2012 Fiscal Year Final Research Report
Strategic research for elucidation of molecular pathophysiology and identification of therapeutic target of lumbar spondylosis
| Project/Area Number |
22249056
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TOKUNAGA Katsushi 東京大学, 医学系研究科, 教授 (40163977)
AKUNE Toru 東京大学, 医学部附属病院, 特任准教授 (60282662)
TAKESHITA Katsushi 東京大学, 医学部附属病院, 准教授 (30262009)
SAITO Taku 東京大学, 医学部附属病院, 特任准教授 (30456107)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脊椎脊髄病学 / 変形性腰椎症 |
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| Research Abstract |
We identified two candidate genes associated with lumbar spondylosis by GWAS of our cohort. These genes were abundantly expressed in mouse and human anulus fibrosus of intervertebral disc, and their expression was decreased with the degeneration of intervertebral disc. We have established conditional knockout mice of the two genes and are analyzing their functional roles.
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[Journal Article] Lack of a chondroprotective effect of cyclooxygenase 2 inhibition in a surgically induced model of osteoarthritis in mice.2012
Author(s)
Fukai A, Kamekura S, Chikazu D, Nakagawa T, Hirata M, Saito T, Hosaka Y, Ikeda T, Nakamura K, Chung UI, and Kawaguchi H:
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Journal Title
Arthritis Rheum-US
Volume: 64
Pages: 198-203
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[Journal Article] C/EBP-β and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as theinducer in chondrocytes.2012
Author(s)
Hirata M, Kugimiya F, Fukai A, Saito T, Yano F, Ikeda T, Mabuchi A, Sapkota BR, Akune T, Nishida N, Yoshimura N, Nakagawa T, Tokunaga K, Nakamura K, Chung UI, and Kawaguchi H
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Journal Title
Hum Mol Genet
Volume: 21
Pages: 1111-1123
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[Journal Article] SP7 inhibits osteoblast differentiation at a latestage in mice.2012
Author(s)
Yoshida CA, Komori H, Maruyama Z, Miyazaki T, Kawasaki K, Furuichi T, Fukuyama R, Mori M, Yamana K, Nakamura K, Liu W, Toyosawa S, MoriishiT, Kawaguchi H, Takada K, Komori T
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Journal Title
PLoS ONE
Volume: 7
Pages: e32364
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[Journal Article] Gli1 participates in the hedgehog-mediated specification of the osteoblast lineage during endochondralossification.2012
Author(s)
Hojo H, Ohba S, Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, and Ung-il Chung
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Journal Title
J Biol Chem
Volume: 287
Pages: 17860-17869
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[Journal Article] Prevalence of symptomatic lumbar spinal stenosis and its association with physical performance in apopulation-based cohort in Japan: The Wakayama Spine Study.2012
Author(s)
Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, OkaH, Kawaguchi H, Nakamura K, Akune T, Yoshida M
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Journal Title
Osteoarthritis Cartilage
Volume: 20
Pages: 1103-1108
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[Journal Article] Physical performance, bone and joint diseases, and incidence of falls in Japanese men and women
Author(s)
Muraki S, Akune T, Oka H, Ishimoto Y, Nagata K, Yoshida M, Tokimura F, Nakamura K, Kawaguchi H, Yoshimura N
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Journal Title
A longitudinal cohort study. Osteoporosis Int (inpress)
DOI
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[Journal Article] Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line C3H10T1/2 by modulating bone morphogenetic protein(BMP) signaling.
Author(s)
Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung UI, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, and Hoshi K
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Journal Title
J Cell Physiol
Volume: (in press)
DOI
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[Journal Article] A novel disease-modifying osteoarthritis drug candidate targeting Runx1.
Author(s)
Yano F, Hojo H, Ohba S, Fukai A, Hosaka Y, Ikeda T, Saito T, Hirata M, Chikuda H,Takato T, Kawaguchi H, and Chung UI
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Journal Title
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[Journal Article] Poly(2-methacryloyloxyethyl phosphorylcholine)-grafted highlycross-linked polyethylene liner in primary total hip replacement: One-year results of a prospective cohort study.
Author(s)
Takatori Y, Moro T, Kamogawa M, Oda H, Morimoto S, Umeyama T, Minami M, Sugimoto H, Nakamura S, Karita T, Kim J, Koyama Y, Ito H, Kawaguchi H, and Nakamura K
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Journal Title
J Artif Organs
Volume: (in press)
DOI
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[Presentation] RBPjκ-dependent Notch signaling in chondrocytes modulates skeletal growth and osteoarthritis development.
Author(s)
Hosaka Y, Saito T, Sugita S, Fukai A, Hikata T, Akiyama H, Nakamura T, Nakamura K, Chung UI, Kawaguchi H
Organizer
2012 Cold Spring Harbor Asia Conference: Bone & Cartilage: From Development to Human Diseases. 2012. 6. 11-15 (Suzhou, China).
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[Presentation] Gli1 participates in the Indian Hedgehog-mediated osteogenesis during endochondral ossification. 2012 American Society for Bone and Mineral Research (ASBMR).
Author(s)
Hojo H, Ohba S, Yano F, Saito T, Ikeda T,Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Takato T, Kawaguchi H, Chung UI
Organizer
2012. 10.12-15 (Minneaplis, Minnesota, USA).
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[Presentation] Osteo-chondrogenic function of BMP isdirected toward osteogenesis by Hh-Gli1 in the perichondrium.
Author(s)
Hojo H, Ohba S, Taniguchi K, Shirai M,Yano F, Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N, Suzuki K, Mishina Y, Yamada M, Konno T, Takato T, Kawaguchi H, Kambara H, Chung UI
Organizer
2012 American Society for Bone and Mineral Research (ASBMR).2012. 10.12-15 (Minneaplis, Minnesota, USA).
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