Evolutionary diversity and adaption of sensory genes evaluated for natural populations of primates

2013 Fiscal Year Final Research Report

• Project/Area Number: 22247036
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical anthropology
• Research Institution: The University of Tokyo
• Principal Investigator: KAWAMURA Shoji 東京大学, 新領域創成科学研究科, 教授 (40282727)
• Co-Investigator(Kenkyū-buntansha): TOUHARA Kazushige 東京大学, 大学院農学生命科学研究科, 教授 (00280925) ; OOTA Hiroki 北里大学, 医学部, 准教授 (40401228) ; IMAI Hiroo 京都大学, 霊長類研究所, 准教授 (60314176) ; MATSUMOTO Akiko 琉球大学, 環境産業科学部, 教授 (80369206)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 霊長類 / 感覚受容遺伝子 / 野生集団 / 遺伝的多型 / 適応進化 / 国際情報交換 / 色覚 / 苦味受容体

Research Abstract

Our findings on evolutionary diversity and adaptation of color vision and gustation in primates are summarized as follows. Atelines improved chromatic discrimination of dietary fruits through unique mutations in L/M opsin alleles. Against a norm, howler monkeys regained color vision variation through recombination between L and M opsin genes. By modeling visibility of dietary fruit to variations of color vision in capuchin monkeys, we showed that trichromacy would have advantage in long-distance detection. However, this advantage is judged not translated into fitness advantage based on 26 years survival and fertility data. By studying L/M opsin gene of tarsiers, we proposed that trichromacy evolved under dim light conditions. By investigating sensitivities of TAS2R16 bitter taste receptor gene, we found that the sensitivity in fact varied among primate species. We presented an evidence of eco-geographical diversification of bitter taste receptor genes among subspecies of chimpanzees.

Research Products

• [Journal Article] Divergent selection for opsin gene variation in guppy (Poecilia reticulata) populations of Trinidad and Tobago (2014)
  • Author(s): Tezuka, A., Kasagi, S., van Oosterhout, C., McMullan, M., Iwasaki, W. M., Kasai,D., Yamamichi, M., Innan, H., Kawamura, S. and Kawata, M.
  • Journal Title: Heredity Volume: (Published Online)
  • DOI: 10.1038/hdy.2014.35
  • Peer Reviewed
• [Journal Article] Evolutionary renovation of L/M opsin polymorphism confers a fruit discrimination advantage to ateline New World monkeys (2014)
  • Author(s): Matsumoto, Y., Hiramatsu, C., Matsushita, Y., Ozawa, N., Ashino, R., Nakata, M., Kasagi, S., Di Fiore, A. Schaffner, C. M., Aureli, F., Melin, A. D. and Kawamura, S.
  • Journal Title: Molecular Ecology Volume: 23 Pages: 1799-1812
  • DOI: 10.1111/mec.12703
  • Peer Reviewed
• [Journal Article] Color vision variation as evidenced by hybrid L/M opsin genes in wild populations of trichromatic Alouatta New World monkeys. (2014)
  • Author(s): Matsushita, Y., Oota, H., Welker, B. J., Pavelka, M. S. and Kawamura, S.
  • Journal Title: International Journal of Primatology Volume: 35 Pages: 71-87
  • DOI: 10.1007/s10764-013-9705-9
  • Peer Reviewed
• [Journal Article] The behavioral ecology of color vision : considering fruit conspicuity, detection distance and dietary importance (2014)
  • Author(s): Melin, A. D., Hiramatsu, C., Parr, N. A., Matsushita, Y., Kawamura, S. and Fedigan, L. M.
  • Journal Title: International Journal of Primatology Volume: 35 Pages: 258-287
  • DOI: 10.1007/s10764-013-9730-8
  • Peer Reviewed
• [Journal Article] The heterozygote superiority hypothesis for polymorphic color vision is not supported by long-term fitness data from wild Neotropical monkeys (2014)
  • Author(s): Fedigan, L.M., Melin, A.D., Addicott, J.F. and Kawamura, S.
