The effects of prenatal exposures to environmental chemicals and genetic susceptibility on growth, neurodevelopment and allergy of next generation

2013 Fiscal Year Final Research Report

• Project/Area Number: 22249021
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Hokkaido University
• Principal Investigator: KISHI REIKO 北海道大学, 学内共同利用施設等, その他 (80112449)
• Co-Investigator(Kenkyū-buntansha): YOSHIOKA Eiji 旭川医科大学, 医学部, 准教授 (70435957) ; SASAKI Seiko 北海道大学, 医学(系)研究科(研究院), 助教 (30448831) ; MUROHASHI Harumitsu 北海道大学, 教育学研究科(研究院), 教授 (00182147) ; NAKAJIMA Sonomi 札幌医科大学, 保健医療学部, 准教授 (70325877) ; SHIRAISHI Hideaki 北海道大学, 大学病院, 助教 (80374411)
• Co-Investigator(Renkei-kenkyūsha): AZUMI Kaoru 北海道大学, 環境健康科学研究教育センター, 特任講師 (90221720) ; IKENO Tamiko 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715) ; ARAKI Atsuko 北海道大学, 環境健康科学研究教育センター, 特任講師 (00619885) ; HANAOKA Tomoyuki 北海道大学, 環境健康科学研究教育センター, 客員教授 (00228503) ; KAJIWARA Junboku 福岡県保健環境研究所, 保健科学部生活科学科課, 専門研究員 (80446848) ; SAITO Kouichi 星薬科大学, 薬学部, 准教授 (40386347) ; SATA Fumihiro 国立保健医療科学院, 生活環境研究部, 室長 (90187154) ; SAIJO Yasuaki 旭川医科大学, 医学部, 教授 (70360906) ; ITOH Sachiko 北海道大学, 環境健康科学研究教育センター, 学術研究員 (90580936) ; MIYASHITA Chihiro 北海道大学, 環境健康科学研究教育センター, 学術研究員 (70632389)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 母子保健 / 環境化学物質 / 次世代影響 / リスク評価 / 神経行動発達 / 環境遺伝交互作用 / 出生体格 / 出生コホート

Research Abstract

514 pregnant women were recruited in one obstetric hospital in Sapporo. We investigated the correlation of prenatal exposures to PCBs/PCDDs/PCDFs, PFOS and PFOA with child growth, neurodevelopment, and allergy in next generation until school age. A follow-up questionnaire was used at 18, 42, and 84 months of age to obtain relevant information including infant symptoms and lifestyle factors. The Bayley Scale of Infant Development second edition at age of 6 and 18 months, and the Kaufman Assessment Battery for Children and the Child Behavior Checklist at age 42 to 43, 84 months were employed to collect information on child behavior. At age of 84 months the Wechsler Intelligence Scale for Children was used to assess the effects of environmental chemicals on cognitive ability. The levels of PCBs/PCDDs/PCDFs and PFOS/PFOA in maternal blood were analyzed by a high-resolution gas chromatography/high-resolution mass spectrometer and liquid chromatography-tandem mass spectrometry respectively.

