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2012 Fiscal Year Annual Research Report

動脈硬化プラーク脆弱化の分子機構の解明と急性冠症候群予測因子の同定

Research Project

Project/Area Number 22390159
Research InstitutionThe University of Tokushima

Principal Investigator

佐田 政隆  徳島大学, ヘルスバイオサイエンス研究部, 教授 (80345214)

Co-Investigator(Kenkyū-buntansha) 添木 武  徳島大学, ヘルスバイオサイエンス研究部, 講師 (60393211)
平田 恭信  東京大学, 医学部附属病院, 准教授 (70167609)
Project Period (FY) 2010-04-01 – 2013-03-31
Keywords動脈硬化 / 循環器・高血圧 / 急性冠症候群 / プラーク破裂 / 血管新生 / 慢性炎症 / HMGB-1
Research Abstract

急性冠症候群の多くは,軽度内腔を狭窄する動脈硬化プラークの破裂やびらんを基礎とした血栓性閉塞を原因とする。この動脈硬化プラーク脆弱化の分子機構を明らかにするために、臨床材料ならびに動物モデルを用いて検討した。
冠動脈疾患患者の冠状静脈洞採血において、核内非ヒストン蛋白質であるHMGB1の濃度が亢進していた。その病態生理学的意義を明らかにするため、遺伝子欠損マウスと骨髄移植を用いた実験を行った。
Wire 傷害後の血清HMGB1濃度は、傷害4日目に高値となった。抗HMGB1抗体は、血管傷害後の新生内膜増殖を有意に抑制した。また、傷害血管局所へのHMGB1投与は、TLR9を刺激し、新生内膜形成の増悪を引き起こすだけでなく、血管外膜周辺のマクロファージの誘導を有意に増強することがわかった。骨髄由来細胞におけるTLR9と血管リモデリングとの関連を検討するため、C57BL/6とTLR9ノックアウト(KO)マウスを用いて骨髄移植実験を行ったところ、骨髄由来細胞におけるTLR9が新生内膜形成に重要であることが明らかとなった。また、C57BL/6とTLR9KOマウスから単離した腹腔内マクロファージに対して、HMGB1とTLR9 の合成リガンドであるCpG-ODN(CpG-oligodeoxynucleotide)の共刺激を行い、培養上清中のTNF-αの発現量を検討したところ、HMGB1-DNA複合体シグナルがTLR9を介して相乗効果的に炎症反応を増悪させ、新生内膜形成を引き起こしている可能性が示唆された。
以上の結果より、HMGB1-DNA複合体シグナルは、TLR9を介して病的炎症を血管壁に惹起しており、血管壁の不安化に重要な役割を担っていると考えられた。HMGB1を、急性冠症候群の発症予測に使用するための手段を現在開発中である。

Current Status of Research Progress
Reason

24年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

24年度が最終年度であるため、記入しない。

  • Research Products

    (99 results)

All 2013 2012 Other

All Journal Article (43 results) (of which Peer Reviewed: 43 results) Presentation (49 results) (of which Invited: 10 results) Book (6 results) Remarks (1 results)

  • [Journal Article] Ulcer-like projection caused by a penetrating branch to the bronchial artery.2013

    • Author(s)
      Ise T, Fujioka K, Iwase T, Hotchi J, Akaike M, Sata M.
    • Journal Title

      J Am Coll Cardiol.

      Volume: 61 Pages: e147.

    • DOI

      doi:10.1016/j.jacc.2012.10.047

    • Peer Reviewed
  • [Journal Article] Constrictive pericarditis with intrapericardial abscess.2013

    • Author(s)
      H, Ogasawara K, Bando S, Ise T, Niki T, Kusunose K, Ueda Y, Tomita N, Yamaguchi K, Taketani Y, Iwase T, Soeki T, Wakatsuki T, Horiguchi H, Sakashita N, Sata M
    • Journal Title

      Circ J.

