2012 Fiscal Year Final Research Report
Sleep and arousal regulation in Drosophila melanogaster
Project/Area Number |
22300132
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Fusional basic brain science
|
Research Institution | Kumamoto University |
Principal Investigator |
KUME Kazuhiko 熊本大学, 発生医学研究所, 准教授 (30251218)
|
Project Period (FY) |
2010 – 2012
|
Keywords | 睡眠 / 覚醒 / 概日周期 / ショウジョウバエ / ドーパミン / 時系列解析 / モザイク解析 / 代謝 / 加齢 / 寿命 / 温度嗜好性 |
Research Abstract |
Using Drosophila melanogaster as a model animal for sleep research,we identified calcineurin and others as novel sleep related genes and showed therelationship between sleep and memory retention. By the analysis of dopamine functions,which is an arousal regulator, we showed its role in rest length regulation, metabolismand temperature preference. We also identified arousal regulating dopamine circuit infly brain at the single cell level.
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