2013 Fiscal Year Final Research Report
Elucidation of Evidence-based Physiological Functions of Small Peptides
| Project/Area Number |
22248014
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
MATSUI TOSHIRO 九州大学, (連合)農学研究科(研究院), 教授 (20238942)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATO Masao 九州大学, 大学院農学研究院, 准教授 (90294909)
TSUDA Takanori 中部大学, 応用生物学部, 准教授 (90281568)
NAMBU Nobutaka 上智大学, 理工学部, 教授 (00249955)
|
|---|
| Project Period (FY) |
2010-05-31 – 2014-03-31
|
| Keywords | 低分子ペプチド / 生活習慣病予防 / 機能性食品 / カルシウムシグナル / MSシミュレーション |
|---|
| Research Abstract |
In order to get new insights on physiological functions of small peptides, their potentials in tissues such as vessels and muscles were investigated in this study. As a result, it was clarified that basic di-peptides could relax contracted thoraces aorta in an endothelium-independent manner through the suppression of Ca2+-related signaling pathways by cell -line experiments and in silica analyses. Furthermore, we have demonstrated for the first time that the potent vasorelaxation power of basic do-peptides was ameliorated with aging and hypertension. We further got new evidence that basic di-peptides could absorb intact across intestinal membrane by our proposed new visualization technique (MADL-MS), and show anti-diabetic effect in muscle cells.
|
