社会脳を担う前頭葉ネットワークの解明―微小電極からｆＭＲＩまでの垂直的統合研究―

2013 Fiscal Year Annual Research Report

• Project/Area Number: 22220003
• Research Institution: Kyoto University
• Principal Investigator: 苧阪 直行 京都大学, 文学研究科, 名誉教授 (20113136)
• Co-Investigator(Kenkyū-buntansha): 蘆田 宏 京都大学, 文学研究科, 准教授 (20293847) ; 福山 秀直 京都大学, 医学(系)研究科(研究院), 教授 (90181297) ; 村井 俊哉 京都大学, 医学(系)研究科(研究院), 教授 (30335286) ; 船橋 新太郎 京都大学, 学内共同利用施設等, 教授 (00145830) ; 渡辺 正孝 公益財団法人東京都医学総合研究所, その他部局等, その他 (50092383) ; 苧阪 満里子 大阪大学, その他の研究科, 教授 (70144300)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 前頭葉 / 社会脳 / ワーキングメモリ / 社会適応障害 / 脳画像法 / 高齢者

Outline of Annual Research Achievements

本研究プロジェクトは，社会脳の動作メカニズムを前頭葉機能の観点から解き明かし，また，社会性障害の原因究明と治療法の探究を進めることで，健全で豊かな社会脳の仕組みと再生プロセスを見出すことを目標として掲げている。平成25年度は，昨年度に引き続き，前頭連合野を中心としたトップダウン制御ネットワークを種々の課題研究で得られた知見と対応づけ、豊かな社会性を育む社会脳と前頭連合野の役割を明らかにすることを目指した研究を行った。fMRIによる実験では，例えば他者との間に葛藤が生じるような場面において，自分自身に責任を帰属させる（自罰）傾向のある人と，他者（相手）に責任を帰属させる（他罰）傾向のある人とを比較し，前頭連合野が攻撃性の指向性を制御している可能性を見出した。微小電極法による検討では，ワーキングメモリが必要とされる二重課題を実行する際のニューロン活動をサルの前頭前野で計測し，課題負荷の増加に伴って神経活動が実際に変化する様を捉えた。次に社会性障害に関する研究では，例えば統合失調症患者において，他者の心的状態を読み取る心の理論と呼ばれる能力の低下が，脳の灰白質領域の体積の変化と関係していることを突き止め，また他者の感情状態に対する共感能力（エンパシー）の低下が，脳の白質と呼ばれる領域の統合度の低下と関係していることを明らかにした。さらに，同様に患者の主観的なQuality of Lifeと灰白質領域の体積の間にも相関関係があるという知見を得ている。また，経頭蓋直流電気刺激法（tDCS）や経頭蓋磁気刺激法（TMS）といった非侵襲による脳刺激法がヒトの認知的・社会的能力にどのような効果を及ぼすかについての検討も引き続き進められている。こうした一連の研究を通して，私たちの社会行動の基盤となる神経メカニズムと社会適応障害の病理の解明に近づくことができたと言える。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

本研究課題が掲げる4つの目標の達成に向けて，十分な成果を上げることができた。目標1（社会的協調（共感）を支える認知・神経基盤の解明）については，例えば自己認識や他者に対する社会的認知において重要な役割を果たすことが示唆されている前頭前野内側部などの社会脳領域が，自己および他者に対する参照課題を行う際にどのような活動を示すかについて詳細な検討が行われた。さらに，他者との協調・協力を支える神経メカニズムを複数名の脳活動の同期的パタンから捉える試みにも着手しつつある。目標2（社会性障害の原因究明と適応をもたらす介入方法の探索）に関しては，MRIによって脳の灰白質・白質領域の体積を測定するという新しい手法を用いて，統合失調症患者の社会的能力との相関関係を明らかにした。また，tDCSやTMSなどの脳刺激法がヒトの認知的・社会的能力にどのような効果を及ぼすかについての検討も進められている。目標3（ワーキングメモリと社会脳の相互作用のメカニズムの解明）についても，ワーキングメモリを支える前頭前野のはたらきが，社会的場面における個人差の発現と関係していることなどが明らかとなった。これらの研究成果から，社会脳を制御するワーキングメモリのモデル化（目標4）の達成に向けて本研究プロジェクトが順調に進んでいると言える。また，これらの成果は研究代表者である苧阪直行が中心となって取りまとめられ，一般向けの「社会脳シリーズ」（新曜社）として順次刊行されつつある。以上より，本研究プロジェクトはおおむね順調に進展してきていると考えている。

Strategy for Future Research Activity

今後の研究では，前頭連合野を中心とするトップダウンの制御ネットワークと高度な社会性認知を支える社会脳領域との相互関係をモデル化することを目指す。まず，ヒトの脳イメージング研究の結果と，サルの電気生理学的研究で得られた結果を照合することで，高次認知を支える脳内ワーキングメモリネットワークの特性を垂直統合的な観点から明らかにすることを目指す。特に，認知資源の容量制約に着目し，容量制約の基盤となる前頭連合野の仕組みに関する仮説を，神経細胞レベルから全脳レベルまでの幅広い視点を踏まえて提唱する。続いて，これまでの臨床研究で蓄積された疾患群の社会脳研究データと健常者のデータとを比較することで，社会性認知の基盤となる社会脳領域の仕組みに関するモデルを提言すると同時に，社会性障害における前頭葉ネットワークの関与についても実証データに基づく仮説を提唱したい。本研究課題の中心的仮説である，社会脳領域を司る前頭葉ネットワークの実態と仕組みについては，これまで研究を進めてきた高次誤信念課題や，責任帰属課題，自己参照課題，顔認識課題，感情性ワーキングメモリ課題遂行時の脳活動結果や非侵襲脳刺激法を用いた研究結果を踏まえて，その詳細なモデルを提唱することを目指す。さらに，他者との協調・協力を支える神経メカニズムを複数名の脳活動の同期的パタンから捉えることを試みる。具体的には，心理的な幸福感や心理的結びつきを強めることが指摘されている合唱（コーラス）に着目し，合唱中の2名の脳活動の同期強度を測定し，協調・共感の基盤となる脳部位の特定に挑戦する。

Research Products

• [Journal Article] Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke. (2014)
  • Author(s): Takenobu, Y., Hayashi, T., Moriwaki, H., Nagatsuka, K., Naritomi, H., & Fukuyama, H.
