2012 Fiscal Year Final Research Report
Study of the mechanisms of GABAergic neurotransmission using inducible glutamate decarboxylase knockout mice
| Project/Area Number |
22300105
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Gunma University |
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Principal Investigator |
YANAGAWA Yuchio 群馬大学, 大学院・医学系研究科, 教授 (90202366)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKIZAKI Toshikazu 群馬大学, 大学院・医学系研究科, 助教 (50375531)
MIWA Hideki 群馬大学, 大学院・医学系研究科, 助教 (80468488)
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| Project Period (FY) |
2010 – 2012
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| Keywords | GABA / グルタミン酸脱炭酸酵素 / 誘導型遺伝子欠損マウス / GAD65 / GAD67 |
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| Research Abstract |
GABA is a major inhibitory neurotransmitter and is synthesized by glutamate decarboxylases, GAD65 and GAD67. We tried to generate inducible GAD67 knockout mice in order to clarify the role of GAD67 in the CNS. We characterized GAD67-tTA2 mice used for inducible knockout mice, and demonstrated that the GAD67-tTA2 mice were useful for expressing functional probes or fluorescent proteins in a part of GABAergic neurons.
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[Journal Article] Two specific populations of GABAergic neurons originating from the medial and the caudal ganglionic eminences aid in proper navigation of callosal axons2013
Author(s)
Niquille M, Shilpi Minocha S, Hornung JP, Rufer N, Valloton D, Kessaris N, Alfonsi F, Vitalis T, Yanagawa Y, Devenoges C, Dayer A, Lebrand C
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Journal Title
Develop Neurobiol
Volume: (in press)
Peer Reviewed
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[Journal Article] Expanding the repertoire of optogenetically targeted cells with an enhanced gene expression system2012
Author(s)
Tanaka KF, Matsui K, Sasaki T, Sano H, Sugio S, Fan K, Hen R, Nakai J, Yanagawa Y, Hasuwa H, Okabe M, Deisseroth K, Ikenaka K, Yamanaka A
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Journal Title
Cell Rep
Volume: 2
Pages: 397-406
Peer Reviewed
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[Journal Article] The physiological roles of vesicular GABA transporter during embryonic development: a study using knockout mice2010
Author(s)
Saito K, Kakizaki T, Hayashi R, Nishimaru H, Furukawa T, Nakazato Y, Takamori S, Ebihara S, Uematsu M, Mishina M, Miyazaki JI, Yokoyama M, Konishi S, Inoue K, Fukuda A, Fukumoto M, Nakamura K, Obata K, Yanagawa Y
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Journal Title
Molecular Brain
Volume: 3
Pages: 40
Peer Reviewed
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[Journal Article] Secretagogin is a Ca^<2+>-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon2010
Author(s)
Mulder J, Spence L, Tortoriello G, DiNieri JA, Uhlen M, Shui B, Kotlikoff MI, Yanagawa Y, Aujard F, Hokfelt T, Hurd YL, Harkany T
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Journal Title
Eur J Neurosci
Volume: 31
Pages: 2166-2177
Peer Reviewed
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[Presentation] Synapse formation, functional integration, and seizure suppression following engraftment of MGE progenitors in the dentate gyrus of mice with temporal lobe epilepsy2012
Author(s)
Tagliatela S, Gupta J, Woods N, Livina E, Zheng XT, Vallo M, Lin D, Maisano X, Yanagawa Y, Aaron GB, Naegele JR
Organizer
42nd Annual Meeting of the Society for Neuroscience
Place of Presentation
New Orleans, USA
Year and Date
20121013-17
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