ゲノム科学の総合的推進に向けた大規模ゲノム情報生産・高度情報解析支援

2014 Fiscal Year Annual Research Report

• Project Area: ゲノム科学の総合的推進に向けた大規模ゲノム情報生産・高度情報解析支援
• Project/Area Number: 221S0002
• Research Institution: National Institute of Genetics
• Principal Investigator: 小原 雄治 国立遺伝学研究所, 系統生物研究センター, 特任教授 (70135292)
• Co-Investigator(Kenkyū-buntansha): 久原 哲 九州大学, (連合)農学研究科(研究院), 教授 (00153320) ; 井ノ上 逸朗 国立遺伝学研究所, 総合遺伝研究系, 教授 (00192500) ; 林 哲也 宮崎大学, フォロンティア科学実験総合センター, 教授 (10173014) ; 加藤 和人 大阪大学, 医学(系)研究科(研究院), 教授 (10202011) ; 豊田 敦 国立遺伝学研究所, 生命情報研究センター, 特任准教授 (10267495) ; 榊原 康文 慶應義塾大学, 理工学部, 教授 (10287427) ; 矢田 哲士 九州工業大学, 大学院情報工学研究院, 教授 (10322728) ; 黒木 陽子 東北大学, 東北メディカル・メガバンク機構, 准教授 (10344037) ; 桑野 良三 新潟大学, 脳研究所, フェロー (20111734) ; 黒川 顕 東京工業大学, 地球生命研究所, 教授 (20343246) ; 浅井 潔 東京大学, 新領域創成科学研究科, 教授 (30356357) ; 徳永 勝士 東京大学, 医学(系)研究科(研究院), 教授 (40163977) ; 鈴木 穣 東京大学, 新領域創成科学研究科, 教授 (40323646) ; 菅野 純夫 東京大学, 新領域創成科学研究科, 教授 (60162848) ; 山本 健 久留米大学, 医学部, 教授 (60274528) ; 中村 保一 国立遺伝学研究所, 生命情報研究センター, 教授 (60370920) ; 笠原 雅弘 東京大学, 新領域創成科学研究科, 講師 (60376605) ; 辻 省次 東京大学, 医学部附属病院, 教授 (70150612) ; 田畑 哲之 公益財団法人かずさDNA研究所, その他部局等, 所長 (70197549) ; 森下 真一 東京大学, 新領域創成科学研究科, 教授 (90292854) ; 岩崎 渉 東京大学, 大学院理学系研究科, 准教授 (50545019)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 次世代DNAシーケンサ / RNA-seq / ChIP-seq / de novo配列決定 / 個人ゲノム / リシーケンシング / GWAS / インフォームドコンセント

Outline of Annual Research Achievements

支援課題公募では161件の応募があり、90件を選定し支援した。ゲノム関係は論文発表まで時間がかかるが、支援成果も加えて、本年度は112報が発表され、今後のさらなる増加が見込まれる。
多細胞生物支援では、大型ゲノムの新たな配列決定は本年度12課題に上った。シロオビアゲハのゲノム解読支援は擬態に関するスーパージーンの構造解明につながり、論文化に至った（藤原ら）。スンクス、ポリプテルスゲノム解読は論文化進行中である。また、様々な角度からトランスクリプトーム、エピゲノム解析を行い、RIP Seq/RNA Seq/ChIP Seq法を駆使して免疫担当細胞におけるRegnase1の作用機序の詳細の解明（竹内ら）等の成果を得た。微生物支援では、環境中の窒素・硫黄循環を担う微生物共生系の解析（淡水性のものとしては世界初であり、２種類の難培養細菌のドラフト配列、代謝中心菌のメタゲノム配列から完全配列再構成に成功、福井ら）等の論文発表につながった。ゲノム医科学支援では、レット症候群、変形性関節症、痛風、小児交互性片麻痺等の遺伝子解析、PAR-CLIP法による神経変性機構解明等で成果が得られた。ゲノム解析技術開発においては、1分子シーケンシング手法（PacBio、ナノポア）、1細胞解析技術の開発整備を進めた。情報解析支援では、MetaVelvet-SLやSprai等のアッセンブラー、GPGPUによる超高速相同性検索ソフトウェア、エピゲノムデータからクロマチン状態を推定する手法、ChIP-Seqデータからタンパク質配列解析手法等の開発改良を進めるとともに、ゲノム支援講習会を開催した。ゲノムELSIユニットでは個人ゲノム解読の倫理問題への実務的支援について効率的なシステムを構築し、昨年度に引き続き医科学支援を推進した。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

医科学分野は，研究倫理審査委員会の承諾を得ることに時間を要することも含め、研究開始から論文発表まで長期間を要するが、論文発表が実現した研究が増えてきており，支援の達成度は高まっている。
多細胞生物支援については、当初懸念された多くの困難にも関わらず、ほとんどの課題について一定の成果が得られている。
微生物支援については、一部を除くと全て希望した支援ができている。
情報解析支援については、PacBioに特化したアセンブラの開発や、メタゲノムデータに対するアセンブラの開発、またGPUを利用した超高速相同性検索ソフトウェアの開発、解析パイプラインの整備も進んでおり、論文化も進んだ。多様な支援課題に柔軟に対応する体制の構築ができたが、一方で、解析を担当する研究員が不足しており、OJT形式による教育を含めたさらなる人材育成の推進が課題である。
ELSI、実務的支援については、相当な経験が蓄積し、活動の流れが確立した。

Strategy for Future Research Activity

1年間の延長となったことにより、改めて最終年度としてのとりまとめのために論文化を推進する。このために情報解析支援班の更なる強化を図る。また、1分子解析、１細胞解析などの最新技術開発整備を推進する。
このような課題への対策とともに、次期体制の構築を進める。

Research Products

• [Journal Article] Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance. (2015)
  • Author(s): Maekawa S., Imamachi N., Irie T., Tani H., Matsumoto K., Mizutani R., Imamura K., Kakeda M., Yada T., Sugano S., Suzuki Y. and Akimitsu N.
  • Journal Title: BMC Genomics Volume: 16 Pages: 154
  • DOI: 10.1186/s12864-015-1358-y
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ecophysiology of Thioploca ingrica as revealed by the complete genome sequence supplemented with proteomic evidence. (2015)
  • Author(s): Hisaya Kojima, Yoshitoshi Ogura, Nozomi Yamamoto, Tomoaki Togashi, Hiroshi Mori, Tomohiro Watanabe, Fumiko Nemoto, Ken Kurokawa, Tetsuya Hayashi and Manabu Fukui
  • Journal Title: The ISME Journal Volume: 9 Pages: 1166-1176
  • DOI: 10.1038/ismej.2014.209
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] How should the legal framework for the protection of human genomic data be formulated?―Implications from the revision processes of the Act on the Protection of Personal Information (PPI Act). (2015)
  • Author(s): Natsuko Yamamoto, Minae Kawashima, Takanori Fujita, Masatomo Suzuki and Kazuto Kato.
  • Journal Title: Journal of Human Genetics Volume: 60 Pages: 225-226
  • DOI: 10.1038/jhg.2014.121
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] DomSign: a top-down annotation pipeline to enlarge enzyme space in the protein universe. (2015)
  • Author(s): Wang T, Mori H, Zhang C, Kurokawa K, Xing XH, Yamada T
  • Journal Title: BMC Bioinfo. Volume: 16 Pages: 96
  • DOI: 10.1186/s12859-015-0499-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A genetic mechanism for female-limited Batesian mimicry in Papilio butterfly (2015)
  • Author(s): Hideki Nishikawa, Takuro iijima, Rei Kajitani, Junichi Yamaguchi, Toshiya Ando, Yutaka Suzuki, Sumio Sugano, Asao Fujiyama, Shunichi Kosugi, Hideki Hirakawa, Satoshi Tabata, Katsuhisa Ozaki, Hiroya Morimoto, Kunio Ihara, Madoka Obara, Hiroshi Hori, Takehiko Ito & Haruhiko Fujiwara
  • Journal Title: Nature Genetics Volume: 47（4） Pages: 405-409
  • DOI: doi:10.1038/ng.3241
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Complete genome sequence of Methylobacterium aquaticum strain 22A isolated from a moss, Racomitrium japonicum. (2015)
  • Author(s): Akio Tani Yoshitoshi Ogura, Tetsuya Hayashi, Kazuhide Kimbara.
  • Journal Title: Genome Announcements Volume: 3（2） Pages: e00266-15
  • DOI: doi:10.1128/genomeA.00266-15.
  • Peer Reviewed
• [Journal Article] A Colony Multiplex Quantitative PCR-Based 3S3DBC Method and Variations of It for Screening DNA Libraries (2015)
  • Author(s): Yang An, Atsushi Toyoda, Chen Zhaom, Asao Fujiyama, Kiyokazu Agata
  • Journal Title: PLoS One Volume: 10 Pages: e0116997
  • DOI: DOI: 10.1371/journal.pone.0116997
  • Peer Reviewed
• [Journal Article] Gene activation-associated long noncoding RNAs function in mouse preimplantation development. (2015)
  • Author(s): Nobuhiko Hamazaki, Masahiro Uesaka, Kinichi Nakashima, Kiyokazu Agata, and Takuya Imamura.
  • Journal Title: Development Volume: 142 Pages: 910-920
  • DOI: doi: 10.1242/dev.116996
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genome-wide analysis of long noncoding RNA turnover (2015)
  • Author(s): Tani H., Imamachi N., Mizutani R., Imamura K., Kwon Y., Miyazaki S., Maekawa S., Suzuki Y. and Akimitsu N.