  • Journal Title: Neuroimage Clinical Volume: 4 Pages: 201-208
  • DOI: 10.1016/j.nicl.2013.12.003
  • Peer Reviewed
• [Journal Article] Age and individual differences in visual working memory deficit induced by overload. (2014)
  • Author(s): Matsuyoshi, D., Osaka, M., & Osaka, N.
  • Journal Title: Frontiers in Psychology Volume: 5 Pages: 384
  • DOI: 10.3389/fpsyg.2014.00384
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Extrapunitive and intropunitive individuals activate different parts of the prefrontal cortex under an ego-blocking frustration. (2014)
  • Author(s): Minamoto, T., Yaoi, K., Osaka, M., & Osaka, N.
  • Journal Title: PLoS ONE Volume: 9 Pages: e86036
  • DOI: 10.1371/journal.pone.008603
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Raise two effects with one scene: Scene contexts have two separate effects in visual working memory of target faces. (2014)
  • Author(s): Tanabe-Ishibashi, A., Ikeda, T., & Osaka, N.
  • Journal Title: Frontiers in Psychology Volume: 5 Pages: 400
  • DOI: 10.3389/fpsyg.2014.00400
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of the thalamus in recovery from tactile extinction and crossed tactile extinction. (2014)
  • Author(s): Asada, T., Takeda, K., Okiyama, R., Isozaki, E., & Fukuyama, H.
  • Journal Title: Neurocase Volume: 20 Pages: 37-41
  • DOI: 10.1080/13554794.2012.732082
  • Peer Reviewed
• [Journal Article] The modulation of rolandic oscillation induced by digital nerve stimulation and self-paced movement of the finger: A MEG study. (2014)
  • Author(s): Enatsu, R., Nagamine, T., Matsubayashi, J., Maezawa, H., Kikuchi, T., Fukuyama, H., Mikuni, N., Miyamoto, S., & Hashimoto, N.
  • Journal Title: Journal of Neurological Sciences Volume: 337 Pages: 201-211
  • DOI: 10.1016/j.jns.2013.12.011
  • Peer Reviewed
• [Journal Article] Impaired empathic abilities and reduced white matter integrity in schizophrenia. (2014)
  • Author(s): Fujino, J., Takahashi, H., Miyata, J., Sugihara, G., Kubota, M., Sasamoto, A., Fujiwara, H., Aso, T., Fukuyama, H., & Murai, T.
  • Journal Title: Progress in Neuropsychopharmacology & Biological Psychiatry Volume: 48 Pages: 117-123
  • DOI: 10.1016/j.pnpbp.2013.09.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Modafinil augments brain activation associated with reward anticipation in the nucleus accumbens. (2014)
  • Author(s): Funayama, T., Ikeda, Y., Tateno, A., Takahashi, H., Okubo, Y., Fukuyama, H., & Suzuki, H.
  • Journal Title: Psychopharmacology Volume: 231 Pages: 3217-3228
  • DOI: 10.1007/s00213-014-3499-0
  • Peer Reviewed
• [Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia. (2014)
  • Author(s): Sasamoto, A., Miyata, J., Kubota, M., Hirao, K., Kawada, R., Fujimoto, S., Tanaka, Y., Hazama, M., Sugihara, G., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: Schizophrenia Bulletin Volume: 40 Pages: 420-427
  • DOI: 10.1093/schbul/sbt030
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of sports participation on psychiatric symptoms and brain activations during sports observation in schizophrenia. (2014)
  • Author(s): Takahashi, H., Sassa, T., Shibuya, T., Kato, M., Koeda, M., Murai, T., Matsuura, M., Asai, K., Suhara, T., & Okubo, Y.
  • Journal Title: Translational Psychiatry Volume: 20 Pages: e96
  • DOI: 10.1038/tp.2012.22
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neural mechanisms of dual-task interference and cognitive capacity limitation in prefrontal cortex. (2014)
  • Author(s): Watanabe, K., & Funahashi, S.
  • Journal Title: Nature Neuroscience Volume: 17 Pages: 601-611
  • DOI: 10.1038/nn.3667
  • Peer Reviewed
• [Journal Article] Individual differences in autistic traits predict the perception of direct gaze for males, but not for females. (2014)
  • Author(s): Matsuyoshi, D., Kuraguchi, K., Tanaka, Y., Uchida, S., Ashida, H., & Watanabe, K.
