Organizer: 第29回日本DDS学会学術集会
  • Place of Presentation: 京都テルサ、京都市
• [Presentation] マイクロ RNA を用いた革新的がん診断・治療
  • Author(s): 田原栄俊
  • Organizer: 第14 回ホルモンと癌研究会
  • Place of Presentation: 東京大学山上会館、東京都文京区
• [Presentation] 老化を誘導する抗腫瘍核酸医薬の可能性
  • Author(s): 田原栄俊
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜
• [Presentation] テロメア・マイクロＲＮＡを用いた次世代健康診断システム
  • Author(s): 田原栄俊
  • Organizer: 第3回臨床ゲノム医療学会大阪大会
  • Place of Presentation: 大阪大学谷口記念講堂、大阪府吹田市
• [Presentation] Therapeutic role of microRNAs in cancer and cellular senescence
  • Author(s): Hidetoshi Tahara
  • Organizer: Small RNAs to Stem Cells & Epigenetic Reprogramming Asia-2013 Meeting
  • Place of Presentation: 東京大学山上会館、東京都文京区
• [Presentation] Proteomic analysis of EV in senescence and cancer
  • Author(s): Hidetoshi Tahara
  • Organizer: ISEV Workshop on EV Proteomics and Lipidomics
  • Place of Presentation: Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Australia
• [Presentation] The origin of human cancer
  • Author(s): Haruhiko Sugimura
  • Organizer: 101st Indian Science Congress
  • Place of Presentation: Jammu, India.
• [Presentation] 乳がんの疫学
  • Author(s): 永田知里
  • Organizer: 日本医学会シンポジウム
  • Place of Presentation: 東京
• [Presentation] サンパウロにおけるがんの移民研究
  • Author(s): 岩崎 基
  • Organizer: サンパウロ大学医学部主催 Scientific workshop: Non communicable diseases and global health
  • Place of Presentation: サンパウロ大学、ブラジル
• [Presentation] EGFRを標的とした大腸癌分子イメージング
  • Author(s): 宮本佳彦、六車直樹、高山哲治
  • Organizer: 消化管学会
  • Place of Presentation: 東京
• [Presentation] 大腸発癌におけるACF-SSA/P-cancer sequenceの検証
  • Author(s): 藤野泰輝、岡本耕一、六車直樹、高山哲治
  • Organizer: 第21回浜名湖シンポジウム
  • Place of Presentation: アクトシティ浜松コングレスセンター、浜松市
• [Presentation] ピロール・イミダゾール(PI)ポリアミドを用いた、前立腺癌新規遺伝子治療薬の検討. 第6回ヤングリサーチグラント受賞者記念講演
  • Author(s): 大日方大亮
  • Organizer: 第101回日本泌尿器科学会総会
  • Place of Presentation: 札幌
• [Presentation] ピロール・イミダゾール(PI)ポリアミドを用いた、前立腺癌新規遺伝子治療薬の開発
  • Author(s): 大日方大亮，藤原恭子，伊藤亜希子，村田保貴，芦苅大作，山口健哉，高山賢一，浦野友彦，藤村哲也，福田 昇，永瀬浩喜， 相馬正義，井上 聡，高橋 悟
  • Organizer: 第14回ホルモンと癌研究会
  • Place of Presentation: 東京
• [Presentation] 前立腺癌特異的融合遺伝子TMPRSS2-ERG の生成を抑制するピロール・イミダゾール(PI)ポリアミドの開発
  • Author(s): 大日方大亮，藤原恭子，高山賢一，浦野友彦，永瀬浩喜，相馬正義，井上 聡，高橋 悟
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] デュタステリド投与中のPSA管理に関する考察～5ARIはPCaの診断に影響を及ぼすのか～
  • Author(s): 高橋 悟
  • Organizer: 第65回西日本泌尿器科学会総会
  • Place of Presentation: 佐賀
• [Presentation] The efficacy of Pyrrole-imidazole (PI) polyamide targeted to TMPRSS2 and ERG gene fusion for prostate cancer
  • Author(s): Obinata D, Fujiwara K, Takayama K, Urano T, Nagase H, Fukuda N, Soma M, Inoue S, Takahashi S.
  • Organizer: The 18th Korea-Japan Cancer Research Workshop
  • Place of Presentation: Gifu
• [Presentation] State-of-the-art lecture「proPSA：新規腫瘍マーカーとしての臨床応用への期待（座長）
  • Author(s): 高橋 悟
  • Organizer: 第21回日本がん検診・診断学会
  • Place of Presentation: 前橋
• [Presentation] Immunological control of HTLV-1: Prospective therapy towards prophylaxis of disease.
