2012 Fiscal Year Final Research Report
Protein interaction analysis of circadian clock protein
| Project/Area Number |
22370037
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Structural biochemistry
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
NAKATSU Toru 京都大学, 大学院・薬学研究科, 准教授 (50293949)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Keywords | 生体リズム |
|---|
| Research Abstract |
BMAL1 and CLOCK are the transcription factors of the circadian clock in mammals. The human BMAL1:CLOCK bHLH domain forms hetero or homo dimer and binds to E-box DNA. The hetero dimer of bHLH domain was more preferable to recognize the E-BOX DNA compared to the homo dimer based on the ITC analysis. Next we investigated the region related to the formation of the bHLH PAS-A domain of the human BMAL1:CLOCK hetero dimer. It is suggested that the bHLH domain is more important for the hetero dimer formation than the PAS-A domain.
|
Research Products
(11 results)