  • Journal Title: Molecular Autism Volume: 5 Pages: 12
  • DOI: 10.1186/2040-2392-5-12
  • Peer Reviewed
• [Journal Article] Priming and implicit recognition depend on similar temporal changes in perceptual representations. (2014)
  • Author(s): Miyoshi, K., & Ashida, H.
  • Journal Title: Acta Psychologica Volume: 148 Pages: 6-11
  • DOI: 10.1016/j.actpsy.2013.12.012
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cognitive neuroscience of social emotions and implications for psychopathology: Examining embarrassment, guilt, envy, and schadenfreude. (2014)
  • Author(s): Jankowski, K. F., & Takahashi, H.
  • Journal Title: Psychiatry and clinical neuroscience Volume: 68 Pages: 319-336
  • DOI: 10.1111/pcn.12182
  • Peer Reviewed
• [Journal Article] Abnormal white matter integrity in the corpus callosum among smokers: tract-based spatial statistics. (2014)
  • Author(s): Umene-Nakano, W., Yoshimura, R., Kakeda, S., Watanabe, K., Hayashi, K., Nishimura, J., Takahashi, H., Moriya, J., Ide, S., Ueda, I., Hori, H., Ikenouchi-Sugita, A., Katsuki, A., Atake, K., Abe, O., Korogi, Y., & Nakamura, J.
  • Journal Title: PLoS One Volume: 9 Pages: e87890
  • DOI: 10.1371/journal.pone.0087890
  • Peer Reviewed / Open Access
• [Journal Article] Spike synchronization in cat primary visual cortex depends on similarity of surround suppression magnitude. (2014)
  • Author(s): Naito, T., Kasamatsu, T., & Sato, H.
  • Journal Title: European Journal of Neuroscience Volume: 39 Pages: 934-945
  • DOI: 10.1111/ejn.12469
  • Peer Reviewed
• [Journal Article] 動物におけるデフォルト脳活動とその機能的意義. (2014)
  • Author(s): 渡邊正孝
  • Journal Title: 生理心理学と精神生理学 Volume: 31 Pages: 5-17
  • DOI: http://doi.org/10.5674/jjppp.1302si
  • Peer Reviewed
• [Journal Article] 携帯電話メールによる感情の伝達に顔文字と絵文字が及ぼす影響. (2014)
  • Author(s): 廣瀬信之・牛島悠介・森周司
  • Journal Title: 感情心理学研究 Volume: 22 Pages: 20-27
  • DOI: http://doi.org/10.4092/jsre.22.20
  • Peer Reviewed / Open Access
• [Journal Article] Medial prefrontal cortex dissociation between self and others in a referential task: An fMRI study based on word traits. (2013)
  • Author(s): Yaoi, K., Osaka, M., & Osaka, N.
  • Journal Title: Journal of Physiology (Paris) Volume: 107 Pages: 517-525
  • DOI: dx.doi.org/10.1016/j.jphysparis.2013.09.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Environmental reverberation affects processing of sound intensity in right temporal cortex. (2013)
  • Author(s): Altmann, C. F., Ono, K., Callan, A., Matsuhashi, M., Mima, T., & Fukuyama, H.
  • Journal Title: European Journal of Neuroscience Volume: 38 Pages: 3210-
  • DOI: 10.1111/ejn.12318
  • Peer Reviewed
• [Journal Article] Effects of mental rotation on acalculia: Differences in the direction of mental rotation account for the differing characteristics of acalculia induced by right and left hemispheric brain injury. (2013)
  • Author(s): Asada, T., Takayama, Y., Oita, J., & Fukuyama, H.
  • Journal Title: Neurocase Volume: 20 Pages: 163-174
  • DOI: 10.1080/13554794.2012.741254
  • Peer Reviewed
• [Journal Article] A prospective comparison of nursing- and healthcare-associated pneumonia (NHCAP) with community-acquired pneumonia (CAP). (2013)
  • Author(s): Fukuyama, H., Yamashiro, S., Tamaki, H., & Kishaba, T.
  • Journal Title: Journal of Infection and Chemotherapy Volume: 19 Pages: 719-726
  • DOI: 10.1007/s10156-013-0557-1
  • Peer Reviewed
• [Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques. (2013)
  • Author(s): Hayashi, T., Wakao, S., Kitada, M., Ose, T., Watabe, H., Kuroda, Y., Mitsunaga, K., Matsuse, D., Shigemoto, T., Ito, A., Ikeda, H., Fukuyama, H., Onoe, H., Tabata, Y., Dezawa, M.
  • Journal Title: The Journal of Clinical Investigation Volume: 123 Pages: 272-284
  • DOI: 10.1172/JCI62516
  • Peer Reviewed
• [Journal Article] Differences in dopaminergic modulation to motor cortical plasticity between Parkinson's disease and multiple system atrophy. (2013)
  • Author(s): Kawashima, S., Ueki, Y., Mima, T., Fukuyama, H., Ojika, K., & Matsukawa, N.
