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2012 Fiscal Year Final Research Report

Regenerative therapy following severe insults : Establishment of cell transplantation in the blood

Research Project

  • PDF
Project/Area Number 22249060
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionOsaka University

Principal Investigator

OGURA Hiroshi  大阪大学, 医学系研究科, 准教授 (70301265)

Co-Investigator(Kenkyū-buntansha) KUWAGATA Yasuyuki  大阪大学, 医学系研究科, 招へい教授 (50273678)
MATSUMOTO Naoya  大阪大学, 医学部附属病院, 助教 (50359808)
TASAKI Osamu  長崎大学, 長崎大学病院, 教授 (90346221)
IRISAWA Tarou  大阪大学, 医学部附属病院, 特任助教 (50379202)
TAHARA Kenichi  大阪大学, 医学部附属病院, 特任助教 (30570361)
Project Period (FY) 2010-04-01 – 2013-03-31
Keywords侵襲 / 再生 / 血管内皮 / 骨髄間質細胞 / 移植 / 前駆細胞 / 治療 / 多臓器障害
Research Abstract

The objectives of this study were to evaluate the pathophysiology and regenerative response of endothelium after various severe insults and to examine the effects of intravascular transplantation of various stem cells in rats. Transplantation of mesenchymal stem cells protect against endothelial damage and improve survival in a rat model with multiple organ dysfunction syndrome. Our established co-culture system clarified that some regenerative factors produced by mesenchymal stem cells directly inhibit the endothelial damage. We also clarified that transplantation of bone marrow derived mononuclear cells exerted anti-inflammatory effects and improved the survival in a rat model of crush injury.

  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Systemic involvement of high-mobility group box l protein and therapeutic effect of anti-high-mobility group box 1 protein antibody in a rat model of crush injury2012

    • Author(s)
      Shimazaki J, Matsumoto N, Ogura H, Muroya T, Kuwagata Y, Nakagawa J, Yamakawa K, Hosotsubo H, Imamura Y, Shimazu T
    • Journal Title

      Shock

      Volume: Vol. 37 Pages: 634-8

    • Peer Reviewed
  • [Presentation] ラット敗血症モデルに対する経静脈的骨髄間質細胞移植とその血管内皮保護効果2012

    • Author(s)
      松本直也、小倉裕司, ら
    • Organizer
      第40回日本救急医学会
    • Place of Presentation
      東京
    • Year and Date
      2012-11-15
  • [Presentation] クラッシュ症候群ラットモデルに対する抗HMGB-1抗体治療の有効性2011

    • Author(s)
      島崎淳也、松本直也、小倉裕司, ら
    • Organizer
      第39回日本救急医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-19
  • [Presentation] 重症敗血症に対する新たな抗炎症治療の開発(骨髄間質細胞移植、脳症へのIL-1ra治療)2011

    • Author(s)
      松本直也、小倉裕司, ら
    • Organizer
      第39回日本救急医学会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-18
  • [Presentation] ラット敗血症・多臓器不全モデルにおける骨髄間質細胞移植による抗炎症効果の評価2010

    • Author(s)
      松本直也、小倉裕司, ら
    • Organizer
      第38回日本救急医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-09

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Published: 2014-08-29   Modified: 2015-06-25  

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