2013 Fiscal Year Final Research Report
Functional analysis of chromosomal bouquet formation in meiosis.
| Project/Area Number |
22370074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | National Institute of Information and Communications Technology |
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Principal Investigator |
CHIKASHIGE Yuji 独立行政法人情報通信研究機構, 未来ICT研究所バイオICT研究室, 主任研究員 (60359081)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 核構造 |
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| Research Abstract |
The chromosomal bouquet arrangement, in which ends of chromosomes cluster near a centrosome, is widely observed at the meiotic prophase. Bouquet defective mutants of Schizosaccharomyces pombe show defects in pairing of homologous chromosomes, spindle formation, and segregation of chromosomes. In this research, it was demonstrated that such defects in meiotic spindle formation are caused by disengagement of centrosome from the nuclear envelope. That is, if the centrosome is normally located on the nuclear envelope even though the bouquet arrangement is aberrant, the normal bi-polar spindle can be formed. It was additionally shown that defects in chromosome segregation were not rescued in the bouquet mutants that forms normal bi-polar spindle. These results suggest that the defects in chromosome segregation in bouquet mutants should be caused by different mechanism from that of defects in spindle formation.
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Research Products
(9 results)
