Genetic nutrition research regarding oseoporosis risk modification and prevention in pubescent girls

2014 Fiscal Year Final Research Report

• Project/Area Number: 22300265
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kyoto Gakuen University (2011-2014); Mukogawa Women's University (2010)
• Principal Investigator: TAKII Yukio 京都学園大学, バイオ環境学部, 客員研究員 (70154937)
• Co-Investigator(Kenkyū-buntansha): SEKIYA Jirou 京都学園大学, バイオ環境学部, 教授 (10035123) ; YAMAMOTO Syuumi 武庫川女子大学, 生活環境学部, 講師 (60441234) ; NISHIMURA Sayaka 武庫川女子大学, 生活環境学部, 助手 (00509177) ; AIZAWA Toru 武庫川女子大学, 文学部, 教授 (10340944)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 遺伝栄養学 / 骨粗しょう症 / 運動 / 思春期女子 / カルシウム摂取 / 乳酸菌 / 腸内細菌 / 食育

Outline of Final Research Achievements

Forty-four female students (mean age, 20.2 ± 3.3 years) consumed 30 g pickles for 2 weeks and were divided into 3 groups: viable-cell intake subjects (n = 14), dead-cells intake subjects (n = 15), and placebo subjects (n = 15). Natural killer (NK)-cell activity in serum from dead-cell intake subjects was 37.5 ± 17.0% before the start of the test-food intake and 47.7 ± 20.1% after intake, indicating statistically significant effects (p < 0.01). The number of days with bowel movements significantly increased from 3.8 ± 1.5 to 4.9 ± 1.8 days in the dead-cell intake group., Feeling of incomplete evacuation reduced and refreshed feeling increased among the subjects with constipation. Thus, marked enhancement of NK-cell activity and improved bowel symptoms were observed in subjects consuming pickles containing dead lactobacillus cells. Daily adequate calcium intake is predicted to be crucial to develop optimal peak bone mass and to preserve bone mass throughout life.

Free Research Field

総合領域