2012 Fiscal Year Final Research Report
Regenerative therapy following severe insults : Establishment of cell transplantation in the blood
| Project/Area Number |
22249060
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Osaka University |
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Principal Investigator |
OGURA Hiroshi 大阪大学, 医学系研究科, 准教授 (70301265)
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| Co-Investigator(Kenkyū-buntansha) |
KUWAGATA Yasuyuki 大阪大学, 医学系研究科, 招へい教授 (50273678)
MATSUMOTO Naoya 大阪大学, 医学部附属病院, 助教 (50359808)
TASAKI Osamu 長崎大学, 長崎大学病院, 教授 (90346221)
IRISAWA Tarou 大阪大学, 医学部附属病院, 特任助教 (50379202)
TAHARA Kenichi 大阪大学, 医学部附属病院, 特任助教 (30570361)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 侵襲 / 再生 / 血管内皮 / 骨髄間質細胞 / 移植 / 前駆細胞 / 治療 / 多臓器障害 |
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| Research Abstract |
The objectives of this study were to evaluate the pathophysiology and regenerative response of endothelium after various severe insults and to examine the effects of intravascular transplantation of various stem cells in rats. Transplantation of mesenchymal stem cells protect against endothelial damage and improve survival in a rat model with multiple organ dysfunction syndrome. Our established co-culture system clarified that some regenerative factors produced by mesenchymal stem cells directly inhibit the endothelial damage. We also clarified that transplantation of bone marrow derived mononuclear cells exerted anti-inflammatory effects and improved the survival in a rat model of crush injury.
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