包括型脳科学研究推進支援ネットワーク

2015 Fiscal Year Annual Research Report

• Project Area: 包括型脳科学研究推進支援ネットワーク
• Project/Area Number: 221S0003
• Research Institution: Center for Novel Science Initatives, National Institutes of Natural Sciences
• Principal Investigator: 木村 實 大学共同利用機関法人自然科学研究機構(新分野創成センター), 新分野創成センター, 客員教授 (40118451)
• Co-Investigator(Kenkyū-buntansha): 丹治 順 玉川大学, 脳科学研究所, 客員教授 (10001885) ; 高田 昌彦 京都大学, 霊長類研究所, 教授 (00236233) ; 大塚 稔久 山梨大学大学院, 総合研究部, 教授 (40401806) ; 青木 茂樹 順天堂大学, 医学部・放射線医学教室, 教授 (80222470) ; 阿部 修 日本大学, 医学部・放射線医学系画像診断学分野, 教授 (50302716) ; 増本 智彦 筑波大学, 医学医療系, 准教授 (60302717) ; 下地 啓五 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 放射線診断科, 研究員 (20348931) ; 吉浦 敬 鹿児島大学, 医歯学域医学系, 教授 (40322747) ; 松村 明 筑波大学大学院, 人間総合科学研究科, 副学長 (90241819) ; 後藤 政実 北里大学, 医療衛生学部, 講師 (30375844) ; 高尾 英正 東京大学, 医学部附属病院, 講師 (10444093) ; 桐野 衛二 順天堂大学, 医学部附属静岡病院, 教授 (90276460) ; 徳丸 阿耶 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 放射線診断科, 研究員 (60507391) ; 笠井 清登 東京大学, 医学部附属病院, 教授 (80322056) ; 鈴木 道雄 富山大学大学院, 医学薬学研究部(医学), 教授 (40236013) ; 橋本 亮太 大阪大学大学院, 連合小児発達学研究科, 准教授 (10370983) ; 根本 清貴 筑波大学, 医学医療系, 講師 (80550152) ; 丹羽 真一 福島県立医科大学, 医学部, 名誉教授 (30110703) ; 富田 博秋 東北大学, 災害科学国際研究所, 教授 (90295064) ; 加藤 忠史 国立研究開発法人理化学研究所, 脳科学総合研究センター, チームリーダー (30214381) ; 入谷 修司 名古屋大学, 医学系研究科, 教授 (60191904) ; 村山 繁雄 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (50183653) ; 赤津 裕康 医療法人さわらび会福祉村病院, 長寿医学研究所, 研究員 (00399734) ; 齊藤 祐子 国立研究開発法人国立精神・神経医療研究センター病院, 臨床検査部臨床検査科, 医長 (60344066) ; 高尾 昌樹 公益財団法人脳血管研究所, 美原記念病院, 研究員 (50245487) ; 尾藤 晴彦 東京大学大学院, 医学系研究科, 教授 (00291964) ; 吉村 由美子 生理学研究所, 生体情報研究系, 教授 (10291907) ; 松崎 政紀 基礎生物学研究所, 光脳回路研究部門, 教授 (50353438) ; 古田 寿昭 東邦大学, 理学部, 教授 (90231571) ; 岡戸 晴生 公益財団法人東京都医学総合研究所, 脳発達神経再生分野, 副参事研究員 (60221842) ; 貝淵 弘三 名古屋大学大学院, 医学系研究科, 教授 (00169377) ; 五十嵐 道弘 新潟大学, 医歯学系, 教授 (50193173) ; 長谷川 成人 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 分野長 (10251232) ; 饗場 篤 東京大学大学院, 医学系研究科, 教授 (20271116) ; 椎名 伸之 大学共同利用機関法人自然科学研究機構(岡崎共通研究施設), 岡崎統合バイオサイエンスセンター, 准教授 (30332175) ; 西岡 朋生 名古屋大学大学院, 医学系研究科, 助教 (70435105) ; 渡辺 雅彦 北海道大学大学院, 医学研究科, 教授 (70210945) ; 阪上 洋行 北里大学, 医学部, 教授 (90261528) ; 小池 正人 順天堂大学, 医学研究科, 教授 (80347210) ; 深澤 有吾 福井大学, 医学部, 教授 (60343745) ; 崎村 建司 新潟大学, 脳研究所, 教授 (40162325) ; 三品 昌美 立命館大学, 総合科学技術研究機構, 教授 (80144351) ; 森 寿 富山大学大学院, 医学薬学研究部(医学), 教授 (00239617) ; 小林 和人 福島県立医科大学, 医学部, 教授 (90211903) ; 柳川 右千夫 群馬大学大学院, 医学系研究科, 教授 (90202366) ; 上村 匡 京都大学, 生命科学研究科, 教授 (80213396) ; 能瀬 聡直 東京大学大学院, 新領域創成科学研究科, 教授 (30260037) ; 飯野 雄一 東京大学大学院, 理学系研究科, 教授 (40192471) ; 石原 健 九州大学大学院, 理学研究院, 教授 (10249948) ; 宮川 剛 藤田保健衛生大学, 総合医科学研究所・システム医科学研究部門, 教授 (10301780) ; 高雄 啓三 生理学研究所, 行動・代謝分子解析センター, 教授(兼任) (80420397) ; 虫明 元 東北大学大学院, 医学系研究科, 教授 (80219849) ; 田中 徹 東北大学大学院, 医工学研究科, 教授 (40417382) ; 片山 統裕 東北大学大学院, 情報科学研究科, 准教授 (20282030)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 脳科学 / 研究支援 / 研究集会 / 研究リソース / 技術開発

Outline of Annual Research Achievements

（１）「冬のシンポジウム」と「３分野合同シンポジウム」の開催：「冬のシンポジウム」を12月17（木）～19（土）に学術総合センター（東京）で開催した。包括脳企画イベント「次期支援活動の枠組みと脳科学研究の今後」では、「包括脳ネットワーク」を発展的に継承する次期支援活動の枠組みについて説明するとともに、上部組織における活動を紹介し、我が国の脳科学研究推進戦略の現状と中・長期的な展望に立った今後の脳科学研究発展のための取り組みや方向性について、情報共有と意見交換をおこなった。さらに、例年と同様、複数の新学術領域研究の連携による合同公開シンポジウムや合同若手育成シンポジウムを企画した。また、第４回となる生命科学系３分野（がん、ゲノム、脳）支援活動合同シンポジウム（８月１９日）を合同開催し、次期支援活動の枠組みに基づく３分野の今後の連携・協力体制に向けた構想について議論した。
（２）リソース・技術開発支援：現在3項目12拠点において実施しているリソース・技術開発支援活動の更なる推進を図るとともに、次期支援活動に発展的に継承できるような先進的基盤技術開発に関する国内外の動向について意見集約した。
（３）研究集会および研究者育成支援：シンポジウム、ワークショップ、若手研究者が主体的に企画する研究会の開催を支援するとともに、先端技術習得のための若手研究者派遣プログラムを実施した。
（４）データベースの更新と研究者コミュニティへの情報発信：ホームページの更なる充実を図るとともに、リソース・技術開発情報や研究者情報等に関するデータベースの更新と脳科学研究者コミュニティへの情報発信をとおして研究者交流の基盤提供を推進した。
（５）一般社会への普及・啓発：脳科学研究と研究支援活動の一般社会への普及・啓発を目的として、市民公開講座やサイエンスコミュニケーション等、さまざまなアウトリーチ活動を実施した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

Research Products

• [Journal Article] The Abundance of Nonphosphorylated Tau in Mouse and Human Tauopathy Brains Revealed by the Use of Phos-Tag Method. (2016)
  • Author(s): Kimura, T.; Hatsuta, H.;Masuda-Suzukake, M.;Hosokawa, M.;Ishiguro, K.;Akiyama, H.;Murayama, S.;Hasegawa, M.;Hisanaga, S.
  • Journal Title: Am J Pathol Volume: 186 Pages: 398-409
  • DOI: 10.1016/j.ajpath.2015.10.009
  • Peer Reviewed
• [Journal Article] Dorsal Forebrain-Specific Deficiency of Reelin-Dab1 Signal Causes Behavioral Abnormalities Related to Psychiatric Disorders. (2016)
  • Author(s): Imai, H.;Shoji, H.;Ogata, M.;Kagawa, Y.;Owada, Y.;Miyakawa, T.;Sakimura, K.;Terashima, T.;Katsuyama, Y.
