2012 Fiscal Year Final Research Report
Activation of transcription factor by functional food constituents inhibits the onset and progression of obesity-related liver diseases through attenuating the enhanced innate immunity levels.
| Project/Area Number |
22300260
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
YANAGAWA Toru 筑波大学, 医学医療系, 准教授 (10312852)
UTSUNOMIYA Hirotoshi 和歌山県立医科大学, 医学部, 准教授 (60264876)
OKAMOTO Yoshikazu 筑波大学, 医学医療系, 講師 (90420083)
ISHII Tetshurou 筑波大学, 医学医療系, 教授 (20111370)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 肥満 / 脂肪性肝疾患 / 自然免疫 / 転写因子 / 酸化ストレス |
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| Research Abstract |
In Keap1-kd mice (with Nrf2 overexpression) fed an MCD diet, steatohepatitis did not develop over the observation periods. However, in Nrf2-null mice fed the diet, the pathological state of the steatohepatitis was aggravated. Iron accumulation was greater in the livers of the Nrf2-null mice compared to those of the WT mice, and it was not observed in Keap1-kd mice. Further, the iron release from the isolated hepatocyte of Nrf2-null mice was significantly decreased. Sulforaphane, an activator of Nrf2, suppressed the pathological states and oxidative stress in the livers.Nrf2 has protective roles against nutritional steatohepatitis through inhibition of hepatic iron accumulation and counteraction against oxidative stress-induced liver injury.
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[Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis.2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M,Tokushige K, Ueda T,Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T,Utsunomiya H, Yamamoto M, Shoda J
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Journal Title
J Gastroenterol
Volume: 47
Pages: 924-35
Peer Reviewed
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[Journal Article] Deletion of Nrf2leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet2012
Author(s)
Okada K, Warabi E, Sugimoto H, Horie M,Gotoh N, Tokushige K, Hashimoto E,Utsunomiya H, Takahashi H,Ishii T,Yamamoto M, Shoda J
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Journal Title
DOI
Peer Reviewed
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