Innovation of cancer treatment based on the refractory mechanism

2012 Fiscal Year Final Research Report

• Project/Area Number: 22249050
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: TANAKA Shinji 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (30253420)
• Co-Investigator(Kenkyū-buntansha): ARII Shigeki 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (50151171) ; MOII Masaki 大阪大学, 医学(系)研究科(研究院), 教授 (70190999)
• Project Period (FY): 2010 – 2012
• Keywords: 難治性癌 / プロテアソーム / 低酸素 / 活性酸素 / 幹細胞 / マクロファージ / 転移 / 再発

Research Abstract

Hepatocellular carcinoma (HCC) is one of the aggressive malignancies mainly due to the recurrence and/or metastasisevenaftercurativeresection.Thereis emergingevidencethattumormetastasisand recurrencemight be driven by a small subpopulation of stemness cells, so-called cancer stem cells (CSCs). PreviousinvestigationsrevealedthatgliomaandbreastCSCswerefoundtoexhibitintrinsicallylowproteasomeactivity. It was reported that breast CSCs contained lower level of reactive oxygen species (ROS) than corresponding non-tumorigenic cells. We visualized two stem cell features, low proteasome activity and low intracellular ROSinHCCcells. We usedtwo-color FACSsortingtoisolatethecellswith these stemcellfeatures.Avisualized smallsubpopulationofHCCcellsdemonstratedasymmetricdivisions.TheirremarkabletumorigenicityinNOD/SCID micesuggestedthecancerinitiation potentialofthe HCCCSCs.Comprehensivegeneexpression analysisrevealedthat chemokine-related genes were upregulated in the CSCs subpopulation. Our identified HCC CSCs facilitated the migration of macrophages in vitro, and demonstrated the metastatic potentials with recruitment of macrophages in vivo. In the patients after curative operation for HCC, the CSC-specific gene signature in the liver microenvironments has a significant correlation to the recurrence. The monitoring system of the stem cell features is a promising tool to analyze the in vivo significance of CSCs microenvironments in human HCC.

Research Products

• [Journal Article] Contrast-enhanced intraoperative ultrasonography for vascular imaging of hepatocellular carcinoma; clinical and biological significance (2013)
  • Author(s): Sato K, Tanaka S, Mitsunori Y, Mogushi K,Yasen M, Aihara A, Ban D, Ochiai T, Irie T,Kudo A, Nakamura N, Tanaka H, Arii S
  • Journal Title: Hepatology Volume: 57(4) Pages: 1436-1447
  • DOI: doi:10.1002/hep.26122.
  • Peer Reviewed
• [Journal Article] The Tumor-suppressive mir-497-195 cluster targets multiple cell-cycle regulators in hepatocellular carcinoma (2013)
  • Author(s): Furuta M, Kozaki KI, Tanimoto K, Tanaka S, Arii S, Shimamura T, Niida A, Miyano S, Inazawa J
  • Journal Title: PLoS One Volume: 8(3) Pages: e60155
  • URL: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0060155
  • Peer Reviewed
• [Journal Article] Contrast-enhanced intraoperative ultrasound for hepatocellular carcinoma: high sensitivity of diagnosis and therapeutic impact (2013)
  • Author(s): Mitsunori Y, Tanaka S, Nakamura N, Ban D, Irie T, Noguchi N, Kudo A, Iijima H, Arii S
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 20(2) Pages: 234-42
  • DOI: doi:10.1007/s00534-012-0507-9.
  • Peer Reviewed
• [Journal Article] Upregulation of protein tyrosine phosphatase type IVA member 3 (PTP4A3/PRL-3) associated with tumor differentiation and a poor prognosis in human hepatocellular carcinoma (2013)
  • Author(s): Mayinuer A, Yasen M, Mogushi K, Obulhasim G, Xieraili M, Aihara A, Tanaka S, Mizushima H, Tanaka H, Arii S
  • Journal Title: Annals of Surgical Oncology Volume: 20(1) Pages: 305-17
  • DOI: doi:10.1245/s10434-012-2395-2.