  • Journal Title: Methods in Mol. Biol. Volume: 1262 Pages: 305-320
  • DOI: DOI10.1007/978-1-4939-2253-6_19
  • Peer Reviewed
• [Journal Article] Gene activation-associated long noncoding RNAs function in mouse preimplantation development (2015)
  • Author(s): Hamazaki N, Uesaka M, Nakashima K, Agata K, Imamura T
  • Journal Title: Development Volume: 142(5) Pages: 910-920
  • DOI: doi: 10.1242/dev.116996
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel mitochondria-targeted heat-soluble proteins identified in the anhydrobiotic Tardigrade improve osmotic tolerance of human cells. (2015)
  • Author(s): Tanaka S, Tanaka J, Miwa Y, Horikawa DD, Katayama T, Arakawa K, Toyoda A, Kubo T, Kunieda T
  • Journal Title: PLoS One. Volume: 10(2) Pages: e0118272
  • DOI: 10.1371/journal.pone.0118272.
  • Peer Reviewed
• [Journal Article] Draft genome sequence of the archiascomycetous yeast Saitoella complicata. (2015)
  • Author(s): Kenta Yamauchi, Shinji Kondo, Makiko Hamamoto, Yurika Takahashi, Yoshitoshi Ogura, Tetsuya Hayashi, Hiromi Nishida
  • Journal Title: Genome Announc. Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Genome-wide association study identifies a PSMD3 variant associated with neutropenia in interferon-based therapy for chronic hepatitis C. (2015)
  • Author(s): Iio E, Matsuura K, Nishida N, Maekawa S, Yatsuhashi H, Kurosaki M, Izumi N, Hiasa Y, Masaki N, Ide T, Hino K, Tamori A, Honda M, Kaneko S, Mochida S, Nomura H, Nishiguchi S, Okuse C, Itoh Y, Yoshiji H, Sakaida I, Yamamoto K, Watanabe H, Hige S, Matsumoto A, Tanaka E, Tokunaga K, and Tanaka Y.
  • Journal Title: Hum. Genet. Volume: 134 Pages: 279-289
  • DOI: 10,1007/s00439-014-1520-7.
  • Peer Reviewed
• [Journal Article] A Polymorphism in CCR1/CCR3 Is Associated with Narcolepsy (2015)
  • Author(s): Toyoda H, Miyagawa T, Koike A, Kanbayashi T, Kawamura Y, Otowa T, Miyashita A, Kashiwase K, Khor SS, Yamasaki M, Kuwano R, Sasaki T, Ishigooka J, Kuroda K, Kume K, Chiba S, Yamada N, Okawa M, Hirata K, Mizuki N, Uchimura N, Shimizu T, Inoue Y, Honda Y, Mishima K, Honda M, Tokunaga K
  • Journal Title: Brain Behav. Immun. Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Rapid detection of expanded short tandem repeats in personal genomics using hybrid sequencing (2015)
  • Author(s): Koichiro Doi, Taku Monjo, Pham H Hoang, Jun Yoshimura, Hideaki Yurino, Jun Mitsui, Hiroyuki Ishiura, Yuji Takahashi, Yaeko Ichikawa, Jun Goto, Shoji Tsuji, Shinichi Morishita
  • Journal Title: Bioinformatics Volume: 30 Pages: 815-822
  • DOI: 10.1093/bioinformatics/btt647
  • Peer Reviewed
• [Journal Article] A linear time algorithm for detecting long genomic regions enriched with a specific combination of epigenetic states (2015)
  • Author(s): Kazuki Ichikawa, Shinichi Morishita
  • Journal Title: BMC Genomics Volume: 16 Pages: S8
  • DOI: 10.1186/1471-2164-16-S2-S8
  • Peer Reviewed
• [Journal Article] Tepidicaulis marinus gen. nov., sp. nov., a novel marine bacterium reducing nitrate to nitrous oxide strictly under microaerobic conditions. (2015)
  • Author(s): Mio Takeuchi, Takao Yamagishi, Yoichi Kamagata, Kenshiro Oshima, Masahira Hattori, Taiki Katayama, Satoshi Hanada, Hideyuki Tamaki, Katsumi Marumo, Hiroto Maeda, Munetomo Nedachi, Wataru Iwasaki, Yuichi Suwa, and Susumu Sakata.
  • Journal Title: International Journal of Systematic and Evolutionary Microbiology Volume: in press Pages: in press
  • DOI: 10.1099/ijs.0.000167
  • Peer Reviewed
• [Journal Article] A machine learning based approach to de novo sequencing of glycans from tandem mass spectrometry spectrum. (2015)
  • Author(s): Kumozaki, S., Sato, K., and Sakakibara, Y.
  • Journal Title: IEEE/ACM Trans Comput Biol Bioinform, Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] MetaVelvet-SL: An extension of the Velvet assembler to a de novo metagenomic assembler utilizing supervised learning. (2015)
  • Author(s): Afiahayati, Sato, K., and Sakakibara, Y.
  • Journal Title: DNA Research Volume: 22(1) Pages: 69-77
  • DOI: 10.1093/dnares/dsu041.
  • Peer Reviewed
• [Journal Article] Learning chromatin states with factorized information criteria (2015)
  • Author(s): Michiaki Hamada, Yukiteru Ono, Ryohei Fujimaki and Kiyoshi Asai
  • Journal Title: Bioinformatics Volume: in press Pages: in press
  • DOI: 10.1093/bioinformatics/btv163
  • Peer Reviewed
• [Journal Article] Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance (2015)
  • Author(s): Sho Maekawa, Naoto Imamachi, Takuma Irie, Hidenori Tani, Kyoko Matsumoto, Rena Mizutani, Katsutoshi Imamura, Miho Kakeda, Tetsushi Yada, Sumio Sugano, Yutaka Suzuki and Nobuyoshi Akimitsu
  • Journal Title: BMC Genomics Volume: 16 Pages: 154
  • DOI: 10.1186/s12864-015-1358-y
  • Peer Reviewed
• [Journal Article] 医療情報の共有・利用における現状と課題―医療情報共有における一般市民の意識調査 (2015)
  • Author(s): 橋本泰成
  • Journal Title: 医療・生命と倫理・社会 Volume: 12 Pages: 67-87
• [Journal Article] 「全ゲノム解析研究に関する一般市民を対象とした意識調査」の結果報告 (2015)
  • Author(s): 大橋範子・大北全俊
  • Journal Title: 医療・生命と倫理・社会 Volume: 12 Pages: 88-104
• [Journal Article] パーソナルゲノム時代の解析データの共有―データ公開・共有方針と倫理的対応 (2015)
  • Author(s): 三成寿作
  • Journal Title: 医療・生命と倫理・社会 Volume: 12 Pages: 105-114
• [Journal Article] 個人の遺伝情報の保護における国レベルでのルール形成に向けた試論―個人情報保護法とその改正法を中心に (2015)
  • Author(s): 山本奈津子・鈴木正朝・川嶋実苗・藤田卓仙
  • Journal Title: 医療・生命と倫理・社会 Volume: 12 Pages: 115-123
• [Journal Article] 社会とともに進めるゲノム医学研究―国際ワークショップ開催報告 (2015)
  • Author(s): 吉澤剛
  • Journal Title: 医療・生命と倫理・社会 Volume: 12 Pages: 131-145
• [Journal Article] Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment. (2015)
  • Author(s): Suzuki A, Matsushima K, Makinoshima H, Sugano S, Kohno T, Tsuchihara K, Suzuki Y
  • Journal Title: Genome Biology Volume: 16 Pages: 66-66
  • DOI: doi:10.1186/s13059-015-0636-y
• [Journal Article] DBTSS as an integrative platform for transcriptome, epigenome and genome sequence variation data. DNA methylation patterns. (2015)
  • Author(s): Suzuki A, Wakaguri H, Yamashita R, Kawano S, Tsuchihara K, Sugano S, Suzuki Y, Nakai K.
  • Journal Title: Nucleic Acids Res. Volume: 43 Pages: D87-91
  • DOI: 10.1093/nar/gku1080
  • Peer Reviewed
• [Journal Article] Regnase-1 and Roquin regulate common inflammation-related mRNAs in translation-dependent and independent manners. (2015)
  • Author(s): Takashi Mino, Yasuhiro Murakawa, Akira Fukao, Alexis Vandenbon, Hans-Hermann Wessels, Daisuke Ori, Takuya Uehata, Sarang Tartey, Shizuo Akira, Yutaka Suzuki, Carola G. Vinuesa, Uwe Ohler, Daron M. Standley, Markus Landthaler, Toshinobu Fujiwara, Osamu Takeuchi
  • Journal Title: Cell Volume: in press Pages: in press
  • Peer Reviewed
• [Journal Article] Discovery of osmotic sensitive transcription factors in fish intestine via a transcriptomic approach. (2014)
  • Author(s): Marty KS Wong, Haruka Ozaki, Yutaka Suzuki, Wataru Iwasaki and Yoshio Takei
  • Journal Title: BMC Genomics Volume: 15 Pages: 1134
  • DOI: doi:10.1186/1471-2164-15-1134
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans (2014)
  • Author(s): Akane Ohta, Tomoyo Ujisawa, Satoru Sonoda & Atsushi Kuhara
  • Journal Title: Nature Communications Volume: 5 Pages: 4412
  • DOI: DOI: 10.1038/ncomms5412
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The newt reprograms mature RPE cells into a unique multipotent state for retinal regeneration. (2014)
  • Author(s): Islam, M.R., Nakamura, K., Casco-Robles, M.M., Kunahong, A., Inami, W., Toyama, F., Maruo, F. and Chiba, C
  • Journal Title: Sci. Rep. Volume: 4 Pages: 6043
  • DOI: doi:10.1038/srep06043
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sperm proteases that may be involved in the initiation of sperm motility in the newt, Cynops pyrrhogaster. (2014)
  • Author(s): Yokoe M., Sano, M., Shibata, H., Shibata, D., Takayama-Watanabe, E., Inaba, K. and Watanabe, A
  • Journal Title: Int. J. Mol. Sci. Volume: 15 Pages: 15210-15224
  • DOI: doi:10.3390/ijms150915210
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A transcriptome for the study of early processes of retinal regeneration in the adult newt, Cynops pyrrhogaster. (2014)
  • Author(s): Nakamura, K., Islam, M.R., Takayanagi, M., Yasumuro, H., Inami, W., Kunahong, A., Casco-Robles, R.M., Toyama, F*. and Chiba, C
  • Journal Title: PLoS One Volume: 9(10) Pages: e109831
  • DOI: DOI: 10.1371/journal.pone.0109831
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] HAP2/GCS1 is involved in the sexual reproduction system of the marine macroalga Ulva compressa (Ulvales, Chlorophyta). (2014)
  • Author(s): Yamazaki, T., Endo, M., Ito, Kan., Suzuki, R., Ota, S., Kuwano K., Miyamura, S., Toyoda, A., Kawano, S.
