Development of a new method to analyzethe micro-distribution of 10B in tissues and its application to BNCT research

2012 Fiscal Year Final Research Report

• Project/Area Number: 22240091
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: Kyoto University
• Principal Investigator: ONO Koji 京都大学, 原子炉実験所, 教授 (90122407)
• Co-Investigator(Kenkyū-buntansha): SUZUKI Minoru 京都大学, 原子炉実験所, 准教授 (20273534) ; KIRIHATA Mitsunori 大阪府立大学, 21世紀科学研究機構, 教授 (60128767) ; TANAKA Hiroki 京都大学, 原子炉実験所, 助教 (70391274) ; KINASHI Yuko 京都大学, 原子炉実験所 (80252534)
• Project Period (FY): 2010 – 2012
• Keywords: αオートラジオグラフィ / ホウ素化合物 / ミクロ分布 / 中性子 / 抗腫瘍効果

Research Abstract

In boron neutron capture therapy (BNCT) research, an examination of 10B distribution in tissue is very important. The a-autoradiography is useful as an imaging method for this purpose. We have developed a simple and rapid new method to precisely identify the position of 10B using the shape of etched pits such as a circularity. In this method, no special track detectors or special microscope is needed. By this new method, it is possible to identify a real position of 10B in um tissue specimen within 1.7um error.

Research Products

• [Journal Article] Effects of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor (2013)
  • Author(s): Y. Liu, K. Ono, et al
  • Journal Title: J Radiat Res Volume: 54(2) Pages: 260-267
• [Journal Article] Biological evaluation of dodecaborate-containing L -amino acids for boron neutron capture therapy (2012)
  • Author(s): Y. Hattori, M. Kirihata et al
  • Journal Title: J Med Chem Volume: 55(5) Pages: 6980-6984
• [Journal Article] Multistep Lattice-Voxel method utilizing lattice function for Monte Carlo treatment planning with pixel based voxel model (2011)
  • Author(s): H. Kumada,K. Saito,T. Nakamura,T. Sa kae, H. Sakurai,A. Matsumura,K. Ono
  • Journal Title: Applied Radiation and Isotopes Volume: 69 Pages: 1866-1869
• [Journal Article] BNCT for locally recurrent head and neck cancer : Preliminary clinical experience from a phase I/II trial at Tsing Hua Open-Pool Reactor (2011)
  • Author(s): L. W. Wang,S. J.Wang,P. Y. C h u,C. Y. Ho, ,S.H.Jiang,Y.W.H.Li u,Y.H.Li u,H.M. Liu,J. J. Peir, F. I . Cho u,S.H. Yen, Y. L. Lee,C. W. Chang,C. S. Liu, Y. W. Che n,K. Ono
  • Journal Title: Applied Radiation and Isotopes Volume: 69 Pages: 1803-1806
• [Journal Article] The optimization study of Bonnersphere in the epithermal neutron irradiation field (2011)
  • Author(s): H. Ueda,H. Tanaka,A. Maruhashl,K. Ono, Y. Sakurai
  • Journal Title: Applied Radiation and Isotopes Volume: 69 Pages: 1657-1659
• [Journal Article] Evaluation for activities of component of Cyclotron-Based Epithermal Neutron Source (C-BENS) and the surface of concrete wall in irradiation room (2011)
  • Author(s): M. Imoto,H. Tanaka,K. Fujitac,T. Mi t sumto,K. Ono,A. Maruhashi,Y. Sa kura I
  • Journal Title: Applied Radiation and Isotopes Volume: 69 Pages: 1646-1648
• [Journal Article] Experimental verification of beam characteristics for cyclotron-based epithermal neutron source (C-8ENS) (2011)
  • Author(s): H. Tanaka,Y. Sakurai,M. Suzuki,S. Masunaga,T. Mi tsumoto,K. Fujita,G. Kashinoa,Y. Ki na shi, Y. Liu, M. Takada,K.Ono,A. Maruhashi
  • Journal Title: Applied Radiation and Isotopes Volume: 69 Pages: 1642-1645
• [Journal Article] Induction of multi-nucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy (2011)
  • Author(s): Y. Fuji t a,N. Yamamoto,1. Kato,S. lwai,K. Ono,Y. Sakurai,K. Ohni5hi,Y. Yura
  • Journal Title: Int. J. Radiat. Biol Volume: 87 Pages: 293-301
• [Journal Article] Ascorbic acid 2-g1ucocide reduces micronucleus induction in distant splenic T lymphocytes following head irradiation (2010)
  • Author(s): Y. Ki nashi,H. Tanaka,S. Masunaga,M. Suzuki,G. Kashino,Y Liu,S. Takahashi. K. Ono
  • Journal Title: Mutation Research Volume: 695 Pages: 69-74
• [Journal Article] A General and Practical Access to Chiral Quinoxalinones with Low Coppe r-Catalyst Loading (2010)
  • Author(s): Tanimori,H. Kashiwagi,T. Ni shi mura,M. Kirihata
  • Journal Title: Advanced Synthesis & Catalysis Volume: 352 Pages: 2531-2537
• [Journal Article] Increase in irradiation beam intensity by using a hybrid target system in cyclotron based neutron capture therapy (2010)
  • Author(s): Takata,H. Tanaka,Y.Sakurai and A. Maruhashi
  • Journal Title: J. Nucl. Sci. Technol Volume: 47 Pages: 575-581
• [Presentation] BNCT 1N JAPAN.Experiences in Kyoto University Research Reactor Institute (KURRI) (2011)
  • Author(s): K. Ono
  • Organizer: (Invited Speaker) 6th Young Researchers BNCT Meeting
  • Place of Presentation: Tsing Hua, Taiwan
  • Year and Date: 20111205-08
• [Presentation] Boron Neutron Capture Therapy (BNCT) past, present and subjects in the future (2011)
  • Author(s): K. Ono
  • Organizer: (Invited Speaker) 6th Young Researchers BNCT Meeting, Tsing Hua Univ.,Taiwan International Congress of Radiation Research 2011
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 20110827-0901
• [Presentation] Boron Neutron Capture Therapy for Cancers in Kyoto University Research Reactor Institute (KURRI) (Invited Speaker) (2011)
  • Author(s): K. Ono
  • Organizer: International Symposium for Radiation Research and Medical Physics
  • Place of Presentation: Shanghai,China
  • Year and Date: 20110531-0602
• [Presentation] Development of Accelerator Neutron Source for BNCT -Present in KURRI and Future Prospects (2011)
  • Author(s): K. Ono
  • Organizer: (Invited Speaker) 2011 BNCT Workshop on Clinical Applications
  • Place of Presentation: VGH Taipei, Taiwan
  • Year and Date: 2011-12-10
• [Presentation] BNCT Research in Japan -Present and Future (2010)
  • Author(s): K. Ono
  • Organizer: Hatanaka Award Lecture in 14ThInternational Congress of Neutron Capture Therapy
  • Place of Presentation: Buenos Aires
  • Year and Date: 2010-10-25