  • Peer Reviewed
• [Journal Article] Epigenetic silencing of miR-335 and its host gene MEST in hepatocellular carcinoma (2013)
  • Author(s): Dohi O, Yasui K, Gen Y, Takada H, Endo M,Tsuji K, Konishi C, Yamada N, Mitsuyoshi H, Naito Y, Tanaka S, Arii S, Yoshikawa T
  • Journal Title: Int J Oncol Volume: 42(2) Pages: 411-8
  • DOI: doi:10.3892/ijo.2012.1724.
  • Peer Reviewed
• [Journal Article] Molecular targeted therapy (2012)
  • Author(s): Tanaka S, Arii S
  • Journal Title: "New Perspectives in Hepatocellular Carcinoma" Seminars in Oncology Volume: 39(6) Pages: 486-92
  • DOI: doi:10.1053/j.seminoncol.2012.05.005.
  • Peer Reviewed
• [Journal Article] Identification of pancreatic cancer stem cells and selective toxicity of chemotherapeutic agents (2012)
  • Author(s): Adikrisna R, Tanaka S, Muramatsu S, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Yamaoka S, Arii S
  • Journal Title: Gastroenterology Volume: 143(1) Pages: 234-245
  • DOI: doi:10.1111/j.1872-034X.2012.00989.x.
  • Peer Reviewed
• [Journal Article] Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor inhepatocellular carcinoma (2012)
  • Author(s): Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J
  • Journal Title: Clin Cancer Res Volume: 18(13) Pages: 3541-3551
  • DOI: doi:10.1158/1078-0432.CCR-11-1007.
  • Peer Reviewed
• [Journal Article] Multicellular tumor spheroid formation in duplex microcapsules foranalysis of chemosensitivity (2012)
  • Author(s): Sakai S, Inamoto K, Liu Y, Tanaka S, Arii S, Taya M
  • Journal Title: CancerScience Volume: 103(3) Pages: 549-54
  • DOI: doi:10.1111/j.1349-7006.2011.02187.x.
  • Peer Reviewed
• [Journal Article] Villin 1 is a predictive factor for the recurrence of high serum AFP associated hepatocellular carcinoma after hepatectomy (2012)
  • Author(s): Xieraili M, Yasen M, Mogushi K, Obulhasim G, Mayinuer A, Aihara A, Tanaka S, Mizushima H,Tanaka H, Arii S
  • Journal Title: Cancer Science Volume: 103(8) Pages: 1493-501
  • DOI: doi:10.1111/j.1349-7006.2012.02315.x.
  • Peer Reviewed
• [Journal Article] Decreased Mrp2 transport in severe macrovesicular fatty liver grafts (2012)
  • Author(s): Kudo A, Ban D, Aihara A, Irie T, Ochiai T,Nakamura N, Tanaka S, Arii S
  • Journal Title: Journal of Surgical Research Volume: 78(2) Pages: 915-21
  • DOI: doi:10.1016/j.jss.2012.04.057.
  • Peer Reviewed
• [Journal Article] rognoses of GEP-NETs with undetermined malignant potentials of their primary sites (2012)
  • Author(s): Kudo A, Akashi T, Kumagai J, Ban D, Inokuchi M, Kojima K, Kawano T, Tanaka S, Arii S
  • Journal Title: Hepatogastroenterology Volume: 59(118) Pages: 1682-6
  • URL: http://link.springer.com/article/10.1007%2Fs00535-013-0791-4
  • Peer Reviewed
• [Journal Article] The importance of clinical information inpatients with gastroenteropancreatic neuroendocrine tumor (2012)
  • Author(s): Kudo A, Akashi T, Kumagai J, Ban D, Inokuchi M, Kojima K, Kawano T, Tanaka S, Arii S
  • Journal Title: Hepatogastro- enterology Volume: 59(120) Pages: 2450-3
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22584507
  • Peer Reviewed
• [Journal Article] DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue (2012)
  • Author(s): Yasen M, Obulhasim G, Kajino K, Mogushi K, Mizushima H, Tanaka S, Tanaka H, Hino O, Ari S
  • Journal Title: International Journal of Oncology, Mar Volume: 40(3) Pages: 789-97
  • DOI: doi:10.3892/ijo.2011.1282.