  • Journal Title: PLoS One Volume: 8 Pages: e62515
  • DOI: 10.1371/journal.pone.0062515
  • Peer Reviewed / Open Access
• [Journal Article] MDR1 C3435T polymorphism and interaction with environmental factors in risk of Parkinson's disease: a case-control study in Japan. (2013)
  • Author(s): Kiyohara, C., Miyake, Y., Koyanagi, M., Fujimoto, T., Shirasawa, S., Tanaka, K., Fukushima, W., Sasaki, S., Tsuboi, Y., Yamada, T., Oeda, T., Shimada, H., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., Nagai, M., & Fukuoka Kinki Parkinson Disease Study Group
  • Journal Title: Drug metabolism and Pharmacokinetics Volume: 28 Pages: 138-143
  • Peer Reviewed
• [Journal Article] Impact of gray matter reductions on theory of mind abilities in patients with schizophrenia. (2013)
  • Author(s): Koelkebeck, K., Hirao, K., Miyata, J., Kawada, R., Saze, T., Dannlowski, U., Ubukata, S., Ohrmann, P., Bauer, J., Pedersen, A., Fukuyama, H., Sawamoto, N., Takahashi, H., & Murai, T.
  • Journal Title: Social Neuroscience Volume: 8 Pages: 631-639
  • DOI: 10.1080/17470919.2013.837094
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia. (2013)
  • Author(s): Kubota, M., Miyata, J., Sasamoto, A., Sugihara, G., Yoshida, H., Kawada, R., Fujimoto, S., Tanaka, Y., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: JAMA Psychiatry Volume: 70 Pages: 12-21
  • DOI: 10.1001/archgenpsychiatry.2012.1023
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Internal structural changes in the hippocampus observed on 3-Tesla MRI in patients with mesial temporal lobe epilepsy. (2013)
  • Author(s): Mitsueda-Ono, T., Ikeda, A., Sawamoto, N., Aso, T., Hanakawa, T., Kinoshita, M., Matsumoto, R., Mikuni, N., Amano, S., Fukuyama, H., & Takahashi, R.
  • Journal Title: Internal Medicine Volume: 52 Pages: 877-885
  • Peer Reviewed
• [Journal Article] Mirror visual feedback can induce motor learning in patients with callosal disconnection. (2013)
  • Author(s): Nojima, I., Oga, T., Fukuyama, H., Kawamata, T., & Mima, T.
  • Journal Title: Expeimental Brain Research Volume: 227 Pages: 79-83
  • DOI: 10.1007/s00221-013-3486-4
  • Peer Reviewed
• [Journal Article] Overlapping connections within the motor cortico-basal ganglia circuit: fMRI-tractography analysis. (2013)
  • Author(s): Oguri, T., Sawamoto, N., Tabu, H., Urayama, S., Matsuhashi, M., Matsukawa, N., Ojika, K., & Fukuyama, H.
  • Journal Title: Neuroimage Volume: 78 Pages: 353-362
  • DOI: 10.1016/j.neuroimage.2013.04.026
  • Peer Reviewed
• [Journal Article] Effects of regularity on the processing of sound omission in a tone sequence in musicians and non-musicians. (2013)
  • Author(s): Ono, K., Matsuhashi, M., Mima, T., Fukuyama, H., & Altmann, C. F.
  • Journal Title: European Journal of Neuroscience Volume: 38 Pages: 2786-2792
  • DOI: 10.1111/ejn.12254
  • Peer Reviewed
• [Journal Article] Regional gray matter reduction correlates with subjective quality of life in schizophrenia. (2013)
  • Author(s): Ubukata, S., Miyata, J., Yoshizumi, M., Uwatoko, T., Hirao, K., Fujiwara, H., Kawada, R., Fujimoto, S., Tanaka, Y., Kubota, M., Sasamoto, A., Sawamoto, N., Fukuyama, H., Takahashi, H., & Murai, T.
  • Journal Title: Journal of Psychiatric Research Volume: 47 Pages: 548-554
  • DOI: 10.1016/j.jpsychires.2013.01.002
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pre-SMA actively engages in conflict processing in human: a combined study of epicortical ERPs and direct cortical stimulation. (2013)
  • Author(s): Usami, K., Matsumoto, R., Kunieda, T., Shimotake, A., Matsuhashi, M., Miyamoto, S., Fukuyama, H., Takahashi, R., & Ikeda, A.
  • Journal Title: Neuropsychologia Volume: 51 Pages: 1011-1017
  • DOI: 10.1016/j.neuropsychologia.2013.02.002
  • Peer Reviewed
• [Journal Article] Paradise Lost: The Relationships Between Neurological and Psychological Changes in Nicotine-Dependent Patients. (2013)
  • Author(s): Isomura, T., Suzuki, J., & Murai, T.
  • Journal Title: Addiction Research & Theory Volume: 22 Pages: 158-165
  • Peer Reviewed
• [Journal Article] Thalamic mediodorsal nucleus and its participation in spatial working memory processes: comparison with the prefrontal cortex. (2013)
  • Author(s): Funahashi, S.
  • Journal Title: Frontier in Systems Neuroscience Volume: 7 Pages: 36
  • DOI: 10.3389/fnsys.2013.00036
  • Peer Reviewed / Open Access
• [Journal Article] Prefrontal cortex and neural mechanisms of executive function. (2013)
  • Author(s): Funahashi, S., & Andreau, J. M.