      Volume: 77 Pages: 786-788

    • DOI

      doi:10.1253/circj.CJ-12-1098

    • Peer Reviewed
  • [Journal Article] Perivascular adipose tissue-secreted angiopoietin-like protein2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury.2013

    • Author(s)
      Tian Z, Miyata K, Tazume H, Sakauguchi H, Kadomatsu T, Horio E, Takahashi O, Komohara Y, Araki K, Hirata Y, Tabata M, Takanashi S, Takeya M, Hao H, Shimabukuro M, Sata M, Kawasuji M, Oike Y.
    • Journal Title

      J Mol Cell Cardiol

      Volume: 57 Pages: 1-12.

    • DOI

      doi:10.1016/j.yjmcc.2013.01.004

    • Peer Reviewed
  • [Journal Article] Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.2013

    • Author(s)
      Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, Fukuda D, Soeki T, Kitagawa T, Takanashi S, Sata M.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 33 Pages: 1077-1084

    • DOI

      doi:10.1161/ATVBAHA.112.300829

    • Peer Reviewed
  • [Journal Article] Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model.2013

    • Author(s)
      Yoichiro Hirata
    • Journal Title

      European Journal of Pharmacology

      Volume: 699 Pages: 81-87

    • DOI

      10.1016/j.ejphar.2012.11.045

    • Peer Reviewed
  • [Journal Article] Exendin-4, a glucagon-like peptide-1 receptor agonist, attenuates neointimal hyperplasia after vascular injury.2013

    • Author(s)
      Yoichiro Hirata
    • Journal Title

      European Journal of Pharmacology

      Volume: 699 Pages: 106-111

    • DOI

      10.1016/j.ejphar.2012.11.057

    • Peer Reviewed
  • [Journal Article] Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model.2013

    • Author(s)
      Yamauchi Haruo
    • Journal Title

      The Journal of Thoracic and Cardiovascular Surgery

      Volume: 145 Pages: 522-530

    • DOI

      10.1016/j.jtcvs.2012.03.010

    • Peer Reviewed
  • [Journal Article] Eosinophilic Myocarditis due to Churg-Strauss syndrome with markedly elevated Eosinophil Cationic Protein.2013

    • Author(s)
      Tomoya Hara
    • Journal Title

      International Heart Journal

      Volume: 54 Pages: 51-53

    • DOI

      10.1536/ihj.54.51

    • Peer Reviewed
  • [Journal Article] Spectacular migration of a central venous catherter into the pulmonary artery.2013

    • Author(s)
      Tomoya Hara
    • Journal Title

      Heart Asia

      Volume: 5 Pages: 42-43

    • DOI

      10.1136/heartasia-2013-010287

    • Peer Reviewed
  • [Journal Article] A novel doppler echocardiographic index integrating left and right ventricular function is superior to conventional indices for predicting adverse outcome of acute myocardial infarction.2013

    • Author(s)
      Yamato Fukuda
    • Journal Title

      The Journal of Medical Investigation

      Volume: 60 Pages: 97-105

    • Peer Reviewed
  • [Journal Article] Ectopic fat deposition and global cardiometabolic risk: New paradigm in cardiovascular medicine.2013

    • Author(s)
      Michio Shimabukuro
    • Journal Title

      The Journal of Medical Investigation

      Volume: 60 Pages: 1-14

    • Peer Reviewed
  • [Journal Article] Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis.2013

    • Author(s)
      Kenya Kusunose
    • Journal Title

      JACC: Cardiovascular Imaging

      Volume: 6 Pages: 528-530

    • DOI

      10.1016/j.jcmg.2012.10.025

    • Peer Reviewed
  • [Journal Article] Patent foramen ovale diagnosed by real-time three-dimensional contrast transesophageal echocardiography: A case report.2013

    • Author(s)
      Noriko Tomita
    • Journal Title

      Journal of Cardiology Cases

      Volume: 7 Pages: e91-e92

    • DOI

      10.1016/j.jccase.2012.10.011

    • Peer Reviewed
  • [Journal Article] Miglitol, α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: A randomized comparable study.2013

