2014 Fiscal Year Annual Research Report
社会脳を担う前頭葉ネットワークの解明―微小電極からfMRIまでの垂直的統合研究―
Project/Area Number |
22220003
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Research Institution | Kyoto University |
Principal Investigator |
苧阪 直行 京都大学, 文学研究科, 名誉教授 (20113136)
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Co-Investigator(Kenkyū-buntansha) |
船橋 新太郎 京都大学, こころの未来研究センター, 教授 (00145830)
蘆田 宏 京都大学, 文学研究科, 教授 (20293847)
村井 俊哉 京都大学, 医学研究科, 教授 (30335286)
渡辺 正孝 公益財団法人東京都医学総合研究所, 認知症・高次脳機能研究分野, 特任研究員 (50092383)
苧阪 満里子 大阪大学, 人間科学研究科, 教授 (70144300)
福山 秀直 京都大学, 学際融合教育研究推進センター, 特任教授 (90181297)
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Project Period (FY) |
2010-04-01 – 2016-03-31
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Keywords | 前頭葉 / 社会脳 / ワーキングメモリ / 社会適応障害 / 脳画像法 / 高齢者 |
Outline of Annual Research Achievements |
本研究プロジェクトは、社会脳の動作メカニズムを前頭葉機能の観点から解き明かし、また、社会適応障害の原因究明と治療法の探求を進めることで、健全で豊かな社会脳の仕組みと再生プロセスを見出すことを目標として掲げている。平成26年度は、昨年度に引き続き、前頭連合野を中心としたトップダウン制御ネットワークを種々の課題研究で得られた知見と対応づけ、豊かな社会性を育む社会脳と前頭連合野の役割を明らかにすることを目指した研究を行った。例えば複数の実験参加者の脳活動を同時に計測するハイパースキャニングと呼ばれる先端的な手法を機能的近赤外分光法(fNIRS)によって実施し、2人の実験参加者が合唱という社会的な協調活動を行う際には両者の下前頭回と呼ばれる領域などが同期的な活動を示すことを明らかにした。またfMRIを利用した研究では、自分自身と結びつけられた情報をよりよく記憶しているという自己参照効果について検討し、そのような情報を思い出す(想起する)際に前頭前野内側部という社会脳領域がより活動していることを示した。次に社会適応障害に関する研究では、例えばうつ病患者において、前部帯状回と呼ばれる領域の大きさがその患者の認知行動療法に対する反応を予測することを明らかにした。さらに経頭蓋直流電気刺激法(tDCS)や経頭蓋磁気刺激法(TMS)といった非侵襲による脳刺激法がヒトの認知的・社会的能力にどのような効果を及ぼすかについての検討も引き続き進められている。こうした一連の研究を通して、私たちの社会行動の基礎となる神経メカニズムと社会適応障害の病理の解明に近づくことができたと言える。また、本研究課題のこれまでの成果を中心に、社会脳に関わる幅広い知見を一般向けに概説した「社会脳シリーズ」全9巻を新曜社より刊行している。
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Research Progress Status |
27年度が最終年度であるため、記入しない。
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Strategy for Future Research Activity |
27年度が最終年度であるため、記入しない。
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[Journal Article] Disturbance of time orientation, attention and verbal memory in amnesic patients with confabulation.2016
Author(s)
Shingaki, H., Park, P., Ueda, K., Murai, T., & Tsukiura, T.
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Journal Title
Journal of Clinical and Experimental Neuropsychology
Volume: 38(2)
Pages: 171-182
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] How Two Brains Make One Synchronized Mind in the Inferior Frontal Cortex: fNIRS-Based Hyperscanning During Cooperative Singing.2015
Author(s)
Osaka, N., Minamoto, T.,Yaoi, K., Azuma, M., Shimada Minamoto, Y., & Osaka, M.
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Journal Title
Frontiers in Phychology
Volume: 6
Pages: 1811
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Functional relevance of the precuneus in verbal politeness.2015
Author(s)
Ashizuka, A., Mima, T., Sawamoto, N., Aso, T., Oishi, N., Sugihara, G., Kawada, R., Takahashi, H., Murai, T., & Fukuyama, H.