  • Journal Title: Journal of Physiology Paris Volume: 107 Pages: 471-482
  • DOI: 10.1016/j.jphysparis.2013.05.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Space representation in the prefrontal cortex. (2013)
  • Author(s): Funahashi, S.
  • Journal Title: Progresss in Neurobiology Volume: 103 Pages: 131-155
  • DOI: 10.1016/j.pneurobio.2012.04.002
  • Peer Reviewed
• [Journal Article] The neural mechanism of encountering misjudgment by the justice system. (2013)
  • Author(s): Cui, Q., Zhang, Q., & Takahashi, H.
  • Journal Title: PLoS One Volume: 8 Pages: e75434
  • DOI: 10.1371/journal.pone.0075434
  • Peer Reviewed / Open Access
• [Journal Article] PET neuroimaging of extrastriatal dopamine receptors and prefrontal cortex function. (2013)
  • Author(s): Takahashi, H.
  • Journal Title: Journal of Physiology Paris Volume: 107 Pages: 503-509
  • DOI: 10.1016/j.jphysparis.2013.07.001
  • Peer Reviewed
• [Journal Article] Superiority illusion arises from resting-state brain network modulated by dopamine. (2013)
  • Author(s): Yamada, M., Uddin, L. Q., Takahashi, H., Kimura, Y., Takahata, K., Kousa, R., Ikoma, Y., Eguchi, Y., Takano, H., Ito, H., Higuchi, M., & Suhara, T.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 Pages: 4363-4367
  • DOI: 10.1073/pnas.1221681110
  • Peer Reviewed
• [Journal Article] Molecular neuroimaging of emotional decision-making. (2013)
  • Author(s): Takahashi, H.
  • Journal Title: Neuroscience Research Volume: 75 Pages: 269-274
  • DOI: 10.1016/j.neures.2013.01.011
  • Peer Reviewed
• [Journal Article] Spatiotemporal receptive field structures in retinogeniculate connections of cat. (2013)
  • Author(s): Suematsu, N., Naito, T., Miyoshi, T., Sawai, H., & Sato, H.
  • Journal Title: Frontiers in Systems Neuroscience Volume: 7 Pages: 103
  • DOI: 10.3389/fnsys.2013.00103
  • Peer Reviewed / Open Access
• [Journal Article] Effects of stimulus spatial frequency, size, and luminance contrast on orientation tuning of neurons in the dorsal lateral geniculate nucleus of cat. (2013)
  • Author(s): Naito, T., Okamoto, M., Sadakane, O., Shimegi, S., Osaki, H., Hara, S. I., Kimura, A., Ishikawa, A., Suematsu, N., & Sato, H.
  • Journal Title: Neuroscience Research Volume: 77 Pages: 143-154
  • DOI: 10.1016/j.neures.2013.08.009
  • Peer Reviewed
• [Journal Article] Larger Right Posterior Parietal Volume in Action Video Game Experts: A Behavioral and Voxel-Based Morphometry (VBM) Study. (2013)
  • Author(s): Tanaka, S., Ikeda, H., Kasahara, K., Kato, R., Tsubomi, H., Sugawara, S. K., Mori, M., Hanakawa, T., Sadato, N., Honda, M., & Watanabe, K.
  • Journal Title: PLoS ONE Volume: 8 Pages: e66998
  • DOI: 10.1371/journal.pone.0066998
  • Peer Reviewed / Open Access
• [Journal Article] Neural limits to representing objects still within view. (2013)
  • Author(s): Tsubomi, H., Fukuda, K., Watanabe, K., & Vogel, E. K.
  • Journal Title: The Journal of Neuroscience Volume: 33 Pages: 8257-8263
  • DOI: 10.1523/JNEUROSCI.5348-12.2013
  • Peer Reviewed
• [Journal Article] A Comparison of Actual and Artifactual Features based on Fractal Analyses: Resting-State MEG Data. (2013)
  • Author(s): Phothisonothai, M., Tsubomi, H., Kondo, A., Kikuchi, M., Yoshimura, Y., Minabe, Y., & Watanabe, K.
  • Journal Title: Lecture Notes in Computer Science Volume: 212 Pages: 1257-1265
  • DOI: 10.1007/978-3-642-37502-6_146
  • Peer Reviewed
• [Journal Article] GazeParser: an open-source and multiplatform library for low-cost eye tracking and analysis. (2013)
  • Author(s): Sogo, H.
  • Journal Title: Behavior Research Methods Volume: 45 Pages: 684-695
  • DOI: 10.3758/s13428-012-0286-x
  • Peer Reviewed
• [Journal Article] 脳内ネットワークの競合と協調：デフォルトモードネットワークとワーキングメモリネットワークの相互作用. (2013)
  • Author(s): 越野英哉・苧阪満里子・苧阪直行
  • Journal Title: 心理学評論 Volume: 56 Pages: 376-391
  • Peer Reviewed
• [Journal Article] 社会脳とホモコントリビューエンス. (2013)
  • Author(s): 苧阪直行
  • Journal Title: ホモコントリビューエンス研究所報告 Volume: 24 Pages: 1-34
• [Journal Article] 顔魅力が再認成績に及ぼす効果―社会的関係性の影響と性差―. (2013)
  • Author(s): 藏口佳奈・蘆田宏
  • Journal Title: Vision Volume: 25 Pages: 157-166
  • Peer Reviewed
• [Journal Article] 両耳時間的融合状況における閉鎖子音の知覚. (2013)
  • Author(s): 菊池洋祐・廣瀬信之・森周司
  • Journal Title: 日本音響学会聴覚研究会資料 Volume: 43 Pages: 553-558
• [Presentation] Neural synchronization during cooperated humming: A hyperscanning study using fNIRS. (2014)
  • Author(s): Osaka, N., Minamoto, T., Yaoi, K., Azuma, M., & Osaka, M.
