2012 Fiscal Year Final Research Report
Vascular stabilization and destabilization by angiopoietin-1/Tie2 system
| Project/Area Number |
22390040
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
FUKUHARA Shigetomo 独立行政法人国立循環器病研究センター, 研究所, 室長 (70332880)
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| Project Period (FY) |
2010 – 2012
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| Keywords | アンジオポエチン / Tie2 / 血管新生 / 血管安定化 |
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| Research Abstract |
In this study, we investigated the mechanism how Angiopoietin-1 (Ang1)-Tie2 signal promotes vascular stabilization. Here, we show that Ang1-Tie2 signal potentiates Notch signal through β-catenin-dependent up-regulation of Delta-like 4 expression, leading to basement membrane formation required for vascular stabilization. In addition, we report that Ang1-Tie2 signal induces reorganization of actin cytoskeleton through Rap1 small GTPase, thereby enhancing endothelial barrier function.
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Research Products
(26 results)
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[Journal Article] The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice.2012
Author(s)
Fukuhara S., Simmons S., Kawamura S., Inoue A., Orba Y., Tokudome T., Sunden Y., Arai Y., Moriwaki K., Ishida J., Uemura A, Kiyonari H., Abe T., Fukamizu A., Hirashima M., Sawa H., Aoki J., Ishii M and Mochizuki N.
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Journal Title
J. Clin. Invest.
Volume: 122
Pages: 1416-1426
DOI
Peer Reviewed
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[Journal Article] Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells.2012
Author(s)
Kusuhara S., Fukushima Y., Fukuhara S., Jakt L.M., Okada M., Shimizu Y., Hata M., Nishida K., Negi A., Hirashima M., Mochizuki N., Nishikawa S. and Uemura A.
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Journal Title
PLoS One
Volume: 7
Pages: e45858
DOI
Peer Reviewed
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[Journal Article] Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis.2012
Author(s)
Endo M., Nakano M., Kadomatsu T., Fukuhara S., Kuroda H., Mikami S., Hato T., Aoi J., Horiguchi H., Miyata K., Odagiri H., Masuda T., Harada M., Horio H., Hishima T., Nomori H., Ito T., Yamamoto Y., Minami T., Okada S., Takahashi T., Mochizuki N., Iwase H., Oike Y.
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Journal Title
Cancer Res.
Volume: 72
Pages: 1784-1794
DOI
Peer Reviewed
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