2012 Fiscal Year Final Research Report
Local circuit of a motor areas: For network analysis to theoretical modeling
| Project/Area Number |
22300113
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Keywords | 神経解剖学 / 運動皮質 / 神経回路網 / 遺伝子工学 / 理論構築 |
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| Research Abstract |
We examined the local circuit of the motor-associated cerebral cortex morphologically by combining the molecular biological technique, such as transgenic animals and viral vectors, with the intracellular labeling method of sharp electrode and whole cell recording. From the experimental results, we propose that partially overlapping two circuits are embedded in the cerebral cortex:1) thalamic nuclei -> layer 4 -> layer 2/3 -> layer 5 -> subcortical output, or thalamic nuclei -> layer 4 -> layer 2/3 -> other cortical areas;2) thalamic nuclei -> layer 4 -> layer 6 -> thalamic nuclei.The former circuit is likely to be used for the feedforward information processing, and the latter one constitutes a dynamical system which may be associated with the autonomous activity of the corticothalamic loop. In addition to the information processing circuit for the cerebellar inputs in motor-associated areas, the basal ganglia information to layer 1 separately enters the apical dendrites of layer 2/3 and layer 5 pyramidal neurons via motor thalamic nuclei (IZ and VM), and probably prepares the cortical activity for motor control. Finally, the dynamical system may be helpful in keeping the autonomous activity that is required for the motor control system.
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[Journal Article] Differential expression of VGLUT1 or VGLUT2 in the trigeminothalamic or trigeminocerebellar projection neurons in the rat2013
Author(s)
Ge S-N, Li Z-H, Tang J, Ma Y, Hioki H, Zhang T, Lu Y-C, Zhang F-X, Mizuno N, Kaneko T, Liu Y-Y, Lung MSY, Gao G-D,Li J-L
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Journal Title
Brain Structure and Function
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Local connections of excitatory neurons to corticothalamic neurons in the rat barrel cortex.2011
Author(s)
Tanaka YR, Tanaka YH, Konno M,Fujiyama F, Sonomura T, Okamoto-FurutaK, Kameda H, Hioki H, Furuta T,Nakamura KC, Kaneko T
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Journal Title
Journal of Neuroscience
Volume: vol. 31 (no. 50)
Pages: 18223-28236
DOI
Peer Reviewed
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[Presentation] 運動系視床皮質投射の神経回路2013
Author(s)
倉本恵梨子, 藩世秀, 大野幸, 田中康裕、 雲財知, 古田貴寛, 日置寛之, 中村公一、 藤山文乃, 金子武嗣
Organizer
第118回 日本解剖学会・全国学術集会
Place of Presentation
高松
Year and Date
20130328-30
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