2012 Fiscal Year Final Research Report
Roles of mTOR in neuronal development, synaptic plasticity and learning and memory
| Project/Area Number |
22300106
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AIBA Atsu 東京大学, 大学院・医学系研究科, 教授 (20271116)
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| Co-Investigator(Kenkyū-buntansha) |
KASSAI Hidetoshi 東京大学, 大学院・医学系研究科, 助教 (40403232)
HARADA Takeshi 東京大学, 大学院・医学系研究科, 助教 (30362768)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 脳・神経 / 遺伝学 / シグナル伝達 / 神経科学 |
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| Research Abstract |
Aberrant activation of mTOR pathway has been found in many human neurological diseases such as tuberous sclerosis and autism. To determine mTOR function in neurons, transgenic mice having constitutively active mTOR mutant were generated and analyzed. Forebrain-specific active mTOR transgenic mice displayed epileptic seizure and neurodegeneration. Abnormalities of both neuronal morphology and synapse elimination were induced by the activation of mTOR pathway in cerebellar Purkinje cells. These results will provide insights into pathogenic mechanisms of human diseases.
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Asahara S, Shibutani Y, Teruyama K, Inoue HY, Kawada Y, Etoh H, Matsuda T, Kimura-Koyanagi M, Hashimoto N, Sakahara M, Fujimoto W, Takahashi H, Ueda S, Hosooka T, Satoh T, Inoue H, Matsumoto M, Aiba A, Kasuga M, Kido Y
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Journal Title
Mechanisms of Development
Volume: 129
Pages: 38-50
DOI
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Volume: 119
Pages: e45-56
DOI
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Volume: 120
Pages: 2672-2683
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[Journal Article] Crucial role of the small GTPase Rac1 in insulin-stimulated translocation of glucose transport 4 to the mouse skeletal muscle sarcolema.2010
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Volume: 24
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