  • Journal Title: Cytologia Volume: 79(4) Pages: 575-584
  • DOI: DOI: 10.1508/cytologia.79.575
  • Peer Reviewed
• [Journal Article] Technical Note: A transformation system using rbcS N-terminal region fused with GFP demonstrates pyrenoid targeting of the small subunit of RubisCO in Ulva compress (2014)
  • Author(s): Suzuki, R., Yamazaki, T., Toyoda, A. and Kawano, S.
  • Journal Title: Cytologia Volume: 79(4) Pages: 427-428
  • DOI: DOI: 10.1508/cytologia.79.427
  • Peer Reviewed
• [Journal Article] Long noncoding RNA NEAT1-dependent SFPQ relocation between nuclear body paraspeckle and promoter mediates IL8 expression in response to immune stimuli. (2014)
  • Author(s): Imamura K., Imamachi N., Akizuki G., Kumakura M., Kawaguchi A., Nagata K., Kato A., Kawaguchi Y., Sato H., Yoneda M., Kai C., Yada T., Suzuki Y., Yamada T., Ozawa T., Kaneki K., Inoue T., Kobayashi M., Kodama T., Wada Y., Sekimizu K. and Akimitsu N.
  • Journal Title: Mol. Cell Volume: 53 Pages: 393-406
  • DOI: doi.org/10.1016/j.molcel.2014.01.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Identification of the Carotenoid Modifying Gene PALE YELLOW PETAL 1 as an Essential Factor in Xanhtophyll Esterification and Yellow Flower Pigmentation in Tomato (Solanum lycopersicum). (2014)
  • Author(s): Tohru Ariizumi, Sanae Kishimoto, Ryo Kakami, Takashi Maoka, Hideki Hirakawa, Yutaka Suzuki, Yuko Ozeki, Kenta Shirasawa, Stephane Bernillon, Yoshihiro Okabe, Annick Moing, Erika Asamizu, Christophe Rothan, Akemi Ohmiya and Hiroshi Ezura
  • Journal Title: The Plant Journal Volume: 79 Pages: 453-465
  • DOI: DOI: 10.1111/tpj.12570
  • Peer Reviewed
• [Journal Article] Inermediate Form Between Alternating Hemiplegia of Childhood and Rapid-Onset Dystonia-Parkinsonism. (2014)
  • Author(s): Sasaki M., Ishii A., Saito Y. and Hirose S.
  • Journal Title: Movement Disorders Volume: 29(1) Pages: 153-154
  • DOI: DOI: 10.1002/mds.25659
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Distinct neurologocal disorders with ATP1A3 mutations. (2014)
  • Author(s): Erin L. Heinzen, Alexis Arzimanoglou, Allison Brashear, Steven J. Clapcote, Fiorella Gurrieri, David B. Goldstein, Sigurour H. Johannesson, Mohamad A. Mikati, M.D., Brian Neville, FRCPCH, Sophie Nicole, Laurie J. Ozelius,
  • Journal Title: Lancent Neurol. Volume: 13 Pages: 503-514
  • DOI: doi: 10.1016/S1474-4422(14)70011-0
  • Peer Reviewed
• [Journal Article] Genotype-Phenotype Correlations in Alternating Hemiplegia of Childhood. (2014)
  • Author(s): Masayuki Sasaki, Atsushi Ishii, Yoshiaki Saito, Naoya Morisada, Kazumoto Iijima, Satoshi Takada, Atsushi Araki, Yuko Tanabe, Hidee Arai, Sumimasa Yamashita, Tsukasa Ohashi, Yoichiro Oda, Hiroshi Ichiseki, Shininchi Hirabayashi, Akihiro Yasuhara, Hisashi Kawawaki,and Shinichi Hirose
  • Journal Title: NEUROLOGY Volume: 82(6) Pages: 482-490
  • DOI: doi: 10.1212/WNL.0000000000000102
  • Peer Reviewed
• [Journal Article] Gene Content Evolution in Discobid Mitochondria Deduced from Phylogenic Position and Complete Mitochondrial Genome of Tsukubamonas globosa. (2014)
  • Author(s): Ryoma Kamikawa, Martin Kolisko, Yuki Nishimura, Akinori Yabuki, Matthew W. Brown, Sohta A. Ishikawa, Ken-ichiro Ishida, Andrew J. Roger, Tetsuo Hashimoto and Yuji Inagaki
  • Journal Title: Genome Biol. Evol. Volume: 6(2) Pages: 306-315
  • DOI: doi: 10.1093/gbe/evu015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Bead-based Normalization for Uniform Sequencing depth (BeNUS) protocol for multi-samples sequencing exemplified by HLA-B. (2014)
  • Author(s): Kazuyoshi Hosomichi, Shigeki Mitsunaga, Hideki Nagasaki and Ituro Inoue
  • Journal Title: BMC Genomics Volume: 15 Pages: 645
  • DOI: doi:10.1186/1471-2164-15-645
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals. (2014)
  • Author(s): Masahiro Uesaka, Osamu Nishimura, Yasuhiro Go, Kinichi Nakashima, Kiyokazu Agata and Takuya Imamura
  • Journal Title: BMC Genomics Volume: 15 Pages: 35
  • DOI: doi:10.1186/1471-2164-15-35
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Tif1β-Hp1 system maintains transcriptional integrity of hematopoietic stem cells. (2014)
  • Author(s): Satoru Miyagi, Shuhei Koide, Atsunori Saraya, George R. Wendt, Motohiko Oshima, Takaaki Konuma, Satoshi Yamazaki, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Issay Kitabayashi, Hiromitsu Nakauchi, Atsushi Iwama
  • Journal Title: Stem Cell Reports Volume: 2 Pages: 145-152
  • DOI: doi.org/10.1016/j.stemcr.2013.12.008.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An evolutionarily conserved protein CHORD regulates scaling of dendritic arbors with body size. (2014)
  • Author(s): Kohei Shimono, Kazuto Fujishima, Takafumi Nomura, Masayoshi Ohashi, Tadao Usui, Mineko Kengaku, Atsushi Toyoda & Tadashi Uemura
  • Journal Title: Scientific Reports Volume: 4 Pages: 4415
  • DOI: DOI: 10.1038/srep04415
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Defects in the synthetic pathway prevent DIF-1 mediated stalk lineage specification cascade in the non-differentiating social amoeba, Acytostelium subglobosum. (2014)
  • Author(s): Kurato Mohri, Takashi Hata, Haruhisa Kikuchi, Yoshiteru Oshima and Hideko Urushihara
  • Journal Title: Biol Open Volume: 3 Pages: 553-560
  • DOI: doi:10.1242/bio.20148359
  • Peer Reviewed
• [Journal Article] Molecular evidence that the genes for dioecism and monoecism in Spinacia oleracea L. are located at different loci in a chromosomal region. (2014)
  • Author(s): K Yamamoto, Y Oda, A Haseda, S Fujito, T Mikami and Y Onodera
  • Journal Title: Heredity Volume: 112(3) Pages: 317-324
  • DOI: doi:10.1038/hdy.2013.112
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Methyloceanibacter caenitepidi gen. nov., sp. nov., a novel facultatively methylotrophic bacterium isolated from marine sediments near the hydrothermal vent area. (2014)
  • Author(s): Takeuchi M. et al, Mio Takeuchi, Taiki Katayama, Takao Yamagishi, Satoshi Hanada, Hideyuki Tamaki, Yoichi Kamagata, Kenshiro Oshima, Masahira Hattori, Katsumi Marumo, Munetomo Nedachi, Hiroto Maeda Yuichi Suwa and Susumu Sakata
  • Journal Title: International Journal of Systematic and Evolutionary Microbiology. Volume: 64 Pages: 462-468
  • DOI: doi:10.1099/ijs.0.053397-0
  • Peer Reviewed
• [Journal Article] Methylocaldum marinum sp. nov., a thermotolerant methane-oxidizing bacterium isolated from marine sediments, and emended description of the genus Methylocaldum. (2014)
  • Author(s): Mio Takeuchi, Yoichi Kamagata, Kenshiro Oshima, Satoshi Hanada, Hideyuki Tamaki, Katsumi Marumo, Hiroto Maeda, Munetomo Nedachi, Masahira Hattori, Wataru Iwasaki and Susumu Sakata
  • Journal Title: International Journal of Systematic and Evolutionary Microbiology. Volume: 64 Pages: 462-468
  • DOI: doi:10.1099/ijs.0.053397-0
  • Peer Reviewed
• [Journal Article] Direct binding of Ataxin-2 to distinct elements in 3’UTRs promotes mRNA stability and protein expression. (2014)
  • Author(s): Moe Yokoshi, Quan Li, Munetaka Yamamoto, Hitomi Okada, Yutaka Suzuki, Yukio Kawahara
  • Journal Title: Molecular Cell Volume: 55 Pages: 186-198
  • DOI: doi.org/10.1016/j.molcel.2014.05.022.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Divergent selection for opsin gene variation in guppy (Poecilia reticulata) populations of Trinidad and Tobago. (2014)
  • Author(s): Tezuka, A., Kasagi, S., van Oosterhout, C., McMullan, M., Iwasaki, W. M., Kasai, D., Yamamichi, M., Innan, H., Kawamura, S. and Kawata, M.