Research Products

• [Journal Article] Association between maternal antenatal depression and infant development: a hospital-based prospective cohort study (2014)
  • Author(s): Otake Y, Nakajima S, Uno A, Kato S, Sasaki S, Yoshioka E, Ikeno T, Kishi R
  • Journal Title: Environment Health Preventive Medicine Volume: 19(1) Pages: 30-45
  • DOI: 10.1007/s12199-013-0353-7
  • Peer Reviewed
• [Journal Article] Genetic association of aromatic hydrocarbon receptor (AHR) and cytochrome P450, family 1, subfamily A, polypeptide 1 (CYP1A1) polymorphisms with dioxin blood concentrations among pregnant Japanese women (2013)
  • Author(s): Kobayashi S, Sata F, Sasaki S, Ban S, Miyashita C, Okada E, Limpar M, Yoshioka E, Kajiwara J, Todaka T, Saijo Y, Kishi R
  • Journal Title: Toxicology Letters Volume: 219(3) Pages: 269–278
  • DOI: 10.1016/j.toxlet.2013.03.013
  • Peer Reviewed
• [Journal Article] Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and tobacco smoking on infant birth weight in a Japanese population (2012)
  • Author(s): Yila TA, Sasaki S, Miyashita C, Braimoh T S, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, EndoT, Sengoku K, Kishi R
  • Journal Title: Journal of epidemiology / Japan Epidemiological Association Volume: 22 Pages: 91-102
  • DOI: 10.2188/jea.JE20110039
  • Peer Reviewed
• [Journal Article] Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants (2012)
  • Author(s): Okada E, Sasaki S, Saijo Y, Washino N, Miyashita C, Kobayashi S, Konishi K, Ito Y M, Ito R, Nakata A, Iwasaki Y, Saito K, Nakazawa H, Kishi R
  • Journal Title: Environmental research Volume: 112 Pages: 118-125
  • DOI: 10.1016/j.envres.2011.10.003
  • Peer Reviewed
• [Journal Article] Malnutrition of fetal age and the infant health, Nihon eiseigaku zasshi (2012)
  • Author(s): Nakajima T, Kishi R
  • Journal Title: Japanese journal of hygiene Volume: 67 Pages: 21
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22449816
• [Journal Article] Blood persistent organochlorine pesticides in pregnant women in relation to physical and environmental variables in The Hokkaido Study on Environment and Children's Health (2012)
  • Author(s): Kanazawa K, Miyashita C, Okada E, Kobayashi S, Washino N, Sasaki S, Yoshioka E, Mizutani F, Chisaki Y, Saijo Y, Kishi R
  • Journal Title: The Science of the total environment Volume: 426 Pages: 73-82
  • DOI: 10.1016/j.scitotenv.2012.02.073
  • Peer Reviewed
• [Journal Article] Maternal folate, alcohol and energy metabolism-related gene polymorphisms and the risk of recurrent pregnancy loss (2012)
  • Author(s): Sata F, Yamada H, Kishi R, Minakami H
  • Journal Title: Journal of Developmental Origins of Health and Disease Volume: 3 Pages: 327-332
  • DOI: 10.1017/S2040174412000359
  • Peer Reviewed
• [Journal Article] Self-reported tobacco smoke exposure and plasma cotinine levels duringpregnancy - A validation study in Northern Japan (2011)
  • Author(s): Sasaki S, Braimoh TS, Yila TA, Yoshioka E, Kishi R
  • Journal Title: Science of the Total Environment Volume: 412-413 Pages: 114-118
  • DOI: 10.1016/j.scitotenv.2011.10.019
