2013 Fiscal Year Final Research Report
Epigenetic control of the genome functions of transgenic insect
| Project/Area Number |
22248004
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied entomology
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| Research Institution | Kyushu University |
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Principal Investigator |
KUSAKABE Takahiro 九州大学, (連合)農学研究科(研究院), 教授 (30253595)
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| Co-Investigator(Kenkyū-buntansha) |
山本 公子 独立行政法人農業生物資源研究所, その他部局等, その他 (40370689)
李 在萬 九州大学, 大学院農学研究院, 助教 (50404083)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | ヘテロクロマチン / 染色体 / エピジェネティクス / ヒストンコード |
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| Research Abstract |
In order to understand the molecular relationship between the epigenetic modification of chromatin and DNA metabolism, and maintenance of chromosomal structure, we analyzed the histone code of silkworm holocentric chromosomes and its role on the formation of constitutive heterochromatin. First, the histone code of silkworm histone H3 was determined. Then, almost all components of H3K9-HP1and H3K27-Polycomb systems had been cloned and their roles on the formation of constitutive heterochromatin were analyzed. Finally, the molecular structure of silkworm kinetochore was revealed.
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