  • Peer Reviewed
• [Journal Article] Splenic artery ligation: a protection against hepatic ischemia/reperfusion injury in partially hepatectomized rats (2012)
  • Author(s): Irie T, Ito K, Ozawa H, Noda Y, Ikeda S,Tanaka S, Arii S, Horikawa S
  • Journal Title: Hepatology Research Volume: 42(8) Pages: 819-27
  • DOI: doi:10.1111/j.1872-034X.2012.00989.x.
  • Peer Reviewed
• [Journal Article] Fate of metastatic foci after chemotherapy and usefulness of contrast-enhanced intraoperative ultrasonography to detect minute hepatic lesions (2012)
  • Author(s): Uetake H, Tanaka S, Ishikawa T, Sugihara K,Arii S.
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 19(5) Pages: 509-14
  • DOI: doi:10.1007/s00534-012-0510-1.
  • Peer Reviewed
• [Journal Article] Identification of pathogenesis-related microRNAs in hepatocellular carcinoma by expression profiling. (2012)
  • Author(s): Katayama Y, Maeda M, Miyaguchi K, Nemoto S,Yasen M, Tanaka S, Mizushima H, Fukuoka Y,Arii S, Tanaka H.
  • Journal Title: Oncol Lett Volume: 4(4) Pages: 817-823
  • URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3506695/
  • Peer Reviewed
• [Journal Article] Alterations of the SWI/SNF chromatin remodeling subunit-BRG1 and BRM in hepatocellular carcinoma (2012)
  • Author(s): Endo M, Yasui K, Zen Y, Gen Y, Zen K, Tsuji , Dohi O, Mitsuyoshi H, Tanaka S, Taniwaki M, Nakanuma Y, Arii S, Yoshikawa T
  • Journal Title: Liver Int Volume: 33(1) Pages: 105-172013
  • DOI: doi:10.1111/liv.12005.
  • Peer Reviewed
• [Journal Article] Oxidative stress pathways innon-cancerous human liver tissue to predict hepatocellular carcinoma recurrence;a prospective multi-center study (2011)
  • Author(s): Tanaka S, Mogushi K, Yasen M, Ban D, Noguchi N, Kudo A, Nakamura N, Tanaka H, Yamamoto M, Kokudo N, Takayama T, Kawasaki S, Sakamoto M, Arii S
  • Journal Title: Hepatology Volume: 54(4) Pages: 1273-1281
  • DOI: doi:10.1002/hep.24536.
  • Peer Reviewed
• [Journal Article] Molecular targetedtherapy for hepatocellular carcinoma in the current and potential next strategies (2011)
  • Author(s): Tanaka S, Arii S
  • Journal Title: Journal of Gastroenterology Volume: 46(3) Pages: 289-96
  • DOI: doi:10.1007/s00535-011-0387-9.
  • Peer Reviewed
• [Journal Article] Gene expression signature of the gross morphology in hepatocellular carcinoma (2011)
  • Author(s): Murakata A, Tanaka S, Mogushi K, Yasen M, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S
  • Journal Title: Annals of Surgery Volume: 253(1) Pages: 94-100
  • DOI: doi:10.1097/SLA.0b013e3181f9bc00.
  • Peer Reviewed
• [Journal Article] Importin-alpha1 as a novel prognostic target for hepatocellular carcinoma (2011)
  • Author(s): Yoshitake Y, Tanaka S, Mogushi K, Aihara A, Murakata A, Matsumura S, Mitsunori Y, Yasen M, Ban D, Noguchi N, Irie T, Kudo A, Nakamura N, Tanaka H, Arii S
  • Journal Title: Ann Surg Oncol Volume: 18(7) Pages: 2093-103
  • DOI: doi:10.1245/s10434-011-1569-7.
