2012 Fiscal Year Final Research Report
Studies for NACC1,a pluripotent transcriptional factor, in tumorcells
| Project/Area Number |
22390071
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIDUKA Satoshi 岩手医科大学, 医学部, 講師 (50453311)
WAKABAYASI Go 岩手医科大学, 医学部, 教授 (50175064)
NONAKA Takamasa 岩手医科大学, 薬学部, 教授 (30242457)
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| Project Period (FY) |
2010 – 2012
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| Keywords | NACC1 / ケミカルバイオロジー / 多能性 / 病理 / 翻訳後修飾 / 転写因子 |
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| Research Abstract |
NACC1 is a member of pluripotent transcription factor, and associates with malignant phenotypes of tumor cells. The present study investigated the molecular mechanisms of NACC1 in malignant tumors. We represented that NACC1 directly bound to HDAC6, and deacetylated tubulin and cortactin. This deacetylation introduced acceleration of motility and invasion of tumor cells. NACC1 also contributed to stabilization of ERBB2 protein expression through the deacetylation of HSP90. The SUMOlylation of NACC1 introduced the binding with PML protein. Our study demonstrated that overexpression of NACC1 protein contributes to motility, invasion, proliferation activities of tumor cells, and may be a good candidate for molecular target medicine in cancer therapy.
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[Journal Article] Molecular marker identification for relapse prediction in 5-FU-based adjuvant chemotherapy in gastric and colorectal cancers.2012
Author(s)
Ishida K, Nishiduka S, Chiba T, Ikeda M, Kume K, Endo F, Katagiri H, Matsuo T, Noda H, Iwaya T, Yamada N, Fujiwara H, Takahashi M, Itabashi T, Uesugi N,Maesawa C, Tamura G, Sugai T, Otsuka K, Koeda K, Wakabayashi G.
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Journal Title
PLoS One
Volume: 7(8)
Pages: e43236
DOI
Peer Reviewed
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[Journal Article] Nucleusaccumbens-associated 1 contributes to cortactin deacetylation and augments the migration of melanoma cells.2011
Author(s)
Tsunoda K, Oikawa H, Tada H, Tatemichi Y, Muraoka S, Miura S, Shibazaki M,Maeda F, Takahashi K, Akasaka T, Masuda T, Maesawa C
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Journal Title
J Invest Dermatol.
Volume: 131(8)
Pages: 1710 -9
DOI
Peer Reviewed
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