Designing and Developing Innovative Use of Newly Discovered Colonic Epithelial Culture Method Applicable to Clinical Medicine.

2014 Fiscal Year Final Research Report

• Project/Area Number: 22229005
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Gastroenterology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: WATANABE Mamoru 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (10175127)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Tetsuya 東京医科歯科大学, 医歯学総合研究科, 教授 (70265809)
• Project Period (FY): 2010-05-31 – 2015-03-31
• Keywords: 幹細胞移植 / 再生医療 / 大腸炎創傷治癒 / 大腸上皮 / 組織幹細胞 / 体外培養技術 / 細胞治療

Outline of Final Research Achievements

It has been expected that the elucidation of the mechanism for the regenerative regulation of intestinal epithelial cells would be applied to the gastrointestinal regenerative medicine.
It has however been technically impossible to assess the normal intestinal epithelial cells ex vivo. In this study, we therefore aimed to assess the function of normal intestinal epithelial cells and to establish the technical basis of clinical application for the primary culture of colonic epithelial cells by developing the long-term, serum-free, 3-dimential culture system of mice normal colon.

Free Research Field

消化器病学