  • Journal Title: Cereb Cortex Volume: － Pages: －
  • DOI: 10.1093/cercor/bhv334
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Orbitofrontal sulcogyral pattern and olfactory sulcus depth in the schizophrenia spectrum. (2016)
  • Author(s): Nishikawa, Y.;Takahashi, T.;Takayanagi Y.;Furuichi, A.;Kido, M.;Nakamura, M.;Sasabayashi, D.;Noguchi, K.;Suzuki, M.
  • Journal Title: Eur Arch Psychiatry Clin Neurosci Volume: 266 Pages: 15-23
  • DOI: 10.1007/s00406-015-0587-z
  • Peer Reviewed
• [Journal Article] A possible aid in targeted insertion of large DNA elements by CRISPR/Cas in mouse zygotes. (2016)
  • Author(s): Nakao, H.;Harada, T.;Nakao, K.;Kiyonari, H.;Inoue, K.;Furuta, Y.;Aiba, A.
  • Journal Title: Genesis Volume: 54 Pages: 65-77
  • DOI: 10.1002/dvg.22914
  • Peer Reviewed
• [Journal Article] Gain-of-function profilin 1 mutations linked to familial amyotrophic lateral sclerosis cause seed-dependent intracellular TDP-43 aggregation. (2016)
  • Author(s): Tanaka, Y.;Nonaka, T.;Suzuki, G.;Kametani, F.;Hasegawa, M.
  • Journal Title: Hum Mol Genet Volume: 25 Pages: 1420-143
  • DOI: 10.1093/hmg/ddw024
  • Peer Reviewed
• [Journal Article] Phosphorylation of TAR DNA-binding Protein of 43 kDa (TDP-43) by Truncated Casein Kinase 1delta Triggers Mislocalization and Accumulation of TDP-43. (2016)
  • Author(s): Nonaka, T.;Suzuki, G.;Tanaka, Y.;Kametani, F.;Hirai, S.;Okado, H.;Miyashita, T.;Saitoe, M.;Akiyama, H.;Masai, H.;Hasegawa, M.
  • Journal Title: J Biol Chem Volume: 291 Pages: 5473-5483
  • DOI: 10.1074/jbc.M115.695379
  • Peer Reviewed
• [Journal Article] PI3K regulates endocytosis after insulin secretion by mediating signaling crosstalk between Arf6 and Rab27a. (2016)
  • Author(s): Yamaoka, M.;Ando, T.;Terabayashi, T.;Okamoto, M.;Takei, M.;Nishioka, T.;Kaibuchi, K.;Matsunaga, K.;Ishizaki, R.;Izumi, T.;Niki, I.;Ishizaki, T.;Kimura, T.
  • Journal Title: J Cell Sci Volume: 129 Pages: 637-649
  • DOI: 10.1242/jcs.180141
  • Peer Reviewed / Open Access
• [Journal Article] Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder. (2016)
  • Author(s): Hashimoto, R.;Nakazawa, T.;Tsurusaki, Y.;Yasuda, Y.;Nagayasu, K.;Matsumura, K.;Kawashima, H.;Yamamori, H.;Fujimoto, M.;Ohi, K.;Umeda-Yano, S.;Fukunaga, M.;Fujino, H.;Kasai, A.;Hayata-Takano, A.;Shintani, N.;Takeda, M.;Matsumoto, N.;Hashimoto, H.
  • Journal Title: J Hum Genet Volume: 61 Pages: 199-206
  • DOI: 10.1038/jhg.2015.141
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nicotinic acetylcholine receptor-mediated responses in medial vestibular and prepositus hypoglossi nuclei neurons showing distinct neurotransmitter phenotypes. (2016)
  • Author(s): Zhang, Y.;Yanagawa, Y.;Saito, Y.
  • Journal Title: J Neurophysiol, Volume: － Pages: jn 00852 02015
  • DOI: 10.1152/jn.00852.2015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Neural FFA3 activation inversely regulates anion secretion evoked by nicotinic ACh receptor activation in rat proximal colon. (2016)
  • Author(s): Kaji, I.;Akiba, Y.;Konno, K.;Watanabe, M.;Kimura, S.;Iwanaga, T.;Kuri, A.;Iwamoto, K. I.;Kuwahara, A.;Kaunitz, J. D.
  • Journal Title: J Physiol Volume: － Pages: －
  • DOI: 10.1113/JP271441
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comprehensive behavioral phenotyping of a new Semaphorin 3 F mutant mouse. (2016)
  • Author(s): Matsuda, I.;Shoji, H.;Yamasaki, N.;Miyakawa, T.;Aiba, A.
  • Journal Title: Mol Brain Volume: 9 Pages: 15
  • DOI: 10.1186/s13041-016-0196-4
  • Peer Reviewed / Open Access
• [Journal Article] Age-related changes in behavior in C57BL/6J mice from young adulthood to middle age. (2016)
  • Author(s): Shoji, H.;Takao, K.;Hattori S.;Miyakawa, T.
  • Journal Title: Mol Brain Volume: 9 Pages: 11
  • DOI: 10.1186/s13041-016-0191-9
  • Peer Reviewed / Open Access
• [Journal Article] Abnormal asymmetries in subcortical brain volume in schizophrenia. (2016)
  • Author(s): Okada, N.;Nemoto, K.;Hibar, D. P.;van Erp, T. G.;Fujino, H.;Isobe, M.;Isomura, S.;Natsubori, T.;Narita, H.;Hashimoto, N.;Miyata, J.;Koike, S.; Suzuki, M.;Turner, J. A.; Ozaki, N.;Kasai, K.;Hashimoto, R.
  • Journal Title: Mol Psychiatry Volume: － Pages: －
  • DOI: 10.1038/mp.2015.209
  • Peer Reviewed
• [Journal Article] Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders. (2016)
  • Author(s): Nakazawa, T.;Hashimoto, R.;Sakoori, K.;Sugaya, Y.;Tanimura, A.;Hashimotodani, Y.;Ohi, K.;Yamamori, H.;Yasuda, Y.;Umeda-Yano, S.;Kiyama, Y.;Konno, K.;Inoue, T.;Yokoyama, K.;Inoue, T.;Numata, S.;Ohnuma, T.;Iwata, N.;Ozaki, N.;Hashimoto, H.;Watanabe, M.;Manabe, T.;Yamamoto, T.;Takeda, M.;Kano, M.
  • Journal Title: Nat Commun Volume: 7 Pages: 10594
  • DOI: 10.1038/ncomms10594
  • Peer Reviewed / Open Access
• [Journal Article] Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo. (2016)
  • Author(s): Nagai, T.;Nakamuta, S.,Kuroda, K.;Nakauchi, S.;Nishioka, T.;Takano, T.;Zhang, X.;Tsuboi, D.;Funahashi, Y.;Nakano, T.;Yoshimoto, J.;Kobayashi, K.;Uchigashima, M.;Watanabe, M.;Miura, M.;Nishi, A.;Kobayashi, K.;Yamada, K.;Amano, M.;Kaibuchi, K.
  • Journal Title: Neuron Volume: 89 Pages: 550-565
  • DOI: 10.1016/j.neuron.2015.12.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] An autopsy case of cortical superficial siderosis with persistent abnormal behavior. (2016)
  • Author(s): Torii ,Y.;Iritani, S.;Fujishiro, H.;Sekiguchi, H.;Habuchi, C.;Umeda, K.;Matsunaga, S.;Mimuro, M.;Ozaki, N.;Yoshida, M.;Fujita, K.
  • Journal Title: Neuropathology Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed
• [Journal Article] Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase. (2016)
  • Author(s): Yamamoto, T.;Nakayama, T.;Yamaguchi, J.;Matsuzawa, M.;Mishina, M.;Ikeda, K.;Yamamoto, H.
  • Journal Title: Neurosci Lett Volume: 610 Pages: 48-53
  • DOI: 10.1016/j.neulet.2015.10.049
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Assessment of a multi-assay biological diagnostic test for mood disorders in a Japanese population. (2016)
  • Author(s): Yamamori, H.;Ishima, T.;Yasuda, Y.;Fujimoto, M.;Kudo, N.;Ohi, K.;Hashimoto, K.;Takeda, M.;Hashimoto, R.