  • Journal Title: Molecular Cell Volume: 55 Pages: 186-198
  • DOI: doi.org/10.1016/j.molcel.2014.05.022.
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Evolutionary renovation of L/M opsin polymorphism confers a fruit discrimination advantage to ateline New World monkeys. (2014)
  • Author(s): Matsumoto, Y., Hiramatsu, C., Matsushita, Y., Ozawa, N., Ashino, R., Nakata, M., Kasagi, S., Di Fiore, A. Schaffner, C. M., Aureli, F., Melin, A. D. and Kawamura, S.
  • Journal Title: Molecular Ecology Volume: 23 (7) Pages: 1799-1812
  • DOI: DOI: 10.1111/mec.12703
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The heterozygote superiority hypothesis for polymorphic color vision is not supported by long-term fitness data from wild Neotropical monkeys. (2014)
  • Author(s): Fedigan, L. M., Melin, A. D., Addicott, J. F. and Kawamura, S.
  • Journal Title: PLoS One Volume: 9 (1) Pages: e84872.
  • DOI: DOI: 10.1371/journal.pone.0084872
  • Peer Reviewed
• [Journal Article] The behavioral ecology of color vision: considering fruit conspicuity, detection distance and dietary importance. (2014)
  • Author(s): Melin, A. D., Hiramatsu, C., Parr, N. A., Matsushita, Y., Kawamura, S. and Fedigan, L. M.
  • Journal Title: International Journal of Primatology Volume: 35 (1): Pages: 258-287
  • DOI: DOI 10.1007/s10764-013-9730-8
  • Peer Reviewed
• [Journal Article] Color vision variation as evidenced by hybrid L/M opsin genes in wild populations of trichromatic Alouatta New World monkeys. (2014)
  • Author(s): Yuka Matsushita, Hiroki Oota, Barbara J. Welker, Mary S. Pavelka and Shoji Kawamura
  • Journal Title: International Journal of Primatology, Volume: 35（1） Pages: 71-87
  • DOI: DOI 10.1007/s10764-013-9705-9
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genome-Wide SNP Analysis Reveals Population Structure and Demographic History of the Ryukyu Islanders in the Southern Part of the Japanese Archipelago (2014)
  • Author(s): Sato T, Nakagome S, Watanabe C, Yamaguchi K, Kawaguchi A, Koganebuchi K, Haneji K, Yamaguchi T, Hanihara T, Yamamoto K, Ishida H, Mano S, Kimura R, Oota H
  • Journal Title: Mol Biol Evol. Volume: 31(11) Pages: 2929-2940
  • DOI: doi:10.1093/molbev/msu230
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Epigenetics as a basis for diagnosis of neurodevelopmental disorders: challenges and opportunities. (2014)
  • Author(s): Kubota T, Miyake K, Hariya M, Mochizuki K.
  • Journal Title: Expert Rev Mol Diagn Volume: 14(6) Pages: 685-697
  • DOI: doi: 10.1586/14737159.2014.925805
  • Peer Reviewed
• [Journal Article] Breakpoint analysis of the recurrent constitutional t(8;22)(q24.13;q11.21) translocation. (2014)
  • Author(s): Mishra D, Kato T, Inagaki H, Kosho T, Wakui K, Kido Y, Sakazume S, Taniguchi-Ikeda M, Morisada N, Iijima K, Fukushima Y, Emanuel BS, Kurahashi H.
  • Journal Title: Mol Cytogenet, Volume: 7 Pages: 55
  • DOI: doi:10.1186/s13039-014-0055-x
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Co-option of a photoperiodic growth-phase transition system during land plant evolution (2014)
  • Author(s): Akane Kubota, Shogo Kita, Kimitsune Ishizaki, Ryuichi Nishihama, Katsuyuki T. Yamato & Takayuki Kohchi
  • Journal Title: Nature Communication Volume: 5 Pages: 3668
  • DOI: DOI: 10.1038/ncomms4668
  • Peer Reviewed
• [Journal Article] Phototropin encoded by a single-copy gene mediates chloroplast photorelocation movement in the liverwort Marchantia polymorpha L. (2014)
  • Author(s): Aino Komatsu, Mika Terai, Kimitsune Ishizaki, Noriyuki Suetsugu, Hidenori Tsuboi, Ryuichi Nishihama, Katsuyuki T. Yamato, Masamitsu Wada, and Takayuki Kohchi
  • Journal Title: Plant Physiol. Volume: 166 Pages: 411-427
  • DOI: doi/10.1104/pp.114.245100
  • Peer Reviewed
• [Journal Article] The polycomb component Ring 1B regulates the timed termination of subcerebral projection neuron production during neocortical development. (2014)
  • Author(s): Nao Morimoto-Suzki, Yusuke Hirabayashi, Kelsey Tyssowski, Jun Shinga, Miguel Vidal, Haruhiko Koseki and Yukiko Gotoh
  • Journal Title: Development. Volume: 141 Pages: 4343-4353
  • DOI: doi:10.1242/dev.112276
  • Peer Reviewed
• [Journal Article] Study of MHC class II region polymorphism in the Filipino cynomolgus macaque population. (2014)
  • Author(s): Blancher A, Aarnink A, Yamada Y, Tanaka K, Yamanaka H, Shiina T.
  • Journal Title: Immunogenetics Volume: 66 Pages: 219-230
  • DOI: DOI 10.1007/s00251-014-0764-7
  • Peer Reviewed
• [Journal Article] Massive Gene Transfer and Extensive RNA Editing of a Symbiotic Dinoflagellate Plastid Genome (2014)
  • Author(s): Sutada Mungpakdee, Chuya Shinzato, Takeshi Takeuchi, Takeshi Kawashima, Ryo Koyanagi,
  • Journal Title: Genome Biol. Evol. Volume: 6(6): Pages: 1408-1422
  • DOI: doi:10.1093/gbe/evu109
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Occupancy of Tissue-Specific cis-Regulatory Modules by Otx2 and TLE/Groucho for Embryonic Head Specification (2014)
  • Author(s): Yuuri Yasuoka, Yutaka Suzuki, Shuji Takahashi, Haruka Someya, Norihiro Sudou, Yoshikazu Haramoto, Ken W. Cho, Makoto Asashima, Sumio Sugano & Masanori Taira
  • Journal Title: Nature Communications Volume: 5 Pages: 4322
  • DOI: doi: 10.1038/ncomms5322
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Large hypomethylated domains serve as strong repressive machinery for key developmental genes in vertebrates (2014)
  • Author(s): Nakamura R, Tsukahara T, Qu W, Ichikawa K, Otsuka T, Ogoshi K, Saito TL, Matsushima K, Sugano S, Hashimoto S, Suzuki Y, Morishita S and Takeda H,
  • Journal Title: Development Volume: 141 Pages: 2568-1580
  • DOI: doi:10.1242/dev.108548
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Occurence of the endangered species Nitellopsis obtusa (Charales, Charophyceae) in western Japan and the genetic differences within and among Japanese populations. (2014)
  • Author(s): Kato, S., Kawai, H., Takimoto, M., Suga, H., Yohda, K., Horiya, K., Higuchi, S., & Sakayama, H.
  • Journal Title: Phycological Research Volume: 62 Pages: 222-227
  • DOI: DOI: 10.1111/pre.12057
  • Peer Reviewed
• [Journal Article] Characterization of sexual reproductive processes in Chara braunii (Charales, Charophyceae). (2014)
  • Author(s): Sato, M., Sakayama, H., Sato, M., Ito, M. & Sekimoto, H.
  • Journal Title: Phycological Research Volume: 62 Pages: 214-221
  • DOI: DOI: 10.1111/pre.12056
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Heterotrimeric G proteins control stem cell proliferation through CLAVATA signaling in Arabidopsis. (2014)
  • Author(s): Ishida, T., Tabata, R., Yamada, M., Aida, M., Mitsumasu, K., Fujiwara, M., Yamaguchi, K., Shigenobu, S., Higuchi, M., Tsuji, H., Shimamoto, K., Hasebe, M., Fukuda, H., and Sawa, S.
  • Journal Title: EMBO rep. Volume: 15(11) Pages: 1202-1209
  • DOI: DOI 10.15252/embr.201438660
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Maturation processes and structures of secreted peptides in plants. (2014)
  • Author(s): Tabata, R. and Sawa, S.
  • Journal Title: Frontiers in Plant Science Volume: 5 Pages: 311
  • DOI: doi: 10.3389/fpls.2014.00311
  • Peer Reviewed
• [Journal Article] CLE6 expression recovers gibberellin deficiency to promote shoot growth in Arabidopsis. (2014)
  • Author(s): Bidadi, H., Matsuoka, K., Sage-Ono, K., Fukushima, J., Pitaksaringkarn, W., Asahina, M., Yamaguchi, S., Sawa, S., Fukuda, H, Matsubayashi, Y., Ono, M., Satoh, S.