  • Organizer: International Conference on Timing and Time Perception
  • Place of Presentation: Corfu, Greek
  • Year and Date: 2014-04-02 – 2014-04-02
• [Presentation] ドーパミンの基礎的知見から統合失調症の症状を考えてみよう. (2014)
  • Author(s): 高橋英彦
  • Organizer: 脳科学若手の会合宿
  • Place of Presentation: ホテルウィングインターナショナル相模原
  • Year and Date: 2014-03-29 – 2014-03-30
• [Presentation] Electrophysiological study to reveal brain mechanism of will for voluntary action. (2014)
  • Author(s): Matsuhashi, M., Fumuro, T., Mima, T., & Fukuyama, H.
  • Organizer: 30th International Congress of Clinical Neurophysiology (ICCN) of the International Federation of Clinical Neurophysiology (IFCN)
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-03-20 – 2014-03-23
• [Presentation] The role of primary motor cortices in awareness of intention to move studied by repetitive TMS. (2014)
  • Author(s): Ashizuka, A., Mima, T., Ueki, Y., Aso, T., Matsuhashi, M., & Fukuyama, H.
  • Organizer: 30th International Congress of Clinical Neurophysiology (ICCN) of the International Federation of Clinical Neurophysiology (IFCN)
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-03-20 – 2014-03-23
• [Presentation] Intracortical water diffusion can retain plasticity-induced changes after repetitive transcranial magnetic stimulation through coupling between the stimulated and remote regions. (2014)
  • Author(s): Abe, M., Fukuyama, H., & Mima, T.
  • Organizer: 30th International Congress of Clinical Neurophysiology (ICCN) of the International Federation of Clinical Neurophysiology (IFCN)
  • Place of Presentation: Berlin, Germany
  • Year and Date: 2014-03-20 – 2014-03-23
• [Presentation] 精神・神経疾患の意思決定障害をターゲットにした薬物治療に向けて. (2014)
  • Author(s): 高橋英彦
  • Organizer: 日本薬理学会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2014-03-19 – 2014-03-21
• [Presentation] 情動的意思決定の脳イメージング. (2014)
  • Author(s): 高橋英彦
  • Organizer: 第26回ヒューマンストレス産業技術研究会
  • Place of Presentation: （独）産業技術総合研究所 関西センター
  • Year and Date: 2014-03-11 – 2014-03-11
• [Presentation] 日本脳機能画像研究の現状と今後. (2014)
  • Author(s): 福山秀直
  • Organizer: 第16回日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台国際ホテル
  • Year and Date: 2014-03-06 – 2014-03-07
• [Presentation] 機能的MRIによる皮質ネットワークの実在性の検証. (2014)
  • Author(s): 麻生俊彦・福山秀直
  • Organizer: 第16回日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台国際ホテル
  • Year and Date: 2014-03-06 – 2014-03-07
• [Presentation] 自己組織化マップと局所脳血流に基づく脳梗塞の層別化と認知機能の関連. (2014)
  • Author(s): 大石直也・中奥由里子・長谷佳樹・猪原匡史・福山秀直
  • Organizer: 第16回日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台国際ホテル
  • Year and Date: 2014-03-06 – 2014-03-07
• [Presentation] びまん性軸索損傷患者における認知機能障害の神経基盤に関する研究. (2014)
  • Author(s): 生方志浦・上田敬太・Walid Yassin・杉原玄一・麻生俊彦・福山秀直・村井俊哉
  • Organizer: 第16回日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台国際ホテル
  • Year and Date: 2014-03-06 – 2014-03-07
• [Presentation] アノーダル経頭蓋直流刺激後に観察されるヒト運動関連脳磁場振動の可塑的変化. (2014)
  • Author(s): 三上佑介・美馬達哉・松橋眞生・福山秀直
  • Organizer: 第16回日本ヒト脳機能マッピング学会
  • Place of Presentation: 仙台国際ホテル
  • Year and Date: 2014-03-06 – 2014-03-07
• [Presentation] Interhemispheric differences in the perception of human gaze direction. (2014)
  • Author(s): Matsuyoshi, D., Kuraguchi, K., Ashida, H., & Watanabe, K.
  • Organizer: Proceedings of the 2014 6th International Conference on Knowledge and Smart Technology (KST)
  • Place of Presentation: Chonburi, Thailand
  • Year and Date: 2014-01-30 – 2014-01-31
• [Presentation] The temporal dynamics and underlying mechanisms of orientation tuning of neurons in the cat lateral geniculate nucleus. (2014)
  • Author(s): Naito, T., Suematsu, N., Miyotshi, T., Sawai, H., & Sato, H.
