Investigation between intestinal flora and general health status

2013 Fiscal Year Final Research Report

• Project/Area Number: 22249019
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Hirosaki University
• Principal Investigator: NAKAJI Shigeyuki 弘前大学, 医学(系)研究科(研究院), 教授 (10192220)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Ippei 弘前大学, 大学院医学研究科, 准教授 (70400132) ; MATSUZAKA Masashi 弘前大学, 大学院医学研究科, 講師 (70431434) ; UMEDA Takashi 弘前大学, 大学院医学研究科, 准教授 (50311535) ; DANJO Kazuma 弘前大学, 大学院医学研究科, 助教 (90463760)
• Co-Investigator(Renkei-kenkyūsha): BENNO Yoshimi 独立行政法人理化学研究所, 知的財産戦略センター, 特別招聘研究員 (40087599)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 腸内細菌 / 全体的健康度 / T-RELP 法 / OUT / 肥満 / 加齢 / 食事 / 一般住民

Research Abstract

The association between intestinal flora and general health status were investigated among general populations. Following results were obtained; 1. Proportion of OTU657 and 990 increased with age, 2. Proportion of OTU940 decreased with age, 3. Proportion of OTU338 decreased in the subject group with high serum albumin level, 4. Proportion of OTU124 increased in the subject group with high rice intake, 5. Proportion of OTU919 and 124 increased in the subject group with high milk intake, 6. Proportion of OTU124 decreased in the subject group with high raw vegetable intake, 7. Proportion of OTU124 increased in the subject group with sleep disorder, 8.The relationship between proportion of OTU332 (lactobacillus) and body fat percentage - in 65+ -year-old females, significantly high percentage of OTU332 was observed in those with body fat percentage of less than 25% compared to those with greater than 25%. Thus, lactobacillus was suggested to have a preventive effect against obesity.

Research Products

• [Journal Article] 弘前市の一般住民における加齢が腸内常在菌に及ぼす影響 (2014)
  • Author(s): 甲斐知彦 ,高橋一平 ,沢田かほり ,大久保礼由 ,久田貴義 ,辨野義己 ,中路重之
  • Journal Title: アンチ・エイジング医学 Volume: 10(1) Pages: 95-103
  • Peer Reviewed
• [Journal Article] Possible relationship between percentage of body fat and lactobacillales in gut microbiota: results from a community-based study (2014)
  • Author(s): Watanabe K, Takahashi I, Sawada, K, Okubo N, Matsuzaka M, Akimoto N, Umeda T, Nakaji S, Hisada Y, Benno Y
  • Journal Title: Hirosaki Med J Volume: 65 Pages: 12-20
  • Peer Reviewed
• [Journal Article] Helicobacter pylori infection is associated with a decreased risk of tooth loss in healthy Japanese men (2013)
  • Author(s): Shimoyama T, Higuchi H, Matsuzaka M, Chinda D, Nakaji S, Fukuda S
  • Journal Title: Jpn J Infect Dis Volume: 66(6) Pages: 489-492
  • DOI: 10.7883/yoken.66.489
  • Peer Reviewed
• [Journal Article] ABC screening for gastric cancer is not applicable in a Japanese population with high prevalence of atrophic gastritis (2012)
  • Author(s): Shimoyama T, Aoki M, Sasaki Y, Matsuzaka M, Nakaji S, Fukuda S
  • Journal Title: Gastric Cancer Volume: 15(3) Pages: 331-334
  • DOI: 10.1007/s10120-012-0141-x
  • Peer Reviewed
• [Journal Article] 腸内細菌とがん (2012)
  • Author(s): 中路重之、岩根かほり、辨野義己
  • Journal Title: 腫瘍プラクティス Volume: 8(2) Pages: 170-173
  • Peer Reviewed
• [Journal Article] Effect of Human Gut Microbiota on the Methane Production (2011)
  • Author(s): Hasebe T, Umeda T, Danjo K, Takahashi I, Matsuzaka M, Kudo J, Semato M, Saito Y, Hisada T, Benno Y, Nakaji S, Hakamada K
  • Journal Title: Hirosaki Med J Volume: 62(1) Pages: 7-17
  • Peer Reviewed
• [Journal Article] Prevelence of irritable bowel syndrome and its relation to lifestyle and depression quotient in a Japanese general population (2011)
  • Author(s): Kumeda K, Danjo K, Matsuzaka M, Takahashi I, Watanabe K, Iwane K, Tsuya R, Umeda T, Sato K, Fukuda S, Nakaji S
  • Journal Title: Hirosaki Med J Volume: 62(2-4) Pages: 144-165
  • Peer Reviewed
• [Journal Article] 腸内細菌とライフスタイル・健康指標との関係岩木健康増進プロジェクトでの検討 (2011)
  • Author(s): 中路重之 ,長谷部達也 ,津谷亮佑 ,高橋一平 ,檀上和真 ,松坂方士 ,梅田孝 ,辨野義己
  • Journal Title: 日本臨床腸内微生物学会誌 Volume: 13(1) Pages: 4-7
  • Peer Reviewed
• [Presentation] 腸内の乳酸菌と肥満の関連について (2012)
  • Author(s): 渡邉清誉 ,高橋一平 ,本田勝義 ,米田勝朗 ,三輪孝士 ,和田尚子 ,伊東良 ,上谷英史 ,梅田孝 ,中路重之
  • Organizer: 第82回日本衛生学会
  • Place of Presentation: 京都
  • Year and Date: 20120323-26
• [Presentation] 腸内細菌と体脂肪の関連について (2011)
  • Author(s): 渡邊清誉 ,本田勝義 ,矢野智彦 ,米田勝朗 ,三輪孝士 ,和田尚子 ,伊東良 ,小川武志 ,梅田孝 ,中路重之
  • Organizer: 第21回体力・栄養・免疫学
  • Place of Presentation: 東京
  • Year and Date: 20110827-28
• [Presentation] 腸内細菌叢と肥満との関係 (2011)
  • Author(s): 渡邉清誉 ,梅田孝 ,黒岩純 ,竹石洋介 ,田中充洋,松田基子 ,中路重之
  • Organizer: 第81回日本衛生学会
  • Place of Presentation: Web開催
  • Year and Date: 20110323-1003
• [Remarks]
  • URL: http://social.med.hirosaki-u.ac.jp/greeting.html