2013 Fiscal Year Final Research Report
Molecular and physiological approach for addressing the mechanisms of micrometastasis of carcinoma cells within the sentinel lymph node
| Project/Area Number |
22249052
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAWAI Yoshiko 信州大学, 医学部, 准教授 (10362112)
NAGAI Takashi 信州大学, 医学部, 助教 (50514353)
AJIMA Kumiko 信州大学, 医学部, 助教 (70584051)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 循環生理学 / リンパ系 / 癌転移 / リンパ節 / 微小環境 |
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| Research Abstract |
We have considered the sentinel lymph node (SLN) to be constantly subjected to a high lymph flow rate. According to their physiological and biomechanical characteristics, thus we hypothesized that SLN contains lymphatic endothelial cells (LEC) that are constantly loaded with high levels of shear stress. To test this hypothesis, we investigated the effects of shear stress stimulation on the expression of adhesion molecules on human LEC isolated from the lymph vessels nearest the SLN of breast cancers, and on the release of ATP from human LEC. In conclusion, shear stress stimulation induces ICAM-1 expression on human LEC by activity cell surface F1/FO ATP synthase, which might contribute to the development of premetastatic environment within SLN.
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Research Products
(66 results)
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[Journal Article] Tumour PDGF-BB expression levels determine dual effects of anti-PDGF drugs on vascular remodelling and metastasis2013
Author(s)
Hosaka K, Yang Y, Seki T, Nakamura M, Andersson P, Rouhi P, Yang X, Jensen L, Lim S, Feng N, Xue Y, Li X, Larsson O, Ohhashi T, Cao Y
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Journal Title
Nat. Comm
Volume: 4, article number : 2129
Peer Reviewed
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[Journal Article] Thrombin activates Ca2+-permeating nonselective cation channels through protein kinase C in human umbilical vein endothelial cells2011
Author(s)
Tsujino N, Nakada T, Tsubouchi K, Kobayashi M, Kawai Y, Yano S, Matsunaga T, Hirose M, Ohmori S, Ohhashi T, Yamada M
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Journal Title
Shinshu Medical Journal
Volume: 59(1)
Pages: 13-26
Peer Reviewed
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