Social and health sciences fusion research for the elucidation process leading to cardiovascular disease from psychosocial factors

2013 Fiscal Year Final Research Report

• Project/Area Number: 22249022
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Osaka University
• Principal Investigator: ISO Hiroyasu 大阪大学, 医学(系)研究科(研究院), 教授 (50223053)
• Co-Investigator(Kenkyū-buntansha): OOHIRA Tetsuya 大阪大学, 医学系研究科, 招へい教授 (50448031) ; HONJYO Kaori 大阪大学, 医学系研究科, 准教授 (60448032) ; TAMAKOSHI Akiko 北海道大学, 医学系研究科, 教授 (90236737) ; INOUE Manami 東京大学, 医学系研究科, 教授 (70250248) ; KITAMURA Akihiko (財)大阪府保健医療財団大阪がん循環器病予防センター, 予防推進部 循環器病予防 健康開発部, 部長 (80450922) ; TANIGAWA Takeshi 愛媛大学, 医学系研究科, 教授 (80227214) ; YAMAGISHI Kazumasa 筑波大学, 医学系研究科, 講師 (20375504) ; SHIRAI Kokoro 琉球大学, 法文学部, 准教授 (80530211)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Keywords: 循環器疾患 / 社会疫学 / 社会心理 / 生活習慣 / バイオマーカー

Research Abstract

We found that newly identified cardiovascular risk factors such as adiponectin levels and C-reactive protein levels were associated with risk of cardiovascular disease in addition to conventional risk factors.We also identified the possible mechanism of the association between psychological factors and cardiovascular diseases;our results suggested that the association between psychological factors and risk of cardiovascular diseases could be mediated through diabetes mellitus and home high blood pressure.Areal deprivation level was associated with higher cardiovascular mortality and morbidity after adjustment for individual socioeconomic conditions.Unequal distribution of cardiovascular risk factors,in particular biological risk factors,by areal deprivation level be a mechanism of the identified association.Our results suggest that areal environment could be a crucial public health target in addition to the existing individual public health approach.