2013 Fiscal Year Final Research Report
Comprehensive analysis of plasma membrane protein functions by immunomodulation
| Project/Area Number |
22380065
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Ibaraki University |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | イムノモジュレーション / 植物 / ブラシノステロイド / 細胞膜 |
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| Research Abstract |
Immunomodulation study was applied to plasma membrane proteins. ER-targeted accumulation of an antibody against brassinosteroid receptor BRI1 resulted in transformants showing brassinosteroid-defective phenotype like dwarfism. Random introduction of antibodies, which were selected by the affinity to a plasma membrane protein fraction from a phage-display antibody library, gave some phenotypes to plants, which have yet to be related to the introduced antibodies.
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