2012 Fiscal Year Final Research Report
Molecular mechanisms underlying the effects of molecular hydrogen on health promotion and disease control
| Project/Area Number |
22300244
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2011-2012)
Institute of Applied Biochemistry (2010) |
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Principal Investigator |
ITO Masafumi 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (80393114)
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Kinji 名古屋大学, 大学院・医学系研究科, 教授 (80397455)
OHGUHCI Kenji 椙山女学園大学, 生活科学部, 准教授 (80359257)
FUJITA Yasunori 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (30515888)
ITOH Tomohiro 近畿大学, 農学部, 講師 (30435854)
IIO Akio 愛知県心身障害者コロニー発達障害研究所, 発生障害学部, リサーチレジデント (80344349)
ITO Mikako 名古屋大学, 大学院・医学系研究科, 助教 (60444402)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 水素 / シグナル伝達 / 酸化ストレス |
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| Research Abstract |
The effects of molecular hydrogen have been reported in various diseases. A selective scavenging of hydroxyl radicals was proposed as an underlying mechanism of the hydrogen effects and indeed a reduction of the oxidative damage by hydrogen has been observed. In cell culture models of inflammation and fatty liver as well as type I allergy, we have demonstrated that hydrogen does not affect the oxidative signal that is physiologically important but inhibits the intracellular signal transduction, thereby exerting beneficial effects. Based on these findings, we have established the modulation of signal transduction as a novel mechanism of the effects of hydrogen.
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[Journal Article] Metabolomic profiling rationalized pyruvate efficacy in cybrid cells harboring MELAS mitochondrial DNA mutations.2012
Author(s)
Kami K, Fujita Y, Igarashi S, Koike S, Sugawara S, Ikeda S, Sato N, Ito M, Tanaka M, Tomita M, Soga T.
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Journal Title
Mitochondrion
Volume: 12
Pages: 644
Peer Reviewed
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[Journal Article] Involvement of heme oxygenase-1 induction via Nrf2/ARE activation in protection against H_2O_2-induced PC12 cell death by a metabolite of sesamin contained in sesame seeds.2011
Author(s)
Hamada N, Tanaka A, Fujita Y, Itoh T, Ono Y, Kitagawa Y, Tomimori N, Kiso Y, Akao Y, Nozawa Y, Ito M.
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Journal Title
Bioorg Med Chem
Volume: 19
Pages: 1959-1965
Peer Reviewed
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[Journal Article] Inhibitory effects of whisky congeners on IgE-mediated degranulation in rat basophilic leukemia RBL-2H3 cells and passive cutaneous anaphylaxis reaction in mice.2010
Author(s)
Itoh T, Tsukane M, Koike M, Nakamura C, Ohguchi K, Ito M, Akao Y, Nozawa Y, Wakimoto T, Nukaya H, Suwa Y.
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Journal Title
J Agrci Food Chem
Volume: 58
Pages: 7149-7157
Peer Reviewed
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