  • Journal Title: Neurosci Lett Volume: 612, Pages: 167-171
  • DOI: 10.1016/j.neulet.2015.12.019
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A novel reporter rat strain that conditionally expresses the bright red fluorescent protein tdTomato. (2016)
  • Author(s): Hiroyuki Igarashi; Kyo Koizumi; Ryosuke Kaneko; Keiko Ikeda; Ryo Egawa; Yuchio Yanagawa; Shin-ichi Muramatsu; Hiroshi Onimaru; Toru Ishizuka; Hiromu Yawo.
  • Journal Title: PLoS ONE Volume: 印刷中 Pages: 印刷中
  • Peer Reviewed / Open Access
• [Journal Article] Hypochondriasis as an early manifestation of dementia with Lewy bodies: an autopsied case report. (2016)
  • Author(s): Fujishiro, H.;Iritani, S.;Sekiguchi, H.;Habuchi, C.;Torii, Y.;Matsunaga, S.;Ozaki, N.;Yoshida, M.;Fujita, K
  • Journal Title: Psychogeriatrics Volume: 16 Pages: 139-144
  • DOI: 10.1111/psyg.12128
  • Peer Reviewed
• [Journal Article] Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. (2016)
  • Author(s): Tanahashi, H.;Tian, Q.B.; Hara, Y.;Sakagami, H.;Endo, S.;Suzuki, T.
  • Journal Title: Sci Rep Volume: 6 Pages: 20241
  • DOI: 10.1038/srep20241
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. (2016)
  • Author(s): Ohashi, R.;Takao, K.; Miyakawa, T.;Shiina, N.
  • Journal Title: Sci Rep Volume: 6 Pages: 20775
  • DOI: 10.1038/srep20775
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains. (2016)
  • Author(s): Kametani, F.;Obi, T.;Shishido, T.;Akatsu, H.;Murayama, S.;Saito, Y.;Yoshida, M.;Hasegawa, M.
  • Journal Title: Sci Rep Volume: － Pages: －
  • DOI: 10.1038/srep23281
  • Peer Reviewed / Open Access
• [Journal Article] What is NODDI and what is its role in Parkinson's assessment? (2016)
  • Author(s): Kamagata K., Hatano T., Aoki S.
  • Journal Title: Expert Rev Neurother Volume: 16, Pages: 241-243
  • DOI: 10.1586/14737175.2016.1142876
  • Peer Reviewed
• [Journal Article] Computational meta-analysis of statistical parametric maps in major depression. (2016)
  • Author(s): Arnone D., Job D., Selvaraj S., Abe O., Amico F., Cheng Y., Colloby S.J., O'Brien J.T., Frodl T., Gotlib I.H., Ham B.J., Kim M.J., Koolschijn P.C., Perico C.A., Salvadore G.
  • Journal Title: Hum Brain Mapp Volume: 37 Pages: 1393-1404
  • DOI: 10.1002/hbm.23108
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Relationship between G1287A of the NET Gene Polymorphisms and Brain Volume in Major Depressive Disorder: A Voxel-Based MRI Study. (2016)
  • Author(s): Ueda I., Kakeda S., Watanabe K., Yoshimura R., Kishi T., Abe O., Ide S., Moriya J., Katsuki A., Hori H., Iwata N., Nakamura J., Korogi Y.
  • Journal Title: PLoS ONE Volume: 11 Pages: e0150712
  • DOI: 10.1371/journal.pone.0150712
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Knockdown of the Drosophila FIG4 induces deficient locomotive behavior, shortening of motor neuron, axonal targeting aberration, reduction of life span and defects in eye development. (2016)
  • Author(s): Kyotani A., Azuma Y., Yamamoto I., Yoshida H., Mizuta I., Mizuno T., Nakagawa M., Tokuda T., Yamaguchi M.
  • Journal Title: Exp Neurol,().doi: Volume: 277 Pages: 86-95
  • DOI: 10.1016/j.expneurol.2015.12.011
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Decrease in the Volume of Gray Matter as a Risk Factor for Postoperative Delirium Revealed by an Atlas-based Method. (2015)
  • Author(s): Shioiri, A.; Kurumaji, A.;Takeuchi, T.;Nemoto, K.;Arai, H.;Nishikawa, T.
  • Journal Title: Am J Geriatr Psychiatry Volume: － Pages: －
  • DOI: 10.1016/j.jagp.2015.09.002
  • Peer Reviewed
• [Journal Article] CRTH2, a prostaglandin D2 receptor, mediates depression-related behavior in mice. (2015)
  • Author(s): Onaka, Y.; Shintani, N.;Nakazawa, T.;Haba, R.;Ago, Y.;Wang, H.;Kanoh, T.;Hayata-Takano, A.;Hirai, H.;Nagata, K. Y.;Nakamura, M.;Hashimoto, R.;Matsuda, T.;Waschek, J. A.;Kasai, A.;Nagayasu, K.;Baba, A.;Hashimoto, H.
  • Journal Title: Behav Brain Res Volume: 284 Pages: 131-137
  • DOI: 10.1016/j.bbr.2015.02.013
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Arf6 mediates Schwann cell differentiation and myelination. (2015)
  • Author(s): Torii, T.; Miyamoto, Y.;Yamamoto, M.;Ohbuchi, K.;Tsumura, H.;Kawahara, K.;Tanoue, A.;Sakagami, H.;Yamauchi, J.
  • Journal Title: Biochem Biophys Res Commun Volume: 465 Pages: 450-457
  • DOI: 10.1016/j.bbrc.2015.08.038
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• [Journal Article] Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO. (2015)
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  • Journal Title: Cancer Discov Volume: 5 Pages: 198-211
  • DOI: 10.1158/2159-8290.CD-14-0595
  • Peer Reviewed
• [Journal Article] Chronic optogenetic activation augments abeta pathology in a mouse model of Alzheimer disease. (2015)
  • Author(s): Yamamoto, K.;Tanei, Z.;Hashimoto, T.;Wakabayashi, T.;Okuno, H.;Naka, Y.;Yizhar, O.;Fenno, L. E.;Fukayama, M.;Bito, H.;Cirrito, J. R.;Holtzman, D. M.;Deisseroth, K.;Iwatsubo, T.
  • Journal Title: Cell Rep Volume: 11 Pages: 859-865
  • DOI: 10.1016/j.celrep.2015.04.017
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Phosphoproteomic Analysis Using the WW and FHA Domains as Biological Filters. (2015)
  • Author(s): Shohag, M.H.;Nishioka, T.;Ahammad, R. U.;Nakamuta, S.;Yura, Y.;Hamaguchi, T.;Kaibuchi, K.;Amano, M.
  • Journal Title: Cell Struct Funct Volume: 40 Pages: 95-104
  • DOI: 10.1247/csf.15004
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics. (2015)
  • Author(s): Watanabe, T.;Wang, S.; Kaibuchi, K.
  • Journal Title: Cell Struct Funct Volume: 40 Pages: 69-77
  • DOI: 10.1247/csf.15003
  • Peer Reviewed
• [Journal Article] In vivo screening for substrates of protein kinase A using a combination of proteomic approaches and pharmacological modulation of kinase activity. (2015)
  • Author(s): Hamaguchi, T.; Nakamura, S.;Funahashi, Y.;Takano, T.;Nishioka, T.;Shohag, M. H.;Yura, Y.;Kaibuchi, K.;Amano, M.
  • Journal Title: Cell Struct Funct Volume: 40 Pages: 1-12
  • DOI: 10.1247/csf.14014
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• [Journal Article] The zinc finger transcription factor RP58 negatively regulates Rnd2 for the control of neuronal migration during cerebral cortical development. (2015)
  • Author(s): Heng J.I.;Qu, Z.;Ohtaka-Maruyama, C.;Okado, H.;Kasai, M.;Castro, D.;Guillemot, F.;Tan, S. S.