  • Peer Reviewed
• [Journal Article] Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in blood and breast milk collected from pregnant women in Sapporo City, Japan (2011)
  • Author(s): Todaka T, Hirakawa H, Kajiwara J, Onozuka D, Sasaki S, Miyashita C, Yoshioka E, Yuasa M, Kishi R, Iida T, Uchi H, Furue M
  • Journal Title: Chemosphere. Volume: 85(11) Pages: 1694-1700
  • DOI: 10.1016/j.chemosphere.2011.09.014
  • Peer Reviewed
• [Journal Article] Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy (2011)
  • Author(s): Miyashita C, Sasaki S, Saijo Y, Washino N, Okada E, Kobayashi S, Konishi K, Kajiwara J, Todaka T, Kishi R
  • Journal Title: Environ Res. Volume: 111(4) Pages: 551-558
  • DOI: 10.1016/j.envres.2011.01.021
  • Peer Reviewed
• [Journal Article] Ratio variation of congener profiles of PCDD/Fs and dioxin-like PCBs in human milk during lactation (2011)
  • Author(s): Takemura M, Saito K, Falandysz J, Nakazawa H
  • Journal Title: Sci. Total Environ Volume: 409 Pages: 1368-1377
  • DOI: 10.1016/j.scitotenv.2010.12.031
  • Peer Reviewed
• [Journal Article] Relationship between the concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls in maternal blood and those in breast milk (2010)
  • Author(s): Todaka T, Hirakawa H, Kajiwara J, Hori T, Tobiishi K, Yasutake D, Onozuka D, Sasaki S, Miyashita C, Yoshioka E, Yuasa M, Kishi R, Iida T, Furue M
  • Journal Title: Chemosphere. Volume: 78(2) Pages: 185-192
  • DOI: 10.1016/j.chemosphere.2009.09.047
  • Peer Reviewed
• [Journal Article] 発達障害研究と認知科学 (2010)
  • Author(s): 室橋春光
  • Journal Title: 基礎心理学研究 Volume: 29(1) Pages: 47-52
  • URL: http://ci.nii.ac.jp/els/110007987979.pdf?id=ART0009576950&type=pdf&lang=jp&host=cinii&order_no=&ppv_type=0&lang_sw=&no=1367481764&cp=
  • Peer Reviewed
• [Presentation] 母体血中ダイオキシン類と6ヶ月・18ヶ月児の精神・運動発達への影響 (2013)
  • Author(s): 中島そのみ,佐々木成子,加藤静恵,中村裕二,仙石泰仁,梶原淳睦,池野多美子,西條泰明,岸玲子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学,金沢市
  • Year and Date: 20130324-26
• [Presentation] 環境化学物資の胎児期曝露が臍帯血IGF2DNAメチル化に及ぼす影響 (2013)
  • Author(s): 小林祥子,安住薫,宮下ちひろ,小林澄貴,佐々木成子,石塚真由美,岸玲子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学,金沢市
  • Year and Date: 20130324-26
• [Presentation] 母体血PCB・dioxinと臍帯血IgEとの関連-環境と子どもの健康北海道スタディー (2013)
  • Author(s): 宮下ちひろ,佐々木成子,池野多美子,岡田恵美子,小林澄貴,樫野いく子,伊藤久美子,梶原淳睦,戸高尊,岸玲子
  • Organizer: 第83回日本衛生学会学術総会
  • Place of Presentation: 金沢大学,金沢市
  • Year and Date: 20130324-26
• [Presentation] 胎児期ダイオキシン類曝露が3歳半の発達に及ぼす影響-「環境と子どもの健康に関する北海道スタディ」- (2013)
  • Author(s): 池野多美子,小西香苗,中島そのみ,喜多歳子,小林澄貴,馬場俊明,岸玲子
  • Organizer: 第23回日本疫学会学術総会
  • Place of Presentation: 大阪大学,吹田市
  • Year and Date: 20130124-26
• [Presentation] Effects of prenatal exposure to dioxin-like compounds on infant health (2012)
  • Author(s): Miyashita C
  • Organizer: 2012 Birth cohort Consortium of Asia
  • Place of Presentation: National Taiwan University , Taiwan
  • Year and Date: 20121117-20
• [Presentation] Dioxins, Perfluorooctane sulfonate, perfluorooctanoic acid in the blood, and mercury concentrations in the hair during perinatal period in Japan (2012)
  • Author(s): Miyashita C