    • Author(s)
      Michio Shimabukuro
    • Journal Title

      International Journal of Cardiology

      Volume: in press Pages: in press

    • Peer Reviewed
  • [Journal Article] Defects of vascular nitric oxide bioavailability in subjects with impaired glucose tolerance: A potential link to insulin resistance.2013

    • Author(s)
      Michio Shimabukuro
    • Journal Title

      International Journal of Cardiology

      Volume: in press Pages: in press

    • DOI

      10.1016/j.ijcard.2012.09.194

    • Peer Reviewed
  • [Journal Article] A case of successful use of microsnare to hold and pull the retrograde guidewire for the intervention to peripheral chronic total occlusion.2013

    • Author(s)
      Tomoya Hara
    • Journal Title

      Cardiovascular Intervention and Therapeutics

      Volume: in press Pages: in press

    • DOI

      10.1007/s12928-013-0158-z

    • Peer Reviewed
  • [Journal Article] Two cases of acute myocardial infarction during combined chemotherapy in young patients with testicular cancer.2013

    • Author(s)
      Naoko Kawano
    • Journal Title

      Journal of Cardiology Cases

      Volume: in press Pages: in press

    • DOI

      10.1016/j.jccase.2013.02.009

    • Peer Reviewed
  • [Journal Article] Renin-angiotensin-aldosterone system plays a pivotal role in cognitive impairment.2013

    • Author(s)
      Shusuke Yagi
    • Journal Title

      Hypertension Research

      Volume: in press Pages: in press

    • Peer Reviewed
  • [Journal Article] Azelnidipine suppresses the progression of aortic aneurysm in wild mice model through anti-inflammatory effects.2013

    • Author(s)
      Hirotsugu Kurobe
    • Journal Title

      The Journal of Thoracic and Cardiovascular Surgery

      Volume: in press Pages: in press

    • DOI

      10.1016/j.jtcvs.2013.02.073

    • Peer Reviewed
  • [Journal Article] Ghrelin protects the heart against ischemia-induced arrhythmias by preserving connexin-43 protein.2013

    • Author(s)
      Takeshi Soeki
    • Journal Title

      Heart and Vessels

      Volume: in press Pages: in press

    • DOI

      10.1007/s00380-013-0333-2

    • Peer Reviewed
  • [Journal Article] Unique remodeling processes after vascular injury in intracranial arteries: analysis using a novel mouse model.2013

    • Author(s)
      Munehisa Shimamura
    • Journal Title

      Journal of Cerebral Blood Flow & Metabolism

      Volume: in press Pages: in press

    • DOI

      10.1038/jcbfm.2013.62.

    • Peer Reviewed
  • [Journal Article] Expanded roles of the renin-angiotensin system.2013

    • Author(s)
      Daiju Fukuda
    • Journal Title

      Hypertension Research

      Volume: in press Pages: in press

    • DOI

      10.1038/hr.2013.27

    • Peer Reviewed
  • [Journal Article] A synthetic prostacyclin agonist thrombozane synthase inhibitory activity, ONO-1301, protects myocardium from ischemia/reperfusion injury.2012

    • Author(s)
      Hirata Y, Shimabukuro M, Uematsu E, Soeki T, Yamada H, Sakai Y, Nakamura M, Matsumoto K, Igarashi T, Sata M
    • Journal Title

      Eur J Pharmacol.

      Volume: 674 Pages: 352-358.

    • DOI

      doi:10.1016/j.ejphar.2011.10.038

    • Peer Reviewed
  • [Journal Article] Nicorandil attenuates monocrotaline-induced vascular endothelial damage and pulmonary arterial hypertension.2012

    • Author(s)
      Sahara M, Sata M, Morita T, Hirata Y, Nagai R
    • Journal Title

      PLoS One

      Volume: 7 Pages: e33367.