  • Journal Title: Cereb Cortex Volume: 25 Pages: 806-816
  • DOI: 10.1093/cercor/bht277
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• [Journal Article] The Piccolo Intronic Single Nucleotide Polymorphism rs13438494 Regulates Dopamine and Serotonin Uptake and Shows Associations with Dependence-Like Behavior in Genomic Association Study. (2015)
  • Author(s): Uno, K.;Nishizawa, D.;Seo, S.;Takayama, K.; Hashimoto, R.;Ozaki, N.; I.;Higuchi, S.;Sora, I.;Iyo, M.;Kondo, N.;Won, M. J.; Miyamoto, Y.;Nitta, A.
  • Journal Title: Curr Mol Med Volume: 15 Pages: 265-274
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• [Journal Article] Neuronal polarization. (2015)
  • Author(s): Takano, T.; Xu, C.; Funahashi, Y.;Namba, T.;Kaibuchi, K.
  • Journal Title: Development Volume: 142 Pages: 2088-2093
  • DOI: 10.1242/dev.114454
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• [Journal Article] Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency. (2015)
  • Author(s): Kiyota, A.;Iwama, S.;Sugimura, Y.;Takeuchi, S.;Takagi, H.;Iwata, N.;Nakashima, K.;Suzuki, H.;Nishioka, T.;Kato, T.;Enomoto, A.;Arima, H.;Kaibuchi, K.;Oiso, Y.
  • Journal Title: Endocr J Volume: 62 Pages: 153-160
  • DOI: 10.1507/endocrj.EJ14-0369
  • Peer Reviewed
• [Journal Article] RASAL3, a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells. (2015)
  • Author(s): Saito, S.;Kawamura, T.;Higuchi, M.;Kobayashi, T.;Yoshita-Takahashi, M.;Yamazaki, M.;Abe, M.;Sakimura, K.;Kanda, Y.;Kawamura, H.;Jiang, S.;Naito, M.;Yoshizaki, T.;Takahashi, M.;Fujii, M.
  • Journal Title: Eur J Immunol Volume: 45 Pages: 1512-1523
  • DOI: 10.1002/eji.201444977
  • Peer Reviewed
• [Journal Article] Electrophysiological and morphological properties of neurons in the prepositus hypoglossi nucleus that express both ChAT and VGAT in a double-transgenic rat model. (2015)
  • Author(s): Saito, Y.;Zhang, Y.;Yanagawa, Y.
  • Journal Title: Eur J NEUROSCI Volume: 41 Pages: 1036-1048
  • DOI: 10.1111/ejn.12878
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Spatiotemporal profiles of arginine vasopressin transcription in cultured suprachiasmatic nucleus. (2015)
  • Author(s): Yoshikawa, T.;Nakajima, Y.;Yamada, Y.;Enoki, R.;Watanabe, K.;Yamazaki, M.;Sakimura, K.;Honma, S.;Honma, K.
  • Journal Title: Eur J NEUROSC Volume: 42 Pages: 2411-2423
  • DOI: 10.1111/ejn.13061
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• [Journal Article] Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation. (2015)
  • Author(s): Kobayashi, T.;Iwamoto, Y.;Takashima, K.;Isomura, A.;Kosodo, Y.;Kawakami, K.;Nishioka, T.;Kaibuchi, K.;Kageyama, R.
  • Journal Title: FEBS J Volume: 282 Pages: 2411-2423
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  • Peer Reviewed / Open Access
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  • Author(s): Igawa, T.; Abe, Y.; Tsuda, M.;Inoue, K.;Ueda, T.
  • Journal Title: FEBS Lett Volume: 589 Pages: 680-686
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  • Peer Reviewed
• [Journal Article] Standing postural instability in patients with schizophrenia: Relationships with psychiatric symptoms, anxiety, and the use of neuroleptic medications (2015)
  • Author(s): Matsuura, Y.;Fujino, H.;Hashimoto, R.;Yasuda, Y.;Yamamori, H.;Ohi, K.;Takeda, M.;Imura, O.
  • Journal Title: Gait Posture Volume: 41 Pages: 847-851
  • DOI: 10.1016/j.gaitpost.2015.03.006
  • Peer Reviewed
• [Journal Article] The Importance of cGMP Signaling in Sensory Cilia for Body Size Regulation in Caenorhabditis elegans. (2015)
  • Author(s): Fujiwara, M.;Hino, T.;Miyamoto, R.;Inada, H.;Mori, I.;Koga, M.;Miyahara, K.;Ohshima, Y.;Ishihara, T.
  • Journal Title: Genetics Volume: 201 Pages: 1497-1510
  • DOI: 10.1534/genetics.115.177543
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glucocerebrosidase deficiency accelerates the accumulation of proteinase K-resistant alpha-synuclein and aggravates neurodegeneration in a Drosophila model of Parkinson's disease. (2015)
  • Author(s): Suzuki, M.;Fujikake, N.;Takeuchi, T.;Kohyama-Koganeya, A.;Nakajima, K.;Hirabayashi, Y.;Wada, K.;Nagai, Y.
  • Journal Title: Hum Mol Genet Volume: 24 Pages: 6675-6686
  • DOI: 10.1093/hmg/ddv372
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The twenty-four KDa C-terminal tau fragment increases with aging in tauopathy mice: implications of prion-like properties. (2015)
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  • Journal Title: Hum Mol Genet Volume: 24 Pages: 6403-6416
  • DOI: 10.1093/hmg/ddv351
  • Peer Reviewed
• [Journal Article] Increased production of intestinal immunoglobulins in Syntenin-1-deficient mice. (2015)
  • Author(s): Tamura, K.;Ikutani, M.;Yoshida, T.;Tanaka-Hayashi, A.;Yanagibashi, T.;Inoue, R.;Nagai, Y.;Adachi, Y.;Miyawaki, T.;Takatsu, K.;Mori, H.
  • Journal Title: Immunobiology Volume: 220 Pages: 597-604
  • DOI: 10.1016/j.imbio.2014.12.003
  • Peer Reviewed
• [Journal Article] Bcl11b prevents the intrathymic development of innate CD8 T cells in a cell intrinsic manner. (2015)
  • Author(s): Hirose, S.;Touma, M.;Go, R.;Katsuragi, Y.;Sakuraba, Y.;Gondo, Y.;Abe, M.;Sakimura, K.;Mishima, Y.;Kominami, R.
  • Journal Title: Int Immunol Volume: 27 Pages: 205-215
  • DOI: 10.1093/intimm/dxu104
  • Peer Reviewed
• [Journal Article] GlcUAbeta1-3Galbeta1-3Galbeta1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1. (2015)
  • Author(s): Izumikawa, T.;Sato, B.;Mikami, T.;Tamura, J.;Igarashi, M.;Kitagawa, H.
  • Journal Title: J Biol Chem Volume: 290 Pages: 5438-5448
  • DOI: 10.1074/jbc.M114.603266
  • Peer Reviewed
• [Journal Article] TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation. (2015)
  • Author(s): Watanabe, T.;Kakeno, M.;Matsui, T.;Sugiyama, I.;Arimura, N.;Matsuzawa, K.;Shirahige, A.;Ishidate, F.;Nishioka, T.;Taya, S.;Hoshino, M.;Kaibuchi, K.
  • Journal Title: J Cell Biol Volume: 210 Pages: 737-751
  • DOI: 10.1083/jcb.201412075
  • Peer Reviewed / Open Access
• [Journal Article] Kinase-interacting substrate screening is a novel method to identify kinase substrates. (2015)
  • Author(s): Amano, M.;Hamaguchi, T.;Shohag, M. H.;Kozawa, K.;Kato, K.;Zhang, X.;Yura, Y.;Matsuura, Y.;Kataoka, C.;Nishioka, T.;Kaibuchi, K.
  • Journal Title: J Cell Biol Volume: 209 Pages: 895-912
  • DOI: 10.1083/jcb.201412008
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] LRRK1-phosphorylated CLIP-170 regulates EGFR trafficking by recruiting p150Glued to microtubule plus ends. (2015)
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  • Journal Title: J Cell Sci Volume: 128 Pages: 385-396
  • DOI: 10.1242/jcs.161547
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] L-carnitine enhances axonal plasticity and improves white-matter lesions after chronic hypoperfusion in rat brain (2015)
  • Author(s): Ueno, Y.;Koike, M.;Shimada, Y.;Shimura, H.;Hira, K.;Tanaka, R.;Uchiyama, Y.;Hattori, N.;Urabe, T.
