2012 Fiscal Year Final Research Report
Development of a new micelle nanobubble and ultrasoundcombination cancer chemotherapy
| Project/Area Number |
22300182
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FERIL Loreto B 福岡大学, 医学部, 講師 (10435109)
ENDO Hitomi 福岡大学, 医学部, 講師 (00435108)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 超音波 / プロスタグランジン / マイクロバブル |
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| Research Abstract |
Prostaglandin E1(PGE1)Liple is the medication of prostaglandin E1. This drug is a drug delivery system which is in the form of micelles. In the current experiments, a high speed mixing device was devised to entrap gas within its structure. Analysis measurement resulted in significant difference in size before and after treatment at least in the range of 3-10 μm. It was strongly suggested that this new air trapped micelles could act as a contrast agent for ultrasound imaging and for delivery of various drugs, including prostaglandin E1.
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[Journal Article] Ultrasound stimulation restores impaired neovascularization-related capacities of human circulating angiogenic cells2012
Author(s)
Toyama Y, Sasaki K, Tachibana K, Ueno T, Kajimoto H, Yokoyama S, Ohtsuka M, Koiwaya H, Nakayoshi T, Mitsutake Y, Chibana H, Itaya N, Imaizumi T.
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Journal Title
Cardiovasc Res
Volume: 1:95(4)
Pages: 448-59
DOI
Peer Reviewed
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