  • Organizer: 2012 International Society of Exposure Science
  • Place of Presentation: The Westin Seattle, USA
  • Year and Date: 20121028-1101
• [Presentation] 妊婦血と毛髪の環境化学物質に関連する要因-環境と子どもの健康北海道スタディー (2012)
  • Author(s): 宮下ちひろ,佐々木成子,岡田恵美子,小林澄貴,蜂谷紀之,岩崎雄介,中澤裕之,梶原淳睦,戸高尊,岸玲子
  • Organizer: 第82回日本衛生学会学術総会
  • Place of Presentation: 京都大学吉田キャンパス,京都市
  • Year and Date: 20120324-26
• [Presentation] Effects of prenatal environmental tobacco smoke exposure on infant birth size (2011)
  • Author(s): Braimoh TS, Sasaki S, Yila TA, Baba T, Miyashita C, Okada E, Kashino I, Ito K, Kobayashi S, Yoshioka E, Kishi R
  • Organizer: The American Public Health Association (APHA) 139th Annual Meeting and Exposition
  • Place of Presentation: Washington Convention Center, USA
  • Year and Date: 20111029-1102
• [Presentation] The effects of PFOS and PROA in maternal serum on maternal and infant thyroid hormones (2011)
  • Author(s): Itoh S, Kato S, Yuasa M, Sasaki S, Yoshioka E, Kashino I, Okada E, Miyashita C, Kishi R
  • Organizer: ISEE2011
  • Place of Presentation: Palau de Congressos de Barcelona, Spain
  • Year and Date: 20110913-16
• [Presentation] 抗エストロゲン様作用PCBs曝露と出生体格との関連-環境と子どもの北海道スタディ(2)- (2011)
  • Author(s): 宮下ちひろ,佐々木成子,岡田恵美子,小林澄貴,西條泰明,吉岡英治,馬場俊明,梶原淳睦,戸髙尊,岸玲子
  • Organizer: 第81回日本衛生学会学術総会
  • Place of Presentation: 昭和大学旗の台キャンパス,東京都
  • Year and Date: 20110325-28
• [Presentation] 母体血中ダイオキシン類と6ヶ月・18ヶ月児の精神・運動発達への影響-環境と子どもの北海道スタディ(3)- (2011)
  • Author(s): 中島そのみ,佐々木成子,加藤静恵,鵜野安希子,中村裕二,仙石泰仁,梶原淳睦,西條泰明,岸玲子
  • Place of Presentation: 昭和大学旗の台キャンパス,東京都
  • Year and Date: 20110325-28
• [Presentation] 生後42ヶ月児における認知能と胎児期PCB・ダイオキシン類曝露との関連-環境と子どもの北海道スタディ(4) (2011)
  • Author(s): 小西香苗,坂晋,佐々木成子,鷲野考揚,吉岡英治,梶原淳睦,戸高尊,中島そのみ,岸玲子
  • Place of Presentation: 昭和大学旗の台キャンパス,東京
  • Year and Date: 20110325-28
• [Presentation] Relationship between AhR gene polymorphisms and dioxin concentrations in maternal blood-Hokkaido Study on Environment and Children's Health (2010)
  • Author(s): Sasaki S, Kobayashi S, Ban S, Yoshioka E, Miyashita C, Okada E, Limpar M, Yila TA, Baba T, Braimoh TS, Kashino I, Otake Y, Kanazawa A, Yuasa M, Kajiwara J, Todaka T, Kishi R
  • Organizer: ISES-ISEE 2010
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 20100828-0901
• [Presentation] Prenatal Exposure to Dioxins in Relation to Allergy and Infection in Infancy -Hokkaido Study on Environment and Children's Health- (2010)
  • Author(s): Miyashita C, Sasaki S, Yoshioka E, Yila TA, Baba T, Braimoh TS, Kashino I, Okada E, Kobayashi S, Otake Y, Limpar M, Kajiwara J, Todaka T, Kishi R
  • Organizer: ISES-ISEE 2010
  • Place of Presentation: Seoul, South Korea
  • Year and Date: 20100828-0901
• [Book] ‐発達障害と認知:読み書きの困難‐、「発達の基盤:身体、認知、情動」 (2012)
  • Author(s): 室橋春光(著)、日本発達心理学会(編)、根ヶ山光一・仲真紀子(責任編集)
  • Total Pages: 242-254
  • Publisher: 新曜社
• [Book] ‐先天奇形‐、「子どもをとりまく環境と食生活-妊娠期からのすこやかな発育・発達のために-」 (2010)
  • Author(s): 佐田文宏(著)、林謙治(監修)、加藤則子・滝本秀美・藤原武男・須藤紀子(編)
  • Total Pages: 217-256
  • Publisher: 日本小児医事出版社
• [Remarks] 北海道大学環境健康科学研究教育センター
  • URL: http://www.cehs.hokudai.ac.jp/
• [Remarks] 福岡県保健環境研究所
  • URL: http://www.fihes.pref.fukuoka.jp/