2013 Fiscal Year Final Research Report
Neuroactive marine metabolites that modulate synaptic functions
| Project/Area Number |
22380114
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fisheries chemistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
RYUICHI Sakai 北海道大学, 大学院水産科学研究院, 教授 (20265721)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 海洋天然物 / 中枢神経 / 生理活性物質 / グルタミン酸受容体 / GPCR / レクチン / プリン |
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| Research Abstract |
Marine natural products are a rich source of neuroactive compounds that selectively acts to ion channels and receptors that function or modulate synaptic neurotransmission. Here, we have isolated biologically active metabolites that modulate neuronal functions, including new polyamine-modified peptide toxin aculeines, a sponge galectin CchGs that modulate actions of AMPA/KA-type glutamate receptors, a new alkaloids from sponges that target neuronal receptors selectively. We determined chemical structure, target receptors, and modes of activity of those molecules.
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Research Products
(24 results)
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[Journal Article] Studies on an (S)-2-amino-3-(3-hydroxy- 5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159 : asymmetric synthesis, neuroactivity, and structural characterization2013
Author(s)
Juknaite, L.; Sugamata, Y.; Tokiwa, K.; Ishikawa, Y.; Takamizawa, S.; Eng, A.; Sakai, R.; Pickering, D. S.; Frydenvang, K.; Swanson, G. T.; Kastrup, J. S.; Oikawa, M.
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Journal Title
J. Med. Chem
Volume: 56
Pages: 2283-93
DOI
Peer Reviewed
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