  • Journal Title: Plant J. Volume: 78 Pages: 241-252.
  • DOI: DOI: 10.1111/tpj.12475
  • Peer Reviewed
• [Journal Article] CLE-CLAVATA1 peptide-receptor signaling module regulates the expansion of plant root systems in a nitrogen-dependent manner. (2014)
  • Author(s): Araya, T., Miyamoto, M., Mibowo, J., Suzuki, A., Kojima, S., Tsuchiya, Y. N., Sawa, S., Fukuda, H., Wiren, N., Takahashi, H.
  • Journal Title: Proc. Natl. Acad. Sci. Volume: 111 Pages: 2029-2034
  • DOI: doi:10.1073/pnas.1319953111
  • Peer Reviewed
• [Journal Article] Light-dependent green gall formation induced by Meloidogyne incognita. (2014)
  • Author(s): Nishiyama, H., Nakagami, S., Todaka, A., Arita, T., Ishida, T., and Sawa, S.
  • Journal Title: Nematology Volume: 16(8) Pages: 889-893
  • DOI: DOI: 10.1163/15685411-00002814
  • Peer Reviewed
• [Journal Article] Genomic Aspects of Sporadic Neurodegenerative Diseases. (2014)
  • Author(s): Mitsui J, Tsuji S.
  • Journal Title: Biochem Biophys Res Commun. Volume: 452 Pages: 221-225
  • DOI: doi.org/10.1016/j.bbrc.2014.07.098
  • Peer Reviewed
• [Journal Article] Design and experimental application of a novel non-degenerate universal primer set that amplifies prokaryotic 16S rRNA genes with a low possibility to amplify eukaryotic rRNA genes. (2014)
  • Author(s): Hiroshi Mori, Fumito Maruyama, Hiromi Kato, Atsushi Toyoda, Ayumi Dozono, Yoshiyuki Ohtsubo Yuji Nagata, Asao Fujiyama, Masataka Tsuda and Ken Kurokawa
  • Journal Title: DNA Research Volume: 21(2) Pages: 217-227
  • DOI: doi:10.1093/dnares/dst052
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nuclear dynamics of topoisomerase Ⅱβ reflects its catalytic activity that is regulated by binding of RNA to the C-terminal domain. (2014)
  • Author(s): Akihisa Onoda, Osamu Hosoya, Kuniaki Sano, Kazuko Kiyama, Hiroshi Kimura, Shinji Kawano, Ryohei Furuta, Mary Miyaji, Ken Tsutsui, and Kimiko M. Tsutsui
  • Journal Title: Nucleic Acids Res. Volume: 42 Pages: 9005-9020
  • DOI: doi:10.1093/nar/gku640
  • Peer Reviewed
• [Journal Article] Complete genome sequence of Pseudomonas sp.strain TKP isolated from a γ-hexachlorocyclohexane-degrading mixed culture. (2014)
  • Author(s): Ohtsubo Y, Kishida K, Sato T, Tabata M, Kawasumi T, Ogura Y, Hayashi T, Tsuda M, Nagata Y.
  • Journal Title: Genome Announcements Volume: 2 Pages: e01241-13
  • DOI: doi:10.1128/genomeA.01241-13
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Complete genome sequence of Pseudomonas aeruginosa MTB-1 isolated from a microbial community enriched by the technical formulation of hexachlorocyclohexane (2014)
  • Author(s): Ohtsubo Y, Sato T, Kishida K, Tabata M, Ogura Y, Hayashi T, Tsuda M, Nagata Y.
  • Journal Title: Genome Announcements Volume: 2 Pages: e01130-13
  • DOI: doi:10.1128/genomeA.01130-13
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sall1 maintains nephron progenitors and nascent nephrons by acting as both an activator and a repressor. (2014)
  • Author(s): Shoichiro Kanda, Shunsuke Tanigawa, Tomoko Ohmori, Atsuhiro Taguchi, Kuniko Kudo, Yutaka Suzuki, Yuki Sato, Shinjiro Hino, Maike Sander, Alan O. Perantoni, Sumio Sugano, Mitsuyoshi Nakao, and Ryuichi Nishinakamura
  • Journal Title: J Am Soc Nephrol Volume: 25 Pages: 2584-2595
  • DOI: doi:10.1681/ASN.2013080896
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Sex-specific posttranslational regulation of the gamete fusogen GCS1 in the isogamous volvocine alga Gonium pectorale. (2014)
  • Author(s): Hiroko Kawai-Toyooka, Toshiyuki Mori, Takashi Hamaji, Masahiro Suzuki, Bradley J. S. C. Olson, Tomohiro Uemura, Takashi Ueda, Akihiko Nakano, Atsushi Toyoda, Asao Fujiyama, and Hisayoshi Nozaki
  • Journal Title: Eukaryotic Cell Volume: 13 Pages: 648-656
  • DOI: doi:10.1128/EC.00330-13
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Induction of Virulence Gene Expression in Staphylococcus aureus by Pulmonary Surfactant (2014)
  • Author(s): Kenichi Ishii, Tatsuo Adachi, Jyunichiro Yasukawa, Yutaka Suzuki, Hiroshi Hamamoto, and Kazuhisa Sekimizu
  • Journal Title: Infect. Immun. Volume: 82(4) Pages: 1500-1510
  • DOI: doi:10.1128/IAI.01635-13
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] CLOCK-controlled polyphonic regulations of circadian rhythms through canonical and non-canonical E-boxes. (2014)
  • Author(s): Hikari Yoshitane, Haruka Ozaki, Hideki Terajima, Ngoc-Hien Du, Yutaka Suzuki, Taihei Fujimori, Naoki Kosaka, Shigeki Shimba, Sumio Sugano, Toshihisa Takagi, Wataru Iwasaki, and Yoshitaka Fukada
  • Journal Title: Molecular and Cellular Biology Volume: 34(10) Pages: 1776-1787
  • DOI: doi:10.1128/MCB.01465-13
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Methylome diversification through changes in DNA methyltransferase sequence specificity. (2014)
  • Author(s): Yoshikazu Furuta, Hiroe Namba-Fukuyo, Tomoko F. Shibata, Tomoaki Nishiyama, Shuji Shigenobu, Yutaka Suzuki, Sumio Sugano, Mitsuyasu Hasebe, and Ichizo Kobayashi
  • Journal Title: PloS Genetics Volume: 10(4) Pages: e1004272
  • DOI: DOI: 10.1371/journal.pgen.1004272
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Bead-based Normalization for Uniform Sequnecing depth (BeNUS) protocol for multi-samples seqencing exemplified by HLA-B. (2014)
  • Author(s): Kazuyoshi Hosomichi, Shigeki Mitsunaga, Hideki Nagasaki and Ituro Inoue
  • Journal Title: BMC Genomics Volume: 15 Pages: 645
  • DOI: doi:10.1186/1471-2164-15-645
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Novel calmodulin (CALM2) mutations associated with congenital arrhythmia susceptibility. (2014)
  • Author(s): Naomasa Makita, Nobue Yagihara, Lia Crotti, Christopher N. Johnson, Britt-Maria Beckmann, Michelle S. Roh, Daichi Shigemizu, Peter Lichtner, Taisuke Ishikawa, Takeshi Aiba, Tessa Homfray, Elijah R. Behr, Didier Klug, Isabelle Denjoy, Elisa Mastantuono, Daniel and Alfred L. George, Jr
  • Journal Title: Circ Cardiovasc Genet Volume: 7 Pages: 466-474
  • DOI: doi:10.1161/CIRCGENETICS.113.000459
  • Peer Reviewed
• [Journal Article] Phytochrome controls alternative splicing to mediate light responses in Arabidopsis. (2014)
  • Author(s): Hiromasa Shikata, Kousuke Hanada, Tomokazu Ushijima, Moeko Nakashima, Yutaka Suzuki, and Tomonao Matsushita
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 111(52) Pages: 18781-18786
  • DOI: doi:10.1073/pnas.1407147112
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] ABCG2 dysfunction causes hyperuricemia due to both renal urate underexcretion and renal urate overload. (2014)
  • Author(s): Hirotaka Matsuo, Akiyoshi Nakayama, Masayuki Sakiyama, Toshinori Chiba, Seiko Shimizu, Yusuke Kawamura, Hiroshi Nakashima, Takahiro Nakamura, Yuzo Takada, Yuji Oikawa, Tappei Takada, Hirofumi Nakaoka, Junko Abe, Hiroki Inoue, Kenji Wakai, Sayo Kawai, & Nariyoshi Shinomiya
  • Journal Title: Sci Rep. Volume: 4 Pages: 3755
  • DOI: doi:10.1038/srep03755
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Common dysfunctional variants of ABCG2 have strong impact on hyperuricemia progression than typical environmental risk factors. (2014)
  • Author(s): Akiyoshi Nakayama, Hirotaka Matsuo, Hirofumi Nakaoka, Takahiro Nakamura, Hiroshi Nakashima, Yuzo Takada, Yuji Oikawa, Tappei Takada, Masayuki Sakiyama, Seiko Shimizu, Yusuke Kawamura, & Nariyoshi Shinomiya
  • Journal Title: Sci Rep. Volume: 4 Pages: 5227
  • DOI: doi:10.1038/srep05227
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Ethnic differences in ATP-binding cassette tansporter, sub-family G, member 2: Genotype combinations and estimated functions. (2014)
  • Author(s): Masayuki SAKIYAMA, Hirotaka MATSUO, Yuzo TAKADA, Takahiro NAKAMURA, Akiyoshi NAKAYAMA, Tappei TAKADA, Shin-ichiro KITAJIRI, Kenji WAKAI, Hiroshi SUZUKI, Nariyoshi SHINOMIYA