  • Journal Title: J Cereb Blood Flow Metab Volume: 35 Pages: 382-391
  • DOI: 10.1038/jcbfm.2014.210
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genetic overlap between antipsychotic response and susceptibility to schizophrenia. (2015)
  • Author(s): Ikeda, M.;Yoshimura, R.;Hashimoto, R.;Kondo, K.;Saito, T.;Shimasaki, A.;Ohi, K.;Tochigi, M.;Kawamura, Y.;Nishida, N.;Miyagawa, T.;Sasaki, T.;Tokunaga, K.;Kasai, K.;Takeda, M.;Nakamura, J.;Ozaki, N.;Iwata, N.
  • Journal Title: J Clin Psychopharmacol Volume: 35 Pages: 85-88
  • DOI: 10.1097/JCP.0000000000000268
  • Peer Reviewed
• [Journal Article] Novel splice variants in the 5'UTR of Gtf2i expressed in the rat brain: alternative 5'UTRs and differential expression in the neuronal dendrites. (2015)
  • Author(s): Shirai, Y.;Watanabe, M.;Sakagami, H.;Suzuki, T.
  • Journal Title: J Neurochem Volume: 134 Pages: 578-589
  • DOI: 10.1111/jnc.13136
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Structure-function relationships between aldolase C/zebrin II expression and complex spike synchrony in the cerebellum. (2015)
  • Author(s): Tsutsumi, S.;Yamazaki, M.;Miyazaki, T.;Watanabe, M.;Sakimura, K.;Kano, M.;Kitamura, K.
  • Journal Title: J NEUROSCI Volume: 35 Pages: 843-852
  • DOI: 10.1523/JNEUROSCI.2170-14.2015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Radial Glial Cell-Neuron Interaction Directs Axon Formation at the Opposite Side of the Neuron from the Contact Site. (2015)
  • Author(s): Xu, C.;Funahashi, Y.;Watanabe, T.;Takano, T.;Nakamuta, S.;Namba, T.;Kaibuchi, K.
  • Journal Title: J NEUROSCI Volume: 35 Pages: 14517-14532
  • DOI: 10.1523/JNEUROSCI.1266-15.2015
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Short-chain fatty acid sensing in rat duodenum. (2015)
  • Author(s): Akiba, Y.;Inoue, T.;Kaji, I.;Higashiyama, M.;Narimatsu, K.;Iwamoto, K.;Watanabe, M.;Guth, P. H.;Engel, E.;Kuwahara, A.;Kaunitz, J. D.
  • Journal Title: J Physiol Volume: 593 Pages: 585-599
  • DOI: 10.1113/jphysiol.2014.280792
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Correlation between Morphologic Changes and Autism Spectrum Tendency in Obsessive-Compulsive Disorder. (2015)
  • Author(s): Kobayashi, T.;Hirano, Y.;Nemoto, K.;Sutoh, C.;Ishikawa, K.;Miyata, H.;Matsumoto, J.;Matsumoto, K.;Masuda, Y.;Nakazato, M.;Shimizu, E.;Nakagawa, A.
  • Journal Title: Magn Reson Med Sci Volume: 14 Pages: 329-335
  • DOI: 10.2463/mrms.2014-0146
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity. (2015)
  • Author(s): Matsui, T.;Watanabe, T.;Matsuzawa, K.;Kakeno, M.;Okumura, N.;Sugiyama, I.;Itoh, N.;Kaibuchi, K.
  • Journal Title: Mol Biol Cell Volume: 26 Pages: 751-761
  • DOI: 10.1091/mbc.E14-09-1382
  • Peer Reviewed
• [Journal Article] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. (2015)
  • Author(s): Nishizawa, D.;Kasai, S.;Hasegawa, J.;Satoh, Y.;Tagami, M.;Ujike, H.;Ozaki, N.;Inada, T.;Iwata, N.;Sora, I.; Won, M. J.; Itokawa, M.; Hashimoto, R.; Sugimura, H.;Ikeda, K.
  • Journal Title: Mol Brain Volume: 8 Pages: 50
  • DOI: 10.1186/s13041-015-0142-x
  • Peer Reviewed / Open Access
• [Journal Article] Stimulation of Sigma-1 Receptor Ameliorates Depressive-like Behaviors in CaMKIV Null Mice. (2015)
  • Author(s): Moriguchi, S.;Sakagami, H.;Yabuki, Y.;Sasaki, Y.;Izumi, H.;Zhang, C.;Han, F.;Fukunaga, K.
  • Journal Title: Mol Neurobiol Volume: 52 Pages: 1210-1222
  • DOI: 10.1007/s12035-014-8923-2
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization. (2015)
  • Author(s): Udagawa, T.;Fujioka, Y.;Tanaka, M.;Honda, D.;Yokoi, S.;Riku, Y.;Ibi, D.;Nagai, T.;Yamada, K.;Watanabe, H.;Katsuno, M.;Inada, T.;Ohno, K.;Sokabe, M.;Okado, H.;Ishigaki, S.;Sobue, G.
  • Journal Title: Nat Commun Volume: 6 Pages: 7098
  • DOI: 10.1038/ncomms8098
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] CDC42EP4/septin-based perisynaptic glial scaffold facilitates glutamate clearance. (2015)
  • Author(s): Ageta-Ishihara, N.;Yamazaki, M.;Konno, K.;Nakayama, H.;Abe, M.;Hashimoto, K.;Nishioka, T.;Kaibuchi, K.;Hattori, S.;Miyakawa, T.;Tanaka, K.;Huda, F.;Hirai, H.;Hashimoto, K.;Watanabe, M.;Sakimura, K.;Kinoshita, M.
  • Journal Title: Nat Commun Volume: 6 Pages: 10090
  • DOI: 10.1038/ncomms10090
  • Peer Reviewed / Open Access
• [Journal Article] STAT3-dependent reactive astrogliosis in the spinal dorsal horn underlies chronic itch. (2015)
  • Author(s): Shiratori-Hayashi, M.;Koga, K.;Tozaki-Saitoh, H.;Kohro, Y.;Toyonaga, H.;Yamaguchi, C.;Hasegawa, A.;Nakahara, T.;Hachisuka, J.;Akira, S.;Okano, H.;Furue, M.;Inoue, K.;Tsuda, M.
  • Journal Title: Nat Med Volume: 21 Pages: 927-931
  • DOI: 10.1038/nm.3912
  • Peer Reviewed
• [Journal Article] Disrupted-in-schizophrenia 1 regulates transport of ITPR1 mRNA for synaptic plasticity. (2015)
  • Author(s): Tsuboi, D.;Kuroda, K.;Tanaka, M.;Namba, T.;Iizuka, Y.;Taya, S.;Shinoda, T.;Hikita, T.;Muraoka, S.;Iizuka, M.;Nimura, A.;Mizoguchi, A.;Shiina, N.;Sokabe, M.;Okano, H.;Mikoshiba, K.;Kaibuchi, K.
  • Journal Title: Nat Neurosci Volume: 18 Pages: 698-707
  • DOI: 10.1038/nn.3984
  • Peer Reviewed
• [Journal Article] Common genetic variants influence human subcortical brain structures. (2015)
  • Author(s): Hibar, D.P.;Stein, J.L.;Renteria, M.E.;Arias-Vasquez, A.;Desrivieres, S.;Jahanshad, N.;Toro, R.;Wittfeld, K.;Abramovic, L.;Andersson, M.;Aribisala, B. S.; Hashimoto, R.; Thompson, P. M.;Medland, S. E.
  • Journal Title: Nature Volume: 520 Pages: 224-229
  • DOI: 10.1038/nature14101
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nanoscale distribution of presynaptic Ca(2+) channels and its impact on vesicular release during development. (2015)
  • Author(s): Nakamura, Y.;Harada, H.;Kamasawa, N.;Matsui, K.;Rothman, J. S.;Shigemoto, R.;Silver, R. A.;DiGregorio, D. A.;Takahashi, T.
