2013 Fiscal Year Final Research Report
Analysis of candidate genes for heterotic QTL discovered from a gene pool of wild mice
| Project/Area Number |
22380149
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Nagoya University |
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Principal Investigator |
ISHIKAWA Akira 名古屋大学, 生命農学研究科, 准教授 (20211724)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUKADA Akira 名古屋大学, 大学院生命農学研究科, 助教 (20343212)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | 育種学 / 遺伝学 / マウス / ＱＴＬ / ヘテローシス |
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| Research Abstract |
Heterosis was found more than 100 years ago. Since then, it has become a genetic phenomenon essential for animal and plant breeding. However, no causative gene for heterosis has been cloned. I previously discovered a new QTL (quantitative trait locus) for heterosis of body weight from a gene pool of wild mice and I fine-mapped it to a limited chromosomal region by QTL analysis using a congenic mouse strain. In this study, I performed exome analysis, phenotypic analysis and gene-expression analysis using congenic and subcongenic mouse strains developed in previous and present studies. I fine-mapped the body weight QTL to an about 6-Mb genomic region, although its heterotic effect was unfortunately not confirmed in this study. I also revealed that four genes are putative candidate genes for the body weight QTL.
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