  • Journal Title: DMPK Volume: 29(6) Pages: 490-492
  • DOI: doi.org/10.2133/dmpk.DMPK-14-SC-041
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Efficient de novo assembly of highly heterozygous genomes from whole-genome shotgun short reads (2014)
  • Author(s): Rei Kajitani, Kouta Toshimoto, Hideki Noguchi, Atsushi Toyoda, Yoshitoshi Ogura, Miki Okuno, Mitsuru Yabana, Masayuki Harada, Eiji Nagayasu, Haruhiko Maruyama, Yuji Kohara, Asao Fujiyama, Tetsuya Hayashi, and Takehiko Itoh
  • Journal Title: Genome Research Volume: 24 Pages: 1384-1395
  • DOI: doi:10.1101/gr.170720.113
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Assessment of helminth biodiversity in wild rats using 18S rDNA based metagenomics. (2014)
  • Author(s): Ryusei Tanaka, Akina Hino, Isheng J. Tsai, Juan Emilio Palomares-Rius, Ayako Yoshida, Yoshitoshi Ogura, Tetsuya Hayashi, Haruhiko Maruyama, Taisei Kikuchi
  • Journal Title: PLoS One. Volume: 9 Pages: e110769
  • DOI: DOI: 10.1371/journal.pone.0110769
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Karyotype and reproduction mode of the rodent parasite Strongyloides venezuelensis. (2014)
  • Author(s): AKINA HINO, TERUHISA TANAKA, MAHO TAKAISHI, YUMIKO FUJII, JUAN E. PALOMARES-RIUS, KOICHI HASEGAWA, HARUHIKO MARUYAMA and TAISEI KIKUCHI
  • Journal Title: Parasitology Volume: 141 Pages: 1736-1745
  • DOI: doi:10.1017/S0031182014001036
  • Peer Reviewed
• [Journal Article] Genome-wide association study of degenerative bony changes of temporomandibular joint in East Asian populations. (2014)
  • Author(s): T Yamaguchi, H Nakaoka, K Yamamoto, T Fujikawa, Y-I Kim, K Yano, S Haga, K Katayama, T Shibusawa, SB Park, K Maki, R Kimura and I Inoue
  • Journal Title: Oral Dis. Volume: 20(4) Pages: 409-415
  • DOI: DOI: 10.1111/odi.12141
  • Peer Reviewed
• [Journal Article] Functional characterization of flavobacteria thodopsins reveals a unique class of light-driven chloride pump in bacteria. (2014)
  • Author(s): Susumu Yoshizawa, Yohei Kumagai, Hana Kim, Yoshitoshi Ogura, Tetsuya Hayashi, Wataru Iwasaki, Edward F. DeLong and Kazuhiro Kogure
  • Journal Title: Proc. Natl. Acad. Sci. USA. Volume: 111(18) Pages: 6732-6737
  • DOI: doi:10.1073/pnas.1403051111
  • Peer Reviewed
• [Journal Article] 遺伝子から見た根寄生植物の生存戦略 (2014)
  • Author(s): 吉田聡子、若竹崇雅、白須賢
  • Journal Title: 植物の生長調節 Volume: 49(1) Pages: 66
• [Journal Article] Genome-wide analysis of CNV (copy number variation) and their associations with narcolepsy in a Japanese population. (2014)
  • Author(s): Yamasaki M, Miyagawa T, Toyoda H, Khor SS, Koike A, Nitta A, Akiyama K, Sasaki T, Honda M, Tokunaga K.
  • Journal Title: J. Hum. Genet. Volume: 59 Pages: 235-240
  • DOI: 10.1038/jhg.2014.13.
  • Peer Reviewed
• [Journal Article] A genome-wide association study for diabetic retinopathy in a Japanese population: potential association with a long intergenic non-coding RNA. (2014)
  • Author(s): Awata T, Yamashita H, Kurihara S, Morita-Ohkubo T, Miyashita Y, Katayama S, Mori K, Yoneya S, Kohda M, Okazaki Y, Maruyama T, Shimada A, Yasuda K, Nishida N, Tokunaga K, and Koike A.
  • Journal Title: PLoS One Volume: 9 Pages: e111715
  • DOI: 10.1371/journal.pone.0111715.
  • Peer Reviewed
• [Journal Article] CLAST: CUDA implemented large-scale alignment search tool. (2014)
  • Author(s): Yano M, Mori H, Akiyama Y, Yamada T, Kurokawa K
  • Journal Title: BMC Bioinformatics Volume: 15(1) Pages: 406
  • DOI: doi:10.1186/s12859-014-0406-y
  • Peer Reviewed
• [Journal Article] Mutations in ERBB4 That Disrupt The NRG-ErbB4 Pathway Cause Autosomal Dominant Familial ALS Type 19 (2014)
  • Author(s): Yuji Takahashi, Yoko Fukuda, Jun Yoshimura, Atsushi Toyoda, Kari Kurppa, Hiroyoko Moritoyo, Veronique Belzil, Klaus Elenius, Guy Rouleau, Asao Fujiyama, Shinichi Morishita, Jun Goto, Shoji Tsuji
  • Journal Title: Neurology Volume: 82 Pages: 83
  • Peer Reviewed
• [Journal Article] A simple but powerful heuristic method for accelerating k-means clustering of large-scale data in life science (2014)
  • Author(s): Kazuki Ichikawa, Shinichi Morishita
  • Journal Title: IEEE/ACM Transactions on Computational Biology and Bioinformatics (TCBB) Volume: 11 Pages: 681-692
  • DOI: 10.1109/TCBB.2014.2306200
  • Peer Reviewed
• [Journal Article] Whole genome complete resequencing of Bacillus subtilis natto by combining long reads with high-quality short reads. (2014)
  • Author(s): –Kamada, M., Hase, S., Sato, K., Toyoda, A., Fujiyama, A., and Sakakibara, Y
  • Journal Title: PLOS ONE, Volume: 9(10): Pages: e109999,
  • DOI: 10.1371/journal.pone.0109999.
  • Peer Reviewed
• [Journal Article] Efficient calculation of exact probability distributions of integer features on RNA secondary structures (2014)
  • Author(s): ：Ryota Mori, Michiaki Hamada, Kiyoshi Asai
  • Journal Title: BMC genomics Volume: ：15 suppl. 10 Pages: S6
  • DOI: doi:10.1186/1471-2164-15-S10-S6
  • Peer Reviewed
• [Journal Article] Reference-free prediction of rearrangement breakpoint reads (2014)
  • Author(s): Edward Wijaya, Kana Shimizu, Kiyoshi Asai and Michiaki Hamada
  • Journal Title: Bioinformatics Volume: 30 (18) Pages: 2559-2567
  • DOI: 10.1093/bioinformatics/btu360
  • Peer Reviewed
• [Journal Article] Performance comparison of second- and third-generation sequencers using a bacterial genome with two chromosomes (2014)
  • Author(s): Mari Miyamoto, Daisuke Motooka, Kazuyoshi Gotoh, Takamasa Imai, Kazutoshi Yoshitake, Naohisa Goto, Tetsuya Iida, Teruo Yasunaga, Toshihiro Horii, Kazuharu Arakawa, Masahiro Kasahara and Shota Nakamura
  • Journal Title: BMC Genomics Volume: 15 Pages: -
  • DOI: doi:10.1186/1471-2164-15-699
  • Peer Reviewed / Open Access
• [Journal Article] ELSI practices in genomic research in East Asia: implications for research collaboration and public participation (2014)
  • Author(s): Go Yoshizawa, Calvin Wai-Loon Ho, Wei Zhu, Chingli Hu, Yoni Syukriani, Ilhak Lee, Hannah Kim, Daniel Fu Chang Tsai, Jusaku Minari, and Kazuto Kato.
  • Journal Title: Genome Medicine. Volume: 6(5) Pages: 39
  • DOI: doi: 10.1186/gm556
  • Peer Reviewed
• [Journal Article] Ethical considerations of research policy for personal genome analysis: the approach of the Genome Science Project in Japan (2014)
  • Author(s): Jusaku Minari, Tetsuya Shirai and Kazuto Kato.
  • Journal Title: Life Sciences, Society and Policy Volume: 10 Pages: 4
  • DOI: doi:10.1186/s40504-014-0004-9
  • Peer Reviewed
• [Journal Article] Return of genetic research results: the Japanese experience and its implications for the international debate. (2014)
  • Author(s): Jusaku Minari, Donald Chalmers and Kazuto Kato.
  • Journal Title: SCRIPTed Volume: 11 Pages: 180-192
  • DOI: doi:10.2966/scrip.110214.180
  • Peer Reviewed
• [Journal Article] The emerging need for family-centric initiatives for obtaining consent in personal genome research. (2014)
  • Author(s): Jusaku Minari, Harriet Teare, Colin Mitchell, Jane Kaye and Kazuto Kato.
  • Journal Title: Genome Medicine Volume: 6: Pages: 118
  • DOI: doi:10.1186/s13073-014-0118-y
  • Peer Reviewed
• [Journal Article] パーソナルゲノム時代の研究ガバナンス (2014)
  • Author(s): 三成寿作, 加藤和人
  • Journal Title: 医薬ジャーナル Volume: 50 Pages: 55-58
• [Journal Article] 医療情報の利用に関する政策の20年 (2014)
  • Author(s): 吉澤剛
  • Journal Title: 医学のあゆみ Volume: 251(3) Pages: 213-218
• [Journal Article] ヒトゲノム情報は２１世紀の新しい石油となるか？―パーソナルゲノム時代の倫理的・法的・社会的課題 (2014)
  • Author(s): 山本奈津子
  • Journal Title: 医学のあゆみ Volume: 251(3) Pages: 207-212
• [Journal Article] Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines. (2014)
  • Author(s): Suzuki A, Makinoshima H, Wakaguri H, Esumi H, Sugano S, Kohno T, Tsuchihara K, Suzuki Y.