  • Journal Title: Neuron Volume: 85 Pages: 145-158
  • DOI: 10.1016/j.neuron.2014.11.019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anterograde C1ql1 signaling is required in order to determine and maintain a single-winner climbing fiber in the mouse cerebellum. (2015)
  • Author(s): Kakegawa, W.;Mitakidis, N.;Miura, E.;Abe, M.;Matsuda, K.;Takeo, Y. H.;Kohda, K.;Motohashi, J.;Takahashi, A.;Nagao, S.;Muramatsu, S.;Watanabe, M.;Sakimura, K.;Aricescu, A. R.;Yuzaki, M.
  • Journal Title: Neuron Volume: 85 Pages: 316-329
  • DOI: 10.1016/j.neuron.2014.12.020
  • Peer Reviewed
• [Journal Article] Neuron-microglia interaction by purinergic signaling in neuropathic pain following neurodegeneration. (2015)
  • Author(s): Tsuda, M.;Inoue, K.
  • Journal Title: Neuropharmacology Volume: － Pages: －
  • DOI: 10.1016/j.neuropharm.2015.08.042
  • Peer Reviewed
• [Journal Article] Possible involvement of iron-induced oxidative insults in neurodegeneration. (2015)
  • Author(s): Asano, T.;Koike, M.;Sakata, S.;Takeda, Y.;Nakagawa, T.;Hatano, T.;Ohashi, S.;Funayama, M.;Yoshimi, K.;Asanuma, M.;Toyokuni, S.;Mochizuki, H.;Uchiyama, Y.;Hattori, N.;Iwai, K.
  • Journal Title: Neurosci Lett Volume: 588 Pages: 29-35
  • DOI: 10.1016/j.neulet.2014.12.052
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Modulation of different behavioral components by neuropeptide and dopamine signalings in non-associative odor learning of Caenorhabditis elegans. (2015)
  • Author(s): Yamazoe-Umemoto, A.;Fujita, K.;Iino, Y.;Iwasaki, Y.;Kimura, K. D.
  • Journal Title: Neurosci Res Volume: 99 Pages: 22-33
  • DOI: 10.1016/j.neures.2015.05.009
  • Peer Reviewed
• [Journal Article] Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS. (2015)
  • Author(s): Hasegawa, M.;Hara-Miyauchi, C.;Ohta, H.;Sakimura, K.;Okano, H.;Okano, H. J.
  • Journal Title: Neurosci Res Volume: － Pages: －
  • DOI: 10.1016/j.neures.2015.11.009
  • Peer Reviewed
• [Journal Article] Extracellular and Intracellular Signaling for Neuronal Polarity. (2015)
  • Author(s): Namba, T.;Funahashi, Y.; Nakamuta, S.;Xu, C.;Takano, T.;Kaibuchi, K.
  • Journal Title: Physiol Rev Volume: 95 Pages: 995-1024
  • DOI: 10.1152/physrev.00025.2014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Viable neuronopathic Gaucher disease model in Medaka (Oryzias latipes) displays axonal accumulation of alpha-synuclein. (2015)
  • Author(s): Uemura, N.;Koike, M.;Ansai, S.;Kinoshita, M.;Ishikawa-Fujiwara, T.;Matsui, H.;Naruse, K.;Sakamoto, N.;Uchiyama, Y.;Todo, T.;Takeda, S.;Yamakado, H.;Takahashi, R.
  • Journal Title: PLoS Genet Volume: 11 Pages: e1005065
  • DOI: 10.1371/journal.pgen.1005065
  • Peer Reviewed / Open Access
• [Journal Article] Identification of Inhibitory Premotor Interneurons Activated at a Late Phase in a Motor Cycle during Drosophila Larval Locomotion. (2015)
  • Author(s): Itakura, Y.;Kohsaka, H.;Ohyama, T.;Zlatic, M.;Pulver, S. R.;Nose, A.
  • Journal Title: PLoS ONE Volume: 10 Pages: e0136660
  • DOI: 10.1371/journal.pone.0136660
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Heterozygous Disruption of Autism susceptibility candidate 2 Causes Impaired Emotional Control and Cognitive Memory. (2015)
  • Author(s): Hori, K.;Nagai, T.;Shan, W.;Sakamoto, A.;Abe, M.;Yamazaki, M.;Sakimura, K.;Yamada, K.;Hoshino, M.
  • Journal Title: PLoS ONE Volume: 10 Pages: e0145979
  • DOI: 10.1371/journal.pone.0145979
  • Peer Reviewed / Open Access
• [Journal Article] Fever Is Mediated by Conversion of Endocannabinoid 2-Arachidonoylglycerol to Prostaglandin E2. (2015)
  • Author(s): Kita, Y.;Yoshida, K.;Tokuoka, S. M.;Hamano, F.;Yamazaki, M.;Sakimura, K.;Kano, M.;Shimizu, T.
  • Journal Title: PLoS ONE Volume: 10 Pages: e0133663
  • DOI: 10.1371/journal.pone.0133663.
  • Peer Reviewed / Open Access
• [Journal Article] Dietary Intake of Sulforaphane-Rich Broccoli Sprout Extracts during Juvenile and Adolescence Can Prevent Phencyclidine-Induced Cognitive Deficits at Adulthood. (2015)
  • Author(s): Shirai, Y.;Fujita, Y.;Hashimoto, R.;Ohi, K.;Yamamori, H.;Yasuda, Y.;Ishima, T.;Suganuma, H.;Ushida, Y.;Takeda, M.;Hashimoto, K.
  • Journal Title: PLoS ONE Volume: 10 Pages: e0127244
  • DOI: 10.1371/journal.pone.0127244
  • Peer Reviewed / Open Access
• [Journal Article] A naturally occurring null variant of the NMDA type glutamate receptor NR3B subunit is a risk factor of schizophrenia. (2015)
  • Author(s): Matsuno, H.;Ohi, K.;Hashimoto, R.;Yamamori, H.;Yasuda, Y.;Fujimoto, M.;Yano-Umeda, S.;Saneyoshi, T.;Takeda, M.;Hayashi, Y.
  • Journal Title: PLoS ONE Volume: 10 Pages: e0116319
  • DOI: 10.1371/journal.pone.0116319
  • Peer Reviewed / Open Access
• [Journal Article] Na,K-ATPase alpha3 is a death target of Alzheimer patient amyloid-beta assembly. (2015)
  • Author(s): Ohnishi, T.; Kitamura, Y.;Hiroaki, H.;Fukazawa, Y.;Kii, I.;Nishiyama, T.;Kakita, A.;Takeda, H.;Takeuchi, A.;Arai, Y.;Ito, A.;Komura, H.;Hirao, H.; Hagiwara, M.; Nabeshima, Y.;Teplow, D. B.;Hoshi, M.
  • Journal Title: Pro Natl Acad Sci U S A Volume: 112 Pages: E4465-4474
  • DOI: 10.1073/pnas.1421182112
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] IRBIT regulates CaMKIIalpha activity and contributes to catecholamine homeostasis through tyrosine hydroxylase phosphorylation. (2015)
  • Author(s): Kawaai, K.;Mizutani, A.;Shoji, H.;Ogawa, N.;Ebisui, E.;Kuroda, Y.;Wakana, S.;Miyakawa, T.;Hisatsune, C.;Mikoshiba, K.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 112 Pages: 5515-5520
  • DOI: 10.1073/pnas.1503310112
  • Peer Reviewed
• [Journal Article] Relative contribution of TARPs gamma-2 and gamma-7 to cerebellar excitatory synaptic transmission and motor behavior. (2015)
  • Author(s): Yamazaki, M.;Le Pichon, C.E.;Jackson, A.C.;Cerpas, M.;Sakimura, K.;Scearce-Levie, K.;Nicoll, R. A.
  • Journal Title: Proc Natl Acad Sci U S A Volume: 112 Pages: E371-379
  • DOI: 10.1073/pnas.1423670112
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects. (2015)
  • Author(s): Takahashi, T.;Nakamura, M.;Nakamura, Y.;Aleksic, B.;Kido, M.;Sasabayashi, D.;Takayanagi, Y.;Furuichi, A.;Nishikawa, Y.;Noguchi, K.;Ozaki, N.;Suzuki, M.