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Journal Title
Neuroscience Research
Volume: 91
Pages: 48-56
DOI
Peer Reviewed
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[Journal Article] Anterior cingulate volume predicts response to cognitive behavioral therapy in major depressive disorder.2015
Author(s)
Fujino, J., Yamasaki, N., Miyata, J., Sasaki, H., Matsukawa, N., Takemura, A., Tei, S., Sugihara, G., Aso, T., Fukuyama, H., Takahashi, H., Inoue, K., & Murai, T.
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Journal Title
Journal of Affective Disorders
Volume: 174
Pages: 397-399
DOI
Peer Reviewed
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[Journal Article] Alpha-band desynchronization in human parietal area during reach planning.2015
Author(s)
Fumuro, T., Matsuhashi, M., Miyazaki, T., Inouchi, M., Hitomi, T., Matsumoto, R., Takahashi, R., Fukuyama, H., & Ikeda, A.
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Journal Title
Clinical Neurophysiology
Volume: 126(4)
Pages: 756-762
DOI
Peer Reviewed
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[Journal Article] Network hyperexcitability in a patient with partial reading epilepsy: converging evidence from magnetoencephalography, diffusion tractography, and functional magnetic resonance imaging.2015
Author(s)
Fumuro, T., Matsumoto, R., Shimotake, A., Matsuhashi, M., Inouchi, M., Urayama, S., Sawamoto, N., Fukuyama, H., Takahashi, R., & Ikeda, A.
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Journal Title
Clinical Neurophysiology
Volume: 126(4)
Pages: 675-681
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Peer Reviewed
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[Journal Article] The uncinate fasciculus as a predictor of conversion from aMCI to Alzheimer disease.2015
Author(s)
Hiyoshi-Taniguchi, K., Oishi, N., Namiki, C., Miyata, J., Murai, T., Cichocki, A., & Fukuyama, H.
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Journal Title
Journal of Neuroimaging
Volume: 25(5)
Pages: 748-753
DOI
Peer Reviewed
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[Journal Article] Multimodal neuroimaging as a window into the pathological physiology of schizophrenia: Current trends and issues.2015
Author(s)
Isobe, M., Miyata, J., Hazama, M., Fukuyama, H., Murai, T., & Takahashi, H.
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Journal Title
Neuroscience Research
Volume: 102
Pages: 29-38
DOI
Peer Reviewed
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[Journal Article] Different Mode of Afferents Determines the Frequency Range of High Frequency Activities in the Human Brain: Direct Electrocorticographic Comparison between Peripheral Nerve and Direct Cortical Stimulation.2015
Author(s)
Kobayashi, K., Matsumoto, R., Matsuhashi, M., Usami, K., Shimotake, A., Kunieda, T., Kikuchi, T., Mikuni, N., Miyamoto, S., Fukuyama, H., Takahashi, R., & Ikeda, A.
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Journal Title
PLoS One
Volume: 10(6)
Pages: e0130461
DOI
Peer Reviewed / Open Access
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[Journal Article] Task-specific brain reorganization in motor recovery induced by a hybrid-rehabilitation combining training with brain stimulation after stroke.2015
Author(s)
Koganemaru, S., Sawamoto, N., Aso, T., Sagara, A., Ikkaku, T., Shimada, K., Kanematsu, M., Takahashi, R., Domen, K., Fukuyama, H., & Mima, T.
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Journal Title
Neuroscience Research
Volume: 92
Pages: 29-38
DOI
Peer Reviewed
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[Journal Article] Possible induction of multiple seizure foci due to parietal tumour and anti-NMDAR antibody.2015
Author(s)
Matsumoto, R., Mikuni, N., Tanaka, K., Usami, K., Fukao, K., Kunieda, T., Takahashi, Y., Miyamoto, S., Fukuyama, H., Takahashi, R., & Ikeda, A.
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Journal Title
Epileptic Disorders
Volume: 17(1)
Pages: 89-94
DOI
Peer Reviewed
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[Journal Article] Effects of imaging modalities, brain atlases and feature selection on prediction of Alzheimer's disease.2015
Author(s)
Ota, K., Oishi, N., Ito, K., Fukuyama, H., Group S-JS, & Initiative AsDN
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Journal Title
Journal of Neuroscience Methods
Volume: 256
Pages: 168-183
DOI
Peer Reviewed
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[Journal Article] Creativity and positive symptoms in schizophrenia revisited: structural connectivity analysis with diffusion tensor imaging.2015
Author(s)
Son, S., Kubota, M., Miyata, J., Fukuyama, H., Aso, T., Urayama, S., Murai, T., & Takahashi, H.