  • Journal Title: Nucleic Acids Res Volume: 42 Pages: 13557-13572
  • DOI: 10.1093/nar/gku885
  • Peer Reviewed
• [Presentation] HLA解析ツール (2015)
  • Author(s): 長崎英樹
  • Organizer: Galaxy Workshop Tokyo 2015
  • Place of Presentation: 東京大学 先端科学技術研究センター
  • Year and Date: 2015-04-28 – 2015-04-28
  • Invited
• [Presentation] アオサ藻綱ヒラアオノリのゲノム解読と雌雄ゲノムの比較による性決定領域の探索 (2015)
  • Author(s): 山﨑誠和, 鈴木亮吾, 市原健介, 豊田敦, 桑野和可, 鈴木穣, 河野重行
  • Organizer: 日本藻類学会第39回大会
  • Place of Presentation: 九州大学
  • Year and Date: 2015-03-20 – 2015-03-25
• [Presentation] 全ゲノム変異解析のためのパイプラインの構築 (2015)
  • Author(s): 石井 公太郎，平野 智也，風間 裕介，浜田 道昭，小野 幸輝，阿部 知子
  • Organizer: 日本育種学会 第127回講演会
  • Place of Presentation: 玉川大学
  • Year and Date: 2015-03-20 – 2015-03-20
• [Presentation] The Construction of Genome Annotation Database for Liverwort Marchantia polymorpha (2015)
  • Author(s): 長崎英樹、石崎公庸、大和勝幸、河内孝之、中村保一
  • Organizer: 第56回日本植物生理学会年会
  • Place of Presentation: 東京農業大学
  • Year and Date: 2015-03-16 – 2015-03-18
• [Presentation] 納豆菌ゲノムのPacBioシークエンシングと高精度配列の再決定． (2015)
  • Author(s): 鎌田真由美，長谷純崇，木村啓太郎，佐藤健吾，豊田敦，藤山秋佐夫，榊原康文
  • Organizer: 第８回日本ゲノム微生物学会年会
  • Place of Presentation: 東京農業大学
  • Year and Date: 2015-03-07 – 2015-03-07
• [Presentation] 「Gef-seqに対応したマッピングプログラムおよびGUIの開発」 (2015)
  • Author(s): 松本秀太・中村建介
  • Organizer: 第９回 日本ゲノム微生物学会年会
  • Place of Presentation: 神戸大学
  • Year and Date: 2015-03-06 – 2015-03-06
• [Presentation] The Construction of Genome Annotation Database for Liverwort Marchantia polymorpha (2015)
  • Author(s): Yasukazu Nakamura, Hideki Nagasaki, Naoko Iida
  • Organizer: Expanding Frontiers of Genome Science II
  • Place of Presentation: 一橋講堂
  • Year and Date: 2015-01-20 – 2015-01-21
• [Presentation] Pipeline for whole-genome analysis of heavy-ion-induced mutants (2015)
  • Author(s): Kotaro Ishii, Tomonari Hirano, Yusuke Kazama, Michiaki Hamada, Yukiteru Ono, Tomoko Abe
  • Organizer: International Symposium on Genome Science
  • Place of Presentation: 東京 一橋講堂
  • Year and Date: 2015-01-20 – 2015-01-21
• [Presentation] Next generation sequencing data and its bioinformatics analysis dissect genomic regulatory elements (2015)
  • Author(s): Tetsushi Yada, Takuma Irie, Takeaki Taniguchi, Yutaka Suzuki
  • Organizer: International Symposium on Genome Science
  • Place of Presentation: 東京 一橋講堂
  • Year and Date: 2015-01-20 – 2015-01-21
• [Presentation] 定量生物学と情報生物学 (2015)
  • Author(s): 岩崎渉
  • Organizer: 定量生物学の会第七回年会
  • Place of Presentation: 九州大学筑紫キャンパス（春日）
  • Year and Date: 2015-01-11 – 2015-01-11
  • Invited
• [Presentation] The Chara braunii Genome (2015)
  • Author(s): Tomoaki Nishiyama, Atsushi Toyoda, Yutaka Suzuki, Asao Fujiyama, Stefan A. Rensing, Hidetoshi Sakayama
  • Organizer: Plant and Animal Genome XXIII Conference, 2015
  • Place of Presentation: San Diego, CA
  • Year and Date: 2015-01-10 – 2015-01-14
• [Presentation] The Chara braunii Genome Sheds Light on the Origin of Land Plants (2015)
  • Author(s): Hidetoshi Sakayama, Atsushi Toyoda, Yutaka Suzuki, Asao Fujiyama, Stefan A. Rensing, Tomoaki Nishiyama
  • Organizer: Plant and Animal Genome XXIII Conference, 2015
  • Place of Presentation: San Diego, CA
  • Year and Date: 2015-01-10 – 2015-01-14
• [Presentation] The Construction of Genome Annotation Database for Liverwort Marchantia polymorpha (2015)
  • Author(s): Hideki Nagasaki Kimitsune Ishizaki Katsuyuki T. Yamato Takayuki Kohchi Yasukazu Nakamura
  • Organizer: International Plant & Animal Genome XXIII
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2015-01-10 – 2015-01-14
• [Presentation] DDBJ Read Annotation Pipeline の紹介と実習 (2014)
  • Author(s): 長崎英樹
  • Organizer: 第30回 DDBJing 講習会 in 東京
  • Place of Presentation: 独立行政法人 科学技術振興機構 東京本部
  • Year and Date: 2014-12-18 – 2014-12-18
  • Invited
• [Presentation] The Construction of Genome Annotation Database for the Liverwort Marchantia polymorpha (2014)
  • Author(s): Hideki Nagasaki, Naoko Iida, Yasukazu Nakamura
  • Organizer: Marchantia Workshop 2014
  • Place of Presentation: 神戸大学
  • Year and Date: 2014-12-08 – 2014-12-10
  • Invited
• [Presentation] Asian Microbiome Project: 次世代シーケンサーを用いたアジア人腸内細菌叢のプロファイル化 (2014)
  • Author(s): 東佳那子、百田理恵、山本麻寿紗、林 哲也、小椋義俊、黒川 顕、豊田敦、加藤和人、AMP study group、園元謙二、渡辺幸一、Lee Yuan Kun、中山二郎
  • Organizer: 日本生物工学会 第21回九州支部熊本大会
  • Place of Presentation: 熊本大学
  • Year and Date: 2014-12-06 – 2014-12-06
• [Presentation] マウス長期継代系統を用いた生殖系列突然変異率の閾値とその影響 (2014)
  • Author(s): 内村有邦, 樋口真弓, 水口洋平, 西野穣, 豊田敦, 藤山秋佐夫, 八木健
  • Organizer: 日本環境変異原学会第43回大会
  • Place of Presentation: 一橋大学一橋講堂
  • Year and Date: 2014-12-04 – 2014-12-05
• [Presentation] 放射線耐性を示すクマムシの新規タンパク質S261によるDNA損傷の抑制 (2014)
  • Author(s): 橋本 拓磨, 斎藤 裕樹, 尾山 大明, 秦 裕子, 榎本 敦, 宮川 清, 桑原 宏和, 堀川 大樹, 豊田 敦, 片山 俊明, 荒川 和晴, 藤山 秋佐夫, 久保 健雄, 國枝 武和
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] 有殻アメーバ Paulinella chromatophora のゲノム解析 (2014)
  • Author(s): 松尾 充啓, 潟端 篤, 水口 洋平, 野口 英樹, 豊田 敦, 藤山 秋佐夫, 鈴木 穣, 佐藤 壮一郎, 松崎 素道, 中山 卓郎, 神川 龍馬, 野村 真未, 壁谷 如洋, 宮城島 進也, 稲垣 祐司, 石田 健一郎, 小保方 潤一
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] The Construction of Genome Annotation Database for Liverwort ゼニゴケゲノムアノテーションデータベースの構築 (2014)
  • Author(s): 長崎英樹、石崎公庸、大和勝幸、河内孝之、中村保一
  • Organizer: 第37回 日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] 次世代シークエンサーによる変異プロモーターの網羅的解析 (2014)
  • Author(s): 入江拓磨, 門城拓, 劉エイ, 関真秀, 菅野純夫, 矢田哲士, 鈴木穰
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: 横浜, 日本
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] ゲノムおよび健康関連データの責任ある共有のためのフレームワークの作成 (2014)
  • Author(s): 加藤和人
  • Organizer: 日本人類遺伝学会第59回大会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-21 – 2014-11-21
• [Presentation] 個人ゲノム情報の取り扱いに関する倫理的、法的課題 (2014)
  • Author(s): 山本奈津子、川嶋実苗、藤田卓仙、鈴木正朝
  • Organizer: 第59回日本人類遺伝学会 第21回日本遺伝子診療学会 合同大会
  • Place of Presentation: 東京
  • Year and Date: 2014-11-19 – 2014-11-22
• [Presentation] Roles of bacteriophages in the emergence and evolution of enterohemorrhagic Escherichia coli. (2014)
  • Author(s): Hayashi T.
