2012 Fiscal Year Final Research Report
Basic study of evaluation system in vascular diseases
| Project/Area Number |
22390113
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTANI Katsuki 旭川医科大学, 医学部, 講師 (90396367)
SUZUKI Ysuhiko 北海道大学, 人獣共通感染症リサーチセンター, 教授 (90206540)
YOSHIDA Itsuro 旭川医科大学, 医学部, 准教授 (20041816)
MORI Kenichiro 旭川医科大学, 医学部, 助教 (70610236)
MATSUSHITA Misao 東海大学, 工学部, 教授 (00165812)
MATSUDA Yasuyuki 旭川医科大学, 医学部, 特任助教 (10532252)
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| Project Period (FY) |
2010 – 2012
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| Keywords | コレクチン / 血管 / 損傷 |
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| Research Abstract |
The basic study of CL-P1 and CL-K1 has been performed by using recombinant collectins and gene-modified mice. Both established recombinant collectins could produce their antibodies, which were used for the development of ELISA system and evaluation of tissue expressions in those mice and human. The knock-out mice with CL-P1 and CL-K1 have been established. CL-K1 KO mice were analyzed using above antibodies. The prototype ELISA system for the evaluation of its blood concentration was established. The CL-P1 KO and TG mice have been established and their complementation experiments have been performed.
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[Journal Article] Guideline forHereditary Angioedema (HAE) 2010 by the Japanese Association for Complement Research - Secondary Publication2012
Author(s)
Horiuchi T, Ohi H, Ohsawa I, Fujita T,Matsushita M, Okada N, Seya T,Yamamoto T, Endo Y, Hatanaka M,Wakamiya N, Mizuno M, Nakao M, OkadaH, Tsukamoto H, Matsumoto M, Inoue N,Nonaka M, Kinoshita T.
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Journal Title
Allergol Int
Volume: 61(4)
Pages: 559-62
DOI
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[Journal Article] The induction of human CL-P1 expression in hypoxia/reoxygenation culture condition and rat CL-P1 after ischemic/reperfusion treatment2011
Author(s)
Koyama S, Ohtani K, Fukuzawa J, Yao N, Fukuda M, Jang S-J, Hasebe N, KikuchiK, Itabe H, Yoshida I, Suzuki Y, Wakamiya N.
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Journal Title
Biochimica et Biophysica Acta
Volume: 1810
Pages: 836-842
DOI
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[Presentation] The biological functions and blood concentration of CL-K12012
Author(s)
N. Wakamiya, N. K Ohtani, T, Yoshizaki, T. K, Mori, Y, Matsuda, I, Yoshida, Y, Suzuki
Organizer
International Carbohydrate Symposium
Place of Presentation
Madrid (Spain)
Year and Date
20120722-27
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