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 56 Pages: 11-17
  • DOI: 10.1016/j.pnpbp.2014.07.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Autopsy-confirmed hippocampal-sparing Alzheimer's disease with delusional jealousy as initial manifestation. (2015)
  • Author(s): Fujishiro, H.;Iritani, S.;Hattori, M.;Sekiguchi, H.;Matsunaga, S.;Habuchi, C.;Torii, Y.;Umeda, K.;Ozaki, N.;Yoshida, M.;Fujita, K.
  • Journal Title: Psychogeriatrics Volume: 15 Pages: 198-203
  • DOI: 10.1111/psyg.12105
  • Peer Reviewed
• [Journal Article] The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila. (2015)
  • Author(s): Hentze, J.L.;Carlsson, M.A.; Kondo, S.;Nassel, D. R.;Rewitz, K. F.
  • Journal Title: Sci Rep Volume: 5 Pages: 11680
  • DOI: 10.1038/srep11680
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A new minimally-invasive method for microinjection into the mouse spinal dorsal horn. (2015)
  • Author(s): Kohro, Y.;Sakaguchi, E.;Tashima, R.;Tozaki-Saitoh, H.;Okano, H.;Inoue, K.;Tsuda, M.
  • Journal Title: Sci Rep Volume: 5 Pages: 14306
  • DOI: 10.1038/srep14306
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Long-term safety issues of iPSC-based cell therapy in a spinal cord injury model: oncogenic transformation with epithelial-mesenchymal transition. (2015)
  • Author(s): Nori, S.;Okada, Y.;Nishimura, S.;Sasaki, T.;Itakura, G.;Kobayashi, Y.;Renault-Mihara, F.;Shimizu, A.;Koya, I.;Yoshida, R.;Kudoh, J.;Koike, M.;Uchiyama, Y.;Ikeda, E.;Toyama, Y.;Nakamura, M.;Okano, H.
  • Journal Title: Stem Cell Reports Volume: 4 Pages: 360-373
  • DOI: 10.1016/j.stemcr.2015.01.006
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Horizontal Basal Cell-Specific Deletion of Pax6 Impedes Recovery of the Olfactory Neuroepithelium Following Severe Injury. (2015)
  • Author(s): Suzuki, J.;Sakurai, K.;Yamazaki, M.;Abe, M.;Inada, H.;Sakimura, K.;Katori, Y.;Osumi, N.
  • Journal Title: Stem Cells Dev Volume: 24 Pages: 1923-1933
  • DOI: 10.1089/scd.2015.0011
  • Peer Reviewed / Open Access
• [Journal Article] The Infundibular Recess Passes through the Entire Pituitary Stalk. (2015)
  • Author(s): Tsutsumi S., Hori M., Ono H., Tabuchi T., Aoki S., Yasumoto Y.
  • Journal Title: Clin Neuroradiol Volume: － Pages: －
  • DOI: 10.1007/s00062-015-0391-1
  • Peer Reviewed
• [Journal Article] Oxytocin's neurochemical effects in the medial prefrontal cortex underlie recovery of task-specific brain activity in autism: a randomized controlled trial. (2015)
  • Author(s): Aoki Y., Watanabe T., Abe O., Kuwabara H., Yahata N., Takano Y., Iwashiro N., Natsubori T., Takao H., Kawakubo Y., Kasai K., Yamasue H.
  • Journal Title: Mol Psychiatry Volume: 20 Pages: 447-453
  • DOI: 10.1038/mp.2014.74
  • Peer Reviewed
• [Journal Article] For U.J., Investigators U.I. Risk of rupture of unruptured cerebral aneurysms in elderly patients. (2015)
  • Author(s): Hishikawa T., Date I., Tokunaga K., Tominari S., Nozaki K., Shiokawa Y., Houkin K., Murayama Y., Ishibashi T., Takao H., Kimura T., Nakayama T., Morita A.
  • Journal Title: Neurology Volume: 85 Pages: 1879-1885
  • DOI: 10.1212/WNL.0000000000002149
  • Peer Reviewed
• [Journal Article] Brain diffusivity pattern is individual-specific information. (2015)
  • Author(s): Takao H., Hayashi N., Ohtomo K.
  • Journal Title: NeuroScience Volume: 301 Pages: 395-402
  • DOI: 10.1016/j.neuroscience.2015.06.032
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Genetic Variation in the Catechol-O-Methyl Transferase Val108/158Met Is Linked to the Caudate and Posterior Cingulate Cortex Volume in Healthy Subjects: Voxel-Based Morphometry Analysis of Brain Magnetic Resonance Imaging. (2015)
  • Author(s): Watanabe K., Kakeda S., Yoshimura R., Ide S., Hayashi K., Katsuki A., Umene-Nakano W., Watanabe R., Abe O., Korogi Y
  • Journal Title: PLoS ONE Volume: 10, Pages: e0142862
  • DOI: 10.1371/journal.pone.0142862
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment. (2015)
  • Author(s): Okada K., Nakao T., Sanematsu H., Murayama K., Honda S., Tomita M., Togao O., Yoshiura T., Kanba S.
  • Journal Title: Psychiatry Clin Neurosci Volume: 69 Pages: 411-421
  • DOI: 10.1111/pcn.12269
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between a BDNF gene polymorphism and the brain volume in treatment-naive patients with major depressive disorder: A VBM analysis of brain MRI. (2015)
  • Author(s): Ide S., Kakeda S., Watanabe K., Yoshimura R., Abe O., Hayashi K., Ueda I., Kishi T., Katsuki A., Umene-Nakano W., Iwata N., Nakamura J., Korogi Y.
  • Journal Title: Psychiatry Res Volume: 233 Pages: 120-124
  • DOI: 10.1016/j.pscychresns.2015.05.016
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Relationship between the catechol-O-methyl transferase Val108/158Met genotype and brain volume in treatment-naive major depressive disorder: Voxel-based morphometry analysis. (2015)
  • Author(s): Watanabe K., Kakeda S., Yoshimura R., Abe O., Ide S., Hayashi K., Katsuki A., Umene-Nakano W., Watanabe R., Nakamura J., Korogi Y.
  • Journal Title: Psychiatry Res Volume: 233 Pages: 481-487
  • DOI: 10.1016/j.pscychresns.2015.07.024
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] TRPV4 activation at the physiological temperature is a critical determinant of neuronal excitability and behavior. (2015)
  • Author(s): Shibasaki K., Sugio S., Takao K., Yamanaka A., Miyakawa T., Tominaga M., Ishizaki Y.
  • Journal Title: Pflugers Arch Volume: 467 Pages: 2495-2507
  • DOI: 10.1007/s00424-015-1726-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Developing novel methods to search for substrates of protein kinases such as Rho-kinase. (2015)
  • Author(s): Nishioka T., Shohag M.H., Amano M., Kaibuchi K.
  • Journal Title: Biochim Biophys Acta Volume: 1854 Pages: 1663-1666
  • DOI: 10.1016/j.bbapap.2015.03.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Glutamate Networks Implicate Cognitive Impairments in Schizophrenia: Genome-Wide Association Studies of 52 Cognitive Phenotypes. S (2015)
  • Author(s): Ohi K., Hashimoto R., Ikeda M., Yamamori H., Yasuda Y., Fujimoto M., Umeda-Yano S., Fukunaga M., Fujino H., Watanabe Y., Iwase M., Kazui H., Iwata N., Weinberger D.R., Takeda M.
  • Journal Title: Schizophr Bull Volume: 41 Pages: 909-918
  • DOI: 10.1093/schbul/sbu171
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comprehensive behavioral analysis of voltage-gated calcium channel beta-anchoring and -regulatory protein knockout mice. (2015)
  • Author(s): Nakao A., Miki T., Shoji H., Nishi M., Takeshima H., Miyakawa T., Mori Y.
