2012 Fiscal Year Final Research Report
Drug development targeting for regeneration of neurovascular units in neurodegenerative disorders
| Project/Area Number |
22390109
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Tohoku University |
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Principal Investigator |
FUKUNAGA Kohji 東北大学, 大学院・薬学研究科, 教授 (90136721)
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| Co-Investigator(Kenkyū-buntansha) |
IWABUCHI Yoshiharu 東北大学, 大学院・薬学研究科, 教授 (20211766)
ITO Yoshihisa 日本大学, 薬学部, 教授 (50151551)
MORIGUCHI Shigaki 東北大学, 大学院・薬学研究科, 講師 (70374949)
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| Project Period (FY) |
2010 – 2012
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| Keywords | 薬物治療学 |
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| Research Abstract |
ST101 stimulates memory molecule, Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the hippocampus. In the present study, we investigated whether chronic administration of the neurovascular regenerative compound, ST101 elicits long lasting ameliorating effects on brain functions and defined the molecular mechanism underlying their therapeutic effects in the neurodegenerative disorders. ST101 was now under investigation in Phase II clinical trial of U.S.A. We defined T type voltage-gated calcium channel as molecular target of ST101. We next introduced novel and potent derivative, SAK3 by using neuro2A cells overexpressing T type voltage-gated calcium channel. This is the first discovery of activators of T type voltage-gated calcium channel in the world. The most promising evidence in our studies is that T type calcium channel is novel therapeutic target of Alzheimer therapy to restore the neural networks in the neurodegenerative disorders.
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[Journal Article] Reduced expression of the ATRX gene, a chromatin-remodeling factor, causes hippocampal dysfunction in mice2011
Author(s)
Nogami T, Beppu H, Tokoro T, Moriguchi S, Shioda N, Fukunaga K, Ohtsuka T, Ishii Y, Sasahara M, Shimada Y, Nishijo H, Li E, Kitajima I
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Journal Title
Hippocampus
Volume: 21
Pages: 678-687
Peer Reviewed
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[Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons2010
Author(s)
Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H
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Journal Title
Neurosci. Res
Volume: 67
Pages: 126-136
Peer Reviewed
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[Journal Article] Comprehensive behavioral analysis of calcium/calmodulin-dependent protein kinase IV knockout mice2010
Author(s)
Takao K, Tanda K, Nakamura K, Kasahara J, Nakao K, Katsuki M, Nakanishi K, Yamasaki N, Toyama K, Adachi M, Umeda M, Araki T, Fukunaga K, Kondo H, Sakagami H, Miyakawa T
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Journal Title
PLoS One
Volume: 5
Pages: e9460
Peer Reviewed
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[Journal Article] Essential role of neuron-enriched diacylglycerol kinase (DGK), DGKbeta in neurite spine formation, contributing to cognitive function2010
Author(s)
Shirai Y, Kouzuki T, Kakefuda K, Moriguchi S, Oyagi A, Horie K, Morita SY, Shimazawa M, Fukunaga K, Takeda J, Saito N, Hara H
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Journal Title
PLoS One
Volume: 5
Pages: e11602
Peer Reviewed
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