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Journal Title
Schizophrenia Research
Volume: 164
Pages: 221-226
DOI
Peer Reviewed
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[Journal Article] Parkinson's disease patients showed delayed awareness of motor intention.2015
Author(s)
Tabu, H., Aso, T., Matsuhashi, M., Ueki, Y., Takahashi, R., Fukuyama, H., Shibasaki, H., & Mima, T.
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Journal Title
Neuroscience Research
Volume: 95
Pages: 74-77
DOI
Peer Reviewed
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[Journal Article] Sleep modulates cortical connectivity and excitability in humans: Direct evidence from neural activity induced by single-pulse electrical stimulation.2015
Author(s)
Usami, K., Matsumoto, R., Kobayashi, K., Hitomi, T., Shimotake, A., Kikuchi, T., Matsuhashi, M., Kunieda, T., Mikuni, N., Miyamoto, S., Fukuyama, H., Takahashi, R., & Ikeda, A.
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Journal Title
Human Brain Mapping
Volume: 36(11)
Pages: 4714-4729
DOI
Peer Reviewed
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[Journal Article] A possible variant of negative motor seizure arising from the supplementary negative motor area.2015
Author(s)
Yamao, Y., Matsumoto, R., Kunieda, T., Arakawa, Y., Kikuchi, T., Shibata, S., Shimotake, A., Fukuyama, H., Ikeda, A., & Miyamoto, S.
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Journal Title
Clinical Neurology and Neurosurgery
Volume: 134
Pages: 126-129
DOI
Peer Reviewed
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[Journal Article] Neural correlates of mirth and laughter: a direct electrical cortical stimulation study.2015
Author(s)
Yamao, Y., Matsumoto, R., Kunieda, T., Shibata, S., Shimotake, A., Kikuchi, T., Satow, T., Mikuni, N., Fukuyama, H., Ikeda, A., & Miyamoto, S.
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Journal Title
Cortex
Volume: 66
Pages: 134-140
DOI
Peer Reviewed
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[Journal Article] Hypothalamic-amygdalar-brainstem volume reduction in a patient with narcolepsy secondary to diffuse axonal injury.2015
Author(s)
Yassin, W., Sugihara, G., Oishi, N., Kubota, M., Ubukata, S., Murai, T., & Ueda, K.
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Journal Title
Journal of Clinical Sleep Medicine
Volume: 11(5)
Pages: 581-582
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Are ambiguity aversion and ambiguity intolerance identical? A neuroeconomics investigation.2015
Author(s)
Tanaka, Y., Fujino, J., Ideno, T., Okubo, S., Takemura, K., Miyata, J., Kawada, R., Fujimoto, S., Kubota, M., Sasamoto, A., Hirose, K., Takeuchi, H., Fukuyama, H., Murai, T., & Takahashi, H.
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Journal Title
Frontiers in Psychology
Volume: 5
Pages: 1550
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Polymorphism within a neuronal activity-dependent enhancer of NgR1 is associated with corpus callosum morphology in humans.2015
Author(s)
Isobe, M., Tanigaki, K., Murak, K., Miyata, J., Takemura, A., Sugihara, G., Takahashi, H., Aso, T., Fukuyama, H., Hazama, M., & Murai, T.
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Journal Title
Molecular Neuropsychiatry
Volume: 1
Pages: 105-115
DOI
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Common impairments of emotional facial expression recognition in schizophrenia across French and Japanese cultures.2015
Author(s)
Okada, T., Kubota, Y., Sato, W., Murai, T., Pellion, F., & Gorog, F.
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Journal Title
Frontiers in Psychology
Volume: 6
Pages: 1018
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Modulation of alpha activity in the parieto-occipital area by distractors during a visuospatial working memory task: a magnetoencepharographic study.2015
Author(s)
Ichihara-Takeda, S., Yazawa, S., Murahara, T., Toyoshima, T., Shimozaki, J., Ishiguro, M., Shiraishi, H., Ikeda, N., Matsuyama, K., Funahashi, S., & Nagamine, T.