  • Author(s): Kannagi M. Hasegawa A, Suehiro Y, Takamori A, Kinpara S, Ando S, Utsunomiya A, Choi I, Uike N.
  • Organizer: 第3回HTLV-1国際シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] HTLV-1感染者におけるATL発症予防の展望
  • Author(s): 神奈木真理
  • Organizer: ＡＴＬシンポジウムin沖縄2014
  • Place of Presentation: 沖縄市民会館、沖縄市
  • Invited
• [Presentation] HTLV-１感染の免疫学
  • Author(s): 神奈木真理
  • Organizer: 日本HTLV-1学会設立記念シンポジウム
  • Place of Presentation: 東京
• [Presentation] HTLV-1から学ぶウイルスと宿主免疫の攻防
  • Author(s): 神奈木真理
  • Organizer: 第２回日本移植学会若手育成教育セミナー
  • Place of Presentation: 東京
• [Presentation] ヒトT細胞白血病ウイルス1型の生き残り戦略と病原性
  • Author(s): 松岡雅雄
  • Organizer: 桜山学術セミナー
  • Place of Presentation: 名古屋市立大学病院10階第4会議室，名古屋.
• [Presentation] ヒトT細胞白血病ウイルス1型の病原性発現機構と治療戦略
  • Author(s): 松岡雅雄
  • Organizer: 第17回日本がん分子標的治療学会学術集会ランチョンセミナー1
  • Place of Presentation: 国立京都国際会館第1会場、京都
• [Presentation] ATL発症と病態の分子基盤解明の試み
  • Author(s): 渡邉俊樹
  • Organizer: 第１１回東海リンパ腫フォーラム学術講演会
  • Place of Presentation: ホテルキャッスルプラザ、名古屋
  • Invited
• [Presentation] ATL多段階発癌の分子機構解明へのアプローチ
  • Author(s): 渡邉俊樹
  • Organizer: 第１回ATL疾患検討会
  • Place of Presentation: 東京コンファレンスセンター・有明、東京
  • Invited
• [Presentation] 診断と治療法開発につながるATLの分子病態解明の試み
  • Author(s): 渡邉俊樹
  • Organizer: 長崎県産婦人科学会地方会
  • Place of Presentation: 島原、長崎
  • Invited
• [Presentation] HTLV-1総合対策３年目の現状
  • Author(s): 渡邉俊樹
  • Organizer: 長崎県ATLウイルス母子感染防止に関する講習会
  • Place of Presentation: 長崎県医師会館、長崎
  • Invited
• [Presentation] 「がんの分子病態に基づいた診断法の開発研究」
  • Author(s): 醍醐弥太郎
  • Organizer: 生命科学系3分野支援活動合同シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] 「がんの分子病態研究に基づいた個別化医療開発」
  • Author(s): 醍醐弥太郎
  • Organizer: 第761回千葉県がんセンター研究所集談会
  • Place of Presentation: 千葉
• [Presentation] 「ヒトがん関連検体試料の提供事業に於ける質の管理」
  • Author(s): 宮城洋平
  • Organizer: 第60回日本臨床検査医学会学術集会・委員会特別企画4（標準化委員会）
  • Place of Presentation: 神戸国際会議場
• [Presentation] 「がん関連試料の収集・提供 解析実証研究まで含めた病理学の役割」
  • Author(s): 宮城洋平
  • Organizer: 第77回日本病理学会東北支部学術集会
  • Place of Presentation: 東北大学
• [Presentation] エピジェネティクス創薬研究の流れと課題
  • Author(s): 吉田稔
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館
• [Presentation] 新規抗がん剤候補物質の標的分子同定法
  • Author(s): 長田裕之
  • Organizer: アカデミア発のがん創薬・個別化医療への挑戦
  • Place of Presentation: 東京
• [Presentation] Lysine-specific demethylases (LSD1, LSD2)によるTFPI2 (tissue factor pathway inhibitor 1)発現の制御
  • Author(s): 長谷川慎, 佐々木隆造, 水上民夫.