  • Peer Reviewed
• [Journal Article] Pancreatoduodenectomy after coronary artery bypass grafting using the right gastroepiploic artery: a case report (2011)
  • Author(s): Nakamura N, Irie T, Ochiai T, Kudo A, Itoh K, Tanaka S, Teramoto K, Arii S
  • Journal Title: Hepatogastroenterology Volume: 58(109) Pages: 1137-41
  • DOI: doi:10.5754/hge07224.
  • Peer Reviewed
• [Journal Article] Genome-wide integrative analysis revealed a correlation between lengths of copy number segments and corresponding gene expression profile (2011)
  • Author(s): Miyaguchi K, Fukuoka Y, Mizushima H, Yasen M, Nemoto S, Ishikawa T, Uetake H, Tanaka S, Sugihara K, Arii S, Tanaka H
  • Journal Title: Bioinformation Volume: 7(6) Pages: 280-284
  • URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280495/pdf/97320630007280.pdf
  • Peer Reviewed
• [Journal Article] Gene expression phenotypes for vascular invasiveness of hepatocellular carcinomas (2010)
  • Author(s): Tanaka S, Mogushi K, Yasen M, Noguchi N, Kudo A, Nakamura N, Ito K, Miki Y, Inazawa J, Tanaka H, Arii S
  • Journal Title: Surgery Volume: 147(3) Pages: 405-414
  • DOI: doi:10.1016/j.surg.2009.09.037.
  • Peer Reviewed
• [Journal Article] Novel molecular-targeted therapy for hepatocellular carcinoma (2010)
  • Author(s): Tanaka S, Arii S
  • Journal Title: Journal of Hepato-Biliary Pancreatic Surgery Volume: 7(4) Pages: 413-9
  • DOI: doi:10.1007/s00534-009-0238-8.
  • Peer Reviewed
• [Journal Article] Current status ofmolecularly targeted therapy for hepatocellular carcinoma: basic science (2010)
  • Author(s): Tanaka S, Arii S
  • Journal Title: International Journal of Clinical Oncology Volume: 15(3) Pages: 235-41
  • DOI: doi:10.1007/s10147-010-0083-4.
  • Peer Reviewed
• [Journal Article] The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma (2010)
  • Author(s): Aihara A, Tanaka S, Yasen M, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Kudo A, Nakamura N, Ito K, Arii S
  • Journal Title: Journal of Hepatology Volume: 52(1) Pages: 63-71
  • DOI: doi:10.1016/j.jhep.2009.10.013.
  • Peer Reviewed
• [Journal Article] Surgical strategies for hepatocellular carcinoma with special reference to anatomical hepatic resection and intraoperativecontrast-enhanced ultrasonography (2010)
  • Author(s): Arii S, Tanaka S, Mitsunori Y, Nakamura N, Kudo A, Noguchi N, Irie T
  • Journal Title: Oncology Volume: 78 Suppl 1 Pages: 125-30
  • DOI: doi:10.1159/000315240.
  • Peer Reviewed
• [Journal Article] miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma (2010)
  • Author(s): Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I, Inazawa J
  • Journal Title: Carcinogenesis Volume: 31(5) Pages: 766-76
  • DOI: doi:10.1093/carcin/bgp250.
  • Peer Reviewed
• [Journal Article] Preservation solutions alter mrp2-dependent bile flow in cold ischemic rat livers (2010)
  • Author(s): Sui S, Kudo A, Suematsu M, Tanaka S, Nakamura N, Ito K, Arii S
  • Journal Title: Journal of Surgical Research Volume: 159(1) Pages: 572-581
  • DOI: doi:10.1016/j.jss.2008.12.043.