  • Journal Title: PLoS One Volume: 9 Pages: e84872
  • DOI: 10.1371/journal.pone.0084872
  • Peer Reviewed
• [Journal Article] Cone photoreceptor types in zebrafish are generated by symmetric terminal divisions of dedicated precursors (2013)
  • Author(s): Suzuki, S.C., Bleckert, A., Williams, P.R., Takechi, M., Kawamura, S. and Wong, R.O.L.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 110 Pages: 15109-15114
  • DOI: 10.1073/pnas.1303551110
  • Peer Reviewed
• [Journal Article] Characterization of transgenic zebrafish lines that express GFP in the retina, pineal gland, olfactory bulb, hatching gland, and optic tectum (2013)
  • Author(s): Fang, W., Bonaffini, S., Zou, J., Wang, X., Zhang, C., Tsujimura, T., Kawamura, S. and Wei, X.
  • Journal Title: Gene Expression Patterns Volume: 13 Pages: 150-159
  • DOI: 10.1016/j.gep.2013.02.006
  • Peer Reviewed
• [Journal Article] Inferred L/M cone opsin polymorphism of ancestral tarsiers sheds dim light on the origin of anthropoid primates (2013)
  • Author(s): Melin, A.D., Matsushita, Y., Moritz, G.L., Dominy, N.J. and Kawamura, S.
  • Journal Title: Proceedings of the Royal Society B Volume: 280 Pages: 20130189
  • DOI: 10.1098/rspb.2013.0189
  • Peer Reviewed
• [Journal Article] Bipolar cell-photoreceptor connectivity in the zebrafish (Danio rerio) retina (2012)
  • Author(s): Li, Y.N., Tsujimura, T., Kawamura, S. and Dowling, J.E.
  • Journal Title: The Journal of Comparative Neurology Volume: 520 Pages: 3786-3802
  • DOI: 10.1002/cne.23168
  • Peer Reviewed
• [Journal Article] Functional diversity of bitter taste receptor TAS2R16 in primates (2012)
  • Author(s): Imai, H., Suzuki, N., Ishimaru, Y., Sakurai, T., Yin, L., Pan, W., Abe, K., Misaka, T. and Hirai, H.
  • Journal Title: Biology Letters Volume: 8 Pages: 652-656
  • DOI: 10.1098/rsbl.2011.1251
  • Peer Reviewed
• [Journal Article] Eco-geographical diversification of bitter taste receptor genes (TAS2Rs) among subspecies of chimpanzees (Pan troglodytes) (2012)
  • Author(s): Hayakawa, T., Sugawara, T., Go, Y., Udono, T., Hirai, H. and Imai, H.
  • Journal Title: PLoS ONE Volume: 7 Pages: e43277
  • DOI: 10.1371/journal.pone.0043277
  • Peer Reviewed
• [Journal Article] Gene conversion and purifying selection shape nucleotide variation in gibbon L/M opsin genes (2011)
  • Author(s): Hiwatashi, T., Mikami, A., Katsumura, T., Suryobroto, B., Perwitasari-Farajallah, D., Malaivijitnond, S., Siriaroonrat, B., Oota, H., Goto, S. and Kawamura, S.
  • Journal Title: BMC Evolutionary Biology Volume: 11 Pages: 312
  • DOI: 10.1186/1471-2148-11-312
  • Peer Reviewed
• [Presentation] クモザル亜科L/M オプシン多型の進化的改編による果実と背景葉の色識別能の向 (2013)
  • Author(s): 河村正二、松本圭史、平松千尋、松下裕香、小澤範宏、蘆野龍一、中田真紀子、笠木聡、Di Fiore, A.、Schaffner, C. M.、Aureli, F.、Melin, A.