    • DOI

      doi:10.1371/journal.pone.0033367

    • Peer Reviewed
  • [Journal Article] Aliskiren in combination with valsartan exerts synergistic protective effects against ventricular remodeling after myocardial infarction in mice.2012

    • Author(s)
      Yasutomi Higashikuni
    • Journal Title

      Hypertension Research

      Volume: 35 Pages: 62-69

    • DOI

      10.1038/hr.2011.136

    • Peer Reviewed
  • [Journal Article] The ATP-binding cassette transporter ABCG2 protects against pressure overload-induced cardiac hypertrophy and heart failure by promoting angiogenesis and antioxidant response.2012

    • Author(s)
      Yasutomi Higashikuni
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 32 Pages: 654-661

    • DOI

      10.1161/ATVBAHA.111.240341

    • Peer Reviewed
  • [Journal Article] Intensive glucose lowering in cardiovascular risk management.2012

    • Author(s)
      Michio Shimabukuro
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 593-595

    • DOI

      10.1253/circj.CJ-12-0062

    • Peer Reviewed
  • [Journal Article] Massive splenic infarction due to left ventricular apical thrombus in a patient with giant splenomegaly.2012

    • Author(s)
      Tomoya Hara
    • Journal Title

      Heart Asia

      Volume: 4 Pages: 53-53

    • DOI

      10.1136/heartasia-2011-010070

    • Peer Reviewed
  • [Journal Article] Autologous peripheral blood-derived mononuclear cells induced by erythropoietin improve critical ischemic limbs.2012

    • Author(s)
      Tamotsu Kanbara
    • Journal Title

      Annals of Vascular Surgery

      Volume: 5 Pages: 52-60

    • DOI

      10.3400/avd.oa.11.00070

    • Peer Reviewed
  • [Journal Article] Radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation.2012

    • Author(s)
      Yasuharu Watanabe
    • Journal Title

      Diabetes

      Volume: 61 Pages: 1199-1209

    • DOI

      10.2337/db11-1182

    • Peer Reviewed
  • [Journal Article] Effects of statins on cardiorenal syndrome.2012

    • Author(s)
      Shusuke Yagi
    • Journal Title

      International Journal of Vascular Medicine

      Volume: 2012 Pages: 162545

    • DOI

      10.1155/2012/162545

    • Peer Reviewed
  • [Journal Article] A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery.2012

    • Author(s)
      Hirofumi Tomiyama
    • Journal Title

      International Heart Journal

      Volume: 53 Pages: 170-175

    • DOI

      10.1536/ihj.53.170

    • Peer Reviewed
  • [Journal Article] Bicuspid aortic valve endocarditis complicated by perivalvular abscess.2012

    • Author(s)
      Tomoya Hara
    • Journal Title

      The Journal of Medical Investigation

      Volume: 59 Pages: 261-265

    • DOI

      10.2152/jmi.59.261

    • Peer Reviewed
  • [Journal Article] Gender disparities in the association between epicardial adipose tissue volume and coronary atherosclerosis: A 3-dimensional cardiac computed tomography imaging study in Japanese subjects.2012

    • Author(s)
      Munkhbaatar Dagvasumberel
    • Journal Title

      Cardiovascular Diabetology

      Volume: 11 Pages: 106-106

    • DOI

      10.1186/1475-2840-11-106

    • Peer Reviewed
  • [Journal Article] Activation of AMPK-Sirt1 pathway by telmisartan in white adipose tissue: A possible link to anti-metabolic effects.2012

    • Author(s)
      Asuka Shiota
    • Journal Title

      European Journal of Pharmacology

      Volume: 692 Pages: 84-90

    • DOI

      10.1016/j.ejphar.2012.07.026

    • Peer Reviewed
  • [Journal Article] Heparin cofactor II, a serine protease inhibitor, promotes angiogenesis via activation of the AMPK-eNOS signaling pathway.2012

    • Author(s)
      Yasumasa Ikeda
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287 Pages: 34256-34263

    • DOI

      10.1074/jbc.M112.353532

    • Peer Reviewed
  • [Journal Article] Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice.2012

    • Author(s)
      Asuka Shiota
    • Journal Title

      Cardiovascular Diabetology

      Volume: 11 Pages: 139-139

    • DOI

      10.1186/1475-2840-11-139

    • Peer Reviewed
  • [Journal Article] Index-beat Assessment of Left Ventricular Systolic and Diastolic Function during Atrial Fibrillation using Myocardial Strain and Strain Rate.2012