  • Peer Reviewed
• [Journal Article] PEG10 is a probable target for the amplification at 7q21 detected in hepatocellular carcinoma (2010)
  • Author(s): Tsuji K, Yasui K, Gen Y, Endo M, Dohi O, Zen K, Mitsuyoshi H, Minami M, Itoh Y, Taniwaki M, Tanaka S, Arii S, Okanoue T, Yoshikawa T
  • Journal Title: Cancer Genetics and Cytogenetics Volume: 198(2) Pages: 118-25
  • DOI: doi:10.1016/j.cancergencyto.2010.01.004.
  • Peer Reviewed
• [Journal Article] Analogy between sphere forming ability and stemness of human hepatoma cells (2010)
  • Author(s): Uchida Y, Tanaka S, Aihara A, Adikrisna R, Yoshitake K, Matsumura S, Mitsunori Y, Murakata A, Noguchi N, Irie K, Kudo A, Nakamura N, Lai PB, Arii S
  • Journal Title: Oncology Reports Volume: 24 Pages: 1147-51
  • DOI: doi:10.3892/or_00000966
  • Peer Reviewed
• [Journal Article] Visualization of stem cell features in human hepatocellular carcinoma enlightened in vivo significance of tumor-host interaction and clinical implication
  • Author(s): Muramatsu S, Tanaka S, Mogushi K, Adikrisna R, Aihara A, Ban D, Ochiai T, Irie T, Kudo A, Nakamura N, Tanaka H, Nakayama K, Tanaka H, Yamaoka S, Arii S
  • Journal Title: Hepatology Volume: (in press)
  • DOI: doi:10.1002/hep.26345.
  • Peer Reviewed
• [Journal Article] Up-regulation of dbpA mRNA in hepatocellular carcinoma associated with metabolic syndrome
  • Author(s): Obulhasim G, Yasen M, Kajino K, Mogushi K, Tanaka S, Mizushima H, Tanaka H, Arii S, Hino O
  • Journal Title: Hepatology International Volume: (in press)
  • DOI: DOI 10.1007/s12072-012-9357-4.
  • Peer Reviewed
• [Journal Article] Mitochondrial metabolism in the noncancerous liver determine the occurrence of hepatocellular carcinoma: a prospective study
  • Author(s): Kudo A, Mogushi K, Takayama T, Matsumura S, Ban D, Irie T, Ochiai T, Nakamura N, Tanaka H, Anzai N, Sakamoto M, Tanaka S, Arii S
  • Journal Title: J Gastroenterol Volume: (in press)
  • URL: http://link.springer.com/article/10.1007%2Fs00535-013-0791-4
  • Peer Reviewed
• [Presentation] ワークショップ「進行肝細胞癌の治療」高度進行肝細胞癌に対する治療戦略 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第74回日本臨床外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-12-01
• [Presentation] シンポジウム「がん幹細胞の検出と生物学的意義」招待講演.がん幹細胞の生物学的特徴に基づいた根治的治療開発 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第23回日本消化器癌発生学会総会
  • Place of Presentation: 徳島
  • Year and Date: 2012-11-15
• [Presentation] シンポジウム「分子標的治療の限界を超える新しい肝癌治療法の開発」VEGF非依存性メカニズムに基づいた肝癌分子標的治療の開発 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-10
• [Presentation] パネルディスカッション「消化器癌と酸化ストレス」多施設共同前向き研究に よる肝癌再発の解析と酸化ストレス・パスウェイの同定 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第16回日本肝臓学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-10
• [Presentation] JCA-Mauvernay Award 受賞講演.Surgical oncology to develop novel targeted therapies for advanced digestive cancer (2012)
  • Author(s): Tanaka S
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] Symposia: Molecular targeting to cancer stem cell/cancer initiating. Real-time imaging of pancreatic cancer stem cells to identify the selectively targeting therapy (2012)