  • Organizer: 第29回日本霊長類学会・日本哺乳類学会2013年度合同大会
  • Place of Presentation: 岡山理科大学、岡山市 (口演)
  • Year and Date: 20130906-09
• [Presentation] クモザル亜科にみられるL/M オプシン多型の進化的改編がもたらした果実と背景葉の色識別能の向上 (2013)
  • Author(s): 河村正二、松本圭史、平松千尋、松下裕香、小澤範宏、蘆野龍一、中田真紀子、笠木聡、Di Fiore, A.、Aureli, F.、Schaffner, C. M.、Melin, A.
  • Organizer: 第15回日本進化学会
  • Place of Presentation: 筑波大学筑波キャンパス、つくば市 (口演))
  • Year and Date: 20130828-31
• [Presentation] ホエザル属3色型色覚の多様性実証による霊長類における定向的色覚進化モデル妥当性の検討 (2013)
  • Author(s): 松下裕香、太田博樹、Welker, B.、Pavelka, M.、河村正二
  • Organizer: 第15回日本進化学会
  • Place of Presentation: 筑波大学筑波キャンパス、つくば市 (口演)
  • Year and Date: 20130828-31
• [Presentation] 色覚多型を示す新世界ザル野生集団における苦味受容体遺伝子群の種内変異と採食果実の香気成分分析 (2012)
  • Author(s): 河村正二、櫻井児太摩、白須未香、松下裕香、Melin, A.、Bergstrom, M.、今井啓雄、東原和成、太田博樹、Aureli, F.、Fedigan, L.
  • Organizer: 第66回日本人類学会
  • Place of Presentation: 慶應義塾大学日吉キャンパス、横浜市 (口演)
  • Year and Date: 20121102-04
• [Presentation] 夜行性メガネザル3種のL/Mオプシン遺伝子と共通祖先に維持された色覚多型の検討 (2012)
  • Author(s): 河村正二、松下裕香、Melin, A.、Moritz, G.、Dominy, N.
  • Organizer: 第84回日本遺伝学会
  • Place of Presentation: 九州大学医学部百年講堂・同窓会館、福岡 (口演)
  • Year and Date: 20120926-24
• [Presentation] 新世界ザル野生集団における苦味受容体遺伝子群の種内変異と採食果実の香気成分分析 (2012)
  • Author(s): 河村正二、櫻井児太摩、白須未香、松下裕香、Melin, A.、Bergstrom, M.、今井啓雄、東原和成、太田博樹、Aureli, F.、Fedigan, L.
  • Organizer: 第14回日本進化学会
  • Place of Presentation: 首都大学東京南大沢キャンパス、八王子 (口演)
  • Year and Date: 20120821-24
• [Presentation] Improvement of chromatic resolution of L/M opsin alleles in atelid New World monkeys (2012)
  • Author(s): Kawamura, S., Matsumoto, Y., Matsushita, Y., Ozawa, N., Nakata, M., Kasagi, S. and Hiramatsu, C.
  • Organizer: The 24th Congress of the International Primatological Society (IPS 2012)
  • Place of Presentation: Cancun Convention Center, Cancun, Mexico (Oral)
  • Year and Date: 20120812-17
• [Presentation] Assessment of bitter taste receptor gene variation and dietary fruit odorants in natural populations of color-vision polymorphic New World Monkeys (2012)
  • Author(s): Kawamura, S., Sakurai, K., Bergstrom, M., Shirasu, M., Matsushita, Y., Melin, A., Imai, H., Touhara, K., Oota, H., Aureli, F. and Fedigan, L.
  • Organizer: The 24th Congress of the International Primatological Society (IPS 2012)
  • Place of Presentation: Cancun Convention Center, Cancun, Mexico (Oral))
  • Year and Date: 20120812-17
• [Presentation] Possible anomalous trichromacy of color vision by hybrid L/M opsin genes in wild howler monkeys, Alouatta (2012)
  • Author(s): Matsushita, Y., Oota, H., Welker, B., Pavelka, M. and Kawamura, S.
