2012 Fiscal Year Final Research Report
Bioengineering of artificial red cells for clinical application
| Project/Area Number |
22300161
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Waseda University |
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Principal Investigator |
SAKAI Hiromi 早稲田大学, 重点領域研究機構, 教授 (70318830)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Koichi 慶應義塾大学, 医学部, 名誉教授 (80051704)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 人工臓器工学 / 再生医工学 / 人工血液 / リポソーム / 輸血代替 |
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| Research Abstract |
One of the characteristics of artificial red cells (hemoglobin-vesicles) as a molecular assembly is that their physicochemical properties can be manipulated. New function can also be added to the particles. In this reasech we take the advantages of such artificial red cells to apply for new clinical indications which blood transfusion cannot be attained. We establish “gas bioengineering” using artificial red cells.
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[Journal Article] Physiolgical capacity of the reticuloendothelial system for the degradation of hemoglobin-vesicles (artificial oxygen carriers) after massive intravenous doses by daily repeated infusion for 7 days in Pregnant rats and fetuses.2012
Author(s)
M. Kaga, H. Ohta, Y. Lee, R. Kamii, H. Yamamoto, S. Akiyama, S. Watanabe, T. Matsuda, Y. Kimura, S. Tsuchiya, H. Tei, L. Okamura, H. Sakai, N. Yaegashi
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Journal Title
Life Sci.
Volume: 91
Pages: 420-428
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[Journal Article] Phagocytosis of liposome particles by rat splenic immature monocytes makes them transiently and highly immunosuppressive in ex vivo culture condition.2011
Author(s)
D. Takahashi, H. Azuma, H. Sakai, K. Sou, D. Wakita, H. Abe, M. Fujihara, H. Horinouchi, K. Kobayashi, T. Nishimura, H. Ikeda.
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Journal Title
J. Pharmacol. Exp. Therap
Volume: 337
Pages: 42-49
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[Journal Article] Hepatically-metabolized and .excreted artificial oxygen carrier, hemoglobin-vesicles, can be safely used under conditions of hepatic impairment.2010
Author(s)
K. Taguchi, M. Miyasato, H. Ujihara, H. Watanabe, D. Kadowaki, H. Sakai, E. Tsuchida, H. Horinouchi, K. Kobayashi, T. Maruyama, M. Otagiri
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Journal Title
Toxicol. Appl. Pharmacol.
Volume: 248
Pages: 234-241
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[Remarks] NHK E テレ「サイエンスZERO」人工赤血球の研究を紹介(2012年7月15日) 報道等
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[Remarks] J-CAST ニュースに紹介記事。「早大グループが「人工赤血球」を開発大学見本市で発表」(2012年10月19日) 報道等
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[Remarks] 日本経済新聞朝刊に紹介記事。「知の明日を築く、アジア発、生命科学研究」(2012年12月6日) 報道等
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