2013 Fiscal Year Final Research Report
Positive and negative regulations of cytoskeletal dynamism and neuronal lifespan
| Project/Area Number |
22300121
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MORI Nozomu 長崎大学, 医歯(薬)学総合研究科, 教授 (00130394)
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| Co-Investigator(Kenkyū-buntansha) |
MASAHIKO Sibazaki 長崎大学, 医歯薬学総合研究科, 助教 (20445109)
SHO Kakizawa 長崎大学, 医歯薬学総合研究科, 講師 (40291059)
KYOJI Ohyama 長崎大学, 医歯薬学総合研究科, 准教授 (00255423)
KUNIHIKO Yasuda 長崎大学, 医歯薬学総合研究科, 助教 (50278446)
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| Co-Investigator(Renkei-kenkyūsha) |
YOKO Hiraishi-yamaguchi 長崎大学, 先導生命研究センター (50311345)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 老化 / 寿命 / 脳 / 神経可塑性 / シグナル伝達 / 蛋白質凝集 / アセチル化 |
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| Research Abstract |
While we explored functional deficits in the newly made N-Shc and Grit/RICS double KO mice, we were unable to define a specific phenotype. However, in ShcB deficient mice, we found a unique change in cerebellar-dependent motor learning, which was associated with reduced long-term depression as well as a deficit in calcium release from the endoplasmic reticulum store of Purkinje cells. We also examined a potential role of Mdm20, an auxiliary subunit of protein N-terminal acetyl transferase, and found that Mdm20 promotes polyQ aggregation via inhibiting autophagy through affecting serine-473 phosphorylation of AKT, an upstream kinase in the regulation of cytoplasmic proteostasis. These results suggest that neural enriched ShcB and Mdm20 play independent roles in neuronal synaptic plasticity and proteostasis, respectively.
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Research Products
(26 results)
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[Journal Article] a novel drebrin-binding protein, regulates the formation and stabilization of dendritic spines2014
Author(s)
Yamazaki H1, Kojima N, Kato K, Hirose E, Iwasaki T, Mizui T, Takahashi H, Hanamura K, Roppongi RT, Koibuchi N, Sekino Y, Mori N, Shirao T., Spikar
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Journal Title
J Neurochem.
Volume: 128(4)
Pages: 507-522
Peer Reviewed
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[Journal Article] Nitric oxide-induced calcium release via ryanodine receptors regulates neuronal function2012
Author(s)
Kakizawa S, Yamazawa T, Chen Y, Ito A, Murayama T, Oyamada H, Kurebayashi N, Sato O, Watanabe M, Mori N, Oguchi K, Sakurai T, Takeshima H, Saito N, and Iino M
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Journal Title
EMBO J.
Volume: 31
Pages: 417-428
Peer Reviewed
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[Journal Article] Transcriptional and post-transcriptional regulation ofβIII-tubulin protein expression in relation with cell cycle-dependent regulation of tumor cells2012
Author(s)
Shibazaki M, Maesawa C, Akasaka K, Kasai S, Yasuhira S, Kanno K, Nakayama I, Sugiyama T, Wakabayasi G, Masuda T, Mori N
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Journal Title
Int J Oncol.
Volume: 40(3)
Pages: 695-702
Peer Reviewed
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[Journal Article] FoxO1 is involved in the antineoplastic effect of calorie restriction2010
Author(s)
Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I
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Journal Title
Aging Cell
Volume: 9
Pages: 372-382
Peer Reviewed
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