  • Author(s): Tanaka S, et al
  • Organizer: 第71回日本癌学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-19
• [Presentation] 基調シンポジウム『肝癌の分子病理学的個別化診断の現状と将来展望』指定演題.切除標本を用いたバイオマーカー・分子標的の探索 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第48回日本肝癌研究会
  • Place of Presentation: 金沢
  • Year and Date: 2012-07-20
• [Presentation] ワークショップ「臨床応用に向 かう消化器外科領域基礎研究」多施設共同前向き研究による肝癌バイオマーカーの同定と応用展開 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第67回日本消化器外科学会総会
  • Place of Presentation: 富山
  • Year and Date: 2012-07-19
• [Presentation] ワークショップ「肝再生、幹細胞研究が臨床医学にもたらす可能性」幹細胞特性の可視化に基づいたヒト肝癌細胞の解析 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2012-06-07
• [Presentation] ミニシンポジウム「肝癌」肝細胞癌に対する系統的肝切除およびSurgical Marginの意義と術中造影超音波検査の有用性 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第24回日本肝胆膵外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-05-30
• [Presentation] シンポジウム「治療抵抗性固形癌の克服に向けた基礎研究」指定演題.難治性消化器癌における幹細胞特性の可視化に基づいた治療開発 (2012)
  • Author(s): 田中真二、他
  • Organizer: 第112回日本外科学会定期学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2012-04-13
• [Presentation] Asia-Pacific Symposium,国際シンポジウム、招待講演.Angiogenesis and stemness potentials in hepatocellularcarcinoma (2011)
  • Author(s): Tanaka S, et al
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2011-12-10
• [Presentation] Symposium: Liver Pathology.Gene expression signature and the specific role of EpCAM stem cell marker in grossmorphology of hepatocellular carcinoma.21st World Congress of the International Association of Surgeons (2011)
  • Author(s): Tanaka S, et al
  • Organizer: Gastroenterologists and Oncologists
  • Place of Presentation: 東京
  • Year and Date: 2011-11-10
• [Presentation] パネルディスカッション「がん幹細胞研究の進展と治療展開」指定講演.ヒト固形癌の休眠型癌幹細胞の特性に基づいた解析と治療開発 (2011)
  • Author(s): 田中真二、他
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-27
• [Presentation] パネルディスカッション「消化器癌の悪性度・予後における分子診断」幹細胞性GSEA/パスウェイ解析に基づいた肝癌臨床への展開 (2011)
  • Author(s): 田中真二、他
  • Organizer: 第9回日本消化器外科学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-23
• [Presentation] English Oral Sessions; Hepatocellular cancer (1). Molecular targets identified by omics analysis topredict the recurrence of hepatocellular carcinoma (2011)
  • Author(s): Tanaka S, et al
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] シンポジウム「肝細胞癌の再発機構の解明と対策」指定講演.肝細胞癌の再発様式と遺伝子発現パターンから見た再発機序の解明 (2011)
  • Author(s): 田中真二、他
  • Organizer: 第47回日本肝癌研究会
  • Place of Presentation: 静岡
  • Year and Date: 2011-07-28
• [Presentation] ワークショップ「消化器癌に対する分子生物学の臨床応用(肝胆膵・上部消化 管)」肝胆膵癌の包括的オミックス解析による臨床応用 (2011)
  • Author(s): 田中真二、他
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-15
• [Presentation] シンポジウム「進行肝癌に対する治療戦略と手術の実際」進行肝癌に対する治療方針と集学的治療の意義 (2011)
  • Author(s): 田中真二、他
  • Organizer: 第23回日本肝胆膵外科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-10
• [Presentation] シンポジウム「テーラーメイド医療時代へ向けた肝癌治療」肝癌の臨床解析に基づく治療戦略 (2011)
  • Author(s): 田中真二、他
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-03
• [Presentation] Gene expression signature of the non-cancerous liver tissue associated with the early recurrence of hepatocellular carcinoma (2011)