  • Organizer: The 24th Congress of the International Primatological Society (IPS 2012)
  • Place of Presentation: Cancun Convention Center, Cancun, Mexico (Oral)
  • Year and Date: 20120812-17
• [Presentation] 新世界ザル野生集団における苦味受容体遺伝子群の多様性と採食果実の香気成分分析 (2012)
  • Author(s): 河村正二、櫻井児太摩、白須未香、松下裕香、Melin, A.、Bergstrom, M.、今井啓雄、東原和成、太田博樹、Aureli, F.、Fedigan, L.
  • Organizer: 第28回日本霊長類学会
  • Place of Presentation: 椙山女学園星ヶ丘キャンパス、名古屋 (口演)
  • Year and Date: 20120706-08
• [Presentation] メガネザル3種のL/M オプシン遺伝子解析による共通祖先色覚多型の検討 (2012)
  • Author(s): 松下裕香、Melin, A.、Moritz, G.、Dominy, N.、河村正二
  • Organizer: 第28回日本霊長類学会
  • Place of Presentation: 椙山女学園星ヶ丘キャンパス、名古屋 (口演)
  • Year and Date: 20120706-08
• [Presentation] Molecular mechanism and adaptive significance of evolutionary diversification of visual opsins (2012)
  • Author(s): Kawamura, S.
  • Organizer: The 89th Annual Meeting of the Physiological Society of Japan: Symposium 38 : Functional evolution of sensing receptors : Toward the comprehensive understanding by fusion of research in the different fields (Organized by Makoto Tominaga and Hioo Imai)
  • Place of Presentation: Shinshu University Matsumoto Campus, Matsumoto, Japan (Oral)
  • Year and Date: 20120529-31
  • Invited
• [Presentation] Color vision polymorphism in wild New World monkeys and adaptive significance of primate color vision (2012)
  • Author(s): Kawamura, S.
  • Organizer: The 8th Okazaki Biology Conference (OBC8) : Speciation and Adaptation II - Environment and Epigenetics -
  • Place of Presentation: Okazaki Conference Center, Okazaki, Japan (Oral)
  • Year and Date: 20120518-23
  • Invited
• [Presentation] 魚類と霊長類の研究から見えてきた色覚進化の秘密 (2012)
  • Author(s): 河村正二
  • Organizer: 日本塗装技術協会 第27回塗料・塗装研究発表会
  • Place of Presentation: 東京大学生産技術研究所、駒場リサーチキャンパス・コンベンションホール、駒場 (口演)
  • Year and Date: 2012-03-09
  • Invited
• [Presentation] ヒトを含む旧世界霊長類型3色型色覚とされてきた新世界ホエザル野生群における色覚多型性調査 (2011)
  • Author(s): 松下裕香、太田博樹、Welker, B、Pavelka, M.、河村正二
  • Organizer: 第65回日本人類学会
  • Place of Presentation: 沖縄県立博物館・美術館、那覇 (口演)
  • Year and Date: 20111104-06
• [Presentation] 色覚種内多型を示す新世界ザル野生集団における苦味受容体遺伝子の多型解析と採食果実匂い物質の同定 (2011)
  • Author(s): 櫻井児太摩、Bergstrom, M.、白須未香、今井啓雄、東原和成、太田博樹、Aureli, F.、Fedigan, L.、河村正二
  • Organizer: 第65回日本人類学会
  • Place of Presentation: 沖縄県立博物館・美術館、那覇 (口演)
  • Year and Date: 20111104-06
• [Presentation] Evolution of visual opsin genes in fish and primates (2011)
  • Author(s): Kawamura, S.