  • Journal Title: Front Behav Neurosci Volume: 9 Pages: 141
  • DOI: 10.3389/fnbeh.2015.00141
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Quenching-type of fluorescent Ca2+ indicator for detecting neuronal inhibition (2015)
  • Author(s): S. Kuge, T. Nishihara, T. Matsuda, H. Furuie, T. Teramoto, T. Nagai and T. Ishihara
  • Organizer: 2015 International Chemical Congress of Pacific Basin Societies
  • Place of Presentation: The Hawaii Convention Center (Honolulu, USA)
  • Year and Date: 2015-12-15 – 2015-12-20
  • Int'l Joint Research
• [Presentation] リン酸化プロテオミクスで同定された、神経成長関連分子群の責任キナーゼの解析 (2015)
  • Author(s): 河嵜 麻実、小林 大記、岡田 正康、野住 素広、武内 恒成、五十嵐 道弘、
  • Organizer: 第38回日本分子生物学会・第88回日本生化学会合同大会
  • Place of Presentation: 神戸国際会議場（神戸市中央区）
  • Year and Date: 2015-12-03
• [Presentation] 神経RNA granuleのダイナミクスと高次脳機能・精神神経疾患 (2015)
  • Author(s): 椎名伸之
  • Organizer: 第38回日本分子生物学会年会 第88回日本生化学会大会 合同大会
  • Place of Presentation: 神戸ポートアイランド（神戸）
  • Year and Date: 2015-12-03
• [Presentation] Palmitoylarion-dependent regulation of AMPA receptor trafficking and excitation-inhibition balance in brain (2015)
  • Author(s): Mariko Yamashita, Hiroyuki Okuno, Manabu Abe, Maya Yamazaki, Rie Natsume, Kenji Sakimura, Mikio Hoshino, Masayoshi Mishina and Takashi Hayashi
  • Organizer: 第38回日本分子生物学会年会第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2015-12-03
• [Presentation] CTCF欠失は大脳皮質抑制性神経細胞の分布と神経活動に影響を及ぼす (2015)
  • Author(s): 有賀理瑛、谷垣宏美、平山晃斉、吉武 講平、足澤悦子、Niels Caljart、吉村由美子、渋木 克栄、八木 健
  • Organizer: 第38回日本分子生物学会・第88回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-02
• [Presentation] BRAG2-Arf6経路による新たなAMPA受容体シナプス発現調節機構 (2015)
  • Author(s): 阪上洋行
  • Organizer: 第88回日本生化学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-12-01 – 2015-12-04
• [Presentation] 線虫の記憶学習に関わるニューロンタイプ特異的な選択的スプライシングの制御機構 (2015)
  • Author(s): 富岡征大、飯野雄一
  • Organizer: 第38回日本分子生物学会年会・第80回日本生化学会大会・合同大会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] CREBリン酸化イメージング法の開発と脳機能解析への応用 (2015)
  • Author(s): 森 寿
  • Organizer: 第27回日本脳循環代謝学会総会
  • Place of Presentation: 富山国際会議場(富山県富山市 )
  • Year and Date: 2015-10-31
  • Invited
• [Presentation] Effect of time-of-day on mouse behavior measured in a comprehensive behavioral test battery“ (2015)
  • Author(s): Takao, K., Shoji, H., Hattori, S., Miyakawa, T.
  • Organizer: 45th Annual Meeting of Society for Neuroscience
  • Place of Presentation: McCormick Place (Chicago, U.S.A.)
  • Year and Date: 2015-10-20
  • Int'l Joint Research
• [Presentation] Dual effects of serotoninergic inputs on the local circuits regulating the corticotropin-releasing factor neurons in the paraventricular nucleus of the hypothalamus: An electrophysioligical study using the CRF-Venus Δneo mouse. (2015)
  • Author(s): T.Sato, T.Sugaya. T.Fuse, K.Uchida, A.H.Talukder,J.Kono, N.Sugimoto,S.Yamagata, M.Abe, M.Yamazaki, A.Fukuda,K.Sakimura,K.Itoi
  • Organizer: Neuroscience2015
  • Place of Presentation: Chicago,USA
  • Year and Date: 2015-10-19
  • Int'l Joint Research
• [Presentation] タウオパチーの生化学 (2015)
  • Author(s): 長谷川成人
  • Organizer: 第9回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 品川プリンス（東京都品川区）
  • Year and Date: 2015-10-16
• [Presentation] Dopamine release is gated by coincidentally stimulated postsynaptic neurons to reinforce plasticity. (2015)
  • Author(s): Ueno, K, Saitoe, M.
  • Organizer: Neuroscience 2015
  • Place of Presentation: McCormic Place (Chicago, IL, USA)
  • Year and Date: 2015-10-10 – 2015-10-19
  • Int'l Joint Research
• [Presentation] 冠状断MRIの海馬厚と側脳室下角径でVSRADによるアルツハイマー病の萎縮を評価する (2015)
  • Author(s): 中塚智也, 石川ルミ子, 粕谷秀輔, 小田島正幸, 稲岡努, 寺田一志
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール青森（青森市）
  • Year and Date: 2015-10-03
• [Presentation] 大規模臨床研究を推進するための体制について、日本における大規模臨床研究のCOCOROによる実践 (2015)
  • Author(s): 橋本亮太
  • Organizer: シンポジウム19：第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都）
  • Year and Date: 2015-09-26
• [Presentation] 修正型電気けいれん療法後のagitationの予測因子に関する脳画像研究 (2015)
  • Author(s): 川口彰子、根本清貴、仲秋秀太郎、橋本伸彦、山田峻寛、川口毅恒、西垣誠、東英樹、明智龍男
  • Organizer: 第37回日本生物学的精神医学会・第45回日本神経精神薬理学会合同年会
  • Place of Presentation: タワーホール船堀（東京都）
  • Year and Date: 2015-09-25
• [Presentation] The neuropathological study of Myeline-Oligodendrocyte in postmortem schizophrenic brain (2015)
  • Author(s): T.Marui, S.Iritani, Y.Torii, S.Morosawa,K.Umeda, H. Sekiguchi ,C. Habuchi, H.Fujishiro, K.Oshima, K.Niizato, K.Masaki, J.Kira & N.Ozaki
  • Organizer: 5th European Conference on Schizophrenia Research
  • Place of Presentation: Berlin, ドイツ
  • Year and Date: 2015-09-24 – 2015-09-26
  • Int'l Joint Research
• [Presentation] Functional imaging of the third-order olfactory neurons Kenyon cells in the mushroom body of Drosophila (2015)
  • Author(s): Hiroi, M, Tabata, T.
  • Organizer: 14th European Symposium for Insect Taste and Olfaction (ESITO)
  • Place of Presentation: Cormoran Hotel (Cagliari, Italy)
  • Year and Date: 2015-09-20 – 2015-09-25
  • Int'l Joint Research
• [Presentation] ラット舌下神経前位核における発火パターンが異なるニューロンが示す異なる発火応答特性 (2015)
  • Author(s): 齋藤康彦、柳川右千夫
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2015-09-02
• [Presentation] FTLD様のフェノタイプを呈するFUS機能喪失モデルマウスにおけるadult neurogenesisの低下 (2015)
  • Author(s): 石垣診祐, 藤岡祐介, 本田大祐, 横井聡, 岡戸晴生、渡辺宏久、勝野雅央、祖父江元 ,藤岡祐介, 石垣診祐, 横井聡, 本田大祐, 宇多川剛, 岡戸晴生, 渡辺宏久, 勝野雅央, 祖父江元
  • Organizer: 第３８回日本神経科学大会
  • Place of Presentation: 神戸国際会議場（神戸市中央区）
  • Year and Date: 2015-07-30
• [Presentation] ゲノム編集による変異マウス作製 (2015)
  • Author(s): 饗場篤
  • Organizer: 第38回日本神経科学大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市)
  • Year and Date: 2015-07-29
• [Presentation] Longitudinal diffusion tensor imaging study in cryptogenic West syndrome (2015)
  • Author(s): 下地啓五, Chikako Ogawa, Jun Natsume, Hiroyuki Kidokoro, Tatsuya Fukasawa, Kazuyoshi Watanabe
  • Organizer: Pediatric Academic Societies (PAS) Annual Meeting 2015
  • Place of Presentation: San Diego, USA.
  • Year and Date: 2015-04-25
• [Remarks] 包括脳ネットワークホームページ
  • URL: https://www.hokatsu-nou.nips.ac.jp
• [Remarks] C.elegans PlasmidSearch WEBサイト
  • URL: http://molecular-ethology.biochem.s.u-tokyo.ac.jp/plasmidDB//index.html
• [Remarks] Mouse Phenotype Database
  • URL: http://www.mouse-phenotype.org/
• [Remarks] 包括脳精神疾患拠点ホームページ
• [Remarks] http://cbsn-mri.umin.jp/