  • Author(s): Tanaka S, et al
  • Organizer: 102nd Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Orlando, FL, USA
  • Year and Date: 2011-04-03
• [Presentation] Microenvironment and stemness potentials in hepatocellular carcinoma (2011)
  • Author(s): Tanaka S, et al
  • Organizer: The 3rd JCA-AACR Special Joint Conference
  • Place of Presentation: Maihama, Japan
  • Year and Date: 2011-03-03
• [Presentation] パネルディスカッション「肝細胞がん治療アルゴリズムの再考:薬剤療法の位置づけ」Adjuvant therapyの適応:非癌部遺伝子発現プロファイルによる肝細胞癌の早期再発予測 (2010)
  • Author(s): 田中真二、他
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] シンポジウム「肝細胞癌治療のこれからの展開」肝細胞癌治療における外科治療の位置付けと方向性 (2010)
  • Author(s): 田中真二、他
  • Organizer: 第14回日本肝臓学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2010-10-13
• [Presentation] English Workshop;Gastroenterological cancer. EpCAM, a molecular target associated with the gross morphology in hepatocellular carcinoma (2010)
  • Author(s): Tanaka S, et al
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] 特別企画「消化器外科領域にお けるリサーチの重要性-具体的アプローチについて-」外科臨床に基づいた肝胆膵癌の分子生物学的解析 (2010)
  • Author(s): 田中真二、他
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関
  • Year and Date: 2010-07-15
• [Presentation] シンポジウム「消化器癌転移のメカニズムに基づいた新たな治療標的分子の 探索」臨床検体オミックス解析に基づく転移分子ネットワークの同定と分子標的治療への展開 (2010)
  • Author(s): 田中真二、他
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関
  • Year and Date: 2010-07-15
• [Presentation] シンポジウム「肝細胞癌の分子標的探索と臨床応用」外科臨床に基づく肝癌分子標的の解析と臨床展開 (2010)
  • Author(s): 田中真二、他
  • Organizer: 第46回日本肝臓学会総会
  • Place of Presentation: 山形
  • Year and Date: 2010-05-28
• [Presentation] ミニシンポジウム.転移性肝癌の治療戦略.大腸癌肝転移に対する肝切除:Bevacizumab併用化学療法と術中造影超音波検査の有用性 (2010)
  • Author(s): 田中真二、他
  • Organizer: 第22回日本肝胆膵外科学会
  • Place of Presentation: 仙台
  • Year and Date: 2010-05-27
• [Presentation] Gene expression signature of the non-cancerous liver tissue associated with the early recurrence ofhepatocellular carcinoma (2010)
  • Author(s): Tanaka S, et al
  • Organizer: 101st Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2010-04-19
• [Presentation] パネルディスカッション「オン コロジストとして外科医に求められる基礎研究とは何か」外科臨床に基づいた難治性消化器癌の分子標的治療の開発 (2010)
  • Author(s): 田中真二、他
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-08
• [Presentation] シンポジウム「肝発癌・進展機序研究に与える幹細胞学のインパクト」幹細胞の機能的特性を基盤とした肝癌のニッチ解析と臨床的意義
  • Author(s): 田中真二、他
  • Organizer: 第10回日本消化器外科学会大会
  • Place of Presentation: 神戸
• [Book] 肝細胞癌の早期診断:画像と分子マーカー (2012)
  • Author(s): 有井滋樹
  • Total Pages: 265
  • Publisher: 松井修(監・編集)株式会社アークメディア
• [Book] Cell-enclosing microparticles and microcapsules production using a water-immiscible fluid under laminar flow and application to cell therapy. in Bioencapsulation of Living Cells for Diverse Medical Applications, ed
  • Author(s): Sakai S, Tanaka S, Kawakami K, Arii S.(Bentham E-book)
  • Publisher: Dangerfield J, Brandtner EM. in press
• [Patent(Industrial Property Rights)] Identification of cancer stem cells and selective toxicity of chemotherapeutic agents (2012)
  • Inventor(s): 田中真二、有井滋樹
  • Industrial Property Rights Holder: 田中真二、有井滋樹
  • Industrial Property Number: 特許、特願2012-227496
  • Filing Date: 2012-10-12