    • Author(s)
      Kenya Kusunose
    • Journal Title

      Journal of the American Society of Echocardiography

      Volume: 25 Pages: 953-959

    • DOI

      10.1016/j.echo.2012.06.009

    • Peer Reviewed
  • [Journal Article] Renoprotective and antioxidant effects of cilnidipine in hypertensive patients.2012

    • Author(s)
      Takeshi Soeki
    • Journal Title

      Hypertension Research

      Volume: 35 Pages: 1058-1062

    • DOI

      10.1038/hr.2012.96

    • Peer Reviewed
  • [Journal Article] Double-chambered right ventricle presenting significant outflow tract obstruction only in the right decubitus position.2012

    • Author(s)
      Shuji Hayashi
    • Journal Title

      Journal of Echocardiography

      Volume: 10 Pages: 146-147

    • DOI

      10.1007/s12574-012-0145-x

    • Peer Reviewed
  • [Journal Article] Eicosapentaenoic acid supplementation changes fatty acid composition and corrects endothelial dysfunction in hyperlipidemic patients.2012

    • Author(s)
      Ken Yamakawa
    • Journal Title

      Cardiology Research and Practice

      Volume: 2012 Pages: 754181

    • DOI

      10.1155/2012/754181

    • Peer Reviewed
  • [Journal Article] The role of epicardial adipose tissue in atrial fibrillation.2012

    • Author(s)
      Takeshi Soeki
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 2738-2739

    • DOI

      10.1253/circj.CJ-12-1283

    • Peer Reviewed
  • [Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodelling in mice.2012

    • Author(s)
      Takeya Minami
    • Journal Title

      The EMBO Journal

      Volume: 31 Pages: 4428-4440

    • DOI

      10.1038/emboj.2012.296

    • Peer Reviewed
  • [Presentation] Epicardial Adipose Tissue Volume as a Novel Determinant of Human Coronary Atherosclerosis: Role of Adipocytokine Imbalance.2013

    • Author(s)
      Michio Shimabukuro
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Eicosapentaenoic Acid Ameliorates Survival and Ventricular Remodeling after Myocardial Infarction by Reducing Inflammatory Responses in Mice.2013

    • Author(s)
      Yasutomi Higashikuni
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Relationship between NLRP3 Inflammasome Activation in Adipose Tissue and Atherosclerosis.2013

    • Author(s)
      Sachiko Bando
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Effect of Eicosapentaenoic Acid on the Stabilization of Vulnerability in Carotid Artery Plaque: Evaluation Using iPlaque® Software.2013

    • Author(s)
      Mika Bando
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Pentraxin 3 is a Local Inflammatory Marker in Atrial Fibrillation.2013

    • Author(s)
      Takeshi Soeki
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Augmentation Index Measured by Tonometry Significantly Underestimates Atrial Stiffness in Ischemic Heart Disease in Japanese Population.2013

    • Author(s)
      Shuji Hayashi
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] MicroRNA-100 Regulates Adipocytokine Expression in Subcutaneous and Visceral Adipose Tissue: An Observation from Human Biopsy Study.2013

    • Author(s)
      Masayoshi Ishida
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Genetic Ablation of TLR9 Improves Insulin Resistance through the Reduction of Hepatic SREBP-1c Expression.2013

    • Author(s)
      Daiju Fukuda
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Effects of Ezetimibe on Oxidized Cholesterol and Fatty-acid Components in Epicardial Fat and Myocardium: A Gas Chromatography-Mass Spectrometry Analysis.2013

    • Author(s)
      Michio Shimabukuro
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Effects of Tolvaptan are Predicted by Vasopressin/Aldosterone Ratio and Urine Osmolality in Patients with Chronic Heart Failure.2013

    • Author(s)
      Toshiyuki Niki
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Differentiation of Left Ventricular Systolic Dysfunction Related to Cardiac Sarcoidosis and Other Heart Diseases Using contrast-enhanced Cardiovascular Magnetic Resonance.2013

