2012 Fiscal Year Final Research Report
Studies on isolation, total synthesis and medicinal chemistryof natural products with regulating activities on memory and pain.
| Project/Area Number |
22390019
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Chiba University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOGURE Noriyuki 千葉大学, 大学院・薬学研究院, 助教 (80396689)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIE Shunji 城西国際大学, 薬学部, 教授 (50209285)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 鎮痛薬 / 脳機能改善薬 / 天然活性物質 / 生物活性物質の探索 / 全合成 / アルカロイト / 構造活性相関 |
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| Research Abstract |
To develop new analgesics for cancer pain, structure of the lead-compound having Corynanthe-type skeleton was modified, resulting in the creation of new derivatives with potent analgesic activity as well as with stability against microsomal metabolism. Iboga-type indole alkaloids were found to be a new class of antagonist of CB1 receptors. Voacangalactonine, a new alkaloid possessing Iboga structure, was synthesized in an asymmetric manner. To investigate the seeds molecules for development of medicines for dementia, isolation, structure elucidation, and total syntheses of Lycopodium alkaloids were performed.
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[Journal Article] Synthesis and Biological Evaluation of 4-Chlorocolchicine Derivatives as Potent Anticancer Agents with Broad Effective Dosage Ranges2012
Author(s)
H. Nishiyama, M. Ono, T. Sugimoto, T.Sasai, N. Asakawa, T. Matsumoto, T. Yaegashi, M. Nagaoka, T. Matsuzaki, N. Kogure, M. Kitajima, and H. Takayama
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Journal Title
Med. Chem. Comm
Volume: 3(12)
Pages: 1500-1504
DOI
Peer Reviewed
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