2013 Fiscal Year Final Research Report
Neural mechanisms of long-term memory formation and memory retrieval in the human temporal cortex
| Project/Area Number |
22300134
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional brain recording science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KONISHI Seiki 東京大学, 医学(系)研究科(研究院), 准教授 (90323609)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Keywords | 機能的磁気共鳴画像法 / 記憶固定 / 側頭葉 |
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| Research Abstract |
Long-term memory is thought to be consolidated into the lateral temporal cortex long after encoding into the hippocampus. However, the details about its neural mechanisms are not well understood. We explored the neural mehcanisms of long-term memory consolidation and retrieval in the human temporal cortex using fMRI.
By employing a pair association task, memory-retlated areas were revealed in the 1) visual areas for faces and places, 2) himmpocampus, 3) posterior lateral temporal cortex, 4) anterior lateral temporal cortex. Analyses of the regional interaction revealed that new visual information was initially encoded into the hippocampus, and was later consolidated in the posterior lateral temporal cortex, and was retreived via integration from the posterior to anterior lateral temporal cortex.
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[Journal Article] Prediction of future recognition performance using brain activity in the medial temporal lobe2011
Author(s)
Watanabe T., Hirose S., Katsura M., Imai Y., Chikazoe J., Kimura H. M., Jimura K., Machida T., Shirouzu I., Miyashita Y., Konishi S
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Journal Title
Neuroimage
Volume: 54
Pages: 3085-3092
DOI
Peer Reviewed
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[Presentation] Prediction of future memory cognition by multivariate pattern analysis2011
Author(s)
Watanabe T., Hirose S., Wada H., Katsura M., Chikazoe J., Jimura K., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
Organizer
Association for the Scientific Study of Consciousness Conference
Year and Date
20110000
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[Presentation] Functional areas in human inferior frontal cortex as revealed by combination of resting-state functional connectivity and high-resolution fMRI2011
Author(s)
Hirose S., Watanabe T., Wada H., Katsura M., Jimura K., Kunimatsu A., Abe O., Ohtomo K., Imai Y., Machida T., Shirouzu I., Miyashita Y., Konishi S
Organizer
Society for Neuroscience Conference
Year and Date
20110000
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[Presentation] Multivoxel pattern analysis of brain activity in the medial temporal lobe and prediction of subsequent recognition performance2010
Author(s)
Watanabe T., Hirose S., Katsura M., Imai Y., Chikazoe J., Kimura H. M., Jimura K., Machida T., Shirouzu I., Miyashita Y., Konishi S
Organizer
Society for Neuroscience Conference
Year and Date
20100000
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