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2012 Fiscal Year Final Research Report

Physiological and pathological analyses of cell adhesion molecules towards the development of diagnostic markers of human cancer

Research Project

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Project/Area Number 22300336
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Tumor diagnosis
Research InstitutionThe University of Tokyo

Principal Investigator

MURAKAMI Yoshinori  東京大学, 医科学研究所, 教授 (30182108)

Co-Investigator(Kenkyū-buntansha) ITO Akihiko  近畿大学, 医学部, 教授 (80273647)
SAKURAI Mika  東京大学, 医科学研究所, 助教 (80508359)
GOTO Akiteru  秋田大学, 大学院・医学系研究科, 教授 (90317090)
MATSUBARA Daisuke  東京大学, 医科学研究所, 講師 (80415554)
Project Period (FY) 2010 – 2012
Keywordsがんの個性診断
Research Abstract

Physiological and pathological roles of cell adhesion molecules in cancer development and progression were analyzed to establish novel molecular markers of human cancer. We found that a splicing variant of a cell adhesion molecule CADM1 was expressed exclusively in small cell lung cancer (SCLC), providing a candidate diagnostic marker of SCLC. We also found that CADM1 could cross-talk with the MET signaling and may play a role in acquired resistance of lung adenocarcinoma against EGFR-TKItreatment.

  • Research Products

    (25 results)

All 2013 2012 2011 2010 Other

All Journal Article (21 results) Presentation (1 results) Book (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Journal Article] Lung cancer with loss of BRG1?BRM,shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.2013

    • Author(s)
      Matsubara D, Murakami Y, Niki T et al.
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 266-273

    • DOI

      DOI:10.1111/cas.12065

  • [Journal Article] Identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line, LC-2/ad.2012

    • Author(s)
      Matsubara D, Murakami Y, Niki T et al.
    • Journal Title

      J Thorac Oncol

      Volume: 7 Pages: 1872-1876

    • DOI

      DOI:10.1097/JTO.0b013e3182721ed1)

  • [Journal Article] Involvement of miR-214 and miR-375 in malign.ant features of non-small-cell lung cancer by down-regulating CADM1.2012

    • Author(s)
      Ishimura M, Sakurai-Yageta M,Maruyama T, Ando T, Fukayama M,Goto A, Murakami Y.
    • Journal Title

      J Cancer Therapy

      Volume: 3 Pages: 379-387

    • DOI

      DOI:10.4236/jct.2012.324050)

  • [Journal Article] Novel application for pseudopodia proteomics using excimer laser ablation and two-dimensional difference gel electrophoresis.2012

    • Author(s)
      Ito A, Murakami Y, Kondo T et al.
    • Journal Title

      Lab Invest

      Volume: 92 Pages: 1374-1385

    • DOI

      DOI:10.1038/labinvest.2012.98.)

  • [Journal Article] Expression of a splicing variant of the CADM1 specific to small cell lung cancer.2012

    • Author(s)
      Kikuchi S, Sakurai-Yageta M, Murakami Y. et al.
    • Journal Title

      Cancer Science

      Volume: 103 Pages: 1051-1057

    • DOI

      DOI:10.1111/j.1349-7006.2012.02277.x.

  • [Journal Article] Notch2 and Six1 are up-regulated during progression of early-stage lung adenocarcinoma and define its unfavorable subset at advanced stages.2012

    • Author(s)
      Mimae T, Murakami Y, Ito A et al.
    • Journal Title

      Clinical Cancer Research

      Volume: 18 Pages: 945-948

    • DOI

      DOI:10.1158/1078-0432.CCR-11-1946

  • [Journal Article] Tumor suppressor cell adhesion molecule 1 (CADM1) is cleaved by A disintegrin and metalloprotease 10 (ADAM10) and subsequently cleaved by gamma-secretase complex.2012

    • Author(s)
      Nagara Y, Murakami Y, Ito A et al.
    • Journal Title

      BiochemBiophys Res Commun

      Volume: 417 Pages: 462-467

    • DOI

      DOI:10.1016/j.bbrc.2011.11.140.

  • [Journal Article] Aberrant expression of tumor suppressors, CADM1 and 4.1B, in invasive lesions of primary breast cancer.2012

    • Author(s)
      Takahashi Y, Sakurai-Yageta M, Ito A, Goto A, Murakami Y et al.
    • Journal Title

      Breast Cancer

      Volume: 19 Pages: 242-252

    • DOI

      DOI:10.1007/s12282-011-0272-7.)

  • [Journal Article] Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma.2012

    • Author(s)
      Nagata M, Sakurai-Yageta M, Murakami Y et al.
    • Journal Title

      Int J Cancer

      Volume: 130 Pages: 1329-1337

    • DOI

      DOI:10.1002/ijc.26160

  • [Journal Article] Genome structure-based screening identifiedepigenetically silenced microRNA associated with invasiveness in non-small-cell lung cancer.2012

    • Author(s)
      Watanabe K, Goto A, Takai D.
    • Journal Title

      Int J Cancer.

      Volume: 130 Pages: 2580-2590

    • DOI

      Doi:10.1002/ijc.26254.