  • Organizer: 脳とこころのメカニズム第14回冬のワークショップ
  • Place of Presentation: ルスツリゾート
  • Year and Date: 2014-01-09 – 2014-01-09
• [Presentation] 経頭蓋直流電気刺激(tDCS)による注意機能の促進―リーディングスパン課題を用いた検討―. (2013)
  • Author(s): 源健宏・東美由紀・矢追健・苧阪満里子・苧阪直行
  • Organizer: 日本ワーキングメモリ学会第11回大会
  • Place of Presentation: 京都大学
  • Year and Date: 2013-11-30 – 2013-11-30
• [Presentation] 発達と脳 (2013)
  • Author(s): 渡邊正孝
  • Organizer: 日本ワーキングメモリ学会第11回大会
  • Place of Presentation: 京都大学
  • Year and Date: 2013-11-30 – 2013-11-30
  • Invited
• [Presentation] Choice deafness of expert musicians to preferred performance. (2013)
  • Author(s): Ishimatsu, Y., Mori, S., & Hirose, N.
  • Organizer: The 54th Annual Meeting of the Psychonomic Society
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2013-11-16 – 2013-11-16
• [Presentation] Capacity limits to representing objects still within view. (2013)
  • Author(s): Tsubomi, H., Fukuda, K., Watanabe, K., & Vogel, E. K.
  • Organizer: The 54th Annual Meeting of the Psychonomic Society
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2013-11-16 – 2013-11-16
• [Presentation] Binaural temporal fusion shifts perceptual boundary of stop consonants (2013)
  • Author(s): Kikuchi, Y., Mori, S., & Hirose, N.
  • Organizer: The 54th Annual Meeting of the Psychonomic Society
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2013-11-15 – 2013-11-15
• [Presentation] Development of visual working memory storage and resistance to distraction in children with Asperger syndrome. (2013)
  • Author(s): Tsubomi, H., & Watanabe, K.
  • Organizer: 21st Annual Meeting on Object Perception, Attention, and Memory
  • Place of Presentation: Toronto, Canada
  • Year and Date: 2013-11-14 – 2013-11-14
• [Presentation] Neural correlates of multimodal emotional perception: An fMRI study with music and facial expressions. (2013)
  • Author(s): Ishii, T., Aso, T., Ono, K., & Fukuyama, H.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-13 – 2013-11-13
• [Presentation] Decrease of dopamine release in the default brain area (medial prefrontal cortex) of the monkey during a working memory task. (2013)
  • Author(s): Kodama, T., Hikosaka, K., Honda, Y., Kojima, T., & Watanabe, M.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-13 – 2013-11-13
• [Presentation] Primate prefrontal activity during simultaneous performance of spatial attention and spatial working memory tasks. (2013)
  • Author(s): Watanabe, K. & Funahashi, S
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-12 – 2013-11-12
• [Presentation] Pair selectivity of primate prefrontal neurons in visual paired association performances. (2013)
  • Author(s): Funahashi, S. & Andreau, J. M.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-12 – 2013-11-12
• [Presentation] Confidence Judgments and prefrontal neuronal activity in monkeys performing a spatial working memory task. (2013)
  • Author(s): Tanaka, A. & Funahashi, S.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-12 – 2013-11-12
• [Presentation] Task-dependent modulation of primate thalamic mediodorsal activities during working memory performances. (2013)
  • Author(s): Watanabe, Y. & Funahashi, S.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-12 – 2013-11-12
• [Presentation] Neural modulation of executive function while performing emotional biased working memory task: An fMRI study. (2013)
  • Author(s): Osaka, M., Yaoi, K., Minamoto, T., & Osaka, N.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-11 – 2013-11-11
• [Presentation] Transient increase of human neuromagnetic oscillation in the primary motor cortex (M1) following anodal transcranial DC stimulation (tDCS). (2013)
  • Author(s): Mikami, Y., Mima, T., Matsuhashi, M., & Fukuyama, H.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-11 – 2013-11-11
• [Presentation] The statistical computation underlying surface property perception in the cat primary visual cortex. (2013)
  • Author(s): Naito, T., Suematsu, N., Miyotshi, T., Sawai, H., & Sato, H.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-11 – 2013-11-11
• [Presentation] Polarity-dependent effect of tDCS on the left posterior parietal cortex in verbal attentional processing. (2013)
  • Author(s): Minamoto, T., Azuma, M., Yaoi, K., Mima, T., Fukuyama, H., & Osaka, N.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-10 – 2013-11-10
• [Presentation] Onomatopoeias and mimetic words represent mirror system but generate different mental images: An fMRI study. (2013)
  • Author(s): Yaoi, K., Minamoto, T., Osaka, M., & Osaka, N.
  • Organizer: 43rd annual meeting of the Society for Neuroscience
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-10 – 2013-11-10
• [Presentation] 大脳皮質活動における鏡効果. (2013)
  • Author(s): 古谷槙子・三上佑介・三田友記・西谷信之・三谷章・福山秀直
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知県立県民文化ホール・ザ クラウンパレス新阪急高知・三翠園
  • Year and Date: 2013-11-07 – 2013-11-09
• [Presentation] ネコ外側膝状体および一次視覚野ニューロンの物体表面光沢感選択性. (2013)
  • Author(s): 内藤智之・末松尚史・三好智満・澤井元・佐藤宏道
  • Organizer: 第106回近畿生理学談話会
  • Place of Presentation: 奈良県立医科大学
  • Year and Date: 2013-11-02 – 2013-11-02
• [Presentation] Function of reciprocal connections between prefrontal cortex and thalamic mediodorsal nucleus in spatial working memory. (2013)
  • Author(s): Funahashi, S.
