2012 Fiscal Year Final Research Report
Signaling and functions of CDM family proteins that acts as Rac GEFs
| Project/Area Number |
22247017
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
FUKUI Yoshinori 九州大学, 生体防御医学研究所, 教授 (60243961)
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| Co-Investigator(Kenkyū-buntansha) |
TANAKA Yoshihiko 九州大学, 生体防御医学研究所, 准教授 (00398083)
NISHIKIMI Nishikimi 九州大学, 生体防御医学研究所, 助教 (70404019)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 細胞情報伝達機構 |
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| Research Abstract |
In this study, we have analyzed signaling and functions of CDM family proteins that are known to act as Rac GEFs. We obtained several important conclusions as follows:
1) DOCK1 acts downstream of CXCR4 in endothelial cells and plays an important role in cardiovascular development.
2) DOCK2 regulates NK cell-mediated cytotoxicity.
3) DOCK5 plays an important role in osteoclast functions.
4) DOCK1 is required for PDGF-induced dorsal ruffle formation.
5) Unlike DOCK5, DOCK1 and DOCK2 bind to phosphatidic acid.
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[Journal Article] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses2012
Author(s)
Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T, Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T, Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y
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Journal Title
Blood
Volume: 119
Pages: 4451-4461
DOI
Peer Reviewed
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[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2.2012
Author(s)
Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saito N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H, Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, Fukui Y
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Journal Title
Chem. Biol.
Volume: 19
Pages: 488-497
DOI
Peer Reviewed
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[Journal Article] Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.2012
Author(s)
Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 109
Pages: 3305-3310
DOI
Peer Reviewed
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[Journal Article] DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.2010
Author(s)
Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y
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Journal Title
Circ. Res.
Volume: 107
Pages: 1102-1105
DOI
Peer Reviewed
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[Journal Article] Comprehensive analysis of lymph node stroma -expressed Ig superfamily members reveals redundant and non-redundant roles for ICAM-1, ICAM-2, and VCAM-1 in lymphocyte homing.2010
Author(s)
Boscacci RT, Pfeiffer F, Gollmer K, Sevilla AC, Martin AM, Soriano SF, Natale D, Henrickson SE, Andrian UH, Fukui Y, Mellado M, Deutsch U, Engelhardt B, Stein JV
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Journal Title
Blood
Volume: 116
Pages: 915-925
DOI
Peer Reviewed
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[Journal Article] Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation.2010
Author(s)
Gotoh K, Tanaka Y, Nishikimi A, Nakamura R, Yamada H, Maeda N, Ishikawa T, Hoshino K, Uruno T, Cao Q, Higashi S, Kawaguchi Y, Enjoji M, Takayanagi R, Kaisho T, Yoshikai Y, Fukui Y
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Journal Title
J. Exp. Med.
Volume: 207
Pages: 721-730
DOI
Peer Reviewed
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[Remarks] 朝日新聞、「免疫制御の物質 特定」、平成24年4月20日
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[Remarks] 毎日新聞、「白血球炎症 抑える化合物」、平成24年4月20日
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[Remarks] 西日本新聞、「免疫異常 抑える化合物」、平成24年4月20日
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[Remarks] 読売新聞、「免疫異常 抑える物質発見」、平成24年4月21日
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[Remarks] 日本経済新聞、「白血球の活性化 制御する化合物」、平成24年4月23日
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