  • Organizer: 第17回日本がん分子標的治療学会学術集会
  • Place of Presentation: 京都
• [Presentation] 肝芽腫メチル化解析による予後予測マーカーの確立
  • Author(s): 本多昌平
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] 次世代シーケンサーを用いた肝芽腫のメチル化解析による予後予測マーカー確立の試み
  • Author(s): 本多昌平
  • Organizer: 第55回日本小児血液・がん学会学術集会
  • Place of Presentation: 福岡
• [Book] 免疫組織染色の定量法．細胞工学 33(3) (2014)
  • Author(s): 藤岡正喜、山野荘太郎、魏 民、鰐渕英機．
  • Total Pages: 316-322
  • Publisher: 学研メディカル秀潤社
• [Book] Surviving Cancer in Asia: Cross-boundary Cancer Studies, The University of Tokyo Japan-Asian Studies Program Academic Year 2012-2013 (2014)
  • Author(s): Editors: Akaza H, Kawahara N
  • Total Pages: 83
  • Publisher: Oxford University Press
• [Book] IV.リンパ球系 3. 成人T細胞白血病/リンパ腫におけるNF-kB経路の活性化 Annual Review 2014 血液 (2014)
  • Author(s): 渡邉俊樹
  • Total Pages: 240
  • Publisher: 中外医学社
• [Book] がん研究読本③ (2013)
  • Author(s): がん研究分野の特性等を踏まえた支援活動 総括支援活動班
  • Total Pages: 100
  • Publisher: 文部科学省科学研究費新学術領域研究 がん研究分野の特性等を踏まえた支援活動
• [Book] 癌と骨 骨転移の病理 (2013)
  • Author(s): 神田浩明(分担執筆) 松本俊夫、米田俊之編
  • Total Pages: 35-45
  • Publisher: メディカルレビュー社
• [Book] 抗CCR4抗体医薬によるT細胞性腫瘍の治療 Annual Review血液2013 (2013)
  • Author(s): 稲垣淳、 石田高司
  • Total Pages: 58-164
  • Publisher: 中外医学社
• [Book] Human T-cell leukemia virus type 1 and 2. Fields Virology, 6th edition (2013)
  • Author(s): Fujii M and Matsuoka M.
  • Total Pages: 474-1501
  • Publisher: Lippincott Williams & Wilkins
• [Book] 成人T細胞性白血病に対する新規治療法 02巻7号 (2013)
  • Author(s): 石田 高司
  • Total Pages: 1744-1750
  • Publisher: 日本内科学会雑誌
• [Book] 成人T細胞白血病・リンパ腫に対する同種移植の成績 血液内科 (2013)
  • Author(s): 宇都宮 與、 石田 高司
  • Total Pages: 781-788
  • Publisher: 科学評論社
• [Book] 末梢性γδT細胞リンパ腫 日本臨床別冊血液症候群 第2版 (2013)
  • Author(s): 森 芙美子, 石田 高司
  • Total Pages: 409-413
  • Publisher: 日本臨牀社
• [Book] ヒト化抗CCR4抗体モガムリズマブのT細胞リンパ腫への臨床応用 腫瘍内科 (2013)
  • Author(s): 小畑長英, 秋永士朗, 石田高司, 上田龍三
  • Total Pages: 325-331
  • Publisher: 科学評論社
• [Book] 「次世代シークエンサーを用いた肺がん分子マーカー研究」雑誌 呼吸 (2013)
  • Author(s): 醍醐弥太郎
  • Total Pages: 901-906
  • Publisher: 一般社団法人 呼吸研究
• [Book] 特集・制がん剤の分子標的スクリーニング成績 化学療法基盤情報支援班報告-制がん候補物質のスクリーニング成績・第14報- (2013)
  • Author(s): 矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 水上民夫, 川田学, 長田裕之, 松浦正明.
  • Total Pages: 1-114ページ
  • Publisher: 癌と化学療法社
• [Book] 特集・制がん剤の分子標的スクリーニング成績 化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報 (2013)
  • Author(s): 矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘
  • Total Pages: 116-146ページ
  • Publisher: 癌と化学療法社
• [Book] 次世代がん戦略研究Update がん基盤生物学 -革新的シーズ育成に向けて- （執筆タイトル：リン酸化依存性タンパク質間相互作用阻害物質の探索と抗がん剤への展開） (2013)
  • Author(s): 渡邉信元, 長田裕之.
  • Total Pages: 336ページ
  • Publisher: 南山堂
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  • Author(s): 水上民夫
  • Total Pages: 2-13
  • Publisher: 南山堂
• [Remarks] 文部科学省科学研究費新学術領域研究 がん研究分野の特性等を踏まえた支援活動
  • URL: http://ganshien.umin.jp/index.html
• [Remarks] 「生命科学系3分野支援活動」の助成による日本多施設共同コーホート研究（ジェイミック スタディ）
  • URL: http://www.jmicc.com/
• [Remarks] がん研究分野の特性等を踏まえた支援活動 化学療法基盤支援活動
  • URL: http://scads.jfcr.or.jp/