2013 Fiscal Year Final Research Report
The final form for highly sensitive and non-labeling separation-detection of non- or less-fluorescent chemicals in liquid solutions
| Project/Area Number |
22350035
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Analytical chemistry
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| Research Institution | Kyushu University |
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Principal Investigator |
HARATA Akira 九州大学, 総合理工学研究科(研究院), 教授 (90222231)
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| Co-Investigator(Renkei-kenkyūsha) |
ISODA Miki 九州大学, 大学院・総合理工学府, 技術専門職員 (70467885)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 分析科学 / １分子計測 / 非蛍光性化学種 / 紫外レーザー分光 / 光熱変換 / ミクロ液体クロマトグラフィー / ヘテロダイン検出 / 生体・環境関連化学種 |
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| Research Abstract |
As an ultimate method for highly sensitive and non-labeling separation-detection of non- or less-fluorescent chemical species in liquid solutions, a new equipment is developed in coupling micro-liquid chromatographic separation with the heterodyne interferometic detection of ultraviolet-laser excited photothermal effects. Photothermal signal is successfully detected with heterodyne interferometer for liquid sample in micro-flow cells. Separation condition is assigned for non-labeled 20 kinds of biologically important amino acids.
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