2012 Fiscal Year Final Research Report
Study on the mode of action of Draper, a multi-ligand engulfmentreceptor of Drosophila
| Project/Area Number |
22370049
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHIRATSUCHI Akiko 金沢大学, 薬学系, 准教授 (90303297)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 貪食 / アポトーシス / 細菌感染症 / 自然免疫 / ショウジョウバエ |
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| Research Abstract |
The modes of action of Draper, an engulfment receptor responsible for the phagocytosis of apoptotic cells in Drosophila, were investigated. Draper underwent tyrosine phosphorylation at the motif NPxY when phagocytes recognized apoptotic cells. This tyrosine residue was required for Draper to transmit signals for the induction of phagocytosis. The endoplasmic reticulum protein CaBP1 and the membrane phospholipid phosphatidylserine were found to serve as ligands for Draper. In addition, integrin αPS3-βν was identified as another engulfment receptor that functions independent of Draper.
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[Journal Article] Phosphatidylserine recognition and induction of apoptotic cell clearance by Drosophila engulfment receptor Draper2013
Author(s)
Tung, T. T., Nagaosa, K., Fujita, Y., Kita, A., Mori, H., Okada, R., Nonaka, S., Nakanishi, Y
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Journal Title
J. Biochem
Volume: 153
Pages: 483-491
DOI
Peer Reviewed
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[Journal Article] Independent recognition of Staphylococcus aureus by two receptors for phagocytosis in Drosophila2012
Author(s)
Shiratsuchi, A., Mori, T., Sakurai, K., Nagaosa, K., Sekimizu, K., Lee, B. L., Nakanishi, Y
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 21663-21672
DOI
Peer Reviewed
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[Journal Article] Apoptosis-dependent externalization and involvement in apoptotic cell clearance of DmCaBP1, an endoplasmic reticulum protein of Drosophila2012
Author(s)
Okada, R., Nagaosa, K., Kuraishi, T., Nakayama, H., Yamamoto, N., Nakagawa, Y., Dohmae, N., Shiratsuchi, A., Nakanishi, Y
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Journal Title
J. Biol. Chem
Volume: 287
Pages: 3138-3146
DOI
Peer Reviewed
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[Journal Article] Integrin βν-mediated phagocytosis of apoptotic cells in Drosophila embryos2011
Author(s)
Nagaosa, K., Okada, R., Nonaka, S., Takeuchi, K., Fujita, Y., Miyasaka, T., Manaka, J., Ando, I., Nakanishi, Y
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Journal Title
J. Biol. Chem
Volume: 286
Pages: 25770-25777
DOI
Peer Reviewed
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[Journal Article] Inhibitory role for D-alanylation of wall teichoic acid in activation of insect Toll pathway by peptidoglycan of Staphylococcus aureus2010
Author(s)
Tabuchi, Y., Shiratsuchi, A., Kurokawa, K., Gong, J. H., Sekimizu, K., Lee, B. L., Nakanishi, Y
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Journal Title
J. Immunol
Volume: 185
Pages: 2424-2431
DOI
Peer Reviewed
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