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-10 – 2014-11-10
  • Invited
• [Presentation] ビッグデータ時代における医療等情報の取り扱い方針に関する検討 (2014)
  • Author(s): 藤田卓仙、山本奈津子、川嶋実苗、鈴木正朝
  • Organizer: 第34回医療情報学連合大会
  • Place of Presentation: 千葉
  • Year and Date: 2014-11-06 – 2014-11-08
• [Presentation] クリニカルシーケンス応用を目指したHLA領域のゲノム解析 (2014)
  • Author(s): 細道一善
  • Organizer: Roche Scientific Symposium 2014 先端医療研究におけるターゲットゲノム解析
  • Place of Presentation: JPタワー ホール＆カンファレンス(東京)
  • Year and Date: 2014-11-05 – 2014-11-05
  • Invited
• [Presentation] 生殖補助医療規制の構築における「子どもを持ちたいという欲望」 (2014)
  • Author(s): 小門穂
  • Organizer: 日本生命倫理学会
  • Place of Presentation: 浜松
  • Year and Date: 2014-10-26 – 2014-10-26
• [Presentation] PCR-based method for complete HLA gene sequencing and capture-based method for entire HLA region sequencing (2014)
  • Author(s): Hosomichi K, Inoue I.
  • Organizer: 64th Annual Meeting of The American Society of Human Genetics (ASHG 2014)
  • Place of Presentation: an Diego Convention Center (San Diego, California)
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] Analysis of ethical and social issues of large scale genome cohort/biobanking projects in Japan. (2014)
  • Author(s): Jusaku Minari, Yoshikazu Hanabusa, Soichiro Toda, Fuji Nagami and Kazuto Kato.
  • Organizer: The 64th American Society of Human Genetics (ASHG) Annual Meeting.
  • Place of Presentation: サンディエゴ（アメリカ）
  • Year and Date: 2014-10-18 – 2014-10-22
• [Presentation] 病原細菌のゲノム解析. (2014)
  • Author(s): 林哲也
  • Organizer: Infection and Immunity Research Symposium V
  • Place of Presentation: 福岡市
  • Year and Date: 2014-10-17 – 2014-10-17
  • Invited
• [Presentation] CLOCKによる古典的・非古典的E-boxを介した概日時計の"多声的"制御 (2014)
  • Author(s): Hikari Yoshitane, Haruka Ozaki, Hideki Terajima, Ngoc-Hien Du, Yutaka Suzuki, Taihei Fujimori, Naoki Kosaka, Shigeki Shimba, Sumio Sugano, Toshihisa Takagi, Wataru Iwasaki, and Yoshitaka Fukada.
  • Organizer: 日本バイオインフォマティクス学会2014年年会・第3回生命医薬情報学連合大会
  • Place of Presentation: 仙台国際センター（仙台）
  • Year and Date: 2014-10-03 – 2014-10-03
• [Presentation] 微生物ゲノム研究、この13年間を振り返る（未来開拓、ゲノム特定、ゲノム支援を経験して） (2014)
  • Author(s): 小椋義俊
  • Organizer: 第8回日本ゲノム微生物学会若手の会研究会
  • Place of Presentation: 静岡市
  • Year and Date: 2014-09-28 – 2014-09-28
  • Invited
• [Presentation] Fundamental bottlenecks in big-data biology (2014)
  • Author(s): 岩崎渉
  • Organizer: 第52回日本生物物理学会年会
  • Place of Presentation: 札幌コンベンションセンター（札幌）
  • Year and Date: 2014-09-27 – 2014-09-27
  • Invited
• [Presentation] Local Package Manager―Database of genome analysis tools with installation procedures (2014)
  • Author(s): Masahiro Kasahara
  • Organizer: Genome Informatics
  • Place of Presentation: Churchill College, Cambridge, UK
  • Year and Date: 2014-09-21 – 2014-09-21
• [Presentation] 長期継代マウス系統を用いた突然変異率の推定と新しい遺伝学 (2014)
  • Author(s): 内村有邦, 樋口真弓, 水口洋平, 西野穣, 豊田敦, 藤山秋佐夫, 三浦郁生, 若菜茂晴, 八木健
  • Organizer: 日本遺伝学会第86回大会
  • Place of Presentation: 長浜バイオ大学
  • Year and Date: 2014-09-17 – 2014-09-19
• [Presentation] ゲノム大規模データを解析する－転写制御領域の解読と設計－ (2014)
  • Author(s): 矢田哲士
  • Organizer: 新生命科学分野開拓とスーパーコンピューター「京」
  • Place of Presentation: 福岡, 日本
  • Year and Date: 2014-09-16 – 2014-09-16
  • Invited
• [Presentation] シャジクモゲノムにみる陸上植物の制御因子ホモログ (2014)
  • Author(s): 西山智明, 豊田敦, 鈴木穣, 藤山秋佐夫, 坂山英俊
  • Organizer: 日本植物学会第78回大会
  • Place of Presentation: 明治大学
  • Year and Date: 2014-09-12 – 2014-09-14
• [Presentation] DDBJ Read Annotation Pipeline の紹介と実習(RNA-Seq配列のde novoアセンブリを中心に) (2014)
  • Author(s): 長崎英樹
  • Organizer: AJACS十勝
  • Place of Presentation: 帯広畜産大学
  • Year and Date: 2014-09-12 – 2014-09-12
  • Invited
• [Presentation] People's opinion toward informed consent/assent of children participating birth cohort study in Japan. (2014)
  • Author(s): Izumi Ishiyama, Zentaro Yamagata, Jusaku Minari, Go Yoshizawa, Kaori Muto and Kazuto Kato
  • Organizer: British Sociological Association Medical Sociology Group 46th Annual Conference 2014
  • Place of Presentation: バーミンガム (イギリス)
  • Year and Date: 2014-09-10 – 2014-09-12
• [Presentation] バイオインフォマティクスから時空間解析へ (2014)
  • Author(s): 岩崎渉
  • Organizer: 日本学術会議学術フォーラム「生命情報ビッグデータ時代における新しい生命科学」
  • Place of Presentation: 日本学術会議講堂（東京）
  • Year and Date: 2014-08-29 – 2014-08-29
  • Invited
• [Presentation] Ethical, legal and social issues of genetic and genomic medicine: a focus on East Asian situations (2014)
  • Author(s): Go Yoshizawa
  • Organizer: Seminar on Biobanking and Ethical, Legal & Social Issues in Genetic and Genomic Medicine,
  • Place of Presentation: University Sains Malaysia
  • Year and Date: 2014-08-27 – 2014-08-27
  • Invited
• [Presentation] Initiating a biobank infrastructures and regulations: Japan experiences (2014)
  • Author(s): Go Yoshizawa
  • Organizer: Seminar on Biobanking and Ethical, Legal & Social Issues in Genetic and Genomic Medicine
  • Place of Presentation: University Sains Malaysia
  • Year and Date: 2014-08-26 – 2014-08-26
  • Invited
• [Presentation] （円卓会議で議論に参加） (2014)
  • Author(s): Kazuto Kato
  • Organizer: Workshop on Data Sharing Between International Consortia
  • Place of Presentation: ジュネーブ（スイス）
  • Year and Date: 2014-06-03 – 2014-06-05
  • Invited
• [Presentation] The research policy regarding disclosure of genetic research results: a historical perspective in Japan. (2014)
  • Author(s): Jusaku Minari and Kazuto Kato.
  • Organizer: Europian Society of Human Genetics (ESHG) 2014 Annual Meeting
  • Place of Presentation: ミラノ（イタリア）
  • Year and Date: 2014-05-31 – 2014-06-04
• [Presentation] Recent situation about rules of sharing, reuse and circulation of personal genome data in Japan (2014)
  • Author(s): Natsuko Yamamoto
  • Organizer: Europian Society of Human Genetics (ESHG) 2014 Annual Meeting
  • Place of Presentation: ミラノ（イタリア）
  • Year and Date: 2014-05-31 – 2014-06-04
• [Presentation] Incorporation of Long-Read Technologies into Hybrid-de novo Genome Sequencing Strategy: An Assessment on PacBio and Moleculo Read (2014)
  • Author(s): Asao Fujiyama, Masahiro Kasahara, Atsushi Toyoda
  • Organizer: PLANT & ANIMAL GENOME ASIA 2014
  • Place of Presentation: SINGAPORE
  • Year and Date: 2014-05-19 – 2014-05-21
• [Presentation] Comments for Panel#3: Big Data, Small Data, Shared Data (2014)
  • Author(s): Kazuto Kato
  • Organizer: Ethics at the Crossroads: Where Public Health, Genomics, Data and Translational Science Meet
  • Place of Presentation: インディアナポリス（アメリカ）
  • Year and Date: 2014-05-07 – 2014-05-07
  • Invited
• [Presentation] （円卓会議で議論に参加） (2014)
  • Author(s): Kazuto Kato
  • Organizer: The Indianapolis ELSI 2.0 Meeting
  • Place of Presentation: インディアナポリス（アメリカ）
  • Year and Date: 2014-05-06 – 2014-05-06
  • Invited
• [Presentation] （円卓会議で議論に参加） (2014)
  • Author(s): Kazuto Kato
  • Organizer: International Code of Conduct for Genomic and Clinical Date Sharing
  • Place of Presentation: リ(フランス)
  • Year and Date: 2014-04-02 – 2014-04-02
  • Invited
• [Remarks] シーラカンス
  • URL: http://coelacanth.nig.ac.jp
• [Remarks] アゲハ
  • URL: http://papilio.nig.ac.jp/
• [Remarks] アフリカツメガエル
  • URL: http://xenopus.lab.nig.ac.jp
• [Remarks] DDBJパイプライン
  • URL: http://p.ddbj.nig.ac.jp
• [Remarks] メタゲノムをアセンブリする改良型ソフトウエア MetaVelvet-SL
  • URL: http://metavelvet.dna.bio.keio.ac.jp/