2012 Fiscal Year Final Research Report
Molecular basis of aberrant cellular pathways in gastrointestinal cancer and its application to diagnosis and treatment
| Project/Area Number |
22249051
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAKAMI Kazuyuki 金沢大学, がん進展制御研究所, 准教授 (00293358)
OHTA Tetsuo 金沢大学, 大学院・医学系研究科, 教授 (40194170)
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| Co-Investigator(Renkei-kenkyūsha) |
OHNO Hiroshi 理化学研究所, 免疫系構築研究チーム, チームリーダー (50233226)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 大腸がん / 細胞特性 / 分子特性 / 診断 / 治療 |
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| Research Abstract |
This study clarified the distinct pathologic roles of oncogenic β-catenin signaling in colorectal cancer (CRC) from the new biological points of view. They include putative pathologic role for coding region determinant-binding protein (CRD-BP), a novel transcriptional target of β-catenin/Tcfcomplex, in promoting CRC by mediating interaction between Wnt and hedgehog pathways; and the causative relationship among loss of cell polarity, cell adhesion disorder and oncogenic activation of β-catenin in CRC tumorigenesis. We also demonstrated the therapeutic effects of GSK3β inhibition against invasion of gastrointestinal (GI) cancer cells and their resistance to therapies, and uncovered the molecular basis for the novel traetment of GI cancer by targeting GSK3β.
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[Presentation] Deregulated GSK3β sustains gastrointestinal cancer cells by modulating hTERT and telomerase.2012
Author(s)
Minamoto T, Mai W, Kyo S, Shakoori A, Miyashita K, Yokoi K, Shimasaki T, Motoo Y, Kawakami K.
Organizer
103rd Annual Meeting of American Association for Cancer Research
Place of Presentation
McCormick Place, Chicago, Illinois, U.S.A.
Year and Date
20120331-0404
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[Presentation] Interleukin-1β is a signal for Trefoil factor 2 promoter methylation in gastric preneoplasia.2011
Author(s)
Menheniott TR, O'Connor L, Minamoto T, - 6 -Kawakami K, Tomita H, Fox JG, Wan g TC,Judd LM, Giraud AS
Organizer
DDW 2011
Place of Presentation
McCormick Place, Chicago, Illinois, U.S.A.
Year and Date
20110507-10
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[Presentation] Pathological role for deregulated GSK3β in pancreatic cancer proliferation and invasion.2010
Author(s)
Kitano A, Shimasaki T, Chikano Y, Nakada M, Higashi T, Ishigaki Y, Sai Y, Miyamoto K, Motoo Y, Kawakami K, Minamoto T
Organizer
The Joint Symposium of the 5thInternational Symposium of Institute Network and the International Symposium of Commemorating Inauguration of Kanazawa University Cancer Research Institute
Place of Presentation
KKRホテル金沢,石川
Year and Date
20100624-25
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[Presentation] Giraud. TFF2 inhibits tumour growth and is a target for epigenetic silencing in gastric cancer.2010
Author(s)
Menheniott T, Peterson AJ, O'Connor L, Wan g TC, Fox JG, Minamoto T, Kawakami K, Judd LM, Andrew S
Organizer
DDW 2010
Place of Presentation
Ernest N. Morial Convention Center, New Orleans, Louisiana, U.S.A.
Year and Date
20100501-06
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