2012 Fiscal Year Final Research Report
Role of p53-citrullination in human carcinogenesis
| Project/Area Number |
22300335
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Tumor diagnosis
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUDA Koichi 東京大学, 医科学研究所, 准教授 (90401257)
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| Co-Investigator(Renkei-kenkyūsha) |
TANIKAWA Chizu 東京大学, 医科学研究所, 助教 (30422421)
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| Project Period (FY) |
2010 – 2012
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| Keywords | バイオマーカー / 53 |
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| Research Abstract |
In this project, we have identified in vivo and in vitro citrullination of the arginine 3 residue of histone H4 (cit-H4R3) in response to DNA damage through the p53-PADI4 pathway. We also show DNA damage-induced citrullination of Lamin C. Padi4(-/-) mice exhibit resistance to radiation-induced apoptosis in the thymus. We also found frequent loss of function mutations in cancer tissues and cell lines. Our findings reveal the possible role of PADI4 as a tumor suppressor gene.
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Research Products
(7 results)
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[Journal Article] Regulation of histone modification andchromatin structure by the p53-PADI4pathway.2012
Author(s)
C. Tanikawa, M. Espinosa, A. Suzuki, K.Masuda, K. Yamamoto, E. Tsuchiya, K.Ueda, Y. Daigo, Y. Nakamura, K. Matsuda,
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Journal Title
Nature communications
Volume: 3
Pages: 676
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