  • Organizer: 15th Evolutionary Biology Meeting at Marseilles (15th EBM), Regional Center of Educational Documentation ("Centre Regional de Documentation Pedagogique")
  • Place of Presentation: Marseilles, France (Oral)
  • Year and Date: 20110927-30
  • Invited
• [Presentation] 新世界ホエザル野生群に対する旧世界霊長類型3色型色覚の多型性調査 (2011)
  • Author(s): 松下裕香、太田博樹、Welker, B、Pavelka, M.、河村正二
  • Organizer: 第83回日本遺伝学会
  • Place of Presentation: 京都大学吉田キャンパス北部構内、京都 (口演)
  • Year and Date: 20110920-23
• [Presentation] Finding a polymorphism of the L-M opsin gene in howler monkeys which have been supposed to have uniform trichromacy in New World monkeys (2011)
  • Author(s): 松下裕香、太田博樹、Welker, B.、Pavelka, M.、河村正二
  • Organizer: 第13回日本進化学会
  • Place of Presentation: 京都大学百周年時計台記念館、京都 (口演)
  • Year and Date: 20110729-31
• [Presentation] Evolutionary study of vertebrate color vision : from fish transgenesis to field primatology, and to human variation (2011)
  • Author(s): Kawamura, S.
  • Organizer: Annual Conference of Soceity for Molecular Biology and Evolution 2011 (SMBE 2011)
  • Place of Presentation: Kyoto University (Clock Tower Centennial Hall and Shiran Kaikan) and Miyako Messe, Kyoto, Japan (Oral) Plenary Talk
  • Year and Date: 20110726-30
  • Invited
• [Presentation] 恒常的3色型色覚とされてきたホエザル属における種内L-M オプシン多型の発見 (2011)
  • Author(s): 松下裕香、太田博樹、Welker, B.、Pavelka, M.、河村正二
  • Organizer: 第27回日本霊長類学会
  • Place of Presentation: 犬山国際観光センター・フロイデ、犬山 (口演)
  • Year and Date: 20110716-18
• [Presentation] 色覚種内多型を示す新世界ザル野生集団における化学物質感覚センサーの多型解析 (経過報告) (2011)
  • Author(s): 櫻井児太摩、今井啓雄、東原和成、太田博樹、Aureli, F.、Fedigan, L.、河村正二
  • Organizer: 第27回日本霊長類学会
  • Place of Presentation: 犬山国際観光センター・フロイデ、犬山 (口演)
  • Year and Date: 20110716-18
• [Presentation] Color vision polymorphism in wild New World monkeys as a model system to understand the adaptive significance of primate color vision (2010)
  • Author(s): Kawamura, S.
  • Organizer: The 4th International Symposium of the Biodiversity and Evolution, Kyoto University Global COE project "Evolution of Sensor, Communication and Society"
  • Place of Presentation: Shiran Kaikan, Kyoto University, Kyoto, Japan (Oral)
  • Year and Date: 20100911-12
  • Invited
• [Book] Polymorphism and adaptation of primate colour vision. In : Evolutionary Biology : Mechanisms and Trends (Pontarotti, P. ed.) (2012)
  • Author(s): *Melin, A. D., Hiramatsu, C., Fedigan, L.M., Schaffner, C.M, Aureli, F. and *Kawamura, S.
  • Total Pages: 225-241
  • Publisher: Springer-Verlag, Berlin Heidelberg
• [Book] Polymorphic color vision in primates : evolutionary considerations. In : Post-Genome Biology of Primates (Hirai, H., Imai, H. and Go, Y. eds.) (2012)
  • Author(s): *Kawamura, S., Hiramatsu, C., Melin, A.D., Schaffner, C.M, Aureli, F. and Fedigan, L.M.
  • Total Pages: 93-120
  • Publisher: Springer, Tokyo
• [Book] Evolutionary diversification of visual opsin genes in fish and primates. In : From Genes to Animal Behavior : Social Structures, Personalities, Communication by Color (Inoue-Murayama, M., Kawamura, S. and Weiss, A. eds.) (2011)
  • Author(s): *Kawamura, S.
  • Total Pages: 329-349
  • Publisher: Springer, Tokyo
• [Remarks]
  • URL: http://www.jinrui.ib.k.u-tokyo.ac.jp/kawamura-home.html
• [Remarks]
  • URL: http://www.jinrui.ib.k.u-tokyo.ac.jp/kawamura-home-E.html