    • Author(s)
      Takashi Iwase
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Ratio of Eicosapentaenoic Acid to Arachidonic Acid is a Predictive Factor of Albuminuria and Endothelial Function in Patients with Dyslipidemia.2013

    • Author(s)
      Shusuke Yagi
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Differential Responses of Local Coagulation after Implantation of Everolimus-Eluting Stent Compared with Early-Generation Drug-Eluting Stents.2013

    • Author(s)
      Koji Yamaguchi
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Local Administration of Suramin Inhibits Angiogenesis in Adventitia and Arterial Lesion Progression in Apolipoprotein E-deficient Mice.2013

    • Author(s)
      Kimie Tanaka
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Evaluation of Right Ventricular Hypertrophy by Cardiac Magnetic Resonance is Useful for Detecting Cardiac Amyloidosis.2013

    • Author(s)
      Takayuki Ise
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Impact of Indoxyl Sulfate, a Uremic Toxin, on Non-Culprit Coronary Plaque Composition Assessed by Integrated Backscatter Intravascular Ultrasound.2013

    • Author(s)
      Koji Yamaguchi
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Macrophage-specific HIF-1a-deficient Mice Suppress Vascular Remodeling.2013

    • Author(s)
      Taisuke Nakayama
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Adaptive Servo-Ventilation Improves Symptoms and Hemodynamics in Both Patients with Systolic and Diastolic Heart Failure.2013

    • Author(s)
      Takayuki Ise
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] A Renin Inhibitor Prevents Atrial Endocardial Dysfunction in Rapidly Paced Rats with Streptozotocin-induced Diabetes.2013

    • Author(s)
      Tomomi Matuura
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20130315-20130317
  • [Presentation] Change in Ultrasonic Tissue Characteristics of Carotid Artery Plaque Reflects That of Coronary Artery Plaque.2013

    • Author(s)
      Mika Bando
    • Organizer
      ACC 2013
    • Place of Presentation
      The Moscone Center (America)
    • Year and Date
      20130309-20130311
  • [Presentation] A Pleitropic effect of N-type Ca channel blocker Up-close to the drug effect of CCB.2012

    • Author(s)
      Masataka Sata
    • Organizer
      The 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization
    • Place of Presentation
      あわぎんホール (徳島県)
    • Year and Date
      20121205-20121207
    • Invited
  • [Presentation] Angiogenesis in atherosclerosis.2012

    • Author(s)
      Kimie Tanaka
    • Organizer
      The 20th Annual Meeting of the Japanese Vascular Biology and Medicine Organization
    • Place of Presentation
      あわぎんホール (徳島県)
    • Year and Date
      20121205-20121207
  • [Presentation] 慢性炎症と心不全2012

    • Author(s)
      佐田政隆
    • Organizer
      第16回日本心不全学会学術集会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Year and Date
      20121130-20121202
    • Invited
  • [Presentation] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Heart Failure.2012

    • Author(s)
      Takayuki Ise
    • Organizer
      第16回日本心不全学会学術集会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Year and Date
      20121130-20121202
  • [Presentation] Prediction of Responder and Influence for Cardio-Renal Interaction by Tolvaptan in Patients with Chronic Heart Failure.2012

    • Author(s)
      Muneyuki Kadota
    • Organizer
      第16回日本心不全学会学術集会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Year and Date
      20121130-20121202
  • [Presentation] Ghrelin protects the heart against ischemia-induced arrhythmias by modulating autonomic nerve activity.2012

    • Author(s)
      Takeshi Soeki
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Relationship Between Nlrp3 Inflammasome and Coronary Atherosclerosis.2012

    • Author(s)
      Sachiko Bando
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Locally Applied Suramin inhibits Angiogenesis in Adventitia and Arterial Lesion Progression in Apolipoprotein E-deficient Mice.2012

    • Author(s)
      Kimie Tanaka
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Cardiac Rehabilitation Reduces Levels of Oxidized LDL.2012