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Journal Title
Journal of Cognitive Neuroscience
Volume: 27
Pages: 453-463
DOI
Peer Reviewed
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[Journal Article] Insular activation during reward anticipation reflects duration of illness in abstinent pathological gamblers.2014
Author(s)
Tsurumi, K., Kawada, R., Yokoyama, N., Sugihara, G., Sawamoto, N., Aso, T., Fukuyama, H., Murai, T., & Takahashi, H.
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Journal Title
Frontiers in Psychology
Volume: 5
Pages: 1013
DOI
Peer Reviewed / Open Access
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[Journal Article] Fiber tract associated with autistic traits in healthy adults.2014
Author(s)
Hirose, K., Miyata, J., Sugihara, G., Kubota, M., Sasamoto, A., Aso, T., Fukuyama, H., Murai, T., & Takahashi, H.
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Journal Title
Journal of Psychiatric Research
Volume: 59
Pages: 117-124
DOI
Peer Reviewed
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[Journal Article] Direct Exploration of the Role of the Ventral Anterior Temporal Lobe in Semantic Memory: Cortical Stimulation and Local Field Potential Evidence From Subdural Grid Electrodes.2014
Author(s)
Shimotake, A., Matsumoto, R., Ueno, T., Kunieda, T., Saito, S., Hoffman, P., Kikuchi, T., Fukuyama, H., Miyamoto, S., Takahashi, R., Ikeda, A., & Lambon Ralph, M. A.
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Journal Title
Cerebral Cortex
Volume: 25(10)
Pages: 3802-3817
DOI
Peer Reviewed
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[Journal Article] Evaluation of lip sensory disturbance using somatosensory evoked magnetic fields.2014
Author(s)
Maezawa, H., Matsuhashi, M., Yoshida, K., Mima, T., Nagamine, T., & Fukuyama, H.
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Journal Title
Clinical Neurophysiology
Volume: 125(2)
Pages: 363-369
DOI
Peer Reviewed
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[Journal Article] Neural correlates of mirth and laughter: A direct electrical cortical stimulation study.2014
Author(s)
Yamao, Y., Matsumoto, R., Kunieda, T., Shibata, S., Shimotake, A., Kikuchi, T., Satow, T., Mikuni, N., Fukuyama, H., Ikeda, A., & Miyamoto, S.
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Journal Title
Cortex
Volume: 66
Pages: 134-140
DOI
Peer Reviewed
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[Journal Article] The anodal tDCS over the left posterior parietal cortex enhances attention toward a focus word in a sentence.2014
Author(s)
Minamoto, T., Azuma, M., Yaoi, K., Ashizuka, A., Mima, T., Osaka, M., Fukuyama, H., & Osaka, N.
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Journal Title
Frontiers in Human Neuroscience
Volume: 8
Pages: 992
DOI
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Independent or integrated processing of interaural time and level differences in human auditory cortex?2014
Author(s)
Altmann, C. F., Terada, S., Kashino, M., Goto, K., Mima, T., Fukuyama, H., & Furukawa, S.
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Journal Title
Hearing Research
Volume: 312
Pages: 121-127
DOI
Peer Reviewed
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[Journal Article] Intraoperative dorsal language network mapping by using single-pulse electrical stimulation.2014
Author(s)
Yamao, Y., Matsumoto, R., Kunieda, T., Arakawa, Y., Kobayashi, K., Usami, K., Shibata, S., Kikuchi, T., Sawamoto, N., Mikuni, N., Ikeda, A., Fukuyama, H., & Miyamoto, S.
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Journal Title
Human Brain Mapping
Volume: 35
Pages: 4345-4361
DOI
Peer Reviewed
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[Journal Article] Altered brain response to others' pain in major depressive disorder.2014
Author(s)
Fujino, J., Yamasaki, N., Miyata, J., Kawada, R., Sasaki, H., Matsukawa, N., Takemura, A., Ono, M., Tei, S., Takahashi, H., Aso, T., Fukuyama, H., & Murai, T.