  • Organizer: The 4th International Conference of Prefrontal Cortex
  • Place of Presentation: Nanchang, China
  • Year and Date: 2013-10-28 – 2013-10-29
• [Presentation] Positive情動の認知神経科学. (2013)
  • Author(s): 高橋英彦
  • Organizer: 第二回ポジティブサイコロジー医学会
  • Place of Presentation: リステル猪苗代
  • Year and Date: 2013-10-18 – 2013-10-18
• [Presentation] 両耳時間的融合状況における閉鎖子音の知覚. (2013)
  • Author(s): 菊池洋祐・廣瀬信之・森周司
  • Organizer: 日本音響学会聴覚研究会
  • Place of Presentation: 神戸セミナーハウス
  • Year and Date: 2013-10-10 – 2013-10-11
• [Presentation] 色情報が絵画・写真の印象評定に与える影響. (2013)
  • Author(s): 内藤智之
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2013-09-21 – 2013-09-21
• [Presentation] 広汎性発達障害児におけるワーキングメモリの機能発達. (2013)
  • Author(s): 坪見博之・渡邊克巳
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2013-09-20 – 2013-09-20
• [Presentation] 顔文字と絵文字が携帯電話メールでの感情伝達に及ぼす影響. (2013)
  • Author(s): 廣瀬信之・牛島悠介・森周司
  • Organizer: 日本心理学会第77回大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2013-09-19 – 2013-09-19
• [Presentation] ネコ一次視覚野ニューロン間の同期発火現象と受容野周囲抑制の関係. (2013)
  • Author(s): 内藤智之・佐藤宏道
  • Organizer: 視覚科学フォーラム第17回研究会
  • Place of Presentation: 立命館大学
  • Year and Date: 2013-08-06 – 2013-08-06
• [Presentation] Comparison of Actual and Artifactual Features based on Fractal Analyses: Resting-State MEG Data. (2013)
  • Author(s): Phothisonothai, M., Tsubomi, H., Kondo, A., Kikuchi, M., Yoshimura, Y., Minabe, Y., & Watanabe, K.
  • Organizer: The 8th Bio-Inspired Computing: Theories and Applications
  • Place of Presentation: Anhui Huangshan, China
  • Year and Date: 2013-07-12 – 2013-07-14
• [Presentation] 情動喚起画像に対する情動的反応と夢特性の関連. (2013)
  • Author(s): 杉江健太・坪見博之・小川景子・海老原直邦
  • Organizer: 日本睡眠学会
  • Place of Presentation: 秋田キャッスルホテル
  • Year and Date: 2013-06-28 – 2013-06-28
• [Presentation] Brain Network Efficiency and Intelligent Scores of Children. (2013)
  • Author(s): Duan, F., Tsubomi, H., Yoshimura, Y., Kikuchi, M., Minabe, Y., Watanabe, K., & Aihara, K.
  • Organizer: The 4th International Conference on Cognitive Neurodynamics
  • Place of Presentation: Sigtune, Sweden
  • Year and Date: 2013-06-23 – 2013-06-27
• [Presentation] ネコ一次視覚野ニューロンは物体表面特性に関連した3次統計量に選択性を示す. (2013)
  • Author(s): 内藤智之・末松尚史・三好智満・澤井元・佐藤宏道
  • Organizer: Neuro 2013
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-21 – 2013-06-21
• [Presentation] Temporal dynamics of functional networks from multivariate electrophysiological time series. (2013)
  • Author(s): Iwayama, K., Hirata, Y., Kondo, A., Tsubomi, H., Takahashi, K., Yoshimura, Y., Ueno, S., Kikuchi, M., Minabe, Y., Watanabe, K., Suzuki, H., & Aihara, K.
  • Organizer: The 35th Annual international conference of the IEEE engineering medicine and biology society (EMBC'13)
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2013-06-03 – 2013-06-07
• [Presentation] Forget all or hold all: Difficulty in selectively dropping items from visual working memory. (2013)
  • Author(s): Tsubomi, H., Fukuda, K., Kikumoto, A., & Vogel, E. K.
  • Organizer: Vision Science Society Annual meeting
  • Place of Presentation: Florida, USA
  • Year and Date: 2013-05-11 – 2013-05-11
• [Book] 自己を知る脳・他者を理解する脳―神経認知心理学からみた心の理論の新展開― (社会脳シリーズ第6巻) (2014)
  • Author(s): 苧阪直行(編著)
  • Total Pages: 234
  • Publisher: 新曜社
• [Book] 報酬を期待する脳―ニューロエコノミクスの新展開―(社会脳シリーズ第5巻) (2014)
  • Author(s): 苧阪直行(編著)
  • Total Pages: 135
  • Publisher: 新曜社
• [Book] 美しさと共感を生む脳―神経美学からみた芸術―(社会脳シリーズ第4巻) (2013)
  • Author(s): 苧阪直行(編著)
  • Total Pages: 136
  • Publisher: 新曜社
• [Remarks] 苧阪研究室
  • URL: http://www.social-brain.bun.kyoto-u.ac.jp/