    • Author(s)
      Akira Takashima
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] The Innate Immune System, Nlrp3 Inflammasome is Intensified in Epicardial Adipose Tissue around Coronary Arterial Lesions: Evidence from Biopsied Adipose Tissue in Coronary Artery Bypass Surgery.2012

    • Author(s)
      Hiromi Sato
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Acute Hemodynamic Effects of Adaptive Servo-Ventilation in Patients with Chronic Left Heart Failure.2012

    • Author(s)
      Takayuki Ise
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Effects of Additional Eicosapentaenoic Acid to Statin Therapy on Inflammatory Cytokines and the Tissue Characterization of Coronary Plaque Assessed by Integrated Backscatter Intravascular Ultrasound Systems.2012

    • Author(s)
      Toshiyuki Niki
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Low Left Ventircular Contractile Capacity and Low eGFR Are Significant Predictors for Hyperkalemia in 364 Patients with Heart Failure.2012

    • Author(s)
      Michio Shimabukuro
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Telmisartan Reduces Coronary Plaque Vulnerability and Instent-neointimal Proliferation in Hypertensive Patients.2012

    • Author(s)
      Yasutomi Higashikuni
    • Organizer
      AHA Scientific Sessions 2012
    • Place of Presentation
      Los Angeles Convention Center (America)
    • Year and Date
      20121103-20121107
  • [Presentation] Inflammation in atherosclerosis and adipose tissue.2012

    • Author(s)
      Masataka Sata
    • Organizer
      The 12th Biennial International Endotoxin & Innate Immunity Society (IEIIS) Meeting 2012
    • Place of Presentation
      学術総合センター (東京都)
    • Year and Date
      20121023-20121026
    • Invited
  • [Presentation] 血管機能診断法2012

    • Author(s)
      佐田政隆
    • Organizer
      第53回日本脈管学会総会
    • Place of Presentation
      東京ステーションコンファレンス (東京都)
    • Year and Date
      20121011-20121013
    • Invited
  • [Presentation] Metabolic Syndrome and Atherosclerosis.2012

    • Author(s)
      Masataka Sata
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル (愛知県)
    • Year and Date
      20120920-20120922
    • Invited
  • [Presentation] 高脂血症から心臓を守る2012

    • Author(s)
      佐田政隆
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      石川県立音楽堂 (石川県)
    • Year and Date
      20120914-20120916
    • Invited
  • [Presentation] 動脈硬化と異所性脂肪2012

    • Author(s)
      佐田政隆
    • Organizer
      第3回Molecular Cardiovascular Conference II
    • Place of Presentation
      ホテルピアノ (北海道)
    • Year and Date
      20120907-20120909
    • Invited
  • [Presentation] The tissue characteristics of coronary plaque with microchannel structure in patients with Coronary Artery Disease assessed by OCT and IB-IVUS.2012

    • Author(s)
      Kimie Tanaka
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      メッセ ミュンヘン (Germany)
    • Year and Date
      20120825-20120829
  • [Presentation] Gender disparities in the association of epicardial adipose tissue volume and coronary atherosclerosis: a 256-slice multidetector computed tomography study.2012

    • Author(s)
      Munkhbaatar Dagvasumberel
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      メッセ ミュンヘン (Germany)
    • Year and Date
      20120825-20120829
  • [Presentation] Region-specific regulation of the innate immune system, NLRP3 inflammasome, in human abdominal adipose tissue.2012

    • Author(s)
      Hiromi Sato
    • Organizer
      ESC Congress 2012
    • Place of Presentation
      メッセ ミュンヘン (Germany)
    • Year and Date
      20120825-20120829
  • [Presentation] Adventitial angiogenesis plays an important role in the pathogenesis of atherosclerosis.2012

    • Author(s)
      Masataka Sata
    • Organizer
      第33回日本炎症・再生医学会
    • Place of Presentation
      ホテル日航福岡 (福岡県)
    • Year and Date
      20120705-20120706
    • Invited
  • [Presentation] Non-invasive Assessment of Left Atrial-Left Ventricular-Arterial Coupling in Patients With Diabetes Mellitus.2012