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Journal Title
Journal of Affective Disorders
Volume: 165
Pages: 170-175
DOI
Peer Reviewed
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[Journal Article] Temporal lobe epilepsy with amygdala enlargement: a morphologic and functional study.2014
Author(s)
Takaya, S., Ikeda, A., Mitsueda-Ono, T., Matsumoto, R., Inouchi, M., Namiki, C., Oishi, N., Mikuni, N., Ishizu, K., Takahashi, R., & Fukuyama, H.
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Journal Title
Journal of Neuroimaging
Volume: 24
Pages: 54-62
DOI
Peer Reviewed
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[Journal Article] Voxel-based clustered imaging by multiparameter diffusion tensor images for glioma grading.2014
Author(s)
Inano, R., Oishi, N., Kunieda, T., Arakawa, Y., Yamao, Y., Shibata, S., Kikuchi, T., Fukuyama, H., & Miyamoto, S.
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Journal Title
Neuroimage Clinical
Volume: 5
Pages: 396-407
DOI
Peer Reviewed
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[Journal Article] Motor recovery and microstructural change in rubro-spinal tract in subcortical stroke.2014
Author(s)
Takenobu, Y., Hayashi, T., Moriwaki, H., Nagatsuka, K., Naritomi, H., & Fukuyama, H.
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Journal Title
Neuroimage Clinical
Volume: 4
Pages: 201-208
DOI
Peer Reviewed
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[Journal Article] fMRI evidence of improved visual function in patients with progressive retinitis pigmentosa by eye-movement training.2014
Author(s)
Yoshida, M., Origuchi, M., Urayama, S. I., Takatsuki, A., Kan, S., Aso, T., Shiose, T., Sawamoto, N., Miyauchi, S., Fukuyama, H., & Seiyama, A.
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Journal Title
Neuroimage Clinical
Volume: 5
Pages: 161-168
DOI
Peer Reviewed
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[Journal Article] Categorical speech perception during active discrimination of consonants and vowels.2014
Author(s)
Altmann, C.F., Uesaki, M., Ono, K., Matsuhashi, M., Mima, T., Fukuyama, H.
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Journal Title
Neuropsychologia
Volume: 64
Pages: 13-23
DOI
Peer Reviewed
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[Journal Article] Silent information regulator 2 homolog 1 counters cerebral hypoperfusion injury by deacetylating endothelial nitric oxide synthase.2014
Author(s)
Hattori, Y., Okamoto, Y., Maki, T., Yamamoto, Y., Oishi, N., Yamahara, K., Nagatsuka, K., Takahashi, R., Kalaria, R.N., Fukuyama, H., Kinoshita, M., & Ihara, M.
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Journal Title
Stroke
Volume: 45
Pages: 3403-3411
DOI
Peer Reviewed
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[Journal Article] The contribution of cortical thickness and surface area to gray matter asymmetries in the healthy human brain.2014
Author(s)
Koelkebeck, K., Miyata, J., Kubota, M., Kohl, W., Son, S., Fukuyama, H., Sawamoto, N., Takahashi, H., & Murai, T.
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Journal Title
Human Brain Mapping
Volume: 35(12)
Pages: 6011-6022
DOI
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 笑いと社会脳.2015
Author(s)
苧阪直行
Organizer
ニューロクリアティブ研究会
Place of Presentation
金沢工業大学東京虎ノ門キャンパス
Year and Date
2015-10-06 – 2015-10-06
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[Presentation] Two brains make one Mind: Hyperscanning study on synchronized singing/humming between two people using fNIRS.2014
Author(s)
Osaka, N., Minamoto, T., Yaoi, K., Azuma, M., & Osaka, M.
Organizer
Psychonomic Society's 55th Annual Meeting
Place of Presentation
Long Beach, California, USA
Year and Date
2014-11-21 – 2014-11-21
Int'l Joint Research
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[Presentation] Rinzai Zen meditators are superior to resolve semantic interference: An fMRI study based on a Stroop paradigm.2014
Author(s)
Osaka, N., Yaoi, K., Minamoto, T., Azuma, M., & Osaka, M.
Organizer
44th annual meeting of the Society for Neuroscience
Place of Presentation
Washington, DC, USA
Year and Date
2014-11-18 – 2014-11-18
Int'l Joint Research
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