  • [Journal Article] B cells regulate antibody responses through the medullary remodeling of inflamed lymph nodes.2012

    • Author(s)
      Abe J, Goto A, Matsushima K et al.
    • Journal Title

      Int Immunol

      Volume: 24 Pages: 17-27

    • DOI

      DOI:10.1093 /intimm/dxr089)

  • [Journal Article] Transcriptional regulation of the CADM1 gene by retinoic acid during the neural differentiation of murine embryonal carcinoma P19 cells.2011

    • Author(s)
      Ito T, Sakurai-Yageta M, Murakami Y et al.
    • Journal Title

      Genes to Cells

      Volume: 16 Pages: 791-802

    • DOI

      DOI:10.1111/j.1365-2443.2011.01525

  • [Journal Article] Steroid Receptor Expression in Thymomas and Thymic Carcinomas2011

    • Author(s)
      Mimae T, Murakami Y, Tsuda H.
    • Journal Title

      Cancer

      Volume: 117 Pages: 4396-4405

    • DOI

      DOI:10.1002/cncr.26061

  • [Journal Article] Enhanced Nerve-Mast Cell Interaction by a Neuronal Short Isoform of Cell Adhesion Molecule-12011

    • Author(s)
      Hagiyama M, Murakami Y and Ito A.
    • Journal Title

      CADM1. J Immunology

      Volume: 186 Pages: 5983-5992

    • DOI

      DOI:10.4049/jimmunol.1002244

  • [Journal Article] Non-contact estimation of intercellular breaking force using a femtosecond laser impulse quantified by atomic force microscopy. Proc.2011

    • Author(s)
      Hosokawa Y, Murakami Y, Ito A.
    • Journal Title

      Natl. Acad. Sci. USA

      Pages: 1777-1872

    • DOI

      DOI:10.1073/pnas.1006847108.

  • [Journal Article] CpG island methylation of microRNAs is associated with tumor size and recurrence of non-small-cell lung cancer.2011

    • Author(s)
      Kitano K, Goto A, Takai D et al.
    • Journal Title

      Cancer Sci.

      Volume: 102 Pages: 2126-31

    • DOI

      DOI:10.1111/j.1349-7006.2011.02101.

  • [Journal Article] Human papillomavirus infection in lung and esophagealcancers: analysis of 485 Asian cases.2011

    • Author(s)
      Goto A, Fukayama M et al.
    • Journal Title

      J Med Virol.

      Volume: 83 Pages: 1383-1390

    • DOI

      DOI:10.1002/jmv.22150.

  • [Journal Article] Multicystic mesothelioma of the pericardium.2011

    • Author(s)
      Morita S, Goto A, Fukayama M et al.
    • Journal Title

      Pathol Int.

      Volume: 61 Pages: 319-21

    • DOI

      DOI:10.1111/j.1440-1827.2011.02654.

  • [Journal Article] Pleural cavity angiosarcoma arising in chronic expanding hematoma after pneumonectomy.2011

    • Author(s)
      Miyazaki H, Goto A, Fukayama M et al.
    • Journal Title

      Hum Pathol

      Volume: 42 Pages: 1576-1579

    • DOI

      DOI:10.1016/j.humpath.2010.06.019.

  • [Journal Article] CADM1 interacts with Tiam1 and promotes invasivephenotype of human T-cell leukemia virus type I (HTLV-I) transformed cells and adult T-cell leukemia (ATL) cells.2010

    • Author(s)
      Masuda M, Murakami Y et al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 285 Pages: 15511-15522

    • DOI

      doi:10.1074/jbc.M109.076653.

  • [Journal Article] Adhesion molecule CADM1 contributes to gap junctional communication among pancreatic islet beta cells and prevents their excessive secretion of glucagon.

    • Author(s)
      Ito A, Murakami Y et al
    • Journal Title

      Islet. in press.

  • [Presentation] Roles of a cell adhesion molecule CADM1 in malignantprogression of non-small cell lung cancer.2013

    • Author(s)
      Yoshinori Murakami.
    • Organizer
      The 3rdJoint Symposium of the Max-Planck Society and University of Tokyo Graduate School of Medicine.
    • Place of Presentation
      東京、日本
    • Year and Date
      2013-03-08
  • [Book] がん生物学イラストレイテッド2011

    • Author(s)
      渋谷正史、湯浅保仁編
    • Publisher
      羊土社
  • [Patent(Industrial Property Rights)] がんの診断、処置および/または予防、および/または浸潤・転移の抑制のための方法、システムおよび組成物ならびに関連するスクリーニング方法2012

    • Inventor(s)
      村上善則、増田万里・国立大学法人東京大学
    • Industrial Property Rights Holder
      村上善則、増田万里・国立大学法人東京大学
    • Industrial Property Number
      特許第5131946号
    • Acquisition Date
      2012-11-16
    • Overseas
  • [Patent(Industrial Property Rights)] 小細胞肺癌がんの診断のための方法、システムおよび組成物ならびに関連するスクリーニング方法2012

    • Inventor(s)
      村上善則・国立大学法人東京大学
    • Industrial Property Rights Holder
      村上善則・国立大学法人東京大学
    • Industrial Property Number
      特許第5131751号
    • Acquisition Date
      2012-11-16
    • Overseas

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Published: 2014-08-29  

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