    • Author(s)
      Susumu Nishio
    • Organizer
      American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
    • Place of Presentation
      Gayload National (America)
    • Year and Date
      20120630-20120703
  • [Presentation] Efficacy of Six-minute Walk Stress Echocardiography for Detection of Pulmonary Arterial Hypertension in Patients With Connective Tissue Disease.2012

    • Author(s)
      Junko Hotchi
    • Organizer
      American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
    • Place of Presentation
      Gayload National (America)
    • Year and Date
      20120630-20120703
  • [Presentation] Effect of Statin Therapy on Regression of Carotid Artery Plaque Assessed by High-Resolution Color Mapping Method Based on Integrated Backscatter.2012

    • Author(s)
      Mika Bando
    • Organizer
      American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
    • Place of Presentation
      Gayload National (America)
    • Year and Date
      20120630-20120703
  • [Presentation] Differentiation Between Hypertrophic Cardiomyopathy and Hypertensive Heart Disease Using Tricuspid Annular Motion Velocity.2012

    • Author(s)
      Shuji Hayashi
    • Organizer
      American Society of Echocardiography (ASE) 23rd Annual Scientific Sessions
    • Place of Presentation
      Gayload National (America)
    • Year and Date
      20120630-20120703
  • [Presentation] 合成低分子化合物による内因性増殖因子発現誘導と循環器疾患の治療への応用2012

    • Author(s)
      佐田政隆
    • Organizer
      第11回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Year and Date
      20120612-20120614
    • Invited
  • [Presentation] Epicardial adipose tissue plays a role in the pathogenesis of Atherosclerosis.2012

    • Author(s)
      Masataka Sata
    • Organizer
      APSC Subspecialty Congress-Intervention and Imaging 2012
    • Place of Presentation
      Taipei International Convention Center (Taiwan)
    • Year and Date
      20120504-20120506
    • Invited
  • [Book] Annual Review 循環器2013(編集 小室一成、佐地勉、坂田隆造、赤阪隆史) (5. 動脈硬化とアレルギー・炎症 共著)2013

    • Author(s)
      田中君枝
    • Total Pages
      288
    • Publisher
      中外医学社
  • [Book] エビデンスに基づく循環器病予防医学-慢性心不全を防ぐ予防戦略とは?-(和泉徹 監修) (第II章 8 トランスレーショナルリサーチに期待する予防医学 共著)2012

    • Author(s)
      田中君枝
    • Total Pages
      417
    • Publisher
      南山堂
  • [Book] 循環器疾患 最新の治療2012-2013(堀正二、永井良三 編集) (心臓病と肥満-メタボリックシンドロームを中心に- 共著)2012

    • Author(s)
      島袋充生
    • Total Pages
      604
    • Publisher
      南江堂
  • [Book] EBM循環器疾患の治療 2012-2013 (小室一成、横井宏佳、山下武志、楽木宏実 編集) (6. 不安定プラーク破裂に関与する因子は何か? 共著)2012

    • Author(s)
      山口浩司
    • Total Pages
      424
    • Publisher
      中外医学社
  • [Book] 増刊 レジデントノート 循環器診療の疑問、これで納得!(村上裕二 編集) (第2章 7. むずかしくてイヤになる動脈硬化のサイエンス 共著)2012

    • Author(s)
      添木武
    • Total Pages
      244
    • Publisher
      羊土社
  • [Book] 今日の循環器疾患治療指針 第3版(編集 井上博、許俊鋭、檜垣實男、代田浩之、筒井裕之) (4. 治療薬総論 硝酸薬 共著)2012

    • Author(s)
      竹谷善雄
    • Total Pages
      938
    • Publisher
      医学書院
  • [Remarks] 徳島大学大学院ヘルスバイオサイエンス研究部循環器内科学

    • URL

      http://square.umin.ac.jp/~TOKUSHIM/

URL: 

Published: 2014-07-24  

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