2014 Fiscal Year Final Research Report
Search for molecular-targeted anti-cancer agents acting on the microenvironment in tumor and analysis of their target molecules
| Project/Area Number |
22241053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ARAI Masayoshi 大阪大学, 大学院薬学研究科, 准教授 (80311231)
KOTOKU Naoyuki 大阪大学, 大学院薬学研究科, 助教 (20362618)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 抗がん剤 / 活性天然物 / 微小環境 / 標的分子 / 海洋生物 / 海洋微生物 |
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| Outline of Final Research Achievements |
We explored bioactive natural products from the extract library of marine medicinal resources by the constructed screening systems focusing on the metabolic and phenotypic changes of the cells on the microenvironment in tumor, which largely contribute to the pathological progression of cancer. We succeeded in isolation of the bioactive natural products, which are expected to be a medicinal seed, and in synthesis of the analog compounds, which showed the activities better than those of natural products. In addition, several responsible molecules expected as new drug targets for cancer chemotherapy were figured out through the target identification of the isolated bioactive compounds. The designed new probe molecule and its synthetic strategy enhanced generality of the method for identifying target molecule of bioactive compound.
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| Free Research Field |
天然物化学
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