2013 Fiscal Year Final Research Report
Molecutar anatomy and medicinal application of laminins, a basement membrane protein
| Project/Area Number |
22390017
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIKKAWA Yamato 東京薬科大学, 薬学部, 准教授 (20274227)
HOZUMI Kentaro 東京薬科大学, 薬学部, 講師 (10453804)
KATAGIRI Fumihiko 東京薬科大学, 薬学部, 助教 (60420642)
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Keywords | ラミニン / 基底膜 / ペプチド / 細胞接着 / インテグリン / シンデカン / バイオマテリアル / 細胞外マトリックス |
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| Research Abstract |
Laminins are a major component of the basement membrane, a thin extracellular matrix, and have diverse biological activities. Our goal is to identify active sequences from laminins and to use the biologically active peptides for medical application including anti-cancer and wound healing drugs, DDS, and biomaterials. We have identified various biologically active peptides using more than 1000 synthetic peptides derived from the laminins. We also identified cellular receptors of the active peptides and evaluated their cellular signaling. We also demonstrated that peptide-conjugated polysaccharide (chitosan, alginate, and agarose) matrices are useful as a biomaterial for cell culture and tissue engineering. Further, mixed peptide-matrices using several types of receptor-binding peptides promoted synergistic effects. Using a combination of tissue-appropriate laminin-derived peptides, the mixed peptide-polysaccharide matrices may serve as a functional biomaterial for tissue engineering.
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